Psychopathological Dissection of Bipolar Disorder and ADHD: Focussing on Racing Thoughts and Verbal Fluency 

References

• Kendell RE. The distinction between mental and physical illness. Br J Psychiatry. 2001;178(6):490–493. doi:10.1192/bjp.178.6.490
   PubMedGoogle Scholar
• Kendell RE, Gourlay J. The clinical distinction between the affective psychoses and schizophrenia. Br J Psychiatry. 1970;117(538):261–266. doi:10.1192/S0007125000193225
   PubMed Web of Science ®Google Scholar
• Wakefield JC. Klerman’s “credo” reconsidered: neo-kraepelinianism, spitzer’s views, and what we can learn from the past. World Psychiatry. 2022;21(1):4–25. doi:10.1002/wps.20942
   PubMed Web of Science ®Google Scholar
• Dayer A, Aubry JM, Roth L, Ducrey S, Bertschy G. A theoretical reappraisal of mixed states: dysphoria as a third dimension. Bipolar Disord. 2000;2(4):316–324. doi:10.1034/j.1399-5618.2000.020404.x
   PubMed Web of Science ®Google Scholar
• Piguet C, Dayer A, Kosel M, Desseilles M, Vuilleumier P, Bertschy G. Phenomenology of racing and crowded thoughts in mood disorders: a theoretical reappraisal. J Affect Disord. 2010;121(3):189–198. doi:10.1016/j.jad.2009.05.006
   PubMed Web of Science ®Google Scholar
• McIntyre RS, Berk M, Brietzke E, et al. Bipolar disorders. Lancet. 2020;396(10265):1841–1856. doi:10.1016/S0140-6736(20)31544-0
   PubMed Web of Science ®Google Scholar
• Merikangas KR, Jin R, He JP, et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 2011;68(3):241–251. doi:10.1001/archgenpsychiatry.2011.12
   PubMed Web of Science ®Google Scholar
• Frey BN, Andreazza AC, Houenou J, et al. Biomarkers in bipolar disorder: a positional paper from the international society for bipolar disorders biomarkers task force. Aust N Z J Psychiatry. 2013;47(4):321–332. doi:10.1177/0004867413478217
   PubMed Web of Science ®Google Scholar
• O’Connell KS, Coombes BJ. Genetic contributions to bipolar disorder: current status and future directions. Psychol Med. 2021;51(13):2156–2167. doi:10.1017/S0033291721001252
   PubMed Web of Science ®Google Scholar
• Chen G, Wang J, Gong J, et al. Functional and structural brain differences in bipolar disorder: a multimodal meta-analysis of neuroimaging studies. Psychol Med. 2022;52(14):2861–2873. doi:10.1017/S0033291722002392
   PubMed Web of Science ®Google Scholar
• AmericanPsychiatricAssociation. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. APA; 2013.
   Google Scholar
• Simon V, Czobor P, Bálint S, Mészáros A, Bitter I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry. 2009;194(3):204–211. doi:10.1192/bjp.bp.107.048827
   PubMed Web of Science ®Google Scholar
• Posner J, Polanczyk GV, Sonuga-Barke E. Attention-deficit hyperactivity disorder. Lancet. 2020;395(10222):450–462. doi:10.1016/S0140-6736(19)33004-1
   PubMed Web of Science ®Google Scholar
• Bonvicini C, Faraone SV, Scassellati C. Attention-deficit hyperactivity disorder in adults: a systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies. Mol Psychiatry. 2016;21(7):872–884. doi:10.1038/mp.2016.74
   PubMed Web of Science ®Google Scholar
• Bernanke J, Luna A, Chang L, Bruno E, Dworkin J, Posner J. Structural brain measures among children with and without ADHD in the adolescent brain and cognitive development study cohort: a cross-sectional US population-based study. Lancet Psychiatry. 2022;9(3):222–231. doi:10.1016/S2215-0366(21)00505-8
   PubMed Web of Science ®Google Scholar
• Hoogman M, Muetzel R, Guimaraes JP, et al. Brain imaging of the cortex in ADHD: a coordinated analysis of large-scale clinical and population-based samples. Am J Psychiatry. 2019;176(7):531–542. doi:10.1176/appi.ajp.2019.18091033
   PubMed Web of Science ®Google Scholar
• Müller A, Vetsch S, Pershin I, et al. EEG/ERP-based biomarker/neuroalgorithms in adults with ADHD: development, reliability, and application in clinical practice. World J Biol Psychiatry. 2020;21(3):172–182. doi:10.1080/15622975.2019.1605198
