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Review

Treatment paradigms for cataplexy in narcolepsy: past, present, and future

Pages 159-169 | Published online: 11 Dec 2015

References

  • McCartyDEA case of narcolepsy with strictly unilateral cataplexyJ Clin Sleep Med201061757620191942
  • OvereemSvan NuesSJvan der ZandeWLDonjacourCEvan MierloPLammersGJThe clinical features of cataplexy: a questionnaire study in narcolepsy patients with and without hypocretin-1 deficiencySleep Med2011121121821145280
  • National Institute of Neurological Disorders and StrokeNarcolepsy Fact SheetNIH publication 13-1637 last updated January 5, 2015 Available from: http://www.ninds.nih.gov/disorders/narcolepsy/detail_narcolepsy.htm#241213201Accessed August 9, 2015
  • PoryazovaRKhatamiRWerthEBassettiCLWeak with sex: sexual intercourse as a trigger for cataplexyJ Sex Med2009682271227719493288
  • SturzeneggerCBassettiCLThe clinical spectrum of narcolepsy with cataplexy: a reappraisalJ Sleep Res200413439540615560774
  • OkunMLLinLPelinZHongSMignotEClinical aspects of narcolepsy-cataplexy across ethnic groupsSleep2002251273511833858
  • Martinez-RodriguezJIranzoASantamariaJStatus cataplecticus induced by abrupt withdrawal of clomipramineNeurologia2002172113116 Spanish11864561
  • WangJGreenbergHStatus cataplecticus precipitated by abrupt withdrawal of venlafaxineJ Clin Sleep Med20139771571623853567
  • DauvilliersYSiegelJMLopezRTorontaliZAPeeverJHCataplexy – clinical aspects, pathophysiology and management strategyNat Rev Neurol201410738639524890646
  • NishinoSClinical and neurobiological aspects of narcolepsySleep Med20078437339917470414
  • LongstrethWTJrKoepsellTDTonTGHendricksonAFvan BelleGThe epidemiology of narcolepsySleep2007301132617310860
  • DauvilliersYMontplaisirJMolinariNAge at onset of narcolepsy in two large populations of patients in France and QuebecNeurology200157112029203311739821
  • American Academy of Sleep MedicineThe International Classification of Sleep Disorders – Third Edition (ICSD-3)Darien, ILAmerican Academy of Sleep Medicine2014
  • AdamantidisARZhangFAravanisAMDeisserothKde LeceaLNeural substrates of awakening probed with optogenetic control of hypocretin neuronsNature2007450716842042417943086
  • EspanaRAScammellTESleep neurobiology from a clinical perspectiveSleep201134784585821731134
  • SerraLMontagnaPMignotELugaresiEPlazziGCataplexy features in childhood narcolepsyMov Disord200823685886518307264
  • AndlauerOMooreHtHongSCPredictors of hypocretin (orexin) deficiency in narcolepsy without cataplexySleep20123591247125522942503
  • NevsimalovaSPiskoJBuskovaJNarcolepsy: clinical differences and association with other sleep disorders in different age groupsJ Neurol2013260376777523070467
  • PlazziGPizzaFPalaiaVComplex movement disorders at disease onset in childhood narcolepsy with cataplexyBrain2011134Pt 1234803492
  • PizzaFFranceschiniCPeltolaHClinical and polysomnographic course of childhood narcolepsy with cataplexyBrain2013136Pt 123787379524142146
  • VanierMTNiemann-Pick diseasesHandb Clin Neurol20131131717172123622394
  • TobiasESTolmieJLStephensonJBCataplexy in the Prader-Willi syndromeArch Dis Child200287217012138077
  • NelsonGBHahnJSStimulus-induced drop episodes in Coffin-Lowry syndromePediatrics20031113e197e20212612271
  • FryssiraHKountoupiSDelaunoyJPThomaidisLA female with Coffin-Lowry syndrome and “cataplexy”Genet Couns200213440540912558110
  • TyagiAHarringtonHCataplexy in association with Moebius syndromeJ Neurol2003250111011112528006
  • VosslerDGWylerARWilkusRJGardner-WalkerGVlcekBWCataplexy and monoamine oxidase deficiency in Norrie diseaseNeurology1996465125812618628463
