125
Views
3
CrossRef citations to date
0
Altmetric
Original Research

Natural History of REM-OSA in Children and Its Associations with Adverse Blood Pressure Outcomes: A Longitudinal Follow-Up Study

, ORCID Icon, , ORCID Icon &
Pages 1967-1984 | Published online: 04 Nov 2021

References

  • Li AM, So HK, Au CT, et al. Epidemiology of obstructive sleep apnoea syndrome in Chinese children: a two-phase community study. Thorax. 2010;65(11):991–997. doi:10.1136/thx.2010.134858
  • Dehlink E, Tan HL. Update on paediatric obstructive sleep apnoea. J Thorac Dis. 2016;8(2):224–235. doi:10.3978/j.issn.2072-1439.2015.12.04
  • Horner RL, Hughes SW, Malhotra A. State-dependent and reflex drives to the upper airway: basic physiology with clinical implications. J Appl Physiol. 2014;116(3):325–336. doi:10.1152/japplphysiol.00531.2013
  • Alzoubaidi M, Mokhlesi B. Obstructive sleep apnea during rapid eye movement sleep: clinical relevance and therapeutic implications. Curr Opin Pulm Med. 2016;22(6):545–554. doi:10.1097/MCP.0000000000000319
  • Vyazovskiy VV, Delogu A. NREM and REM sleep: complementary roles in recovery after wakefulness. Neuroscientist. 2014;20(3):203–219. doi:10.1177/1073858413518152
  • Verginis N, Jolley D, Horne RSC, Davey MJ, Nixon GM. Sleep state distribution of obstructive events in children: is obstructive sleep apnoea really a rapid eye movement sleep-related condition? J Sleep Res. 2009;18(4):411–414. doi:10.1111/j.1365-2869.2009.00760.x
  • Spruyt K, Gozal D. REM and NREM sleep-state distribution of respiratory events in habitually snoring school-aged community children. Sleep Med. 2012;13(2):178–184. doi:10.1016/j.sleep.2011.10.025
  • El-Kersh K, Cavallazzi R, Patel PM, Senthilvel E. Effect of sleep state and position on obstructive respiratory events distribution in adolescent children. J Clin Sleep Med. 2016;12(4):513–517. doi:10.5664/jcsm.5678
  • Joosten SA, Landry SA, Wong A-M, et al. Assessing the physiologic endotypes responsible for REM- and NREM-based OSA. Chest. 2021;159(5):1998–2007. doi:10.1016/j.chest.2020.10.080
  • Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A. Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med. 2013;188(8):996–1004. PMID: 23721582; PMCID: PMC3826282. doi:10.1164/rccm.201303-0448OC
  • Kass JE, Akers SM, Bartter TC, Pratter MR. Rapid-eye-movement-specific sleep-disordered breathing: a possible cause of excessive daytime sleepiness. Am J Respir Crit Care Med. 1996;154(1):167–169. doi:10.1164/ajrccm.154.1.8680674
  • Lee S-A, Paek J-H, Han S-H. REM-related sleep-disordered breathing is associated with depressive symptoms in men but not in women. Sleep Breath. 2016;20(3):995–1002. doi:10.1007/s11325-016-1323-2
  • Varga AW, Kishi A, Mantua J, et al. Apnea-induced rapid eye movement sleep disruption impairs human spatial navigational memory. J Neurosci. 2014;34(44):14571–14577. doi:10.1523/JNEUROSCI.3220-14.2014
  • Hoshino T, Sasanabe R, Tanigawa T, et al. Effect of rapid eye movement-related obstructive sleep apnea on adherence to continuous positive airway pressure. J Int Med Res. 2018;46(6):2238–2248. doi:10.1177/0300060518758583
  • Mokhlesi B, Hagen EW, Finn LA, Hla KM, Carter JR, Peppard PE. Obstructive sleep apnoea during REM sleep and incident non-dipping of nocturnal blood pressure: a longitudinal analysis of the Wisconsin sleep cohort. Thorax. 2015;70(11):1062–1069. doi:10.1136/thoraxjnl-2015-207231
  • Mokhlesi B, Finn LA, Hagen EW, et al. Obstructive sleep apnea during REM sleep and hypertension. results of the Wisconsin sleep cohort. Am J Respir Crit Care Med. 2014;190(10):1158–1167. doi:10.1164/rccm.201406-1136OC
  • Appleton SL, Vakulin A, Martin SA, et al. Hypertension is associated with undiagnosed OSA during rapid eye movement sleep. Chest. 2016;150(3):495–505. doi:10.1016/j.chest.2016.03.010
  • Liu Y, Su C, Liu R, et al. NREM-AHI greater than REM-AHI versus REM-AHI greater than NREM-AHI in patients with obstructive sleep apnea: clinical and polysomnographic features. Sleep Breath. 2011;15(3):463–470. doi:10.1007/s11325-010-0358-z
  • Chami HA, Baldwin CM, Silverman A, et al. Sleepiness, quality of life, and sleep maintenance in REM versus non-REM sleep-disordered breathing. Am J Respir Crit Care Med. 2010;181(9):997–1002. doi:10.1164/rccm.200908-1304OC
  • Oh SM, Choi SH, Kim HJ, Park KS, Lee YJ. The association between obstructive sleep apnea during REM sleep and autonomic dysfunction as measured by heart rate variability. Sleep Breath. 2019;23(3):865–871. doi:10.1007/s11325-018-01779-y
  • Nisbet LC, Yiallourou SR, Biggs SN, et al. Preschool children with obstructive sleep apnea: the beginnings of elevated blood pressure? Sleep. 2013;36(8):1219–1226. doi:10.5665/sleep.2890
