MicroRNA-9-3p Aggravates Cerebral Ischemia/Reperfusion Injury by Targeting Fibroblast Growth Factor 19 (FGF19) to Inactivate GSK-3β/Nrf2/ARE Signaling

References

• Kim T, Mehta SL, Morris-Blanco KC, et al. The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein. Sci Signal. 2018;11. doi:10.1126/scisignal.aat4285
   Web of Science ®Google Scholar
• Zuo G, Zhang D, Mu R, et al. Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats. Mol Brain. 2018;11(1):9. doi:10.1186/s13041-018-0351-129439730
   PubMed Web of Science ®Google Scholar
• Galkin A. Brain ischemia/reperfusion injury and mitochondrial complex I damage. Biochemistry. 2019;84(11):1411–1423. doi:10.1134/s000629791911015431760927
   PubMed Web of Science ®Google Scholar
• Stegner D, Klaus V, Nieswandt B. Platelets as modulators of cerebral ischemia/reperfusion injury. Front Immunol. 2019;10:2505. doi:10.3389/fimmu.2019.0250531736950
   PubMed Web of Science ®Google Scholar
• Yang Q, Huang Q, Hu Z, Tang X. Potential neuroprotective treatment of stroke: targeting excitotoxicity, oxidative stress, and inflammation. Front Neurosci. 2019;13:1036. doi:10.3389/fnins.2019.0103631611768
   PubMed Web of Science ®Google Scholar
• Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141:1202–1207. doi:10.1016/j.jaci.2017.08.03429074454
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215–233. doi:10.1016/j.cell.2009.01.00219167326
   PubMed Web of Science ®Google Scholar
• Morgado AL, Rodrigues CMP, Solá S. MicroRNA-145 regulates neural stem cell differentiation through the Sox2-Lin28/let-7 signaling pathway. Stem Cells. 2016;34(5):1386–1395. doi:10.1002/stem.230926849971
   PubMed Web of Science ®Google Scholar
• Kumar S, Vijayan M, Reddy PH. MicroRNA-455-3p as a potential peripheral biomarker for alzheimer’s disease. Hum Mol Genet. 2017;26(19):3808–3822. doi:10.1093/hmg/ddx26728934394
   PubMed Web of Science ®Google Scholar
• Sun H, Zhong D, Wang C, et al. MiR-298 exacerbates ischemia/reperfusion injury following ischemic stroke by targeting act1. Cell Physiol Biochem. 2018;48(2):528–539. doi:10.1159/00049181030021197
   PubMedGoogle Scholar
• Zheng T, Shi Y, Zhang J, et al. MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway. Biomed Pharmacother. 2019;117:109117. doi:10.1016/j.biopha.2019.10911731226635
   PubMed Web of Science ®Google Scholar
• Bache S, Rasmussen R, Wolcott Z, et al. Elevated miR-9 in cerebrospinal fluid is associated with poor functional outcome after subarachnoid hemorrhage. Transl Stroke Res. 2020;11(6):1243–1252. doi:10.1007/s12975-020-00793-132248435
   PubMed Web of Science ®Google Scholar
• O’Connell GC, Smothers CG, Winkelman C. Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers. Brain Injury. 2020;34(7):965–974. doi:10.1080/02699052.2020.176410232497449
   PubMed Web of Science ®Google Scholar
• Sørensen SS, Nygaard A-B, Carlsen AL, et al. Elevation of brain-enriched miRNAs in cerebrospinal fluid of patients with acute ischemic stroke. Biomarker Res. 2017;5(1):24. doi:10.1186/s40364-017-0104-9
   Web of Science ®Google Scholar
• Rodrigo R, Fernandez-Gajardo R, Gutierrez R, et al. Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS & neurological disorders. Drug Targets. 2013;12(5):698–714. doi:10.2174/1871527311312050015
   Google Scholar
• Fang Y, Zhao Y, He S, et al. Overexpression of FGF19 alleviates hypoxia/reoxygenation-induced injury of cardiomyocytes by regulating GSK-3β/Nrf2/ARE signaling. Biochem Biophys Res Commun. 2018;503(4):2355–2362. doi:10.1016/j.bbrc.2018.06.16129964017
   PubMed Web of Science ®Google Scholar
• Leroy K, Brion JP. Developmental expression and localization of glycogen synthase kinase-3beta in rat brain. J Chem Neuroanat. 1999;16:279–293. doi:10.1016/s0891-0618(99)00012-510450875
   PubMed Web of Science ®Google Scholar
• Satoh T, Okamoto S-I, Cui J, et al. Activation of the keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] Phase II inducers. Proc Natl Acad Sci U S A. 2006;103(3):768–773. doi:10.1073/pnas.050572310216407140