  • PortalaKWestermarkKEkseliusLBromanJESleep in patients with treated Wilson’s disease. A questionnaire studyNord J Psychiatry200256429129712470321
  • NevsimalovaSBuskovaJBruhaRSleep disorders in Wilson’s diseaseEur J Neurol201118118419020550561
  • KanbayashiTAbeMFujimotoSHypocretin deficiency in Niemann-Pick type C with cataplexyNeuropediatrics2003341525312690569
  • OyamaKTakahashiTShojiYNiemann-Pick disease type C: cataplexy and hypocretin in cerebrospinal fluidTohoku J Exp Med2006209326326716778374
  • VankovaJStepanovaIJechRSleep disturbances and hypocretin deficiency in Niemann-Pick disease type CSleep200326442743012841368
  • PeyronCTigheDKvan den PolANNeurons containing hypocretin (orexin) project to multiple neuronal systemsJ Neurosci199818239996100159822755
  • CasonAMSmithRJTahsili-FahadanPMoormanDESartorGCAston-JonesGRole of orexin/hypocretin in reward-seeking and addiction: implications for obesityPhysiol Behav2010100541942820338186
  • BurgessCRScammellTENarcolepsy: neural mechanisms of sleepiness and cataplexyJ Neurosci20123236123051231122956821
  • MiedaMTsujinoNSakuraiTDifferential roles of orexin receptors in the regulation of sleep/wakefulnessFront Endocrinol (Lausanne)201345723730297
  • InutsukaAInuiATabuchiSTsunematsuTLazarusMYamanakaAConcurrent and robust regulation of feeding behaviors and metabolism by orexin neuronsNeuropharmacology20148545146024951857
  • PeyronCFaracoJRogersWA mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brainsNat Med20006999199710973318
  • PeeverJHLaiYYSiegelJMExcitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonismJ Neurophysiol20038952591260012611960
  • DauvilliersYJaussentILecendreuxMCerebrospinal fluid and serum cytokine profiles in narcolepsy with cataplexy: a case-control studyBrain Behav Immun201426026624394344
  • LeeMGHassaniOKJonesBEDischarge of identified orexin/hypocretin neurons across the sleep-waking cycleJ Neurosci200525286716672016014733
  • TakahashiKLinJSSakaiKNeuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouseNeuroscience2008153386087018424001
  • LinLFaracoJLiRThe sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 geneCell199998336537610458611
  • ChemelliRMWillieJTSintonCMNarcolepsy in orexin knockout mice: molecular genetics of sleep regulationCell199998443745110481909
  • NishinoSRipleyBOvereemSLammersGJMignotEHypocretin (orexin) deficiency in human narcolepsyLancet200035591973940 Letter10615891
  • TabuchiSTsunematsuTBlackSWConditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system functionJ Neurosci201434196495650924806676
  • PizzaFVandiSLiguoriRPrimary progressive narcolepsy type 1: the other side of the coinNeurology201483232189219025355832
  • NishinoSOkuroMKotoriiNHypocretin/orexin and narcolepsy: new basic and clinical insightsActa Physiol (Oxf)2010198320922219555382
  • PartinenMKornumBRPlazziGJennumPJulkunenIVaaralaODoes autoreactivity have a role in narcolepsy?Lancet Neurol2014131110721073 Letter25316012
  • MignotEHaydukRBlackJGrumetFCGuilleminaultCHLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patientsSleep19972011101210209456467
  • HallmayerJFaracoJLinLNarcolepsy is strongly associated with the T-cell receptor alpha locusNat Genet200941670871119412176
  • FaracoJLinLKornumBRImmunoChip study implicates antigen presentation to T cells in narcolepsyPLoS Genet201392e100327023459209
  • AhmedSSVolkmuthWDucaJAntibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2Sci Transl Med20157294294ra105
