Why Do They Fall? The Impact of Insomnia on Gait of Older Adults: A Case–Control Study

References

• Altena E, Baglioni C, Espie CA, et al. Dealing with sleep problems during home confinement due to the COVID-19 outbreak: practical recommendations from a task force of the European CBT-I academy. J Sleep Res. 2020;29(4). doi:10.1111/jsr.13052
   Web of Science ®Google Scholar
• Yu BYM, Yeung W-F, Lam JC-S, et al. Prevalence of sleep disturbances during COVID-19 outbreak in an urban Chinese population: a cross-sectional study. Sleep Med. 2020;74:18–24. doi:10.1016/j.sleep.2020.07.009
   PubMed Web of Science ®Google Scholar
• Ellis JG, Perlis ML, Neale LF, Espie CA, Bastien CH. The natural history of insomnia: focus on prevalence and incidence of acute insomnia. J Psychiatr Res. 2012;46(10):1278–1285. doi:10.1016/j.jpsychires.2012.07.001
   PubMed Web of Science ®Google Scholar
• Morin CM, Drake CL, Harvey AG, et al. Insomnia disorder. Nat Rev Dis Prim. 2015;1. doi:10.1038/nrdp.2015.26
   Web of Science ®Google Scholar
• Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6(2):97–111. doi:10.1053/smrv.2002.0186
   PubMed Web of Science ®Google Scholar
• Riemann D, Nissen C, Palagini L, Otte A, Perlis ML, Spiegelhalder K. The neurobiology, investigation, and treatment of chronic insomnia. Lancet Neurol. 2015;14(5):547–558. doi:10.1016/S1474-4422(15)00021-6
   PubMed Web of Science ®Google Scholar
• Fortier-Brochu É, Morin CM. Cognitive impairment in individuals with insomnia: clinical significance and correlates. Sleep. 2014;37(11):1787–1798. doi:10.5665/sleep.4172
   PubMed Web of Science ®Google Scholar
• Fortier-Brochu É, Beaulieu-Bonneau S, Ivers H, Morin CM. Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med Rev. 2012;16(1):83–94. doi:10.1016/j.smrv.2011.03.008
   PubMed Web of Science ®Google Scholar
• Li MJ, Kechter A, Olmstead RE, Irwin MR, Black DS. Sleep and mood in older adults: coinciding changes in insomnia and depression symptoms. Int Psychogeriatr. 2018;30(3):431–435. doi:10.1017/S1041610217001454
   PubMed Web of Science ®Google Scholar
• Stone KL, Ancoli-Israel S, Blackwell T. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med. 2008;168(16):1768–1775. doi:10.1001/archinte.168.16.1768
   PubMedGoogle Scholar
• Takada S, Yamamoto Y, Shimizu S, et al. Association between subjective sleep quality and future risk of falls in older people: results from LOHAS. J Gerontol a Biol Sci. 2018;73(9):1205–1211. doi:10.1093/gerona/glx123
   PubMed Web of Science ®Google Scholar
• Stone KL, Blackwell TL, Ancoli-Israel S. Sleep disturbances and risk of falls in older community-dwelling men: the outcomes of sleep disorders in older men (MrOS sleep) study. J Am Geriatr Soc. 2014;62(2):299–305. doi:10.1111/jgs.12649
   PubMed Web of Science ®Google Scholar
• Hill EL, Cumming RG, Lewis R, Carrington S, Le Couteur DG. Sleep disturbances and falls in older people. J Gerontol A Biol Sci. 2007;62(1):62–66. doi:10.1093/gerona/62.1.62
   Web of Science ®Google Scholar
• Helbig AK, Döring A, Heier M. Association between sleep disturbances and falls among the elderly: results from the German cooperative health research in the region of Augsburg-age study. Sleep Med. 2013;14(12):1356–1363. doi:10.1016/j.sleep.2013.09.004
   PubMed Web of Science ®Google Scholar
