197
Views
1
CrossRef citations to date
0
Altmetric
Review

The Use of Gabapentin for the Treatment of Alcohol and Tobacco Use Disorders: A Review

Pages 43-60 | Published online: 24 Sep 2020

References

  • Zullino DF, Khazaal Y, Hattenschwiler J, Borgeat F, Besson J. Anticonvulsant drugs in the treatment of substance withdrawal. Drugs Today. 2004;40:603–619. doi:10.1358/dot.2004.40.7.850478
  • Howland RH. Gabapentin for substance use disorders: is it safe and appropriate? J Psychosoc Nurs Ment Health Serv. 2004;52:13–16.
  • National Center for Biotechnology Information. Pub chem substance database. Bethesda, U.S.A: U.S. National Library of Medicine; December 1, 2016. Available from: https://pubchem.ncbi.nlm.nih.gov/substance/46506529D. Accessed August 27, 2020.
  • Drug Information Portal. Search Drug Information Portal. Bethesda, U.S.A: U.S. National Library of Medicine. Recovered from: https://druginfo.nlm.nih.gov/drugportal/name/Gabapentin. Accessed August 27, 2020. (April 1, 2016).
  • Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet. 2010;49(10):661–669. doi:10.2165/11536200-000000000-00000
  • Dickenson AH, Ghandehari J. Anti-convulsants and anti-depressants. Handb Exp. 2007;145–177.
  • Landmark CJ. Targets for antiepileptic drugs in the synapse. Med Sci Monit. 2007;13:RA1–7.
  • Rogawski MA, Loscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004;5:553–564. doi:10.1038/nrn1430
  • Coderre TJ, Kumar N, Lefebvre CD, Yu JS. A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. J Neurochem. 2007;100:1289–1299. doi:10.1111/j.1471-4159.2006.04304.x
  • Cunningham MO, Woodhall GL, Thompson SE, Dooley DJ, Jones RS. Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro. Eur J Neurosci. 2004;20:1566–1576. doi:10.1111/j.1460-9568.2004.03625.x
  • Eroglu CAN, Susman MW, O’Rourke NA, et al. Gabapentin receptor a2d-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 2009;139:380–392. doi:10.1016/j.cell.2009.09.025
  • Bauer CST-V-MA, Kadurin I, Dolphin AC. A new look at calcium channel α2δ subunits. Curr Opin Neurobiol. 2010;20:1–9. doi:10.1016/j.conb.2010.05.007
  • Gabapentin and pregabalin: abuse and addiction. Prescrire Int. 2012;21(128):152–154.
  • Hengy H, Kolle EU. Determination of gabapentin in plasma and urine by high-performance liquid chromatography and pre-column labelling for ultraviolet detection. J Chromatogr. 1985;341(2):473–478. doi:10.1016/S0378-4347(00)84064-5
  • Vollmer KO, von Hodenberg A, Kolle EU. Pharmacokinetics and metabolism of gabapentin in rat, dog and man. Arzneimittelforschung. 1986;36(5):830–839.
  • Reimann W. Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: are there common or different sites of action?. Eur J Pharmacol. 1983;94(34):341–344.
  • Schlicker E, Reimann W, Gothert M. Gabapentin decreases monoamine release without affecting acetylcholine release in the brain. Arzneimittelforschung. 1985;35(9):1347–1349.
  • Bartoszyk GD, Hamer M. The genetic animal model of reflex epilepsy in the Mongolian gerbil: differential efficacy of new anticonvulsive drugs and prototype antiepileptics. Pharmacol Res Commun. 1987;19(6):429–440. doi:10.1016/0031-6989(87)90082-8
  • Crawford P, Ghadiali E, Lane R, Blumhardt L, Chadwick D. Gabapentin as an antiepileptic drug in man. J Neurol Neurosurg Psychiatry. 1987;50(6):682–686. doi:10.1136/jnnp.50.6.682
  • Ryback R, Ryback L. Gabapentin for behavioral dyscontrol. Am J Psychiatry. 1995;152(9):1399.
