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Review

Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review

ORCID Icon, ORCID Icon & ORCID Icon
Pages 2397-2419 | Published online: 21 Jul 2021

References

  • World Health Organization. Depression. Who.int. 2021. Available from: https://www.who.int/news-room/fact-sheets/detail/depression. Accessed 106, 2019.
  • Steel Z, Marnane C, Iranpour C, et al. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013. Int J Epidemiol. 2014;43(2):476–493.24648481
  • König H, König H, Konnopka A. The excess costs of depression: a systematic review and meta-analysis. Epidemiol Psychiatr Sci. 2019;29.
  • National Institute for Health and Care Excellence. Depression in Adults: Recognition and Management. London: NICE; 2009. Available fromhttps://www.nice.org.uk/guidance/cg90. Accessed 106, 2019.
  • Treatment Guidelines: Depression. CPNP. 2021. Available from: https://cpnp.org/guideline/external/depression. Accessed 221, 2021.
  • Seemüller F, Obermeier M, Schennach R, et al. Stability of remission rates in a 3-year follow-up of naturalistic treated depressed inpatients. BMC Psychiatry. 2016;16:1.26739960
  • Warden D, Rush A, Trivedi M, Fava M, Wisniewski S. The STAR*D project results: a comprehensive review of findings. Curr Psychiatry Rep. 2007;9(6):449–459.18221624
  • Schulberg H. The ‘usual care’ of major depression in primary care practice. Arch Fam Med. 1997;6(4):334–339.9225703
  • Rost K, Nutting P, Smith J, Elliot C, Dickinson M. Managing depression as a chronic disease: a randomised trial of ongoing treatment in primary care. BMJ. 2002;325(7370):934.12399343
  • Rush A, Trivedi M, Carmody T, et al. One-year clinical outcomes of depressed public sector outpatients: a benchmark for subsequent studies. Biol Psychiatry. 2004;56(1):46–53.15219472
  • Johnston K, Powell L, Anderson I, Szabo S, Cline S. The burden of treatment-resistant depression: a systematic review of the economic and quality of life literature. J Affect Disord. 2019;242:195–210.30195173
  • Tansey K, Guipponi M, Hu X, et al. Contribution of common genetic variants to antidepressant response. Biol Psychiatry. 2013;73(7):679–682.23237317
  • Trivedi M, Rush A, Wisniewski S, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry. 2006;163(1):28–40.16390886
  • Uher R, Tansey K, Henigsberg N, et al. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Am J Psychiatry. 2013;170(2):207–217.23377640
  • Fabbri C, Serretti A. Pharmacogenetics of major depressive disorder: top genes and pathways toward clinical applications. Curr Psychiatry Rep. 2015;17:7.25617039
  • Sanacora G. Is this where we stand after decades of research to develop more personalized treatments for depression? JAMA Psychiatry. 2020;77(6):E560.32074267
  • Abbott R, Chang D, Eyre H, Bousman C, Merrill D, Lavretsky H. Pharmacogenetic decision support tools: a new paradigm for late-life depression? Am J Geriatric Psychiatry. 2018;26(2):125–133.
  • Ielmini M, Poloni N, Caselli I, et al. The utility of pharmacogenetic testing to support the treatment of bipolar disorder. Pharmgenomics Pers Med. 2018;11:35–42.29588611
  • Ielmini M, Poloni N, Caselli I, Diurni M, Grecchi A, Callegari C. The role of pharmacogenetic testing in the treatment of bipolar disorder: preliminary results. Minerva Psichiatr. 2018;59(1):10–15.
  • Altar C, Carhart J, Allen J, Hall-Flavin D, Winner J, Dechairo B. Clinical utility of combinatorial pharmacogenomics-guided antidepressant therapy: evidence from three clinical studies. Mol Neuropsychiatry. 2015;1(3):145–155.27606312
  • Hall-Flavin D, Winner J, Allen J, et al. Utility of integrated pharmacogenomic testing to support the treatment of major depressive disorder in a psychiatric outpatient setting. Pharmacogenet Genomics. 2013;23(10):535–548.24018772
  • Bossuyt P, Reitsma J, Linnet K, Moons K. Beyond diagnostic accuracy: the clinical utility of diagnostic tests. Clin Chem. 2012;58(12):1636–1643.22730450
  • Bousman C, Arandjelovic K, Mancuso S, Eyre H, Dunlop B. Pharmacogenetic tests and depressive symptom remission: a meta-analysis of randomized controlled trials. Pharmacogenomics. 2019;20(1):37–47.30520364
  • Health Quality OntarioH. Pharmacogenomic Testing for Psychotropic Medication Selection: a Systematic Review of the Assurex GeneSight Psychotropic Test. PubMed Central (PMC). 2021. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433545/. Accessed, 2019.