• Robillard R, Prince F, Filipini D, Carrier J. Aging worsens the effects of sleep deprivation on postural control. Dickson CT ed. PLoS One. 2011;6(12):e28731. doi:10.1371/journal.pone.0028731
   PubMed Web of Science ®Google Scholar
• Aguiar SA, Barela JA. Sleep deprivation affects sensorimotor coupling in postural control of young adults. Neurosci Lett. 2014;574:47–52. doi:10.1016/j.neulet.2014.05.028
   PubMed Web of Science ®Google Scholar
• Stevens D, Jackson B, Carberry J, et al. The impact of obstructive sleep apnea on balance, gait, and falls risk: a narrative review of the literature. J Gerontol A. 2020;75(12):2450–2460. doi:10.1093/gerona/glaa014
   Google Scholar
• Gallea C, Ewenczyk C, Degos B, et al. Pedunculopontine network dysfunction in Parkinson’s disease with postural control and sleep disorders. Mov Disord. 2017;32(5):693–704. doi:10.1002/mds.26923
   Web of Science ®Google Scholar
• Montesinos L, Castaldo R, Cappuccio FP, Pecchia L. Day-to-day variations in sleep quality affect standing balance in healthy adults. Sci Rep. 2018;8(1):17504. doi:10.1038/s41598-018-36053-4
   PubMed Web of Science ®Google Scholar
• Agmon M, Shochat T, Kizony R. Sleep quality is associated with walking under dual-task, but not single-task performance. Gait Posture. 2016;49:127–131. doi:10.1016/j.gaitpost.2016.06.016
   PubMed Web of Science ®Google Scholar
• Clark DJ. Automaticity of walking: functional significance, mechanisms, measurement and rehabilitation strategies. Front Hum Neurosci. 2015;9:246. doi:10.3389/fnhum.2015.00246
   PubMed Web of Science ®Google Scholar
• Belghali M, Chastan N, Cignetti F, Davenne D, Decker LM. Loss of gait control assessed by cognitive-motor dual-tasks: pros and cons in detecting people at risk of developing Alzheimer’s and Parkinson’s diseases. GeroScience. 2017;39(3):305–329. doi:10.1007/s11357-017-9977-7
   Web of Science ®Google Scholar
• Rasmussen LJH, Caspi A, Ambler A, et al. Association of neurocognitive and physical function with gait speed in midlife. JAMA Netw open. 2019;2(10):e1913123. doi:10.1001/jamanetworkopen.2019.13123
   PubMed Web of Science ®Google Scholar
• Springer S, Giladi N, Peretz C, Yogev G, Simon ES, Hausdorff JM. Dual-tasking effects on gait variability: the role of aging, falls, and executive function. Mov Disord. 2006;21(7):950–957. doi:10.1002/mds.20848
   PubMed Web of Science ®Google Scholar
• Verghese J, Buschke H, Viola L, et al. Validity of divided attention tasks in predicting falls in older individuals: a preliminary study. J Am Geriatr Soc. 2002;50(9):1572–1576. doi:10.1046/j.1532-5415.2002.50415.x
   PubMed Web of Science ®Google Scholar
• Bayot M, Dujardin K, Dissaux L, et al. Can dual-task paradigms predict falls better than single task? – a systematic literature review. Neurophysiol Clin. 2020;50(6):401–440. doi:10.1016/j.neucli.2020.10.008
   Web of Science ®Google Scholar
• Kelly VE, Janke AA, Shumway-Cook A. Effects of instructed focus and task difficulty on concurrent walking and cognitive task performance in healthy young adults. Exp Brain Res. 2010;207(1–2):65–73. doi:10.1007/s00221-010-2429-6
   PubMed Web of Science ®Google Scholar
• Al-Yahya E, Dawes H, Smith L, Dennis A, Howells K, Cockburn J. Cognitive motor interference while walking: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2011;35(3):715–728. doi:10.1016/j.neubiorev.2010.08.008