  • GulyaniSWuMFNienhuisRJohnJSiegelJMCataplexy-related neurons in the amygdala of the narcoleptic dogNeuroscience2002112235536512044453
  • HongSBTaeWSJooEYCerebral perfusion changes during cataplexy in narcolepsy patientsNeurology200666111747174916769955
  • OvereemSLammersGJvan DijkJGCataplexy: ‘tonic immobility’ rather than ‘REM-sleep atonia’?Sleep Med20023647147714592141
  • OvereemSReijntjesRHuyserWLammersGJvan DijkJGCorticospinal excitability during laughter: implications for cataplexy and the comparison with REM sleep atoniaJ Sleep Res200413325726415339261
  • SchwartzSPonzAPoryazovaRAbnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexyBrain2008131Pt 251452218094020
  • BurgessCROishiYMochizukiTPeeverJHScammellTEAmygdala lesions reduce cataplexy in orexin knock-out miceJ Neurosci201333239734974223739970
  • DauvillersYBilliardMMontplaisirJClinical aspects and pathophysiology of narcolepsyClin Neurophysiol20031142000201714580598
  • PeeverJControl of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsyArch Ital Biol2011149445446622205591
  • SiegelJMNienhuisRFahringerHMNeuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medullaScience19912525010131513181925546
  • LuppiPHClementOSapinEThe neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorderSleep Med Rev201115315316321115377
  • NishinoSTaftiMReidMSMuscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsyJ Neurosci1995157 Pt 1480648147623112
  • ThorpyMJKriegerACDelayed diagnosis of narcolepsy: characterization and impactSleep Med20141550250724780133
  • Anic-LabatSGuilleminaultCKraemerHCMeehanJArrigoniJMignotEValidation of a cataplexy questionnaire in 983 sleep-disorders patientsSleep199922177879989368
  • MooreWRSilberMHDeckerPACataplexy Emotional Trigger Questionnaire (CETQ) – a brief patient screen to identify cataplexy in patients with narcolepsyJ Clin Sleep Med200731374017557451
  • PrinzmetalMBloombergWThe use of benzedrine for the treatment of narcolepsyJAMA19351052020512054
  • ParkesJDFentonGWLevo(–) amphetamine and dextro(+) amphetamine in the treatment of narcolepsyJ Neurol Neurosurg Psychiatry1973366107610814359162
  • DalyDDYossREThe treatment of narcolepsy with methyl phenylpiperidylacetate: a preliminary reportProc Staff Meet Mayo Clin1956312362062513379528
  • AkimotoHHondaYTakahashiYPharmacotherapy in narcolepsyDis Nerv Syst19602170470613681922
  • HishikawaYIdaHNakaiKKanekoZTreatment of narcolepsy with imipramine (tofranil) and desmethylimipramine (pertofran)J Neurol Sci1966354534614380880
  • ShapiroWRTreatment of cataplexy with clomipramineTrans Am Neurol Assoc197499991024463568
  • GuilleminaultCRaynalDTakahashiSCarskadonMDementWEvaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochlorideActa Neurol Scand19765417187936975
  • ParkesJDSchachterMClomipramine and clonazepam in cataplexyLancet1979281511085108691833
  • SchachterMParkesJDFluvoxamine and clomipramine in the treatment of cataplexyJ Neurol Neurosurg Psychiatry19804321711746766990
  • LangdonNShindlerJParkesJDBandakSFluoxetine in the treatment of cataplexySleep1986923713733509809
  • ChenSYCliftSJDahlitzMJDunnGParkesJDTreatment in the narcoleptic syndrome: self assessment of the action of dexamphetamine and clomipramineJ Sleep Res19954211311810607149
  • WinokurAGaryKARodnerSRae-RedCFernandoATSzubaMPDepression, sleep physiology, and antidepressant drugsDepress Anxiety2001141192811568979
  • MorgenthalerTIKapurVKBrownTPractice parameters for the treatment of narcolepsy and other hypersomnias of central originSleep200730121705171118246980
  • BilliardMBassettiCDauvilliersYEFNS guidelines on management of narcolepsyEur J Neurol 2006/10200613101035104816987156
