Risk Factors for Post-Pancreaticoduodenectomy Mortality: Identification and Mitigation

References

• Whipple AO. Pancreaticoduodenectomy for islet carcinoma. Ann Surg. 1945;121(6):847–852. doi:10.1097/00000658-194506000-00008
   PubMed Web of Science ®Google Scholar
• Cameron JL, Riall TS, Coleman J, Belcher KA. One thousand consecutive pancreaticoduodenectomies. Ann Surg. 2006;244(1):10–15. doi:10.1097/01.sla.0000217673.04165.ea
   PubMed Web of Science ®Google Scholar
• Grace PA, Pitt HA, Tompkins RK, DenBesten L, Longmire WP. Decreased morbidity and mortality after pancreatoduodenectomy. Am J Surg. 1986;151(1):141–149. doi:10.1016/0002-9610(86)90024-3
   PubMed Web of Science ®Google Scholar
• Crist DW, Sitzmann JV, Cameron JL. Improved hospital morbidity, mortality, and survival after the whipple procedure. Ann Surg. 1987;206(3):358–365. doi:10.1097/00000658-198709000-00014
   PubMed Web of Science ®Google Scholar
• Cameron JL, He J. Two thousand consecutive pancreaticoduodenectomies. J Am Coll Surg. 2015;220(4):530–536. doi:10.1016/j.jamcollsurg.2014.12.031
   PubMed Web of Science ®Google Scholar
• Narayanan S, Martin AN, Turrentine FE, Bauer TW, Adams RB, Zaydfudim VM. Mortality after pancreaticoduodenectomy: assessing early and late causes of patient death. J Surg Res. 2018;231:304–308. doi:10.1016/j.jss.2018.05.075
   PubMed Web of Science ®Google Scholar
• Vollmer CM, Sanchez N, Gondek S, et al. A root-cause analysis of mortality following major pancreatectomy. J Gastrointestinal Surg. 2012;16(1):89–103. doi:10.1007/s11605-011-1753-x
   PubMed Web of Science ®Google Scholar
• Hill JS, Zhou Z, Simons JP, et al. A simple risk score to predict in-hospital mortality after pancreatic resection for cancer. Ann Surg Oncol. 2010;17(7):1802–1807. doi:10.1245/s10434-010-0947-x
   PubMed Web of Science ®Google Scholar
• Venkat R, Puhan MA, Schulick RD, et al. Predicting the risk of perioperative mortality in patients undergoing pancreaticoduodenectomy: a novel scoring system. Arch Surg. 2011;146(11):1277–1284. doi:10.1001/archsurg.2011.294
   PubMedGoogle Scholar
• Ragulin-Coyne E, Carroll JE, Smith JK, et al. Perioperative mortality after pancreatectomy: a risk score to aid decision-making. Surgery. 2012;152(3 Suppl 1):S120–7. doi:10.1016/j.surg.2012.05.018
   PubMed Web of Science ®Google Scholar
• Gleeson EM, Shaikh MF, Shewokis PA, et al. WHipple-ABACUS, a simple, validated risk score for 30-day mortality after pancreaticoduodenectomy developed using the ACS-NSQIP database. Surgery. 2016;160(5):1279–1287. doi:10.1016/j.surg.2016.06.040
   PubMed Web of Science ®Google Scholar
• Greenblatt DY, Kelly KJ, Rajamanickam V, et al. Preoperative factors predict perioperative morbidity and mortality after pancreaticoduodenectomy. Ann Surg Oncol. 2011;18(8):2126–2135. doi:10.1245/s10434-011-1594-6
   PubMed Web of Science ®Google Scholar
• Kang JS, Kim H, Kim JR, et al. Short- and long-term outcomes of pancreaticoduodenectomy in elderly patients with periampullary cancer. Ann Surg Treat Res. 2020;98(1):7. doi:10.4174/astr.2020.98.1.7
   PubMed Web of Science ®Google Scholar
• Lee DY, Schwartz JA, Wexelman B, Kirchoff D, Yang KC, Attiyeh F. Outcomes of pancreaticoduodenectomy for pancreatic malignancy in octogenarians: an American College of surgeons national surgical quality improvement program analysis. Am J Surg. 2014;207(4):540–548. doi:10.1016/j.amjsurg.2013.07.042
   PubMed Web of Science ®Google Scholar
• Johansen KU, Lundgren LM, Gasslander TR, Sandström P, Björnsson B. There is no increase in perioperative mortality after pancreaticoduodenectomy in octogenarians: results from the Swedish national registry for tumors in the pancreatic and periampullary region. Annals of Surgery Open. 2020;1(2):e015. doi:10.1097/AS9.0000000000000015