   PubMed Web of Science ®Google Scholar
• Malcolm BR, Foxe JJ, Butler JS, De Sanctis P. The aging brain shows less flexible reallocation of cognitive resources during dual-task walking: a mobile brain/body imaging (MoBI) study. Neuroimage. 2015;117:230–242. doi:10.1016/j.neuroimage.2015.05.028
   Web of Science ®Google Scholar
• Menant JC, Sturnieks DL, Brodie MAD, Smith ST, Lord SR. Visuospatial tasks affect locomotor control more than nonspatial tasks in older people. PLoS One. 2014;9(10):e109802. doi:10.1371/journal.pone.0109802
   PubMed Web of Science ®Google Scholar
• Corp DT, Youssef GJ, Clark RA. Reduced motor cortex inhibition and a ‘cognitive-first’ prioritisation strategy for older adults during dual-tasking. Exp Gerontol. 2018;113:95–105. doi:10.1016/j.exger.2018.09.018
   Web of Science ®Google Scholar
• Buysse DJ, Ancoli-Israel S, Edinger JD, Lichstein KL, Morin CM. Recommendations for a standard research assessment of insomnia. Sleep. 2006;29(9):1155–1173. doi:10.1093/sleep/29.9.1155
   PubMed Web of Science ®Google Scholar
• Lichstein KL, Durrence HH, Taylor DJ, Bush AJ, Riedel BW. Quantitative criteria for insomnia. Behav Res Ther. 2003;41(4):427–445. doi:10.1016/S0005-7967(02)00023-2
   PubMed Web of Science ®Google Scholar
• Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213. doi:10.1016/0165-1781(89)90047-4
   PubMed Web of Science ®Google Scholar
• Shochat T, Tzischinsky O, Oksenberg A, Peled R. Validation of the Pittsburgh sleep quality index Hebrew translation (PSQI-H) in a sleep clinic sample. Isr Med Assoc J. 2007;9(12):853–856.
   PubMed Web of Science ®Google Scholar
• Sadeh A, Acebo C. The role of actigraphy in sleep medicine. Sleep Med Rev. 2002;6(2):113–124. doi:10.1053/smrv.2001.0182
   PubMed Web of Science ®Google Scholar
• Weiss AR, Johnson NL, Berger NA, Redline S. Validity of activity-based devices to estimate sleep. J Clin Sleep Med. 2010;6(4):336–342. doi:10.5664/jcsm.27874
   PubMed Web of Science ®Google Scholar
• Mantua J, Gravel N, Spencer RMC. Reliability of sleep measures from four personal health monitoring devices compared to research-based actigraphy and polysomnography. Sensors. 2016;16(5):646. doi:10.3390/s16050646
   PubMed Web of Science ®Google Scholar
• Plummer P, Eskes G. Measuring treatment effects on dual-task performance: a framework for research and clinical practice. Front Hum Neurosci. 2015;9(APR). doi:10.3389/fnhum.2015.00225
   Web of Science ®Google Scholar
• Yogev-Seligmann G, Hausdorff JM, Giladi N. Do we always prioritize balance when walking? Towards an integrated model of task prioritization. Mov Disord. 2012;27(6):765–770. doi:10.1002/mds.24963
   PubMed Web of Science ®Google Scholar
• Liu X, Sun B, Zhang Z, Wang Y, Tang H, Zhu T. Gait can reveal sleep quality with machine learning models. Ostadabbas S ed. PLoS One. 2019;14(9):e0223012. doi:10.1371/journal.pone.0223012
   Web of Science ®Google Scholar
• O’Dowd S, Galna B, Morris R, et al. Poor sleep quality and progression of gait impairment in an incident Parkinson’s disease cohort. J Parkinsons Dis. 2017;7(3):465–470. doi:10.3233/JPD-161062
   Google Scholar