  • Fabbri C, Zohar J, Serretti A. Pharmacogenetic tests to guide drug treatment in depression: comparison of the available testing kits and clinical trials. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:36–44.29777729
  • Rosenblat J, Lee Y, McIntyre R. The effect of pharmacogenomic testing on response and remission rates in the acute treatment of major depressive disorder: a meta-analysis. J Affect Disord. 2018;241:484–491.30149336
  • Rosenblat J, Lee Y, McIntyre R. Does pharmacogenomic testing improve clinical outcomes for major depressive disorder? J Clin Psychiatry. 2017;78(06):720–729.28068459
  • Brown L, Vranjkovic O, Li J, et al. The clinical utility of combinatorial pharmacogenomic testing for patients with depression: a meta-analysis. Pharmacogenomics. 2020;21(8):559–569.32301649
  • Han C, Wang S, Bahk W, et al. A pharmacogenomic-based antidepressant treatment for patients with major depressive disorder: results from an 8-week, randomized, single-blinded clinical trial. Clin Psychopharmacol Neurosci. 2018;16(4):469–480.30466219
  • Greden J, Parikh S, Rothschild A, et al. Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: a large, patient- and rater-blinded, randomized, controlled study. J Psychiatr Res. 2019;111:59–67.30677646
  • Thase M, Parikh S, Rothschild A, et al. Impact of pharmacogenomics on clinical outcomes for patients taking medications with gene-drug interactions in a randomized controlled trial. J Clin Psychiatry. 2019;80:6.
  • PROSPERO. Crd.york.ac.uk. 2021. Available from: https://www.crd.york.ac.uk/prospero/#recordDetails. Accessed 221, 2021.
  • Liberati A, Altman D, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339(jul211):b2700–b2700.19622552
  • Crowe Critical Appraisal Tool (v1.4). Conchra. Conchra.com.au. 2020. Available from: https://conchra.com.au/2015/12/08/crowe-critical-appraisal-tool-v1-4/. Accessed 317, 2020.
  • Crowe M, Sheppard L. A general critical appraisal tool: an evaluation of construct validity. Int J Nurs Stud. 2011;48(12):1505–1516.21802686
  • Crowe M, Sheppard L, Campbell A. Reliability analysis for a proposed critical appraisal tool demonstrated value for diverse research designs. J Clin Epidemiol. 2012;65(4):375.22078576
  • Crowe M, Sheppard L, Campbell A. Comparison of the effects of using the Crowe Critical Appraisal Tool versus informal appraisal in assessing health research: a randomised trial. Int J Evid Based Healthc. 2011;9(4):444–449.22093394
  • Ismail A, Munro K, Armitage C, Dawes P. What do hearing healthcare professionals do to promote hearing aid use and benefit among adults? A systematic review. Int J Audiol. 2019;58(2):63–76.30646766
  • Corrigan F, Broome H, Dorris L. A systematic review of psychosocial interventions for children and young people with epilepsy. Epilepsy Behav. 2016;56:99–112.26859319
  • Sznitman S, Taubman D. Drug use normalization: a systematic and critical mixed-methods review. J Stud Alcohol Drugs. 2016;77(5):700–709.27588528
  • Genecept Assay™ vs. Treatment-as-Usual to Evaluate Efficacy of Assay-Guided Treatment in Adults With MDD - Full Text View - ClinicalTrials.gov. Clinicaltrials.gov. 2021. Available from: https://clinicaltrials.gov/ct2/show/NCT02634177. Accessed 221, 2021.
  • Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Subjects Exhibiting Neuropsychiatric Disorders - Full Text View - ClinicalTrials.gov. Clinicaltrials.gov. 2021. Available from: https://clinicaltrials.gov/ct2/show/NCT02411123. Accessed 221, 2021.
  • Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM - Full Text View - ClinicalTrials.gov. Clinicaltrials.gov. 2021. Available from: https://clinicaltrials.gov/ct2/show/NCT02428660. Accessed 221, 2021.