  • Walden J, Hesslinger B. Value of old and new anticonvulsants in treatment of psychiatric diseases. Fortschr Neurol Psychiatr. 1995;63(8):320–335. doi:10.1055/s-2007-996633
  • Welty DF, Schielke GP, Rothstein JD. Potential treatment of amyotrophic lateral sclerosis with gabapentin: a hypothesis. Ann Pharmacother. 1995;29(11):1164–1167. doi:10.1177/106002809502901118
  • Shimoyama M, Shimoyama N, Inturrisi CE, Elliott KJ. Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail-flick test. Pain. 1997;72(3):375–382. doi:10.1016/S0304-3959(97)00065-1
  • Rosner H, Rubin L, Kestenbaum A. Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain. 1996;12(1):56–58. doi:10.1097/00002508-199603000-00010
  • Ryback RS, Brodsky L, Munasifi F. Gabapentin in bipolar disorder. J Neuropsychiatry Clin Neurosci Spring. 1997;9(2):301. doi:10.1176/jnp.9.2.301
  • Singh L, Field MJ, Ferris P, et al. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology. 1996;127(1):1–9. doi:10.1007/BF02805968
  • Segal AZ, Rordorf G. Gabapentin as a novel treatment for postherpetic neuralgia. Neurology. 1996;46(4):1175–1176. doi:10.1212/WNL.46.4.1175
  • Mellick GA, Mellick LB. Management of restless legs syndrome with gabapentin (Neurontin). Sleep. 1996;19(3):224–226. doi:10.1093/sleep/19.3.224
  • Adler CH. Treatment of restless legs syndrome with gabapentin. Clin Neuropharmacol. 1997;20(2):148–151. doi:10.1097/00002826-199704000-00006
  • Nunes EV. Gabapentin: a new addition to the armamentarium for alcohol dependence? JAMA Intern Med. 2014;174(1):78–79. doi:10.1001/jamainternmed.2013.11973
  • Leung JG, Hall-Flavin D, Nelson S, Schmidt KA, Schak KM. The role of gabapentin in the management of alcohol withdrawal and dependence. Ann Pharmacother. 2015;49:897–906. doi:10.1177/1060028015585849
  • Olive MF, Cleva RM, Kalivas PW, Malcolm RJ. Glutamatergic medications for the treatment of drug and behavioral addictions. Pharmacol Biochem Behav. 2012;100(4):801–810. doi:10.1016/j.pbb.2011.04.015
  • Prince V, Turpin KR. Treatment of alcohol withdrawal syndrome with carbamazepine, gabapentin, and nitrous oxide. Am J Health Syst Pharm. 2008;65(11):1039–1047. doi:10.2146/ajhp070284
  • Muller CA, Geisel O, Banas R, Heinz A. Current pharmacological treatment approaches for alcohol dependence. Expert Opin Pharmacother. 2014;15(4):471–481. doi:10.1517/14656566.2014.876008
  • Muncie HL Jr, Yasinian Y, Oge L. Outpatient management of alcohol withdrawal syndrome. Am Fam Physician. 2013;88(9):589–595.
  • Lyon J. More treatments on deck for alcohol use disorder. JAMA. 2017;317(22):2267–2269. doi:10.1001/jama.2017.4760
  • Soyka M, Muller CA. Pharmacotherapy of alcoholism - an update on approved and off-label medications. Expert Opin Pharmacother. 2017;18(12):1187–1199. doi:10.1080/14656566.2017.1349098
  • Pani PP, Trogu E, Pacini M, Maremmani I. Anticonvulsants for alcohol dependence. Cochrane Database Syst Rev. 2014;2:CD008544.
  • Winslow BT, Onysko M, Hebert M. Medications for alcohol use disorder. Am Fam Physician. 2016;93(6):457–465.
  • Aubin HJ, Luquiens A, Berlin I. Pharmacotherapy for smoking cessation: pharmacological principles and clinical practice. Br J Clin Pharmacol. 2014;77(2):324–336. doi:10.1111/bcp.12116
  • Schnoll RA, Lerman C. Current and emerging pharmacotherapies for treating tobacco dependence. Expert Opin Emerg Drugs. 2006;11(3):429–444. doi:10.1517/14728214.11.3.429
  • Bonnet U, Banger M, Leweke FM, Maschke M, Kowalski T, Gastpar M. Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry. 1999;32:107–109. doi:10.1055/s-2007-979203
  • Bozikas V, Petrikis P, Gamvrula K, Savvidou I, Karavatos A. Treatment of alcohol withdrawal with gabapentin. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:197–199. doi:10.1016/S0278-5846(01)00234-2
  • Rustembegovic A, Sofic E, Tahirovic I, Kundurovic Z. A study of gabapentin in the treatment of tonic-clonic seizures of alcohol withdrawal syndrome. Med Arh. 2004;58(1):5–6.
  • Mariani JJ, Rosenthal RN, Tross S, Singh P, Anand OP. A randomized, open-label, controlled trial of gabapentin and phenobarbital in the treatment of alcohol withdrawal. Am J Addict. 2006;15(1):76–84. doi:10.1080/10550490500419110
  • Malcolm R, Myrick LH, Veatch LM, Boyle E, Randall PK. Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentin. J Clin Sleep Med. 2007;3(1):24–32.