• Bernstein JPK, De Vito A, Weitzner DS, et al. Examining relationships between multiple self-reported sleep measures and gait domains in cognitively healthy older adults. Gerontology. 2020;66(1):47–54. doi:10.1159/000499737
   Web of Science ®Google Scholar
• Bernstein JPK, Calamia M, Keller JN. Multiple self-reported sleep measures are differentially associated with cognitive performance in community-dwelling nondemented elderly. Neuropsychology. 2018;32(2):220–229. doi:10.1037/neu0000407
   PubMed Web of Science ®Google Scholar
• Mcdade EM, Boot BP, Christianson TJH, et al. Subtle gait changes in patients with REM sleep behavior disorder. Mov Disord. 2013;28(13):1847–1853. doi:10.1002/mds.25653
   Web of Science ®Google Scholar
• Allali G, Perrig S, Cleusix M, et al. Gait abnormalities in obstructive sleep apnea and impact of continuous positive airway pressure. Respir Physiol Neurobiol. 2014;201:31–33. doi:10.1016/j.resp.2014.06.012
   PubMed Web of Science ®Google Scholar
• Goldman SE, Stone KL, Ancoli-Israel S. Poor sleep is associated with poorer physical performance and greater functional limitations in older women. Sleep. 2007;30(10):1317–1324. doi:10.1093/sleep/30.10.1317
   PubMed Web of Science ®Google Scholar
• Nakakubo S, Doi T, Shimada H, et al. The association between excessive daytime sleepiness and gait parameters in community-dwelling older adults: cross-sectional findings from the Obu study of health promotion for the elderly. J Aging Health. 2018;30(2):213–228. doi:10.1177/0898264316673253
   Web of Science ®Google Scholar
• Ble A, Volpato S, Zuliani G, et al. Executive function correlates with walking speed in older persons: the InCHIANTI study. J Am Geriatr Soc. 2005;53(3):410–415. doi:10.1111/j.1532-5415.2005.53157.x
   PubMed Web of Science ®Google Scholar
• Yogev G, Plotnik M, Peretz C, Giladi N, Hausdorff JM. Gait asymmetry in patients with Parkinson’s disease and elderly fallers: when does the bilateral coordination of gait require attention? Exp Brain Res. 2007;177(3):336–346. doi:10.1007/s00221-006-0676-3
   PubMed Web of Science ®Google Scholar
• Yogev-Seligmann G, Hausdorff JM, Giladi N. The role of executive function and attention in gait. Mov Disord. 2008;23(3):329–342. doi:10.1002/mds.21720
   PubMed Web of Science ®Google Scholar
• Zimmerman ME, Bigal ME, Katz MJ, Brickman AM, Lipton RB. Sleep onset/maintenance difficulties and cognitive function in nondemented older adults: the role of cognitive reserve. J Int Neuropsychol Soc. 2012;18(3):461–470. doi:10.1017/S1355617711001901
   Web of Science ®Google Scholar
• Haimov I, Shatil E, Laks J. Cognitive training improves sleep quality and cognitive function among older adults with insomnia. PLoS One. 2013;8(4):e61390. doi:10.1371/journal.pone.0061390
   PubMed Web of Science ®Google Scholar
• Contreras-González N, Téllez-Alanís B, Haro R, Jiménez-Correa U, Poblano A. Executive dysfunction in patients with chronic primary insomnia treated with clonazepam. Neurol Res. 2015;37(12):1047–1053. doi:10.1080/01616412.2015.1114740
   PubMed Web of Science ®Google Scholar
• Wei Y, Leerssen J, Wassing R, Stoffers D, Perrier J, Van Someren EJW. Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder. J Sleep Res. 2020;29(2). doi:10.1111/jsr.12953
   Web of Science ®Google Scholar
• Haimov I, Hanuka E, Horowitz Y. Chronic insomnia and cognitive functioning among older adults. Behav Sleep Med. 2008;6(1):32–54. doi:10.1080/15402000701796080