   PubMed Web of Science ®Google Scholar
• Salazar M, Rojo AI, Velasco D, de Sagarra RM, Cuadrado A. Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. J Biol Chem. 2006;281:14841–14851. doi:10.1074/jbc.M51373720016551619
   PubMed Web of Science ®Google Scholar
• Leng Y, Liang M-H, Ren M, et al. Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition. J Neurosci. 2008;28(10):2576–2588. doi:10.1523/jneurosci.5467-07.200818322101
   PubMed Web of Science ®Google Scholar
• Pang T, Wang Y-J, Gao Y-X, et al. A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway. Acta Pharmacol Sin. 2016;37(6):741–752. doi:10.1038/aps.2016.327108601
   PubMed Web of Science ®Google Scholar
• Yang X, Ji H, Yao Y, et al. Downregulation of circ_008018 protects against cerebral ischemia–reperfusion injury by targeting miR-99a. Biochem Biophys Res Commun. 2018;499(4):758–764. doi:10.1016/j.bbrc.2018.03.21829605297
   PubMed Web of Science ®Google Scholar
• Wu N, Zhang X, Bao Y, et al. Down-regulation of GAS5 ameliorates myocardial ischaemia/reperfusion injury via the miR-335/ROCK1/AKT/GSK-3β axis. J Cell Mol Med. 2019;23(12):8420–8431. doi:10.1111/jcmm.1472431625671
   PubMed Web of Science ®Google Scholar
• Dong W, Xie F, Chen X-Y, et al. Inhibition of Smurf2 translation by miR-322/503 protects from ischemia-reperfusion injury by modulating EZH2/Akt/GSK3β signaling. Am J Physiol Cell Physiol. 2019;317(2):C253–C261. doi:10.1152/ajpcell.00375.201830649914
   PubMed Web of Science ®Google Scholar
• Zeng J, Zhu L, Liu J, Zhu T, Xie Z. Metformin protects against oxidative stress injury induced by ischemia/reperfusion via regulation of the lncRNA-H19/miR-148a-3p/Rock2 axis. Oxid Med Cell Longev. 2019;2019:8768327. doi:10.1155/2019/876832731934270
   PubMed Web of Science ®Google Scholar
• Papadakis M, Hadley G, Xilouri M, et al. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med. 2013;19(3):351–357. doi:10.1038/nm.309723435171
   PubMed Web of Science ®Google Scholar
• Clark WM, Lessov NS, Dixon MP, Eckenstein F. Monofilament intraluminal middle cerebral artery occlusion in the mouse. Neurol Res. 1997;19(6):641–648. doi:10.1080/01616412.1997.117408749427967
   PubMed Web of Science ®Google Scholar
• Ma C, Wang X, Xu T, et al. Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 inflammasome signalling pathway. BMC Complement Altern Med. 2019;19(1):320. doi:10.1186/s12906-019-2703-531747940
   PubMed Web of Science ®Google Scholar
• Cheng F, Zhong X, Lu Y, et al. Refined qingkailing protects MCAO mice from endoplasmic reticulum stress-induced apoptosis with a broad time window. Evid Based Complement Alternat Med. 2012;2012:567872. doi:10.1155/2012/56787222536287
   PubMed Web of Science ®Google Scholar
• Sun X, Wang D, Zhang T, et al. Eugenol attenuates cerebral ischemia-reperfusion injury by enhancing autophagy via AMPK-mTOR-P70S6K pathway. Front Pharmacol. 2020;11:84. doi:10.3389/fphar.2020.0008432153404
   PubMed Web of Science ®Google Scholar
• Wang C, Pan Y, Cheng B, Chen J, Bai B. Identification of conserved and novel microRNAs in cerebral ischemia-reperfusion injury of rat using deep sequencing. J Mol Neurosci. 2014;54(4):671–683. doi:10.1007/s12031-014-0383-725063377
   PubMed Web of Science ®Google Scholar
• Tang J, Li Y, Liu K, et al. Exosomal miR-9-3p suppresses HBGF-5 expression and is a functional biomarker in hepatocellular carcinoma. Minerva Med. 2018;109(1):15–23. doi:10.23736/s0026-4806.17.05167-928750499
   PubMed Web of Science ®Google Scholar
• Meng Q, Xiang L, Fu J, et al. Transcriptome profiling reveals miR-9-3p as a novel tumor suppressor in gastric cancer. Oncotarget. 2017;8(23):37321–37331. doi:10.18632/oncotarget.1631028418879
   PubMedGoogle Scholar
• Cai H, Yang X, Gao Y, et al. Exosomal MicroRNA-9-3p secreted from BMSCs downregulates ESM1 to suppress the development of bladder cancer. Mol Ther Nucleic Acids. 2019;18:787–800. doi:10.1016/j.omtn.2019.09.02331734559
