Sick Leave and Costs in Active Workers with Chronic Osteoarthritis Pain in Spain: Outcomes of the OPIOIDS Real World Study

References

• Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res. 2020;72(2):149–162. doi:10.1002/acr.24131
   PubMed Web of Science ®Google Scholar
• Belluzzi E, Stocco E, Pozzuoli A, et al. Contribution of infrapatellar fat pad and synovial membrane to knee osteoarthritis pain. Biomed Res Int. 2019;2019:6390182. doi:10.1155/2019/6390182
   PubMed Web of Science ®Google Scholar
• O’Neill TW, McCabe PS, McBeth J. Update on the epidemiology, risk factors and disease outcomes of osteoarthritis. Best Pract Res Clin Rheumatol. 2018;32(2):312–326. doi:10.1016/j.berh.2018.10.007
   PubMed Web of Science ®Google Scholar
• Blanco FJ, Silva-Díaz M, Quevedo Vila V, et al. Prevalence of symptomatic osteoarthritis in Spain: EPISER2016 study. Reumatol Clínica Engl Ed. 2020:S1699-258X(20)30023–1. doi:10.1016/j.reumae.2020.01.005
   Web of Science ®Google Scholar
• Kroon FPB, Carmona L, Schoones JW, Kloppenburg M. Efficacy and safety of non-pharmacological, pharmacological and surgical treatment for hand osteoarthritis: a systematic literature review informing the 2018 update of the EULAR recommendations for the management of hand osteoarthritis. RMD Open. 2018;4(2):e000734. doi:10.1136/rmdopen-2018-000734
   PubMed Web of Science ®Google Scholar
• Majeed MH, Sherazi SAA, Bacon D, Bajwa ZH. Pharmacological treatment of pain in osteoarthritis: a descriptive review. Curr Rheumatol Rep. 2018;20(12):88. doi:10.1007/s11926-018-0794-5
   PubMed Web of Science ®Google Scholar
• O’Neil CK, Hanlon JT, Marcum ZA. Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics. Am J Geriatr Pharmacother. 2012;10(6):331–342. doi:10.1016/j.amjopharm.2012.09.004
   PubMedGoogle Scholar
• Yip K, Oettinger J. Why are we still using opioids for osteoarthritis? Int J Clin Pract. 2020;74(1):e13416. doi:10.1111/ijcp.13416
   PubMed Web of Science ®Google Scholar
• Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27(11):1578–1589. doi:10.1016/j.joca.2019.06.011
   PubMed Web of Science ®Google Scholar
• McDonough CM, Jette AM. The contribution of osteoarthritis to functional limitations and disability. Clin Geriatr Med. 2010;26(3):387–399. doi:10.1016/j.cger.2010.04.001
   PubMed Web of Science ®Google Scholar
• Xie F, Kovic B, Jin X, He X, Wang M, Silvestre C. Economic and humanistic burden of osteoarthritis: a systematic review of large sample studies. PharmacoEconomics. 2016;34(11):1087–1100. doi:10.1007/s40273-016-0424-x
   PubMed Web of Science ®Google Scholar
• Hermans J, Koopmanschap MA, Bierma-Zeinstra SMA, et al. Productivity costs and medical costs among working patients with knee osteoarthritis. Arthritis Care Res. 2012;64(6):853–861. doi:10.1002/acr.21617
   PubMed Web of Science ®Google Scholar
• Puig-Junoy J, Ruiz Zamora A. Socio-economic costs of osteoarthritis: a systematic review of cost-of-illness studies. Semin Arthritis Rheum. 2015;44(5):531–541. doi:10.1016/j.semarthrit.2014.10.012
   PubMed Web of Science ®Google Scholar
• Sharif B, Garner R, Hennessy D, Sanmartin C, Flanagan WM, Marshall DA. Productivity costs of work loss associated with osteoarthritis in Canada from 2010 to 2031. Osteoarthritis Cartilage. 2017;25(2):249–258. doi:10.1016/j.joca.2016.09.011
   PubMed Web of Science ®Google Scholar
• Wilkie R, Hay EM, Croft P, Pransky G. Exploring how pain leads to productivity loss in primary care consulters for osteoarthritis: a prospective cohort study. PLoS One. 2015;10(4):e0120042. doi:10.1371/journal.pone.0120042
   PubMed Web of Science ®Google Scholar
• Berger A, Hartrick C, Edelsberg J, Sadosky A, Oster G. Direct and indirect economic costs among private-sector employees with osteoarthritis. J Occup Environ Med. 2011;53(11):1228–1235. doi:10.1097/JOM.0b013e3182337620
   PubMed Web of Science ®Google Scholar
• Hubertsson J, Englund M, Hallgårde U, Lidwall U, Löfvendahl S, Petersson IF. Sick leave patterns in common musculoskeletal disorders–a study of doctor prescribed sick leave. BMC Musculoskelet Disord. 2014;15:176. doi:10.1186/1471-2474-15-176
   PubMed Web of Science ®Google Scholar
• Alamanda VK, Wally MK, Seymour RB, Springer BD, Hsu JR. Prescription reporting with immediate medication utilization mapping group. prevalence of opioid and benzodiazepine prescriptions for osteoarthritis. Arthritis Care Res. 2020;72(8):1081–1086. doi:10.1002/acr.23933
   PubMed Web of Science ®Google Scholar
• Spanish Agency of Medicines and Sanitary Products. Use of opioid medicines in Spain during the period 2010–2019. Available from: https://www.aemps.gob.es/medicamentos-de-uso-humano/observatorio-de-uso-de-medicamentos/utilizacion-de-medicamentos-opioides-en-espana-durante-el-periodo-2010-2018/. Accessed May 5, 2021.