   PubMed Web of Science ®Google Scholar
• Holtzer R, Wang C, Lipton R, Verghese J. The protective effects of executive functions and episodic memory on gait speed decline in aging defined in the context of cognitive reserve. J Am Geriatr Soc. 2012;60(11):2093–2098. doi:10.1111/j.1532-5415.2012.04193.x
   PubMed Web of Science ®Google Scholar
• Lewis SJG. Neurological update: emerging issues in gait disorders. J Neurol. 2015;262(6):1590–1595. doi:10.1007/s00415-015-7686-7
   Web of Science ®Google Scholar
• Elcombe EL, Lagopoulos J, Duffy SL, et al. Hippocampal volume in older adults at risk of cognitive decline: the role of sleep, vascular risk, and depression. J Alzheimers Dis. 2015;44(4):1279–1290. doi:10.3233/JAD-142016
   Web of Science ®Google Scholar
• O’Shea A, Cohen RA, Porges EC, Nissim NR, Woods AJ. Cognitive aging and the hippocampus in older adults. Front Aging Neurosci. 2016;8. doi:10.3389/fnagi.2016.00298.
   Web of Science ®Google Scholar
• Allali G, Van Der Meulen M, Beauchet O, Rieger SW, Vuilleumier P, Assal F. The neural basis of age-related changes in motor imagery of gait: an fMRI study. J Gerontol A Biol Sci. 2014;69(11):1389–1398. doi:10.1093/gerona/glt207
   Web of Science ®Google Scholar
• Rosso AL, Verghese J, Metti AL, et al. Slowing gait and risk for cognitive impairment. Neurology. 2017;89(4):336–342. doi:10.1212/WNL.0000000000004153
   Web of Science ®Google Scholar
• Rosso AL, Studenski SA, Chen WG, et al. Aging, the central nervous system, and mobility. J Gerontol A Biol Sci Med Sci. 2013;68(11):1379–1386. doi:10.1093/gerona/glt089
   PubMed Web of Science ®Google Scholar
• Fernandez-Mendoza J, Vgontzas AN, Liao D, et al. Insomnia with objective short sleep duration and incident hypertension: the penn state cohort. Hypertension. 2012;60(4):929–935. doi:10.1161/HYPERTENSIONAHA.112.193268
   PubMed Web of Science ®Google Scholar
• Silva-Costa A, Rotenberg L, Nobre AA, et al. Sex differences in the association between self-reported sleep duration, insomnia symptoms and cardiometabolic risk factors: cross-sectional findings from Brazilian longitudinal study of adult health. Arch Public Health. 2020;78(1). doi:10.1186/s13690-020-00429-8
   Web of Science ®Google Scholar
• Veronese N, Stubbs B, Volpato S, et al. Association between gait speed with mortality, cardiovascular disease and cancer: a systematic review and meta-analysis of prospective cohort studies. J Am Med Dir Assoc. 2018;19(11):981–988.e7. doi:10.1016/j.jamda.2018.06.007
   PubMed Web of Science ®Google Scholar
• Huang Y, Jiang Y, Zhu M. The relationship between global sleep score and inflammatory markers in obese adults from the United States. Nat Sci Sleep. 2019;11:317–324. doi:10.2147/NSS.S220436
   Web of Science ®Google Scholar
• Prather AA, Marsland AL, Hall M, Neumann SA, Muldoon MF, Manuck SB. Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production. Biol Psychol. 2009;82(1):12–17. doi:10.1016/j.biopsycho.2009.04.008
   Web of Science ®Google Scholar
• Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole S. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med. 2006;166(16):1756–1762. doi:10.1001/archinte.166.16.1756
   PubMedGoogle Scholar