   PubMedGoogle Scholar
• Ding Y, Pan Y, Liu S, Jiang F, Jiao J. Elevation of MiR-9–3p suppresses the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via down-regulating FN1, ITGB1 and ITGAV. Cancer Biol Ther. 2017;18(6):414–424. doi:10.1080/15384047.2017.132358528613134
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang S, Zhao R, Zhao Q, Zhang T. Upregulated miR-9-3p promotes cell growth and inhibits apoptosis in medullary thyroid carcinoma by targeting BLCAP. Oncol Res. 2017;25:1215–1222. doi:10.3727/096504016x1479171535595727938505
   PubMed Web of Science ®Google Scholar
• Yang L, Mu Y, Cui H, Liang Y, Su X, Roemer K. MiR-9-3p augments apoptosis induced by H2O2 through down regulation of herpud1 in glioma. PLoS One. 2017;12(4):e0174839. doi:10.1371/journal.pone.017483928430789
   PubMed Web of Science ®Google Scholar
• Higashi T, Hayashi H, Ishimoto T, et al. miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells. Br J Cancer. 2015;113(2):252–258. doi:10.1038/bjc.2015.17026125451
   PubMed Web of Science ®Google Scholar
• Li Y, Zhao L, Li N, et al. miR-9 regulates the multidrug resistance of chronic myelogenous leukemia by targeting ABCB1. Oncol Rep. 2017;37(4):2193–2200. doi:10.3892/or.2017.546428260112
   PubMed Web of Science ®Google Scholar
• Yan Q, Sun SY, Yuan S, Wang XQ, Zhang ZC. Inhibition of microRNA-9-5p and microRNA-128-3p can inhibit ischemic stroke-related cell death in vitro and in vivo. IUBMB Life. 2020;72(11):2382–2390. doi:10.1002/iub.235732797712
   PubMed Web of Science ®Google Scholar
• Krichevsky AM, Sonntag K-C, Isacson O, Kosik KS. Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells. 2006;24(4):857–864. doi:10.1634/stemcells.2005-044116357340
   PubMed Web of Science ®Google Scholar
• Qi X, Zhang D-H, Wu N, et al. ceRNA in cancer: possible functions and clinical implications. J Med Genet. 2015;52(10):710–718. doi:10.1136/jmedgenet-2015-10333426358722
   PubMed Web of Science ®Google Scholar
• Minutoli L, Puzzolo D, Rinaldi M, et al. ROS-mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia/reperfusion injury. Oxid Med Cell Longev. 2016;2016:2183026. doi:10.1155/2016/218302627127546
   PubMed Web of Science ®Google Scholar
• Bougioukas I, Didilis V, Emmert A, et al. Apigenin reduces NF-κB and subsequent cytokine production as protective effect in a rodent animal model of lung ischemia-reperfusion injury. J Invest Surg. 2018;31(2):96–106. doi:10.1080/08941939.2017.129651228340319
   PubMed Web of Science ®Google Scholar
• Shimizu S, Tsounapi P, Dimitriadis F, et al. Testicular torsion-detorsion and potential therapeutic treatments: a possible role for ischemic postconditioning. Int J Urol. 2016;23(6):454–463. doi:10.1111/iju.1311027217335
   PubMed Web of Science ®Google Scholar
• Hu Q, Ren J, Li G, et al. The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway. Cell Death Dis. 2018;9(3):403. doi:10.1038/s41419-018-0436-x29540694
   PubMed Web of Science ®Google Scholar
• Shen Y, Chen S, Zhao Y. Sulfiredoxin-1 alleviates high glucose-induced podocyte injury though promoting Nrf2/ARE signaling via inactivation of GSK-3β. Biochem Biophys Res Commun. 2019;516(4):1137–1144. doi:10.1016/j.bbrc.2019.06.15731284950
   PubMed Web of Science ®Google Scholar
• Liu Y, Cao M, Cai Y, et al. Dissecting the role of the FGF19-FGFR4 signaling pathway in cancer development and progression. Front Cell Dev Biol. 2020;8:95. doi:10.3389/fcell.2020.0009532154250
   PubMed Web of Science ®Google Scholar
• Zhou M, Yang H, Learned RM, Tian H, Ling L. Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis. Nat Commun. 2017;8:15433. doi:10.1038/ncomms1543328508871
   PubMed Web of Science ®Google Scholar
• Guo A, Li K, Xiao Q. Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle. Biochem Biophys Res Commun. 2020;526:1069–1076. doi:10.1016/j.bbrc.2020.04.00232305136
   PubMed Web of Science ®Google Scholar