Association of Serotonin Transporter (SERT) Polymorphisms with Opioid Dependence and Dimensional Aspects of Cocaine Use in a Caucasian Cohort of Opioid Users

References

• Kirby LG, Zeeb FD, Winstanley CA. Contributions of serotonin in addiction vulnerability. Neuropharmacology. 2011;61(3):421–432. doi:10.1016/j.neuropharm.2011.03.02221466815
   PubMed Web of Science ®Google Scholar
• Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science. 1987;237(4819):1219–1223. doi:10.1126/science.28200582820058
   PubMed Web of Science ®Google Scholar
• Verheij MMM, Contet C, Karel P, et al. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry. 2018;83(12):1024–1035. doi:10.1016/j.biopsych.2017.10.03129357981
   PubMed Web of Science ®Google Scholar
• Han DD, Gu HH. Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacol. 2006;6:6. doi:10.1186/1471-2210-6-616515684
   PubMedGoogle Scholar
• Tao R, Ma Z, Auerbach SB. Alteration in regulation of serotonin release in rat dorsal raphe nucleus after prolonged exposure to morphine. J Pharmacol Exp Ther. 1998;286(1):481–488.9655893
   PubMed Web of Science ®Google Scholar
• Mash DC, Staley JK, Izenwasser S, Basile M, Ruttenber AJ. Serotonin transporters upregulate with chronic cocaine use. J Chem Neuroanat. 2000;20(3–4):271–280. doi:10.1016/S0891-0618(00)00102-211207425
   PubMed Web of Science ®Google Scholar
• Caffino L, Verheij MMM, Que L, Guo C, Homberg JR, Fumagalli F. Increased cocaine self-administration in rats lacking the serotonin transporter: a role for glutamatergic signaling in the habenula. Addict Biol. 2019;24(6):1167–1178. doi:10.1111/adb.1267330144237
   PubMed Web of Science ®Google Scholar
• Oliva JM, Urigüen L, Pérez-Rial S, Manzanares J. Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brain. Neuropharmacology. 2005;49(5):618–626. doi:10.1016/j.neuropharm.2005.04.01415936043
   PubMed Web of Science ®Google Scholar
• Valenza M, Butelman ER, Kreek MJ. Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats. Psychopharmacology. 2017;66(6):2621–2624. doi:10.1007/s00213-017-4647-0
   Web of Science ®Google Scholar
• Valenza M, Windisch KA, Butelman ER, Reed B, Kreek MJ. Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat. Psychopharmacology. 2020;237(4):1147–1160. doi:10.1007/s00213-019-05444-431915862
   PubMed Web of Science ®Google Scholar
• Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274(5292):1527–1531. doi:10.1126/science.274.5292.15278929413
   PubMed Web of Science ®Google Scholar
• Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet. 1997;101(2):243–246. doi:10.1007/s0043900506249402979
   PubMed Web of Science ®Google Scholar
• Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996;66(6):2621–2624. doi:10.1046/j.1471-4159.1996.66062621.x8632190
   PubMed Web of Science ®Google Scholar
• Little KY, McLaughlin DP, Zhang L, et al. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry. 1998;155(2):207–213. doi:10.1176/ajp.155.2.2079464199
   PubMed Web of Science ®Google Scholar
• Odgerel Z, Talati A, Hamilton SP, Levinson DF, Weissman MM. Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European- and African-American subjects from the National Institute of Mental Health’s Collaborative Center for Genomic Studies. Transl Psychiatry. 2013;3(9):e307. doi:10.1038/tp.2013.8024064711
   PubMed Web of Science ®Google Scholar
• Patriquin MA, Hamon SC, Harding MJ, et al. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatr Genet. 2017;27(5):178–186. doi:10.1097/ypg.000000000000017828590957
   PubMed Web of Science ®Google Scholar
