Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study

References

• Kapur VK. Obstructive sleep apnea: diagnosis, epidemiology, and economics. Respir Care. 2010;55(9):1155–1167.
   Web of Science ®Google Scholar
• Duong-Quy S, Dang Thi Mai K, Tran Van N, et al. Study about the prevalence of the obstructive sleep apnoea syndrome in Vietnam. Rev Mal Respir. 2018;35(1):14–24. doi:10.1016/j.rmr.2017.10.006
   Web of Science ®Google Scholar
• Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7(8):687–698. doi:10.1016/S2213-2600(19)30198-5
   PubMed Web of Science ®Google Scholar
• Lévy P, Kohler M, McNicholas WT, et al. Obstructive sleep apnoea syndrome. Nat Rev Dis Primers. 2015;1:15015.
   PubMed Web of Science ®Google Scholar
• Gonzaga C, Bertolami A, Bertolami M, et al. Obstructive sleep apnea, hypertension and cardiovascular diseases. J Hum Hypertens. 2015;29(12):705–712. doi:10.1038/jhh.2015.15
   PubMed Web of Science ®Google Scholar
• Dewan NA, Nieto FJ, Somers VK. Intermittent hypoxemia and OSA: implications for comorbidities. Chest. 2015;147(1):266–274. doi:10.1378/chest.14-0500
   PubMed Web of Science ®Google Scholar
• Bjermer L, Alving K, Diamant Z. Current evidence and future research needs for FeNO measurement in respiratory diseases. Respir Med. 2014;108(6):830–841. doi:10.1016/j.rmed.2014.02.005
   PubMed Web of Science ®Google Scholar
• Vicente E, Marin JM, Carrizo SJ, et al. Upper airway and systemic inflammation in obstructive sleep apnoea. Eur Respir J. 2016;48(4):1108–1117. doi:10.1183/13993003.00234-2016
   PubMed Web of Science ®Google Scholar
• Cowan DC, Allardice G, Macfarlane D, et al. Predicting sleep disordered breathing in outpatients with suspected OSA. BMJ Open. 2014;4(4):e004519. doi:10.1136/bmjopen-2013-004519
   Web of Science ®Google Scholar
• Duong-Quy S, Hua-Huy T, Tran-Mai-Thi HT, et al. Study of exhaled nitric oxide in subjects with suspected obstructive sleep apnea: a pilot study in Vietnam. Pulm Med. 2016;2016:3050918. doi:10.1155/2016/3050918
   PubMed Web of Science ®Google Scholar
• Hua-Huy T, Le-dong NN, Duong-Quy S, et al. Increased alveolar nitric oxide concentration is related to nocturnal oxygen desaturation in obstructive sleep apnoea. Nitric Oxide. 2015;45:27–34. doi:10.1016/j.niox.2015.01.008
   PubMed Web of Science ®Google Scholar
• JalilMirmohammadi S, Mehrparvar AH, Safaei S, Samimi E, Torab Jahromi M. The association between exhaled nitric oxide and sleep apnea: the role of BMI. Respir Med. 2014;108(8):1229–1233. doi:10.1016/j.rmed.2014.05.010
   Web of Science ®Google Scholar
• Bikov A, Hull JH, Kunos L. Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea. Sleep Med Rev. 2016;27:1–8. doi:10.1016/j.smrv.2015.07.005
   PubMed Web of Science ®Google Scholar
• Johns MW. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. J Sleep Res Sleep Med. 1991;14(6):540–545.
   Google Scholar
• Pichot P, Brun JP. Questionnaire bref d’auto-évaluation des dimensions dépressive, asthénique et anxieuse. Ann Més-Psychol. 1984;142:862–865.
   PubMed Web of Science ®Google Scholar
• American Academy of Sleep Medicine. International Classification of Sleep Disorders: Diagnostic and Coding Manual. 2. Westchester: American Academy of Sleep Medicine; 2005.
   Google Scholar
• Collop NA, Anderson WM, Boehlecke B, et al. Portable Monitoring Task Force of the American Academy of Sleep Medicine. Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable Monitoring Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med. 2007;3(7):737–747.