   PubMedGoogle Scholar
• Pędziwiatr M, Małczak P, Mizera M, et al. Pancreatoduodenectomy for pancreatic head tumors in the elderly – systematic review and meta-analysis. Surg Oncol. 2018;27(3):346–364. doi:10.1016/j.suronc.2018.05.021
   PubMed Web of Science ®Google Scholar
• Li V, Awan A, Serrano PE. Frailty predicts postoperative complications following pancreaticoduodenectomy. Eur Surg Res. 2022;63(4):232–240. doi:10.1159/000522576
   PubMed Web of Science ®Google Scholar
• Mogal H, Vermilion SA, Dodson R, et al. Modified frailty index predicts morbidity and mortality after pancreaticoduodenectomy. Ann Surg Oncol. 2017;24(6):1714–1721. doi:10.1245/s10434-016-5715-0
   PubMed Web of Science ®Google Scholar
• Hamidi M, O’Grady CL, Brown SD, et al. Does preoperative Estimated Glomerular Filtration Rate (eGFR) predict short-term surgical outcomes in patients undergoing pancreatic resections? J Gastrointestinal Surg. 2022;26(4):861–868. doi:10.1007/s11605-021-05179-8
   PubMed Web of Science ®Google Scholar
• Patnaik R, Khan MTA, Spencer I, Aziz H. Chronic kidney disease classification predicts short-term outcomes of patients undergoing pancreaticoduodenectomy. J Gastrointestinal Surg. 2022;26(12):2534–2541. doi:10.1007/s11605-022-05512-9
   PubMed Web of Science ®Google Scholar
• Nakeeb AE. Impact of cirrhosis on surgical outcome after pancreaticoduodenectomy. World J Gastroenterol. 2013;19(41):7129. doi:10.3748/wjg.v19.i41.7129
   PubMed Web of Science ®Google Scholar
• Enderes J, Teschke J, Manekeller S, Vilz TO, Kalff JC, Glowka TR. Chronic liver disease increases mortality following pancreatoduodenectomy. J Clin Med. 2021;10(11):2521. doi:10.3390/jcm10112521
   PubMed Web of Science ®Google Scholar
• Chang EH, Sugiyama G, Smith MC, et al. Obesity and surgical complications of pancreaticoduodenectomy: an observation study utilizing ACS NSQIP. Am J Surg. 2020;220(1):135–139. doi:10.1016/j.amjsurg.2019.10.030
   PubMed Web of Science ®Google Scholar
• El Nakeeb A, Hamed H, Shehta A, et al. Impact of obesity on surgical outcomes post-pancreaticoduodenectomy: a case-control study. Int j Surg. 2014;12(5):488–493. doi:10.1016/j.ijsu.2014.01.017
   PubMed Web of Science ®Google Scholar
• Zorbas Konstantinos A, Wu J, Reddy Sanjay S, Esnaola Nestor F, Karachristos A. Obesity affects outcomes of pancreatoduodenectomy. Pancreatology. 2021. doi:10.1016/j.pan.2021.02.019
   Web of Science ®Google Scholar
• Gazivoda VP, Greenbaum A, Beier MA, et al. Pancreatoduodenectomy: the metabolic syndrome is associated with preventable morbidity and mortality. J Gastrointestinal Surg. 2022;26(10):2167–2175. doi:10.1007/s11605-022-05386-x
   PubMed Web of Science ®Google Scholar
• Newhook TE, LaPar DJ, Lindberg JM, Bauer TW, Adams RB, Zaydfudim VM. Morbidity and mortality of pancreaticoduodenectomy for benign and premalignant pancreatic neoplasms. J Gastrointestinal Surg. 2015;19(6):1072–1077. doi:10.1007/s11605-015-2799-y
   PubMed Web of Science ®Google Scholar
• Gomes RM, Bal M, Patkar S, Goel M, Shrikhande SV. Unexpected benign histopathology after pancreatoduodenectomy for presumed malignancy: accepting the inevitable. Langenbecks Arch Surg. 2016;401(2):169–179. doi:10.1007/s00423-016-1372-9
   PubMed Web of Science ®Google Scholar
• Mavroeidis V, Russell T, Clark J, et al. Pancreatoduodenectomy for suspected malignancy: nonmalignant histology confers increased risk of serious morbidity. Ann R Coll Surg Engl. 2023;105(5):446–454. doi:10.1308/rcsann.2022.0055
   PubMed Web of Science ®Google Scholar
• Aploks K, Kim M, Stroever S, et al. Radiation therapy prior to a pancreaticoduodenectomy for adenocarcinoma is associated with longer operative times and higher blood loss. World J Gastrointest Surg. 2023;15(8):1663–1672.