  • Xyrem® [sodium oxybate] oral solution US prescribing informationPalo Alto, CAJazz Pharmaceuticals, Inc42014
  • MignotENishinoSEmerging therapies in narcolepsy-cataplexySleep200528675476316477963
  • BroughtonRMamelakMEffects of nocturnal gamma-hydroxybutyrate on sleep/waking patterns in narcolepsy-cataplexyCan J Neurol Sci19807123317388696
  • MamelakMScharfMBWoodsMTreatment of narcolepsy with gamma-hydroxybutyrate. A review of clinical and sleep laboratory findingsSleep198691 Pt 22852893704454
  • PardiDBlackJγ-Hydroxybutyrate/sodium oxybate. Neurobiology, and impact on sleep and wakefulnessCNS Drugs20062012993101817140279
  • HuangYSGuilleminaultCNarcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybatePediatr Neurol200941191619520267
  • MignotEJA practical guide to the therapy of narcolepsy and hypersomnia syndromesNeurotherapeutics20129473975223065655
  • GowdaCRLundtLPMechanism of action of narcolepsy medicationsCNS Spectr201419Suppl 1253425403789
  • MignotERenaudANishinoSArrigoniJGuilleminaultCDementWCCanine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancersPsychopharmacology (Berl)1993113176827862832
  • NishinoSArrigoniJSheltonJDementWCMignotEDesmethyl metabolites of serotonergic uptake inhibitors are more potent for suppressing canine cataplexy than their parent compoundsSleep19931687067128165384
  • NishinoSFruhstorferBArrigoniJGuilleminaultCDementWCMignotEFurther characterization of the alpha-1 receptor subtype involved in the control of cataplexy in canine narcolepsyJ Pharmacol Exp Ther19932643107910848095546
  • LammersGJArendsJDeclerckACFerrariMDSchouwinkGTroostJGammahydroxybutyrate and narcolepsy: a double-blind placebo-controlled studySleep19931632162208506453
  • The US Xyrem Multi-Center Study GroupA randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsySleep200225424911833860
  • Xyrem International Study GroupFurther evidence supporting the use of sodium oxybate for the treatment of cataplexy: a double-blind, placebo-controlled study in 228 patientsSleep Med20056541542116099718
  • US Xyrem Multicenter Study GroupA 12-month, open-label, multicenter extension trial of orally administered sodium oxybate for the treatment of narcolepsySleep2003261313512627729
  • US Xyrem Multicenter Study GroupSodium oxybate demonstrates long-term efficacy for the treatment of cataplexy in patients with narcolepsySleep Med20045211912315033130
  • AlshaikhMKTriccoACTashkandiMMamdaniMStrausSEBahammamASSodium oxybate for narcolepsy with cataplexy: systematic review and meta-analysisJ Clin Sleep Med20128445145822893778
  • Boscolo-BertoRVielGMontagneseSRaduazzoDIFerraraSDDauvilliersYNarcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a systematic review and meta-analysis of randomized controlled trialsSleep Med Rev201216543144322055895
  • MansukhaniMPKotagalSSodium oxybate in the treatment of childhood narcolepsy-cataplexy: a retrospective studySleep Med20121360661022445591
  • CorkeryJMLoiBClaridgeHGamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4-butanediol (1,4-BD; BDO): a literature review with a focus on UK fatalities related to non-medical useNeurosci Biobehav Rev201553527825843781
  • VignatelliLD’AlessandroRCandeliseLAntidepressant drugs for narcolepsyCochrane Database Syst Rev20081CD00372418254030
  • FreyJDarbonneCFluoxetine suppresses human cataplexy: a pilot studyNeurology19944447077098164831
  • IzziFPlacidiFMarcianiMGEffective treatment of narcolepsy-cataplexy with duloxetine: a report of three casesSleep Med2009101153154 Letter18226953