• Vergne DE, Nemeroff CB. The interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depression. Curr Psychiatry Rep. 2006;8(6):452–457. doi:10.1007/s11920-006-0050-y17094925
   PubMedGoogle Scholar
• Gelernter J. SLC6A4 polymorphism, population genetics, and psychiatric traits. Hum Genet. 2014;133(4):459–461. doi:10.1007/s00439-013-1412-224385047
   PubMed Web of Science ®Google Scholar
• Lovallo WR, Enoch MA, Yechiam E, et al. Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res. 2014;38(6):1575–1581. doi:10.1111/acer.1241224796636
   PubMed Web of Science ®Google Scholar
• Lin PY, Wu YS. Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study. Neuropsychiatr Dis Treat. 2016;12:3061–3067. doi:10.2147/NDT.S12078627942217
   PubMed Web of Science ®Google Scholar
• Bauer IE, Graham DP, Soares JC, Nielsen DA. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. 2015;16(11):1307–1314. doi:10.2217/pgs.15.7226265436
   PubMed Web of Science ®Google Scholar
• Cao J, Hudziak JJ, Multi-Cultural LD. Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder. Neuropsychopharmacol. 2013;38(9):1737–1747. doi:10.1038/npp.2013.73
   Web of Science ®Google Scholar
• Gerra G, Garofano L, Santoro G, et al. Association between low-activity serotonin transporter genotype and heroin dependence: behavioral and personality correlates. Comparative Study. Am j Med Genetics Part B Neuropsychiatric Genetics. 2004;126B(1):37–42. doi:10.1002/ajmg.b.2011115048645
   PubMed Web of Science ®Google Scholar
• Tristan-Noguero A, Fernandez-Castillo N, Roncero C, et al. Lack of association between the LPR and VNTR polymorphisms of the serotonin transporter gene and cocaine dependence in a Spanish sample. Psychiatry Res. 2013;210(3):1287–1289. doi:10.1016/j.psychres.2013.09.00424120036
   PubMed Web of Science ®Google Scholar
• Patkar AA, Berrettini WH, Hoehe M, et al. No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals. Psychiatr Genet. 2002;12(3):161–164. doi:10.1097/00041444-200209000-0000712218660
   PubMed Web of Science ®Google Scholar
• Leri F, Stewart J, Fischer B, et al. Patterns of opioid and cocaine co-use: a descriptive study in a Canadian sample of untreated opioid-dependent individuals. Exp Clin Psychopharmacol. 2005;13(4):303–310. doi:10.1037/1064-1297.13.4.30316366760
   PubMed Web of Science ®Google Scholar
• McCall Jones C, Baldwin GT, Compton WM. Recent Increases in Cocaine-Related Overdose Deaths and the Role of Opioids. Am J Public Health. 2017;107(3):430–432. doi:10.2105/ajph.2016.30362728177817
   PubMed Web of Science ®Google Scholar
• Wang L, Min JE, Krebs E, et al. Polydrug use and its association with drug treatment outcomes among primary heroin, methamphetamine, and cocaine users. Int J Drug Policy. 2017;49:32–40. doi:10.1016/j.drugpo.2017.07.00928888099
   PubMed Web of Science ®Google Scholar
• Sloan ME, Gowin JL, Yan J, et al. Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. Addict Biol. 2017;23(1):474–484. doi:10.1111/adb.1249128150397
   PubMed Web of Science ®Google Scholar
• Jackson CB, Varon J, Ho A, Marks KM, Talal AH, Kreek MJ. Identification of substance use and dependence among patients with viral hepatitis. Digestive Liver Dis. 2010;42(9):650–656. doi:10.1016/j.dld.2010.03.002
   Web of Science ®Google Scholar
• Mantsch JR, Yuferov V, Mathieu-Kia AM, Ho A, Kreek MJ. Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Comparative Study Research Support, U.S. Gov’t, P.H.S. Psychopharmacology. 2004;175(1):26–36. doi:10.1007/s00213-004-1778-x15042275
   PubMed Web of Science ®Google Scholar
• Zernig G, Ahmed SH, Cardinal RN, et al. Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests. Pharmacology. 2007;80(2–3):65–119. doi:10.1159/00010392317570954
