The Relationship Between HIF1α and Clock Gene Expression in Patients with Obstructive Sleep Apnea

References

• Gottlieb DJ, Punjabi NM. Diagnosis and management of obstructive sleep apnea: a review. JAMA J Am Med Assoc. 2020;323(14):1389. doi:10.1001/jama.2020.3514
   PubMed Web of Science ®Google Scholar
• Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006–1014. doi:10.1093/aje/kws342
   PubMed Web of Science ®Google Scholar
• Garvey JF, Pengo MF, Drakatos P, Kent BD. Epidemiological aspects of obstructive sleep apnea. J Thorac Dis. 2015;7(5):920–929. doi:10.3978/j.issn.2072-1439.2015.04.52
   PubMed Web of Science ®Google Scholar
• Bangash A, Wajid F, Poolacherla R, Mim FK, Rutkofsky IH. Obstructive Sleep Apnea and Hypertension: a Review of the Relationship and Pathogenic Association. Cureus. 2020;12(5):e8241–e8241. doi:10.7759/cureus.8241
   PubMed Web of Science ®Google Scholar
• Doumit J, Prasad B. Sleep Apnea in Type 2 Diabetes. Diabetes Spectrum. 2016;29(1):14. doi:10.2337/diaspect.29.1.14
   PubMedGoogle Scholar
• Kent BD, Garvey JF, Ryan S, Nolan G, Dodd JD, McNicholas WT. Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study. Eur Respir J. 2013;42(5):1263. doi:10.1183/09031936.00094812
   PubMed Web of Science ®Google Scholar
• Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. N Eng J Med. 2005;353(19):2034–2041. doi:10.1056/NEJMoa043104
   PubMed Web of Science ®Google Scholar
• Butler MP, Thosar SS, Smales C, et al. Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis. Chronobiol Int. 2020;37(6):856–866. doi:10.1080/07420528.2020.1740723
   PubMed Web of Science ®Google Scholar
• Manella G, Aviram R, Bolshette N, Muvkadi S, Asher G. Hypoxia induces a time- And tissue-specific response that elicits intertissue circadian clock misalignment. Proc National Acad Sci. 2019;117(1):201914112. doi:10.1073/pnas.1914112117
   Web of Science ®Google Scholar
• O’Connell EJ, Martinez CA, Liang YG, Cistulli PA, Cook KM. Out of Breath, Out of Time: interactions between HIF and Circadian Rhythms. AJP Cell Physiology. 2020;319(3):9857. doi:10.1152/ajpcell.00305.2020
   Web of Science ®Google Scholar
• Wu Y, Tang D, Liu N, et al. Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals. Cell Metab. 2017;25(1):73–85. doi:10.1016/j.cmet.2016.09.009
   PubMed Web of Science ®Google Scholar
• Gabryelska A, Turkiewicz S, Karuga FF, Sochal M, Strzelecki D, BiaBasiewicz P. Disruption of Circadian Rhythm Genes in Obstructive Sleep Apnea Patient“ Possible Mechanisms Involved and Clinical Implication. Int J Mol Sci. 2022;23. doi:10.3390/ijms23020709
   PubMed Web of Science ®Google Scholar
• Kramer A, Merrow M. Circadian Clocks. Handb Exp Pharmacol. 2013;148(5):S29.
   Google Scholar
• Burioka N, Takata M, Endo M, et al. Treatment with β 2 ‐Adrenoceptor Agonist in Vivo Induces Human Clock Gene, Per1, mRNA Expression in Peripheral Blood. Chronobiol Int. 2007;24:183–189. doi:10.1080/07420520601140043
   PubMed Web of Science ®Google Scholar
• Boivin DB, James FO, Wu A, Cho-Park PF, Xiong H, Sun ZS. Circadian clock genes oscillate in human peripheral blood mononuclear cells. Blood. 2003;102(12):4143–4145. doi:10.1182/blood-2003-03-0779
   PubMed Web of Science ®Google Scholar
• Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002;418(6901):935–941. doi:10.1038/nature00965
   PubMed Web of Science ®Google Scholar
• Schibler U. The daily timing of gene expression and physiology in mammals. Dialogues Clin Neurosci. 2007;9(3):257–272. doi:10.31887/DCNS.2007.9.3/uschibler
   PubMedGoogle Scholar
• Yang M-Y, Lin P-W, Lin H-C, et al. Alternations of Circadian Clock Genes Expression and Oscillation in Obstructive Sleep Apnea. J Clin Med. 2019;8(10):987. doi:10.3390/jcm8101634
   PubMed Web of Science ®Google Scholar
• Canales MT, Holzworth M, Bozorgmehri S, et al. Clock gene expression is altered in veterans with sleep apnea. Physiol Genomics. 2019;51(3):77–82. doi:10.1152/physiolgenomics.00091
   PubMed Web of Science ®Google Scholar
• Burioka N, Koyanagi S, Endo M, et al. Clock gene dysfunction in patients with obstructive sleep apnoea syndrome. Eur Respir J. 2008;32(1):105. doi:10.1183/09031936.00138207
   PubMed Web of Science ®Google Scholar
• Moreira S, Rodrigues R, Barros AB, et al. Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment. Front Med. 2017;4:187. doi:10.3389/fmed.2017.00187
   Web of Science ®Google Scholar
• Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc National Acad Sci. 1995;92(12):5510. doi:10.1073/pnas.92.12.5510
   PubMed Web of Science ®Google Scholar
• Manalo D, Rowan A, Lavoie T, et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood. 2005;105:659–669. doi:10.1182/blood-2004-07-2958
   PubMed Web of Science ®Google Scholar
• Schödel J, Oikonomopoulos S, Ragoussis J, Pugh CW, Ratcliffe PJ, Mole DR. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood. 2011;117(23):e207–17. doi:10.1182/blood-2010-10-314427
   PubMed Web of Science ®Google Scholar
• Gabryelska A, Szmyd B, Panek M, Szemraj J, Biaasiewicz P. Serum Hypoxia-Inducible Factor-1α protein level as a diagnostic marker of obstructive sleep apnea. Polskie Archiwum Medycyny Wewn. 2019;130(2):287. doi:10.20452/pamw.15104
   Web of Science ®Google Scholar
• Gabryelska A, Szmyd B, Szemraj J, Stawski R, Sochal M, Białasiewicz P. Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein. J Clin Sleep Med. 2020;16(10):1761–1768. doi:10.5664/jcsm.8682
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Morinibu A, Koyasu S, Goto Y, Hiraoka M, Harada H. A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes. FEBS J. 2017;284(22):3804–3816. doi:10.1111/febs.14280
   PubMed Web of Science ®Google Scholar
• Peek CB, Levine DC, Cedernaes J, et al. Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle. Cell Metab. 2017;25(1):86–92. doi:10.1016/j.cmet.2016.09.010
   PubMed Web of Science ®Google Scholar
• Gabryelska A, Stawski R, Sochal M, Szmyd B, Bialasiewicz P. Influence of one‐night CPAP therapy on the changes of HIF‐1α protein in OSA patients: a pilot study. J Sleep Res. 2020. doi:10.1111/jsr.12995
   PubMed Web of Science ®Google Scholar
• Berry RB, Albertario CL, Harding SM, et al. The AASM Manual for the Scoring of Sleep and Associated Events: rules, Terminology and Technical Specifications. Original Res. 2018:2018;76.