  • MollerLROstergaardJRTreatment with venlafaxine in six cases of children with narcolepsy and with cataplexy and hypnagogic hallucinationsJ Child Adolesc Psychopharmacol200919219720119364297
  • RatkiewiczMSplaingardMTreatment of cataplexy in a three-year-old using venlafaxineJ Clin Sleep Med201391213411342 Case report24340297
  • SonkaKKemlinkDPretlMCataplexy treated with escitalopram – clinical experienceNeuro Endocrinol Lett2006271–217417616648807
  • KaracanIErectile dysfunction in narcoleptic patientsSleep198691 Pt 22272313704447
  • JuYELarson-PriorLDuntleySChanging demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressantsSleep Med201112327828321317035
  • PoryazovaRSiccoliMWerthEBassettiCLUnusually prolonged rebound cataplexy after withdrawal of fluoxetineNeurology200565696796816186554
  • RistanovicRKLiangHHornfeldtCSLaiCExacerbation of cataplexy following gradual withdrawal of antidepressants: manifestation of probable protracted rebound cataplexySleep Med200910441642118753005
  • JohnJWuMFBoehmerLNSiegelJMCataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behaviorNeuron200442461963415157423
  • ValkoPOGavrilovYVYamamotoMIncrease of histaminergic tuberomammillary neurons in narcolepsyAnn Neurol201374679480424006291
  • LinJSDauvilliersYArnulfIAn inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin−/− mice and patientsNeurobiol Dis2008301748318295497
  • DauvilliersYBassettiCLammersGJPitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trialLancet Neurol201312111068107524107292
  • InocenteCArnulfIBastujiHPitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepinessClin Neuropharmacol2012352556022356925
  • BaierPCHallschmidMSeeck-HirschnerMEffects of intra-nasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexySleep Med2011121094194622036605
  • WeinholdSLSeeck-HirschnerMNowakAHallschmidMGoderRBaierPCThe effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexyBehav Brain Res201426281324406723
  • JohnJWuMFSiegelJMSystemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogsSleep Res Online200031232811382896
  • BlackSWMorairtySRChenTMGABAB agonism promotes sleep and reduces cataplexy in murine narcolepsyJ Neurosci201434196485649424806675
  • FronczekRVerschuurenJLammersGJResponse to intravenous immunoglobulins and placebo in a patient with narcolepsy with cataplexyJ Neurol2007254111607160817762946
  • PlazziGPoliFFranceschiniCIntravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexyJ Neurol2008255101549155418769859
  • ValkoPOKhatamiRBaumannCRBassettiCLNo persistent effect of intravenous immunoglobulins in patients with narcolepsy with cataplexyJ Neurol2008255121900190318825431
  • LecendreuxMMaretSBassettiCMourenMCTaftiMClinical efficacy of high-dose intravenous immunoglobulins near the onset of narcolepsy in a 10-year-old boyJ Sleep Res2003124347348 Letter14633248
  • DauvilliersYCarlanderBRivierFTouchonJTaftiMSuccessful management of cataplexy with intravenous immunoglobulins at narcolepsy onsetAnn Neurol200456690590815562415
  • DauvilliersYFollow-up of four narcolepsy patients treated with intravenous immunoglobulinsAnn Neurol200660115316802296
  • DauvilliersYAbrilBMasEMichelFTaftiMNormalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatmentNeurology200973161333133419841387
  • KnudsenSMikkelsenJDBangBGammeltoftSJennumPJIntravenous immunoglobulin treatment and screening for hypocretin neuron-specific autoantibodies in recent onset childhood narcolepsy with cataplexyNeuropediatrics201041521722221210337
  • KnudsenSBiering-SorensenBKornumBREarly IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiencyNeurology201279110210322722630