  • Geng X, Wu Y, Ge W, et al. Ambulatory blood pressure monitoring in children with obstructive sleep apnea syndrome. Pediatr Investig. 2019;3(4):217–222. doi:10.1002/ped4.12163
  • Au CT, Ho CKW, Wing YK, Li AM. The effect of childhood obstructive sleep apnea on ambulatory blood pressure is modulated by the distribution of respiratory events during rapid eye movement and nonrapid eye movement sleep. Sleep Med. 2013;14(12):1317–1322. doi:10.1016/j.sleep.2013.09.017
  • Chan KC, Au CT, Hui LL, Ng S-K, Wing YK, Li AM. How OSA evolves from childhood to young adulthood: natural history from a 10-year follow-up study. Chest. 2019;156(1):120–130. doi:10.1016/j.chest.2019.03.007
  • Chan KCC, Au CT, Hui LL, Wing YK, Li AM. Childhood OSA is an independent determinant of blood pressure in adulthood: longitudinal follow-up study. Thorax. 2020;75(5):422–431. doi:10.1136/thoraxjnl-2019-213692
  • Li AM, Cheung A, Chan D, et al. Validation of a questionnaire instrument for prediction of obstructive sleep apnea in Hong Kong Chinese children. Pediatr Pulmonol. 2006;41(12):1153–1160. doi:10.1002/ppul.20505
  • Leung SS, Cole TJ, Tse LY, Lau JT. Body mass index reference curves for Chinese children. Ann Hum Biol. 1998;25(2):169–174. doi:10.1080/03014469800005542
  • Berry RB, Brooks R, Gamaldo CE, et al. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, version 2.0. Darien, Illinois: American Academy of Sleep Medicine; 2012.
  • American Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed. Darien, IL: American Academy of Sleep Medicine; 2014.
  • Li AM, Au CT, Sung RY, et al. Ambulatory blood pressure in children with obstructive sleep apnoea: a community based study. Thorax. 2008;63(9):803–809. PMID: 18388205. doi:10.1136/thx.2007.091132
  • Yip GWK, Li AM, So H-K, et al. Oscillometric 24-h ambulatory blood pressure reference values in Hong Kong Chinese children and adolescents. J Hypertens. 2014;32(3):606–619. doi:10.1097/HJH.0000000000000062
  • Leung AA, Daskalopoulou SS, Dasgupta K, et al. Hypertension Canada’s 2017 guidelines for diagnosis, risk assessment, prevention, and treatment of hypertension in adults. Can J Cardiol. 2017;33(5):557–576. doi:10.1016/j.cjca.2017.03.005
  • Kazuomi K. Nocturnal hypertension. Hypertension. 2018;71(6):997–1009. doi:10.1161/HYPERTENSIONAHA.118.10971
  • Li AM, Au CT, Ng C, Lam HS, Ho CKW, Wing YK. A 4-year prospective follow-up study of childhood OSA and its association with BP. Chest. 2014;145(6):1255–1263. doi:10.1378/chest.13-1333
  • Crinion SJ, Ryan S, McNicholas WT. Obstructive sleep apnoea as a cause of nocturnal nondipping blood pressure: recent evidence regarding clinical importance and underlying mechanisms. Eur Respir J. 2017;49(1):1601818. doi:10.1183/13993003.01818-2016
  • Boggia J, Li Y, Thijs L, et al.; International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcomes (IDACO) investigators. Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet. 2007;370(9594):1219–1229. PMID: 17920917. doi:10.1016/S0140-6736(07)61538-4
  • Goh DY, Galster P, Marcus CL. Sleep architecture and respiratory disturbances in children with obstructive sleep apnea. Am J Respir Crit Care Med. 2000;162(2 Pt 1):682–686. doi:10.1164/ajrccm.162.2.9908058
  • Varga AW, Mokhlesi B. REM obstructive sleep apnea: risk for adverse health outcomes and novel treatments. Sleep Breath. 2019;23(2):413–423. doi:10.1007/s11325-018-1727-2
  • Grace KP, Hughes SW, Horner RL. Identification of the mechanism mediating genioglossus muscle suppression in REM sleep. Am J Respir Crit Care Med. 2013;187(3):311–319. doi:10.1164/rccm.201209-1654OC
  • McSharry DG, Saboisky JP, DeYoung P, et al. Physiological mechanisms of upper airway hypotonia during REM sleep. Sleep. 2014;37(3):561–569. doi:10.5665/sleep.3498
  • Ermis U, Krakow K, Voss U. Arousal thresholds during human tonic and phasic REM sleep. J Sleep Res. 2010;19(3):400–406. doi:10.1111/j.1365-2869.2010.00831.x
  • Chowdhuri S, Pranathiageswaran S, Loomis-King H, Salloum A, Badr MS. Aging is associated with increased propensity for central apnea during NREM sleep. J Appl Physiol. 2017;124(1):83–90. doi:10.1152/japplphysiol.00125.2017
  • Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly. J Physiol. 2007;581(Pt 1):291–298. doi:10.1113/jphysiol.2006.126409
  • Peter JH, Grote L, Fus E, Ploch T, Stammnitz A. REM-sleep-hypertension in obstructive sleep apnea. Eur J Med Res. 1995;1(3):132–136.
  • Kohler M, Stradling JR. CrossTalk proposal: most of the cardiovascular consequences of OSA are due to increased sympathetic activity. J Physiol. 2012;590(12):2813–2815; discussion 2823. doi:10.1113/jphysiol.2012.229633
  • Somers VK, Dyken ME, Mark AL, Abboud FM. Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med. 1993;328(5):303–307. doi:10.1056/NEJM199302043280502
  • Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest. 1995;96(4):1897–1904. doi:10.1172/JCI118235