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Review

Current and future developments in the treatment of chronic wounds

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Pages 43-53 | Published online: 06 Nov 2013

References

  • Enoch S, Grey JE, Harding KG. Non-surgical drug treatments. BMJ. 2006;332:900–903.
  • Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89:219–229.
  • Richards A. General Principles: Wound Healing and Skin Grafts. Key Notes in Plastic Surgery. Oxford, UK: Blackwell Publishing; 2002.
  • Posnett J, Franks PJ. The burden of chronic wounds in the UK. Nurs Times. 2008;104:44–45.
  • Medina A, Scott PG, Ghahary A, Tredget EE. Pathophysiology of chronic nonhealing wounds. J Burn Care Rehab'll. 2005;26:306–319.
  • Werdin F, Tennehaus M, Schaller HE, Rennekampff HO. Evidence-based management strategies for treatment of chronic wounds. Open Access Journal of Plastic Surgery. 2009;9:169–179.
  • Ruttermann M, Maier-Hasselmann A, Nink-Grebe B, Burckhardt M. Local treatment of chronic wounds in patients with peripheral vascular disease, chronic venous insufficiency, and diabetes. Dtsch Arztebl Int. 2013;110:25–31.
  • Mustoe TA, O’Shaughnessy K, Kloeters O. Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis. Plast Reconstr Surg. 2006;117:35–41.
  • Romanelli M, Vuerstaek JD, Rogers LC, et al; Wound Management Association. Economic burden of hard-to-heal wounds. In: Position Document: Hard-To-Heal Wounds: A Holistic Approach. London, UK: MEP Ltd; 2008.
  • Simon DA, Dix FP, McCollum CN. Management of venous leg ulcers. BMJ. 2004;328:1358–1362.
  • Valencia IC, Falabella A, Kirsner RS, Eaglestein WH. Chronic venous insufficiency and venous leg ulceration. J Am Acad Dermatol. 2001;44: 401–421.
  • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:2568–2569.
  • Harding KG, Morris HL, Patel GK. Science, medicine, and the future: healing chronic wounds. BMJ. 2002;324:160–163.
  • Mat Saad AZ, Khoo TL, Halim AS. Wound bed preparation for chronic diabetic foot ulcers. ISRNEndocrinol. 2013;2013:608313.
  • Edmonds ME, Foster AVM. Diabetic foot ulcers. BMJ. 2006;332: 407–410.
  • Bowering CK. Diabetic foot ulcers. Pathophysiology, assessment, and therapy. Can Fam Physician. 2001;47:1007–1016.
  • Clayton W, Elasy TA. A review of the pathophysiology, classification, and treatment of foot ulcers in diabetic patients. Clin Diabetes. 2009;27: 52–58.
  • Izadi K, Ganchi P. Chronic wounds. Clin Plast Surg. 2005;32: 209–222.
  • Bennett NT, Schultz GS. Growth factors and wound healing: Part II. Role in normal and chronic wound healing. Am J Surg. 1993;166:74–81.
  • Hasan A, Murata H, Falabella A, et al. Dermal fibroblasts from venous ulcers are unresponsive to the action of transforming growth factor- beta1. J Dermatol Sci. 1997;16:59–66.
  • Mustoe T. Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. Am J Surg. 2004;187(5A): 65S–70S.
  • Healy B, Freedman A. Infections. BMJ. 2006;332:838–841.
  • Krueger JK, Rohrich RJ. Clearing the smoke: the scientific rationale for tobacco abstention with plastic surgery. PlastReconstr Surg. 2001 ;108: 1063–1073.
  • Silverstein P. Smoking and wound healing. Am J Med. 1992;93(1A): 22S–24S.
  • MacKay D, Miller AL. Nutritional support for wound healing. Altern Med Rev. 2003;8:359–377.
  • Little MO. Nutrition and skin ulcers. Curr Opin Clin Nutr Metab Care. 2013;16:39–49.
  • Fan WL, Rashid M, Enoch S. Current advances in modern wound healing. Wounds UK. 2010;6:22–36.
  • Enoch S, Price P. Cellular molecular and biochemical differences in the pathophysiology of healing between acute wounds, chronic wounds and wounds in the aged, 2004. Available from: http://www.worldwidewounds.com/2004/august/Enoch/Pathophysiology-Of-Healing.html. Accessed August 31, 2013.
  • Ayello EA, Dowsett C, Schultz GS, et al. TIME heals all wounds. Nursing. 2004;34:26–41.
  • Humphreys ML, Stewart AH, Gohel MS, Taylor M, Whyman MR, Poskitt KR. Management of mixed arterial and venous leg ulcers. Br J Surg. 2007;94:1104–1107.