  • Myrick H, Malcolm R, Randall PK, et al. A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. Alcohol Clin Exp Res. 2009;33:1582–1588. doi:10.1111/j.1530-0277.2009.00986.x
  • Anton RF, Myrick H, Wright TM, et al. Gabapentin combined with naltrexone for the treatment of alcohol dependence. Am J Psychiatry. 2011;168(7):709–717. doi:10.1176/appi.ajp.2011.10101436
  • Stock CJ, Carpenter L, Ying J, Greene T. Gabapentin versus chlordiazepoxide for outpatient alcohol detoxification treatment. Ann Pharmacother. 2013;47(78):961–969. doi:10.1345/aph.1R751
  • Stock CJ, Carpenter L, Ying J, Greene T. Reply to comment on “gabapentin versus chlordiazepoxide for outpatient alcohol detoxification treatment”. Ann Pharmacother. 2013;47(12):1743. doi:10.1177/1060028013509366
  • Bonnet U, Specka M, Leweke FM, Nyhuis P, Banger M. Gabapentin’s acute effect on mood profile – a controlled study on patients with alcohol withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(2):434–438. doi:10.1016/j.pnpbp.2006.11.006
  • Bonnet U, Banger M, Leweke FM, et al. Treatment of acute alcohol withdrawal with gabapentin: results from a controlled two-center trial. J Clin Psychopharmacol. 2003;23(5):514–519. doi:10.1097/01.jcp.0000088905.24613.ad
  • Bonnet U, Hamzavi-Abedi R, Specka M, Wiltfang J, Lieb B, Scherbaum N. An open trial of gabapentin in acute alcohol withdrawal using an oral loading protocol. Alcohol Alcohol. 2010;45(2):143–145. doi:10.1093/alcalc/agp085
  • Furieri FA, Nakamura-Palacios EM. Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2007;68(11):1691–1700. doi:10.4088/JCP.v68n1108
  • Myrick H, Anton R, Voronin K, Wang W, Henderson S. A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm. Alcohol Clin Exp Res. 2007;31(2):221–227. doi:10.1111/j.1530-0277.2006.00299.x
  • Brower KJ, Myra Kim H, Strobbe S, Karam-Hage MA, Consens F, Zucker RA. A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia. Alcohol Clin Exp Res. 2008;32(8):1429–1438. doi:10.1111/j.1530-0277.2008.00706.x
  • Anton RF, Myrick H, Baros AM, et al. Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. J Clin Psychopharmacol. 2009;29(4):334–342. doi:10.1097/JCP.0b013e3181aba6a4
  • Mason BJ, Quello S, Goodell V, Shadan F, Kyle M, Begovic A. Gabapentin treatment for alcohol dependence: a randomized clinical trial. JAMA Intern Med. 2014;174(1):70–77. doi:10.1001/jamainternmed.2013.11950
  • Mason BJ, Light JM, Williams LD, Drobes DJ. Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin. Addict Biol. 2009;14(1):73–83. doi:10.1111/j.1369-1600.2008.00133.x
  • Bisaga A, Evans SM. The acute effects of gabapentin in combination with alcohol in heavy drinkers. Drug Alcohol Depend. 2006;83(1):25–32. doi:10.1016/j.drugalcdep.2005.10.008
  • Roberto M, Gilpin NW, O’Dell LE, et al. Cellular and behavioral interactions of gabapentin with alcohol dependence. J Neurosci. 2008;28(22):5762–5771. doi:10.1523/JNEUROSCI.0575-08.2008
  • Clemens KJ, Vendruscolo LF. Anxious to drink: gabapentin normalizes GABAergic transmission in the central amygdala and reduces symptoms of ethanol dependence. J Neurosci. 2008;28(37):9087–9089. doi:10.1523/JNEUROSCI.2928-08.2008
  • Sood A, Ebbert JO, Wyatt KD, et al. Gabapentin for smoking cessation. Nicotine Tob Res. 2010;12(3):300–304. doi:10.1093/ntr/ntp195
  • Sood A, Ebbert JO, Schroeder DR, et al. Gabapentin for smoking cessation: a preliminary investigation of efficacy. Nicotine Tob Res. 2007;9(2):291–298. doi:10.1080/14622200601080307
  • White WD, Crockford D, Patten S, El-Guebaly N. A randomized, open-label pilot comparison of gabapentin and bupropion SR for smoking cessation. Nicotine Tob Res. 2005;7(5):809–813. doi:10.1080/14622200500259887
  • Myrick H, Malcolm R, Henderson S, McCormick K. Gabapentin for misuse of homemade nicotine nasal spray. Am J Psychiatry. 2001;158(3):498. doi:10.1176/appi.ajp.158.3.498
  • Myrick H, Malcolm R, Brady KT. Gabapentin treatment of alcohol withdrawal. Am J Psychiatry. 1998;155(11):1632. doi:10.1176/ajp.155.11.1626j
  • Watson WP, Robinson E, Little HJ. The novel anticonvulsant, gabapentin, protects against both convulsant and anxiogenic aspects of the ethanol withdrawal syndrome. Neuropharmacology. 1997;36(10):1369–1375. doi:10.1016/S0028-3908(97)00118-4