• Schram MT, Euser SM, De Craen AJM, et al. Systemic markers of inflammation and cognitive decline in old age. J Am Geriatr Soc. 2007;55(5):708–716. doi:10.1111/j.1532-5415.2007.01159.x
   PubMed Web of Science ®Google Scholar
• Verghese J, Holtzer R, Oh-Park M, Derby CA, Lipton RB, Wang C. Inflammatory markers and gait speed decline in older adults. J Gerontol A Biol Sci. 2011;66 A(10):1083–1089. doi:10.1093/gerona/glr099
   Web of Science ®Google Scholar
• Lasselin J, Sundelin T, Wayne PM, et al. Biological motion during inflammation in humans. Brain Behav Immun. 2020;84:147–153. doi:10.1016/j.bbi.2019.11.019
   Web of Science ®Google Scholar
• Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9(1):46–56. doi:10.1038/nrn2297
   PubMed Web of Science ®Google Scholar
• Furihata R, Hall MH, Stone KL, et al. Aggregate measure of sleep health. Sleep. 2017;40(3). doi:10.1093/sleep/zsw075
   Web of Science ®Google Scholar
• Paudel ML, Taylor BC, Diem SJ, et al. Association between depressive symptoms and sleep disturbances in community-dwelling older men. J Am Geriatr Soc. 2008;56(7):1228–1235. doi:10.1111/j.1532-5415.2008.01753.x
   PubMed Web of Science ®Google Scholar
• Atkinson HH, Rosano C, Simonsick EM, et al. Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study. J Gerontol A Biol Sci. 2007;62(8):844–850. doi:10.1093/gerona/62.8.844
   PubMed Web of Science ®Google Scholar
• Hausdorff JM, Schweiger A, Herman T, Yogev-Seligmann G, Giladi N. Dual-task decrements in gait: contributing factors among healthy older adults. J Gerontol A Biol Sci. 2008;63(12):1335–1343. doi:10.1093/gerona/63.12.1335
   PubMed Web of Science ®Google Scholar
• Best JR, Davis JC, Liu-Ambrose T. Longitudinal analysis of physical performance, functional status, physical activity, and mood in relation to executive function in older adults who fall. J Am Geriatr Soc. 2015;63(6):1112–1120. doi:10.1111/jgs.13444
   PubMed Web of Science ®Google Scholar
• Hajek A, Bock JO, König HH. Psychological correlates of fear of falling: findings from the German aging survey. Geriatr Gerontol Int. 2018;18(3):396–406. doi:10.1111/ggi.13190
   PubMed Web of Science ®Google Scholar
• Holloway KL, Williams LJ, Brennan-Olsen SL, et al. Anxiety disorders and falls among older adults. J Affect Disord. 2016;205:20–27. doi:10.1016/j.jad.2016.06.052
   Web of Science ®Google Scholar
• Boland E, Goldschmied J, Kayser MS, Gehrman PR. Precision medicine for insomnia. Sleep Med Clin. 2019;14(3):291–299. doi:10.1016/j.jsmc.2019.04.001
   Web of Science ®Google Scholar
• Yogev-Seligmann G, Giladi N, Brozgol M, Hausdorff JM. A training program to improve gait while dual tasking in patients with Parkinson’s disease: a pilot study. Arch Phys Med Rehabil. 2012;93(1):176–181. doi:10.1016/j.apmr.2011.06.005
   PubMed Web of Science ®Google Scholar
• Tonetti L, Pasquini F, Fabbri M, Belluzzi M, Natale V. Comparison of two different actigraphs with polysomnography in healthy young subjects. Chronobiol Int. 2008;25(1):145–153. doi:10.1080/07420520801897228
   PubMed Web of Science ®Google Scholar
• Machado FV, Louzada LL, Cross NE, Camargos EF, Dang-Vu TT, Nóbrega OT. More than a quarter century of the most prescribed sleeping pill: systematic review of zolpidem use by older adults. Exp Gerontol. 2020;136:110962. doi:10.1016/j.exger.2020.110962
   Web of Science ®Google Scholar