  • Winter GD. Formation of a scab and the rate of epithelialisation of superficial wounds in the skin of the young domestic pig. Nature. 1962;193:293–294.
  • Chaby G, Senet P, Vaneau M, et al. Dressings for acute and chronic wounds: a systematic review. Arch Dermatol. 2007;143:1297–1304.
  • Vaneau M, Chaby G, Guillot B, et al. Consensus panel recommendations for chronic and acute wound dressings. Arch Dermatol. 2007;143: 1291–1294.
  • Wound Healing Society. Guidelines for the best care of chronic wounds. Wound Repair Regen. 2006;14:647–710.
  • Diehr S, Hamp A, Jamieson B. Do topical antibiotics improve wound healing? J Fam Pract. 2007;56:140–144.
  • Vermeulen H, van Hattem JM, Storm-Versloot MN, Ubbink DT. Topical silver for treating infected wounds. Cochrane Database Syst Rev. 2007;3:CD005486.
  • Hurd T, Chadwick P, Cote J, Cockwill J, Mole TR, Smith JM. Impact of gauze-based NPWT on the patient and nursing experience in the treatment of challenging wounds. Int Wound J. 2010;7:305–311.
  • Kumar S, Wong PF, Leaper DJ. What is new in wound healing? Turk J Med Sci. 2004;34:147–160.
  • Wollina U, Liebold K, Schmidt WD, Hartmann M, Fassler D. Biosurgery supports granulation and debridement in chronic wounds – clinical data and remittance spectroscopy measurement. Int J Dermatol. 2002;41: 635–639.
  • Thackham JA, McElwain DL, Long RJ. The use of hyperbaric oxygen therapy to treat chronic wounds: a review. Wound Repair Regen. 2008;16:321–330.
  • Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16:585–601.
  • Moulin V Growth factors in skin wound healing. Eur J Cell Biol. 1995;68:1–7.
  • Bennett SP, Griffiths GD, Schor AM, Leese GP, Schor SL. Growth factors in the treatment of diabetic foot ulcers. Br J Surg. 2003;90:133–146.
  • Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers. J Vasc Surg. 1995;21:71–81.
  • Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (beclapermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomised placebo-controlled double-blind study. Diabetes Care. 1998;21:822–827.
  • Rees RS, Robson MC, Smiell JM, Perry BH. Becaplermin gel in the treatment of pressure ulcers. Wound Repair Regen. 1997;7:141–147.
  • Robson MC, Phillips LG, Lawrence WT, et al. The safety and effect of topically applied recombinant basic fibroblast growth factor on healing of chronic pressure sores. Ann Surg. 1992;216:401–406.
  • Richard JL, Parer-Richard C, Daures JP, et al. Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. Diabetes Care. 1995;18:64–69.
  • Servold SA. Growth factor impact on wound healing. Clin Pod Med Surg. 1991;8:937–953.
  • Brown GL, Curtsinger L, Brightwell JR, et al. Enhancement of epidermal regeneration by biosynthetic epidermal growth factor. J Exp Med. 1986;163:1319–1324.
  • Nanney LB. Epidermal and dermal effects of epidermal growth factor during wound repair. J Invest Dermatol. 1990;94:624–629.
  • Galiano RD, Mustoe TA. Wound care. In: Thorne CH, Beasley RW, Aston SJ, Bartlett SP, Gurtner GC, Spear SL, editors. Grabb and Smith s Plastic Surgery. 6th ed. Philadelphia, PA: Wolters Kluwer/Lippincoat William & Wilkins; 2007.
  • Schultz G, Sibbald G, Falanga V, et. al. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen. 2003;11:1–28.
  • De Santo NG, Bisaccia C, De Santo LS, Cirillo M, Richet G. PierreJoseph Desault (1738–1795) – a forerunner of modern medical teaching. J Nephrol. 2003;16:742–753.
  • Knox KR, Datiashvili RO, Granick MS. Surgical wound bed preparation of chronic and acute wounds. Clin Plast Surg. 2007;34:633–641.
  • Hoppe IC, Granick MS. Debridement of chronic wounds: a qualitative systematic review of randomized controlled trials. Clin Plast Surg. 2012;39:221–228.
  • Gray D, Acton C, Chadwick P, et al. Consensus guidance for the use of debridement techniques in the UK. Wounds UK. 2011;7:77–84.
  • Golinko MS, Joffe R, de Vinck D, et al. Surgical pathology to describe the clinical margin of debridement of chronic wounds using a wound electronic medical record. J Am Coll Surg. 2009;209:254–260. e1.