   PubMed Web of Science ®Google Scholar
• Schiweck C, Arteaga-Henriquez G, Aichholzer M, et al. Comorbidity of ADHD and adult bipolar disorder: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2021;124:100–123. doi:10.1016/j.neubiorev.2021.01.017
   PubMed Web of Science ®Google Scholar
• Sandstrom A, Perroud N, Alda M, Uher R, Pavlova B. Prevalence of attention-deficit/hyperactivity disorder in people with mood disorders: a systematic review and meta-analysis. Acta Psychiatr Scand. 2021;143(5):380–391. doi:10.1111/acps.13283
   PubMed Web of Science ®Google Scholar
• Klassen LJ, Katzman MA, Chokka P. Adult ADHD and its comorbidities, with a focus on bipolar disorder. J Affect Disord. 2010;124(1–2):1–8. doi:10.1016/j.jad.2009.06.036
   PubMed Web of Science ®Google Scholar
• Coombes BJ, Markota M, Mann JJ, et al. Dissecting clinical heterogeneity of bipolar disorder using multiple polygenic risk scores. Transl Psychiatry. 2020;10(1):314. doi:10.1038/s41398-020-00996-y
   PubMed Web of Science ®Google Scholar
• Faraone SV, Biederman J, Wozniak J. Examining the comorbidity between attention deficit hyperactivity disorder and bipolar I disorder: a meta-analysis of family genetic studies. Am J Psychiatry. 2012;169(12):1256–1266. doi:10.1176/appi.ajp.2012.12010087
   PubMed Web of Science ®Google Scholar
• Asherson P, Young AH, Eich-Höchli D, Moran P, Porsdal V, Deberdt W. Differential diagnosis, comorbidity, and treatment of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality disorder in adults. Curr Med Res Opin. 2014;30(8):1657–1672. doi:10.1185/03007995.2014.915800
   PubMed Web of Science ®Google Scholar
• Brus MJ, Solanto MV, Goldberg JF. Adult ADHD vs. bipolar disorder in the DSM-5 era: a challenging differentiation for clinicians. J Psychiatr Pract. 2014;20(6):428–437. doi:10.1097/01.pra.0000456591.20622.9e
   PubMed Web of Science ®Google Scholar
• Kitsune GL, Kuntsi J, Costello H, et al. Delineating ADHD and bipolar disorder: a comparison of clinical profiles in adult women. J Affect Disord. 2016;192:125–133. doi:10.1016/j.jad.2015.12.024
   PubMed Web of Science ®Google Scholar
• Judd LL, Akiskal HS, Schettler PJ, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry. 2002;59(6):530–537. doi:10.1001/archpsyc.59.6.530
   PubMed Web of Science ®Google Scholar
• Correll CU, Hauser M, Penzner JB, et al. Type and duration of subsyndromal symptoms in youth with bipolar I disorder prior to their first manic episode. Bipolar Disord. 2014;16(5):478–492. doi:10.1111/bdi.12194
   PubMed Web of Science ®Google Scholar
• Agnew-Blais JC, Polanczyk GV, Danese A, Wertz J, Moffitt TE, Arseneault L. Evaluation of the persistence, remission, and emergence of attention-deficit/hyperactivity disorder in young adulthood. JAMA Psychiatry. 2016;73(7):713. doi:10.1001/jamapsychiatry.2016.0465
   PubMed Web of Science ®Google Scholar
• Moffitt TE, Houts R, Asherson P, et al. Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a four-decade longitudinal cohort study. Am J Psychiatry. 2015;172(10):967–977. doi:10.1176/appi.ajp.2015.14101266
   PubMed Web of Science ®Google Scholar
• Sibley MH, Rohde LA, Swanson JM, et al. Late-onset ADHD reconsidered with comprehensive repeated assessments between ages 10 and 25. Am J Psychiatry. 2018;175(2):140–149. doi:10.1176/appi.ajp.2017.17030298
   PubMed Web of Science ®Google Scholar
• Sibley MH, Arnold LE, Swanson JM, et al. Variable patterns of remission from ADHD in the multimodal treatment study of ADHD. Am J Psychiatry. 2022;179(2):142–151. doi:10.1176/appi.ajp.2021.21010032
   PubMed Web of Science ®Google Scholar
• Bertschy G, Weibel S, Giersch A, Weiner L. Racing and crowded thoughts in mood disorders: a data-oriented theoretical reappraisal. Encephale. 2020;46(3):202–208. doi:10.1016/j.encep.2020.01.007
   PubMed Web of Science ®Google Scholar
• Goodwin F, Jamison K. Manic-Depressive Illness: Bipolar Disorder and Recurrent Depression. Oxford University Press; 2007.