   PubMed Web of Science ®Google Scholar
• Horváth I, Barnes PJ, Loukides S, et al. A European Respiratory Society technical standard: exhaled biomarkers in lung disease. Eur Respir J. 2017;49(4):1600965. doi:10.1183/13993003.00965-2016
   PubMed Web of Science ®Google Scholar
• Culla B, Guida G, Brussino L, et al. Increased oral nitric oxide in obstructive sleep apnoea. Respir Med. 2010;104(2):316–320. doi:10.1016/j.rmed.2009.09.020
   Web of Science ®Google Scholar
• Ai-Ping C, Aboussouan Loutfi S, Minai Omar A, et al. Long-term continuous positive airway pressure therapy normalizes high exhaled nitric oxide levels in obstructive sleep apnea. J Clin Sleep Med. 2013;9(6):529–535. doi:10.5664/jcsm.2740
   Web of Science ®Google Scholar
• Devouassoux G, Levy P, Rossini E, et al. Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness. J Allergy Clin Immunol. 2007;119(3):597–603. doi:10.1016/j.jaci.2006.11.638
   PubMed Web of Science ®Google Scholar
• Kheirandish-Gozal L, Gozal D. Obstructive sleep apnea and inflammation: proof of concept based on two illustrative cytokines. Int J Mol Sci. 2019;20(3):459. doi:10.3390/ijms20030459
   PubMed Web of Science ®Google Scholar
• Sabato R, Guido P, Salerno FG, et al. Airway inflammation in patients affected by obstructive sleep apnea. Monaldi Arch Chest Dis. 2006;65(2):102–105. doi:10.4081/monaldi.2006.572
   PubMedGoogle Scholar
• Inancli Hasan M, Murat E. Obstructive sleep apnea syndrome and upper airway inflammation. Recent Pat Inflamm Allergy Drug Discov. 2010;4(1):54–57. doi:10.2174/187221310789895568
   Google Scholar
• May AM, Mehra R. Obstructive sleep apnea: role of intermittent hypoxia and inflammation. Semin Respir Crit Care Med. 2014;35(5):531–544. doi:10.1055/s-0034-1390023
   Web of Science ®Google Scholar
• Lázár Z, Horváth P, Puskás R, et al. A suitable protocol for measuring alveolar nitric oxide in asthma with differing severity to assess peripheral airways inflammation. J Asthma. 2019;56(6):584–593. doi:10.1080/02770903.2018.1477957
   PubMed Web of Science ®Google Scholar
• Girgis RE, Gugnani MK, Abrams J, et al. Partitioning of alveolar and conducting airway nitric oxide in scleroderma lung disease. Am J Respir Crit Care Med. 2002;165(12):1587–1591. doi:10.1164/rccm.2104003
   Web of Science ®Google Scholar
• Vinnikov D, Brimkulov N, Redding-Jones R, Jumabaeva K. Exhaled nitric oxide is reduced upon chronic intermittent hypoxia exposure in well-acclimatized mine workers. Respir Physiol Neurobiol. 2011;175(2):261–264. doi:10.1016/j.resp.2010.11.013
   Web of Science ®Google Scholar
• Liu J, Li Z, Liu Z, et al. Exhaled nitric oxide from the central airway and alveoli in OSAHS patients: the potential correlations and clinical implications. Sleep Breath. 2016;20(1):145–154. doi:10.1007/s11325-015-1198-7
   Web of Science ®Google Scholar
• Garvey JF, Taylor CT, McNicholas WT. Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation. Eur Respir J. 2009;33(5):1195–1205. doi:10.1183/09031936.00111208
   PubMed Web of Science ®Google Scholar
• Fortuna AM, Miralda R, Calaf N, et al. Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome. Respir Med. 2011;105(4):630–636. doi:10.1016/j.rmed.2010.12.004
   PubMed Web of Science ®Google Scholar
• Zhang D, Luo J, Qiao Y, et al. Measurement of exhaled nitric oxide concentration in patients with obstructive sleep apnea: a meta-analysis. Medicine (Baltimore). 2017;96(12):e6429. doi:10.1097/MD.0000000000006429
   Web of Science ®Google Scholar
• Duarte RLM, Rabahi MF, Oliveira-E-Sá TS, et al. Fractional exhaled nitric oxide measurements and screening of obstructive sleep apnea in a sleep-laboratory setting: a cross-sectional study. Lung. 2019;197(2):131–137. doi:10.1007/s00408-018-0190-y
   Web of Science ®Google Scholar