  • Fleischmann W, Strecker W, Bombelli M, Kinzl L. Vacuum sealing as treatment of soft tissue damage in open fractures. Unfallchirurg. 1993;96(9):488–492.
  • Desai KK, Hahn E, Pulikkotill B, Lee E. Negative pressure wound therapy: an algorithm. Clin Plast Surg. 2012;39:311–324.
  • Ubbink DT, Westerbos SJ, Evans D, Land L, Vermeulen H. Topical negative pressure for treating chronic wounds. Cochrane Database Syst Rev. 2008;3:CD001898.
  • Vuerstaek JD, Vainas T, Wuite J, et al. State-of-the-art treatment of chronic leg ulcers: a randomized controlled trial comparing vacuum- assisted closure (VAC) with modern wound dressings. J Vasc Surg. 2006;44:1029–1037.
  • Korber A, Franckson T, Grabbe S, et al. Vacuum assisted closure device improves the take of mesh grafts in chronic leg ulcer patients. Dermatology. 2008;216:250–256.
  • Van den Boogaard M, de Laat E, Spauwen P, Schoonhove L. The effectiveness of topical negative pressure in the treatment of pressure ulcers: a literature review. Eur J Plast Surg. 2008;31:1–7.
  • Mulder G, Wallin K, Tenenhaus M. Regenerative materials that facilitate wound healing. Clin Plast Surg. 2012;39:249–267.
  • Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738–746.
  • Halim AS, Khoo TL, Mohd Yussof SJ. Biologic and synthetic skin substitutes: an overview. Indian J Plast Surg. 2010;43 Suppl: S23–S28.
  • Cervelli V Brinci L, Spallone D, et al. The use of MatriDerm® and skin grafting in post-traumatic wounds. Int Wound J. 2011;8:400–405.
  • Chi KY. Connexins, a new target in wound treatment. J Wound Care. 2011;20:1–5.
  • Mese G, Richard G, White TW Gap junctions: basic structure and function. J Invest Dermatol. 2007;127:2516–2524.
  • Di WL, Rugg EL, Leigh IM, Kelsell DP. Multiple epidermal connexins are expressed in different keratinocyte subpopulations including connexin 31. J Invest Dermatol. 2001;117:958–964.
  • Coutinho P, Qiu C, Frank S, Tamber K, Becker D. Dynamic changes in connexin expression correlate with key events in the wound healing process. Cell Biol Int. 2003;27:525–541.
  • Qiu C, Coutinho P, Frank S, et al. Targeting connexin43 expression accelerates the rate of wound repair. Curr Biol. 2003;13:1697–1703.
  • Brandner JM, Houdek P, Hüsing B, Kaiser C, Moll I. Connexins 26, 30, and 43 : differences among spontaneous, chronic, and accelerated human wound healing. J Invest Dermatol. 2004;122:1310–1320.
  • Hodgins MB. Connecting wounds with connexin. J Invest Dermatol. 2004;122:9–10.
  • Broughton G 2nd, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg. 2006;117:12S–34S.
  • Kretz M, Euwens C, Hombach S, et al. Altered connexin expression and wound healing in the epidermis of connexin-deficient mice. J Cell Sci. 2003;116:3443–3452.
  • Mori R, Power KT, Wang CM, Martin P, Becker DL. Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration. J Cell Sci. 2006;119:5193–5203.
  • Desmoulière A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993;122:103–111.
  • Evans H, Boltano S. Connexin mimetic peptides: specific inhibitors of gap junctional intercellular communication. Biochem Soc Trans. 2001;29:606–612.
  • Pollock S, Pfeiffer AC, Lobmann R, et al. Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells. J Cell Mol Med. 2011;15: 861–873.
  • Lucke T, Choudhry R, Thom R, Selmer IS, Burden AD, Hodgins MB. Upregulation of connexin 26 is a feature of keratinocyte differentiation in hyperproliferative epidermis, vaginal epithelium, and buccal epithelium. J Invest Dermatol. 1999;112:354–361.
  • Dahl E, Manthey D, Chen Y, et al. Molecular cloning and functional expression of mouse connexin-30, a gap junction gene highly expressed in adult brain and skin. J Biol Chem. 1996;271:17903–17910.
  • Smith FJ, Morley SM, McLean WH. A novel connexin 30 mutation in Clouston syndrome. J Invest Dermatol. 2002;118:530–532.
  • Sharma RK, John JR. Role of stem cells in the management of chronic wounds. Indian J Plast Surg. 2012;45:237–243.
  • Hedrick MH, Daniels EJ. The use of adult stem cells in regenerative medicine. Clin Plast Surg. 2003;30:499–505.