   Google Scholar
• Kraepelin E. Manic-Depressive Insanity and Paranoia. E&S Livingstone; 1921.
   Google Scholar
• Salvatore P, Baldessarini RJ, Centorrino F, et al. Weygandt’s on the mixed states of manic-depressive insanity: a translation and commentary on its significance in the evolution of the concept of bipolar disorder. Harv Rev Psychiatry. 2002;10(5):255–275. doi:10.1080/10673220216283
   PubMed Web of Science ®Google Scholar
• AmericanPsychiatricAssociation. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. APA; 1980.
   Google Scholar
• AmericanPsychiatricAssociation. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. APA; 1987.
   Google Scholar
• AmericanPsychiatricAssociation. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. APA; 1995.
   Google Scholar
• AmericanPsychiatricAssociation. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. APA; 2000.
   Google Scholar
• Benazzi F. Mixed depression: a clinical marker of bipolar-II disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(2):267–274. doi:10.1016/j.pnpbp.2004.11.010
   PubMed Web of Science ®Google Scholar
• Braden W, Ho CK. Racing thoughts in psychiatric inpatients. Arch Gen Psychiatry. 1981;38(1):71–75. doi:10.1001/archpsyc.1981.01780260073008
   PubMed Web of Science ®Google Scholar
• Koukopoulos A, Koukopoulos A. Agitated depression as a mixed state and the problem of melancholia. Psychiatr Clin North Am. 1999;22(3):547–564. doi:10.1016/S0193-953X(05)70095-2
   PubMed Web of Science ®Google Scholar
• Benazzi F. Unipolar depression with racing thoughts: a bipolar spectrum disorder? Psychiatry Clin Neurosci. 2005;59(5):570–575. doi:10.1111/j.1440-1819.2005.01416.x
   PubMed Web of Science ®Google Scholar
• Goldberg JF, Garakani A, Ackerman SH. Clinician-rated versus self-rated screening for bipolar disorder among inpatients with mood symptoms and substance misuse. J Clin Psychiatry. 2012;73(12):1525–1530. doi:10.4088/JCP.12m07926
   PubMed Web of Science ®Google Scholar
• Keizer I, Piguet C, Favre S, et al. Subjective experience of thought overactivation in mood disorders: beyond racing and crowded thoughts. Psychopathology. 2014;47(3):174–184. doi:10.1159/000354781
   PubMed Web of Science ®Google Scholar
• Weiner L, Weibel S, de Sousa Gurgel W, et al. Measuring racing thoughts in healthy individuals: the Racing and Crowded Thoughts Questionnaire (RCTQ). Compr Psychiatry. 2018;82:37–44. doi:10.1016/j.comppsych.2018.01.006
   PubMed Web of Science ®Google Scholar
• Dodd AL, Mansell W, Sadhnani V, Morrison AP, Tai S. Principal components analysis of the hypomanic attitudes and positive predictions inventory and associations with measures of personality, cognitive style and analogue symptoms in a student sample. Behav Cogn Psychother. 2010;38(1):15–33. doi:10.1017/S1352465809990476
   PubMed Web of Science ®Google Scholar
• Weiner L, Ossola P, Causin JB, et al. Racing thoughts revisited: a key dimension of activation in bipolar disorder. J Affect Disord. 2019;255:69–76. doi:10.1016/j.jad.2019.05.033
   PubMed Web of Science ®Google Scholar
• Asherson P, Buitelaar J, Faraone SV, Rohde LA. Adult attention-deficit hyperactivity disorder: key conceptual issues. Lancet Psychiatry. 2016;3(6):568–578. doi:10.1016/S2215-0366(16)30032-3
   PubMed Web of Science ®Google Scholar
• Martz E, Weibel S, Weiner L. An overactive mind: investigating racing thoughts in ADHD, hypomania and comorbid ADHD and bipolar disorder via verbal fluency tasks. J Affect Disord. 2022;300:226–234. doi:10.1016/j.jad.2021.12.060
   PubMed Web of Science ®Google Scholar
• Martz E, Bertschy G, Kraemer C, Weibel S, Weiner L. Beyond motor hyperactivity: racing thoughts are an integral symptom of adult attention deficit hyperactivity disorder. Psychiatry Res. 2021;301:113988. doi:10.1016/j.psychres.2021.113988