   PubMed Web of Science ®Google Scholar
• Butelman ER, Chen CY, Brown KG, Kreek MJ. Escalation of drug use in persons dually diagnosed with opioid and cocaine dependence: gender comparison and dimensional predictors. Drug Alcohol Depend. 2019;205:107657. doi:10.1016/j.drugalcdep.2019.10765731698322
   PubMed Web of Science ®Google Scholar
• Blanken P, van den Brink W, Hendriks VM, et al. Heroin-assisted treatment in the Netherlands: history, findings, and international context. Eur neuropsychopharmacol. 2010;20(Suppl 2):S105. doi:10.1016/S0924-977X(10)70001-820362236
   PubMed Web of Science ®Google Scholar
• Zaaijer ER, Bruijel J, Blanken P, et al. van den Brink W. Personality as a risk factor for illicit opioid use and a protective factor for illicit opioid dependence. Drug Alcohol Depend. 2014;145:101–105. doi:10.1016/j.drugalcdep.2014.09.78325454407
   PubMed Web of Science ®Google Scholar
• Randesi M, van den Brink W, Levran O, et al. Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence. Drug Alcohol Depend. 2016;168:164–169. doi:10.1016/j.drugalcdep.2016.08.63427664554
   PubMed Web of Science ®Google Scholar
• Yuferov V, Randesi M, Butelman ER, et al. Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: effect on age trajectory of heroin use. Neurosci Lett. 2019;704:100–105. doi:10.1016/j.neulet.2019.03.03830936032
   PubMed Web of Science ®Google Scholar
• Butelman ER, Chen CY, Fry RS, Kimani R, Levran O, Ott J. Correa da Rosa J, Kreek MJ. Re-evaluation of the KMSK scales, rapid dimensional measures of self-exposure to specific drugs: gender-specific features. Drug Alcohol Depend. 2018;190:179–187. doi:10.1016/j.drugalcdep.2018.05.02830041093
   PubMed Web of Science ®Google Scholar
• Kellogg SH, McHugh PF, Bell K, et al. The Kreek-McHugh-Schluger-Kellogg scale: a new, rapid method for quantifying substance abuse and its possible applications. Drug Alcohol Depend. 2003;69(2):137–150. doi:10.1016/S0376-8716(02)00308-312609695
   PubMed Web of Science ®Google Scholar
• Crystal HA, Hamon S, Randesi M, et al. A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African American women. Research Support, N.I.H., Extramural. Addict Biol. 2012;17(1):181–191. doi:10.1111/j.1369-1600.2010.00265.x21070507
   PubMed Web of Science ®Google Scholar
• Yuferov V, Butelman ER, Kreek MJ. Gender-specific association of functional prodynorphin 68 bp repeats with cannabis exposure in an African American cohort. Neuropsychiatr Dis Treat. 2018;14:1025–1034. doi:10.2147/NDT.S15995429713172
   PubMed Web of Science ®Google Scholar
• Levran O, Awolesi O, Shen PH, Adelson M, Kreek MJ. Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations. Hum Genomics. 2012;6(1):2. doi:10.1186/1479-7364-6-223244743
   PubMed Web of Science ®Google Scholar
• Ducci F, Roy A, Shen PH, et al. Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. Am J Psychiatry. 2009;166(9):1031–1040. doi:10.1176/appi.ajp.2009.0807106819605534
   PubMed Web of Science ®Google Scholar
• Levran O, Londono D, O’Hara K, et al. Genetic susceptibility to heroin addiction: a candidate gene association study. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t. Genes Brain Behav. 2008;7(7):720–729. doi:10.1111/j.1601-183X.2008.00410.x18518925
   PubMed Web of Science ®Google Scholar
• Sasieni PD. From genotypes to genes: doubling the sample size. Biometrics. 1997;53(4):1253–1261. doi:10.2307/25334949423247
   PubMed Web of Science ®Google Scholar
• Randesi M, van den Brink W, Levran O, et al. VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence. Pharmacogenomics. 2019;20(5):331–341. doi:10.2217/pgs-2018-013730983500