  • Benitez J, Jablonski M, Allen J, Winner J. The clinical validity and utility of combinatorial pharmacogenomics: enhancing patient outcomes. Appl Trans Genomics. 2015;5:47–49.
  • RETIRED Local Coverage Determination for MolDX: geneSight Assay for Refractory Depression (L36323). Cms.gov. 2021. Available from: https://www.cms.gov/medicare-coverage-database/details/lcd-details.aspx?LCDId=36323&ContrId=364. Accessed 221, 2020.
  • Eloul L, Ambusaidi A, Al-Adawi S. Silent Epidemic of Depression in Women in the Middle East and North Africa Region: emerging tribulation or fallacy? PubMed. 2021. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21509269. Accessed 317, 2020.
  • Ghubash R, Hamdi E, Bebbington P. The Dubai Community Psychiatric Survey: I prevalence and socio-demographic correlates. Soc Psychiatry Psychiatric Epidemiol. 1992;27(2):53–61.
  • Okasha A, Kamel M, Sadek A, Lotaif F, Bishry Z. Psychiatric Morbidity Among University Students in Egypt. Br J Psychiatry. 1977;131(2):149–154.912216
  • Winner J, Goebert D, Matsu C, Mrazek D. Training in psychiatric genomics during residency: a new challenge. Acad Psychiatry. 2010;34(2):115–118.20224020
  • Dias M, Sorich M, Rowland A, Wiese M, McKinnon R. The routine clinical use of pharmacogenetic tests: what it will require? Pharm Res. 2017;34(8):1544–1550.28236061
  • Teutsch S, Bradley L, Palomaki G, et al. The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: methods of the EGAPP Working Group. Genetics Med. 2009;11(1):3–14.18813139
  • Sorich M, Polasek T, Wiese M Challenges and Limitations in the Interpretation of Systematic Reviews: Making Sense of Clopidogrel and CYP2C19 Pharmacogenetics. 2021.
  • Brown J, Bishop J, Schneiderhan M. Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management. Mental Health Clinician. 2020;10(4):254–258.
  • Hicks J, Bishop J, Sangkuhl K, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline forCYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors. Clin Pharmacol Ther. 2015;98(2):127–134.25974703
  • Gerlach N, Michiels-Corsten M, Viniol A, et al. Professional roles of general practitioners, community pharmacists and specialist providers in collaborative medication deprescribing - a qualitative study. BMC Fam Pract. 2020;21:1.31901226
  • Hasanpoor E, Hallajzadeh J, Siraneh Y, Hasanzadeh E, Haghgoshayie E. Using the Methodology of Systematic Review of Reviews for Evidence-Based Medicine. 2021.
  • DNA Medical Testing. Genetic Testing | geneSight. GeneSight. 2020. Available from: https://genesight.com/. Accessed 1021, 2020.
  • Dynacare - GENECEPT ASSAY (English - Canada). Dynacare.ca. 2020. Available from: https://www.dynacare.ca/specialpages/secondarynav/find-a-test/nat/genecept%C2%A0assay.aspx?sr=ont&st=&. Accessed 1021, 2020.
  • CNSdose | Genetic Testing | Home. Cnsdose.com. 2021. Available from: https://cnsdose.com/. Accessed 1021, 2020.
  • Precision medicine especially developed for psychiatry | AB-Biotics. AB-Biotics. 2021. Available from: https://www.ab-biotics.com/c/precision-medicine/. Accessed 321, 2021.
  • Jain K Applications of AmpliChip™ CYP450. 2020.
  • AltheaDx. Depression and Anxiety. 2020. Available from: https://www.altheadx.com/clinical-trial-portfolio/idgenetix-tests/. Accessed 1021, 2020.
  • Genelex . Precision Medicine Made Possible with Pharmacogenetics. Genelex.com. 2020. Available from: https://www.genelex.com/. Accessed 1021, 2020.
  • Genomas:: Rennova Health, Inc. (RNVA). Rennovahealth.com. 2021. Available from: https://www.rennovahealth.com/brands/genomas. Accessed 1021, 2020.
  • Pillcheck. Tailor your medications with Pillcheck DNA analysis. Pillcheck. 2020. Available from: https://www.pillcheck.ca/. Accessed 1021, 2020.