   PubMed Web of Science ®Google Scholar
• Skirrow C, Asherson P. Emotional lability, comorbidity and impairment in adults with attention-deficit hyperactivity disorder. J Affect Disord. 2013;147(1–3):80–86. doi:10.1016/j.jad.2012.10.011
   PubMed Web of Science ®Google Scholar
• Corbisiero S, Mörstedt B, Bitto H, Stieglitz RD. Emotional dysregulation in adults with attention-deficit/hyperactivity disorder-validity, predictability, severity, and comorbidity. J Clin Psychol. 2017;73(1):99–112. doi:10.1002/jclp.22317
   PubMed Web of Science ®Google Scholar
• Weiner L, Martz E, Kilic-Huck Ü, et al. Investigating racing thoughts in insomnia: a neglected piece of the mood-sleep puzzle? Compr Psychiatry. 2021;111:152271. doi:10.1016/j.comppsych.2021.152271
   PubMed Web of Science ®Google Scholar
• Asherson P. Clinical assessment and treatment of attention deficit hyperactivity disorder in adults. Expert Rev Neurother. 2005;5(4):525–539. doi:10.1586/14737175.5.4.525
   PubMedGoogle Scholar
• Harrow M, Grossman LS, Silverstein ML, Meltzer HY, Kettering RL. A longitudinal study of thought disorder in manic patients. Arch Gen Psychiatry. 1986;43(8):781–785. doi:10.1001/archpsyc.1986.01800080067009
   PubMed Web of Science ®Google Scholar
• Weiner L, Doignon-Camus N, Bertschy G, Giersch A. Thought and language disturbance in bipolar disorder quantified via process-oriented verbal fluency measures. Sci Rep. 2019;9(1):14282. doi:10.1038/s41598-019-50818-5
   PubMedGoogle Scholar
• Raucher-Chéné D, Achim AM, Kaladjian A, Besche-Richard C. Verbal fluency in bipolar disorders: a systematic review and meta-analysis. J Affect Disord. 2017;207:359–366. doi:10.1016/j.jad.2016.09.039
   PubMed Web of Science ®Google Scholar
• Fossati P, Guillaume L, Ergis AM, Allilaire JF. Qualitative analysis of verbal fluency in depression. Psychiatry Res. 2003;117(1):17–24. doi:10.1016/s0165-1781(02)00300-1
   PubMed Web of Science ®Google Scholar
• Tucha O, Mecklinger L, Laufkötter R, et al. Clustering and switching on verbal and figural fluency functions in adults with attention deficit hyperactivity disorder. Cogn Neuropsychiatry. 2005;10(3):231–248. doi:10.1080/13546800444000047
   PubMedGoogle Scholar
• Holst Y, Thorell LB. Neuropsychological functioning in adults with ADHD and adults with other psychiatric disorders. J Atten Disord. 2017;21(2):137–148. doi:10.1177/1087054713506264
   PubMed Web of Science ®Google Scholar
• Bertschy G, Gervasoni N, Favre S, et al. Frequency of dysphoria and mixed states. Psychopathology. 2008;41(3):187–193. doi:10.1159/000120987
   PubMed Web of Science ®Google Scholar
• Judd LL, Schettler PJ, Akiskal H, et al. Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes. J Affect Disord. 2012;138(3):440–448. doi:10.1016/j.jad.2011.12.046
   PubMed Web of Science ®Google Scholar
• de Vries LP, Baselmans BML, Bartels M. Smartphone-based ecological momentary assessment of well-being: a systematic review and recommendations for future studies. J Happiness Stud. 2021;22(5):2361–2408. doi:10.1007/s10902-020-00324-7
   PubMed Web of Science ®Google Scholar
• Judd LL, Akiskal HS, Schettler PJ, et al. Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study. Arch Gen Psychiatry. 2005;62(12):1322–1330. doi:10.1001/archpsyc.62.12.1322
   PubMed Web of Science ®Google Scholar
• Arathimos R, Fabbri C, Vassos E, et al. Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts. Br J Psychiatry. 2022:1–10. doi:10.1192/bjp.2021.184
   PubMedGoogle Scholar
• Sass L, Pienkos E. Beyond words: linguistic experience in melancholia, mania and schizophrenia. Phenomenol Cogn Sci. 2015;2015:475–495.