   PubMed Web of Science ®Google Scholar
• Randesi M, Levran O, den Brink WV, et al. Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence. Pharmacogenomics. 2020;21(13):903–917. doi:10.2217/pgs-2020-004532757697
   PubMed Web of Science ®Google Scholar
• Randesi M, van den Brink W, Levran O, et al. Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls. Pharmacogenomics. 2018;19(2):95–104. doi:10.2217/pgs-2017-013429210332
   PubMed Web of Science ®Google Scholar
• Kellogg SH, McHugh PF, Bell K, et al. The Kreek-McHugh-Schluger-Kellogg scale: a new, rapid method for quantifying substance abuse and its possible applications. Drug Alcohol Depend. 2003;69(2):137–150. doi:10.1016/s0376-8716(02)00308-312609695
   PubMed Web of Science ®Google Scholar
• Tang YL, Khoury L, Bradley B, Gillespie CF, Ressler KJ, Cubells JF. Substance use disorders assessed using the Kreek-McHugh-Schluger-Kellogg (KMSK) scale in an urban low-income and predominantly African American sample of primary care patients. Am j Addictions. 2011;20(3):292–299. doi:10.1111/j.1521-0391.2011.00121.x
   PubMed Web of Science ®Google Scholar
• Butelman ER, Chen CY, Fry RS, Kimani R, Levran O, Ott J. Re-evaluation of the KMSK scales, rapid dimensional measures of self-exposure to specific drugs: gender-specific features. Drug Alcohol Depend. 2018;190:179–187. doi:10.1016/j.drugalcdep.2018.05.02830041093
   PubMed Web of Science ®Google Scholar
• Ducci F, Goldman D. The genetic basis of addictive disorders. Psychiatr Clin North Am. 2012;35(2):495–519. doi:10.1016/j.psc.2012.03.01022640768
   PubMed Web of Science ®Google Scholar
• Goldman D, Oroszi G, Ducci F. The genetics of addictions: uncovering the genes. Nat Rev Genet. 2005;6(7):521–532. doi:10.1038/nrg163515995696
   PubMed Web of Science ®Google Scholar
• Wendland JR, Moya PR, Kruse MR, et al. A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet. 2008;17(5):717–723. doi:10.1093/hmg/ddm34318055562
   PubMed Web of Science ®Google Scholar
• Morey RA, Hariri AR, Gold AL, et al. Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder. BMC Psychiatry. 2011;11(1):76. doi:10.1186/1471-244x-11-7621545724
   PubMed Web of Science ®Google Scholar
• Chen YC, Prescott CA, Walsh D, et al. Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. J Stud Alcohol Drugs. 2011;72(5):752–762. doi:10.15288/jsad.2011.72.75221906503
   PubMed Web of Science ®Google Scholar
• Mantsch JR, Ho A, Schlussman SD, Kreek MJ. Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose-dependent. Research Support, U.S. Gov’t, P.H.S. Psychopharmacology. 2001;157(1):31–39. doi:10.1007/s00213010074411512040
   PubMed Web of Science ®Google Scholar
• Koob GF, Ahmed SH, Boutrel B, et al. Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci Biobehav Rev. 2004;27(8):739–749. doi:10.1016/j.neubiorev.2003.11.00715019424
   PubMed Web of Science ®Google Scholar
• Fagergren P, Smith HR, Daunais JB, Nader MA, Porrino LJ, Hurd YL. Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration. Eur J Neurosci. 2003;17(10):2212–2218. doi:10.1046/j.1460-9568.2003.02636.x12786988
   PubMed Web of Science ®Google Scholar
• Valenza M, Picetti R, Yuferov V, Butelman ER, Kreek MJ. Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration. Neuropharmacology. 2016;105:639–650. doi:10.1016/j.neuropharm.2016.01.00426777278
   PubMed Web of Science ®Google Scholar
• Calipari ES, Beveridge TJ, Jones SR, Porrino LJ. Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. Eur J Neurosci. 2013;38(12):3749–3757. doi:10.1111/ejn.1238124118121
   PubMed Web of Science ®Google Scholar