   Google Scholar
• Luo J, Wang X, Guo Z, et al. Endothelial Function and Arterial Stiffness Should Be Measured to Comprehensively Assess Obstructive Sleep Apnea in Clinical Practice. Original Research. Front Cardiovascular Med. 2021;2021:8. doi:10.3389/fcvm.2021.716916
   Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
   PubMed Web of Science ®Google Scholar
• American Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed. Darien. IL: American Academy of Sleep Medicine; 2014.
   Google Scholar
• Kaczmarek E, Bakker JP, Clarke DN, et al. Molecular biomarkers of vascular dysfunction in obstructive sleep apnea. PLoS One. 2013;8(7):e70559. doi:10.1371/journal.pone.0070559
   PubMed Web of Science ®Google Scholar
• Horst G, Muijtjens M, Kobayashi K, Takano R, Yasui A. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature. 1999;398(6728):627–630. doi:10.1038/19323
   PubMed Web of Science ®Google Scholar
• Yamanaka Y, Suzuki Y, Todo T, Honma K, Honma S. Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice. Genes to Cells. 2010;15(10):1063–1071. doi:10.1111/j.1365-2443.2010.01443.x
   PubMed Web of Science ®Google Scholar
• Unsal-Kaçmaz K, Mullen TE, Kaufmann WK, Sancar A. Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol. 2005;25(8):3109–3116. doi:10.1128/mcb.25.8.3109-3116.2005
   PubMed Web of Science ®Google Scholar
• Gabryelska A, Sochal M, Turkiewicz S, Biaasiewicz P. Relationship between HIF-1 and Circadian Clock Proteins in Obstructive Sleep Apnea Patients—Preliminary Study. J Clin Med. 2020;9(5):1599. doi:10.3390/jcm9051599
   PubMed Web of Science ®Google Scholar
• Akashi M, Takumi T. The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1. Nat Struct Mol Biol. 2005;12(5):441–448. doi:10.1038/nsmb925
   PubMed Web of Science ®Google Scholar
• Sato TK, Panda S, Miraglia LJ, Reyes TM, Hogenesch JB. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 2004;43(4):527–537. doi:10.1016/j.neuron.2004.07.018
   PubMed Web of Science ®Google Scholar
• Hongyu L, Longjian Z, Jun D. Retinoic acid receptor-related orphan receptor ROR regulates differentiation and survival of keratinocytes during hypoxia. J Cell Physiol. 2018;233(1):641–650. doi:10.1111/j.1471-4159.2008.05739.x
   PubMed Web of Science ®Google Scholar
• Suyama K, Silagi ES, Choi H, et al. Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Oncotarget. 2014;7(17):786. doi:10.18632/oncotarget.8521
   Google Scholar
• Chauvet C, Bois-Joyeux B, Berra E, Pouyssegur J, Danan JL. The gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1. Biochem J. 2004;384(Pt 1):84. doi:10.1042/BJ20040709
   Web of Science ®Google Scholar
• Kalousi A, Mylonis I, Politou AS, Chachami G, Simos G. Casein kinase 1 regulates human hypoxia-inducible factor HIF-1. J Cell Sci. 2010;123(Pt 17):2976–2986. doi:10.1242/jcs.068122
   PubMed Web of Science ®Google Scholar
• Kourti M, Ikonomou G, Giakoumakis -N-N, et al. CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation. Cell Signal. 2015;27(6):1129–1140. doi:10.1016/j.cellsig.2015.02.017
   PubMed Web of Science ®Google Scholar
• Koyasu S, Kobayashi M, Goto Y, Hiraoka M, Harada H. Regulatory mechanisms of hypoxia-inducible factor 1 activity: two decades of knowledge. Cancer Sci. 2018;109(3):560–571. doi:10.1111/cas.13483
   PubMed Web of Science ®Google Scholar
• Keenan BT, Kim J, Singh B, et al. Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis. Sleep. 2018;41(3):zsx214. doi:10.1093/sleep/zsx214
   PubMed Web of Science ®Google Scholar