   Google Scholar
• Sicras-Mainar A, Tornero-Tornero C, Vargas-Negrín F, Lizarraga I, Rejas-Gutierrez J. Health outcomes and costs in patients with osteoarthritis and chronic pain treated with opioids in Spain: the OPIOIDS real-world study. Ther Adv Musculoskelet Dis. 2020;12:1–18. doi:10.1177/1759720X20942000
   Web of Science ®Google Scholar
• Big-Pac. European network of centres for pharmacoepidemiology and pharmacovigilance; 2021. Available from: http://www.encepp.eu/encepp/viewResource.htm?id=29236. Accessed April 13, 2021.
   Google Scholar
• Sicras-Mainar A, Enriquez JL, Hernández I, Sicras-Navarro A, Aymerich T, Leon M. PMU146 Validation and representativeness of the Spanish BIG-PAC database: integrated computerized medical records for research into epidemiology, medicines and health resource use (real world evidence). Value Health. 2019;22:S734. doi:10.1016/j.jval.2019.09.1764
   Web of Science ®Google Scholar
• Boletín Oficial del Estado [National Official Bulletin]. Ley Orgánica 3/2018, de 5 de Diciembre, de Protección de Datos Personales y Garantía de Los Derechos Digitales; 2018. Available from: https://www.boe.es/buscar/doc.php?id=BOE-A-2018-16673. Accessed April 13, 2021.
   Google Scholar
• von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344–349. doi:10.1016/j.jclinepi.2007.11.008
   PubMed Web of Science ®Google Scholar
• Vicente-Herrero MT, Delgado-Bueno S, Bandrés-Moyá F, et al. Pain assessment: Comparative review of scales and questionnaires. Rev Soc Esp Dolor. 2018;25(4):228–236. doi:10.20986/resed.2018.3632/2017
   Google Scholar
• Ministry of Health, Consume and Societal Welfare. International Classification of Diseases (ICD); 2020. Available from: https://eciemaps.mscbs.gob.es/ecieMaps/browser/metabuscador.html. Accessed August 31, 2021.
   Google Scholar
• Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):73–383. doi:10.1016/0021-9681(87)90171-8
   Google Scholar
• National Institute on Statistics. Average employment earnings by age and sex. 2018. https://www.ine.es/dynt3/inebase/index.htm?padre=4563&capsel=4563. Accessed August 1, 2020.
   Google Scholar
• Gobelet C, Luthi F, Al-Khodairy AT, Chamberlain MA. Work in inflammatory and degenerative joint diseases. Disabil Rehabil. 2007;29(17):1331–1339. doi:10.1080/09638280701315094
   PubMed Web of Science ®Google Scholar
• Mielke D, Rohde V. Randomized controlled trials-a critical re-appraisal. Neurosurg Rev. 2021;44(4):2085–2089. doi:10.1007/s10143-020-01401-4
   PubMed Web of Science ®Google Scholar
• Bothwell LE, Greene JA, Podolsky SH, Jones DS. Assessing the gold standard — lessons from the history of RCTs. N Engl J Med. 2016;374(22):2175–2181. doi:10.1056/NEJMms1604593
   PubMed Web of Science ®Google Scholar
• Kostev K, Wartenberg F, Richter H, Reinwald M, Heilmaier C. Persistence with opioid treatment in Germany in patients suffering from chronic non-malignant or cancer pain. Curr Med Res Opin. 2015;31(6):1157–1163. doi:10.1185/03007995.2015.1034095
   PubMed Web of Science ®Google Scholar
• Pekkala J, Rahkonen O, Pietiläinen O, Lahelma E, Blomgren J. Sickness absence due to different musculoskeletal diagnoses by occupational class: a register-based study among 1.2 million Finnish employees. Occup Environ Med. 2018;75(4):296–302. doi:10.1136/oemed-2017-104571
   PubMed Web of Science ®Google Scholar
• Rabenda V, Manette C, Lemmens R, Mariani A-M, Struvay N, Reginster J-Y. Direct and indirect costs attributable to osteoarthritis in active subjects. J Rheumatol. 2006;33(6):1152–1158.
   PubMed Web of Science ®Google Scholar
• Mather L, Ropponen A, Mittendorfer-Rutz E, Narusyte J, Svedberg P. Health, work and demographic factors associated with a lower risk of work disability and unemployment in employees with lower back, neck and shoulder pain. BMC Musculoskelet Disord. 2019;20:622. doi:10.1186/s12891-019-2999-9
   PubMed Web of Science ®Google Scholar
• Lalic S, Bell JS, Gyllensten H, et al. Trajectories of sickness absence and disability pension before and after opioid initiation for noncancer pain: a 10-year population-based study. Pain. 2019;160(5):1224–1233. doi:10.1097/j.pain.0000000000001500
   PubMed Web of Science ®Google Scholar
• Tao XG, Lavin RA, Yuspeh L, Weaver VM, Bernacki EJ. The association of the use of opioid and psychotropic medications with workers’ compensation claim costs and lost work time. J Occup Environ Med. 2015;57(2):196–201. doi:10.1097/JOM.0000000000000333
   PubMed Web of Science ®Google Scholar
• Rice JB, Kirson NY, Shei A, et al. Estimating the costs of opioid abuse and dependence from an employer perspective: a retrospective analysis using administrative claims data. Appl Health Econ Health Policy. 2014;12(4):435–436. doi:10.1007/s40258-014-0102-0
   PubMedGoogle Scholar