   Google Scholar
• Weibel S, Bicego F, Muller S, et al. Two facets of emotion dysregulation are core symptomatic domains in adult ADHD: results from the SR-WRAADDS, a broad symptom self-report questionnaire. J Atten Disord. 2022;26(5):767–778. doi:10.1177/10870547211027647
   PubMed Web of Science ®Google Scholar
• Richard-Lepouriel H, Etain B, Hasler R, et al. Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients. J Affect Disord. 2016;198:230–236. doi:10.1016/j.jad.2016.03.047
   PubMed Web of Science ®Google Scholar
• Matthies SD, Philipsen A. Common ground in Attention Deficit Hyperactivity Disorder (ADHD) and Borderline Personality Disorder (BPD)-review of recent findings. Borderline Personal Disord Emot Dysregul. 2014;1:3. doi:10.1186/2051-6673-1-3
   PubMedGoogle Scholar
• Fornaro M, Orsolini L, Marini S, et al. The prevalence and predictors of bipolar and borderline personality disorders comorbidity: systematic review and meta-analysis. J Affect Disord. 2016;195:105–118. doi:10.1016/j.jad.2016.01.040
   PubMed Web of Science ®Google Scholar
• Parker G, Bayes A, Spoelma MJ. Why might bipolar disorder and borderline personality disorder be bonded? J Psychiatr Res. 2022;150:214–218. doi:10.1016/j.jpsychires.2022.03.051
   PubMed Web of Science ®Google Scholar
• Johnson SL, Murray G, Fredrickson B, et al. Creativity and bipolar disorder: touched by fire or burning with questions? Clin Psychol Rev. 2012;32(1):1–12. doi:10.1016/j.cpr.2011.10.001
   PubMed Web of Science ®Google Scholar
• Murray G, Johnson SL. The clinical significance of creativity in bipolar disorder. Clin Psychol Rev. 2010;30(6):721–732. doi:10.1016/j.cpr.2010.05.006
   PubMed Web of Science ®Google Scholar
• Taylor K, Fletcher I, Lobban F. Exploring the links between the phenomenology of creativity and bipolar disorder. J Affect Disord. 2015;174:658–664. doi:10.1016/j.jad.2014.10.040
   PubMed Web of Science ®Google Scholar
• Sedgwick JA, Merwood A, Asherson P. The positive aspects of attention deficit hyperactivity disorder: a qualitative investigation of successful adults with ADHD. Atten Defic Hyperact Disord. 2019;11(3):241–253. doi:10.1007/s12402-018-0277-6
   PubMedGoogle Scholar
• Hoogman M, Stolte M, Baas M, Kroesbergen E. Creativity and ADHD: a review of behavioral studies, the effect of psychostimulants and neural underpinnings. Neurosci Biobehav Rev. 2020;119:66–85. doi:10.1016/j.neubiorev.2020.09.029
   PubMed Web of Science ®Google Scholar
• Lugo-Candelas C, Corbeil T, Wall M, et al. ADHD and risk for subsequent adverse childhood experiences: understanding the cycle of adversity. J Child Psychol Psychiatry. 2021;62(8):971–978. doi:10.1111/jcpp.13352
   PubMed Web of Science ®Google Scholar
• Palmier-Claus JE, Berry K, Bucci S, Mansell W, Varese F. Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. Br J Psychiatry. 2016;209(6):454–459. doi:10.1192/bjp.bp.115.179655
   PubMed Web of Science ®Google Scholar
• Hawi Z, Cummins TD, Tong J, et al. The molecular genetic architecture of attention deficit hyperactivity disorder. Mol Psychiatry. 2015;20(3):289–297. doi:10.1038/mp.2014.183
   PubMed Web of Science ®Google Scholar
• Harrison PJ, Geddes JR, Tunbridge EM. The emerging neurobiology of bipolar disorder. Trends Neurosci. 2018;41(1):18–30. doi:10.1016/j.tins.2017.10.006
   PubMed Web of Science ®Google Scholar
• Wang Y, Kessel E, Lee S, et al. Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial. J Child Psychol Psychiatry. 2022;63(11):1381–1391. doi:10.1111/jcpp.13585
   PubMed Web of Science ®Google Scholar