  • Barker N, Bartfeld S, Clevers H. Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell. 2010;7:656–670.
  • Schneider RK, Neuss S, Stainforth R, et al. Three-dimensional epidermis-like growth of human mesenchymal stem cells on dermal equivalents: contribution to tissue organization by adaptation of myofibroblastic phenotype and function. Differentiation. 2008;76: 156–167.
  • Butler KL, Goverman J, Ma H, et al. Stem cells and burns: review and therapeutic implications. J Burn Care Res. 2010;31:874–881.
  • Weil BR, Markel TA, Herrmann JL, Abarbanell AM, Kelly ML, Meldrum DR. Stem cells in sepsis. Ann Surg. 2009;250:19–27.
  • Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary delivery of bone marrow derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007;179:1855–1863.
  • Burd A, Ahmed K, Lam S, Ayyappan T, Huang L. Stem cell strategies in burns care. Burns. 2007;33:282–291.
  • Kørbling M, Estrov Z. Adult stem cells for tissue repair – a new therapeutic concept? N Engl J Med. 2003;349:570–582.
  • Ko SH, Nauta A, Wong V, Glotzbach J, Gurtner GC, Longaker MT. The role of stem cells in cutaneous wound healing: what do we really know? Plast Reconstr Surg. 2011;127 Suppl:10s-20s.
  • Crisostomo PR, Markel TA, Wang Y, Meldrum DR. Surgically relevant aspects of stem cell paracrine effects. Surgery. 2008;143:577–581.
  • Rasulov MF, Vasilchenkov AV, Onishchenko NA, et al. First experience of the use bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns. Bull Exp Biol Med. 2005;139:141–144.
  • Ayyappan T, Chadha A, Shaikh MF, et al. Topically applied autologous bone marrow in healing of chronic non-healing raw areas – a pilot study. Indian J Burns. 2004;12:42–47.
  • Falanga V Iwamoto S, Chartier M, et al. Autologous bone marrow- derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng. 2007;13:1299–1312.
  • Lataillade JJ, Doucet C, Bey E, et al. New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regen Med. 2007;2:785–794.
  • Yoshikawa T, Mitsuno H, Nonaka I, et al. Wound therapy by marrow mesenchymal cell transplantation. Plast Reconstr Surg. 2008;121: 860–877.
  • Jackson WM, Nesti LJ, Tuan RS. Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells. Expert Opin Biol Ther. 2010;10:505–517.
  • Mizuno H. Adipose-derived stem cells for tissue repair and regeneration: ten years of research and a literature review. J Nippon Med Sch. 2009;76:56–66.
  • Kim WS, Park BS, Sung JH. The wound-healing and antioxidant effects of adipose-derived stem cells. Expert Opin Biol Ther. 2009;9: 879–887.
  • Branski LK, Gauglitz GG, Herndon DN, Jeschke MG. A review of gene and stem cell therapy in cutaneous wound healing. Burns. 2009;35: 171–180.
  • Riedel K, Riedel F, Goessler UR, Holle G, Germann G, Sauerbier M. Current status of genetic modulation of growth factors in wound repair. Int J Mol Med. 2006;17:183–193.
  • Chandler LA, Gu DL, Ma C, et al. Matrix enabled gene transfer for wound healing. Wound Repair Regen. 2000;8:473–479.
  • Eming SA, Krieg T, Davidson JM. Gene therapy and wound healing. Clin Dermatol. 2007;25:79–92.
  • Günter CI, Machens HG. New strategies in clinical care of skin wound healing. Eur Surg Res. 2012;49:16–23.
  • Roman S, Lindeman R, O’Toole G, Poole MD. Gene therapy in plastic and reconstructive surgery. Curr Gene Ther. 2005;5:81–99.
  • Liecthy KW, Nesbit M, Herlyn M, et al. Adenoviral mediated overexpression of PDGF-B corrects ischemic impaired wound healing. JInvest Dermatol. 1999;113:375–383.
  • Benn SI, Whitsitt JS, Broadley KN, et. al. Particle mediated gene transfer with TGF-B1 cDNAs enhances wound repair in rat skin. J Clin Invest. 1996;98:2894–2902.
  • Nanney LB, Paulsen S, Davidson MK, Cardwell NL, Whitsitt JS, Davidson JM. Boosting EGF receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Repair Regen, 2000;8(2):117–127.
  • Jeschke MG, Herndon DN, Baer W, Barrow RE, Jauch KW Possibilities of non-viral gene transfer to improve cutaneous wound healing. Curr Gene Ther. 2001;1:267–278.