   PubMed Web of Science ®Google Scholar
• Davis CH, Beane JD, Gazivoda VP, et al. Neoadjuvant therapy for pancreatic cancer: increased use and improved optimal outcomes. J Am Coll Surg. 2022;234(4):436–443. doi:10.1097/XCS.0000000000000095
   PubMed Web of Science ®Google Scholar
• Cools KS, Sanoff HK, Kim HJ, Yeh JJ, Stitzenberg KB. Impact of neoadjuvant therapy on postoperative outcomes after pancreaticoduodenectomy. J Surg Oncol. 2018;118(3):455–462. doi:10.1002/jso.25183
   PubMed Web of Science ®Google Scholar
• Franko J, Hsu HW, Thirunavukarasu P, Frankova D, Goldman CD. Chemotherapy and radiation components of neoadjuvant treatment of pancreatic head adenocarcinoma: impact on perioperative mortality and long-term survival. Eur J Surg Oncol. 2017;43(2):351–357. doi:10.1016/j.ejso.2016.10.021
   PubMed Web of Science ®Google Scholar
• Sosa JA, Bowman HM, Gordon TA, et al. Importance of hospital volume in the overall management of pancreatic cancer. Ann Surg. 1998;228(3):429–438. doi:10.1097/00000658-199809000-00016
   PubMed Web of Science ®Google Scholar
• Hata T, Motoi F, Ishida M, et al. Effect of hospital volume on surgical outcomes after pancreaticoduodenectomy. Ann Surg. 2016;263(4):664–672. doi:10.1097/SLA.0000000000001437
   PubMed Web of Science ®Google Scholar
• Gooiker GA, Lemmens VEPP, Besselink MG, et al. Impact of centralization of pancreatic cancer surgery on resection rates and survival. Br J Surg. 2014;101(8):1000–1005. doi:10.1002/bjs.9468
   PubMed Web of Science ®Google Scholar
• Gooiker GA, van Gijn W, Wouters MWJM, Post PN, van de Velde CJH, Tollenaar RAEM. Systematic review and meta-analysis of the volume–outcome relationship in pancreatic surgery. Br J Surg. 2011;98(4):485–494. doi:10.1002/bjs.7413
   PubMed Web of Science ®Google Scholar
• Nassour I, Wang SC, Christie A, et al. Minimally invasive versus open pancreaticoduodenectomy. Ann Surg. 2018;268(1):151–157. doi:10.1097/SLA.0000000000002259
   PubMed Web of Science ®Google Scholar
• Wang M, Cai H, Meng L, et al. Minimally invasive pancreaticoduodenectomy: a comprehensive review. Int j Surg. 2016;35:139–146. doi:10.1016/j.ijsu.2016.09.016
   PubMed Web of Science ®Google Scholar
• Doula C, Kostakis ID, Damaskos C, et al. Comparison Between minimally invasive and open pancreaticoduodenectomy. Surg Laparosc Endosc Percutan Tech. 2016;26(1):6–16. doi:10.1097/SLE.0000000000000228
   PubMed Web of Science ®Google Scholar
• Tran TB, Dua MM, Worhunsky DJ, Poultsides GA, Norton JA, Visser BC. The first decade of laparoscopic pancreaticoduodenectomy in the United States: costs and outcomes using the nationwide inpatient sample. Surg Endosc. 2016;30(5):1778–1783. doi:10.1007/s00464-015-4444-y
   PubMed Web of Science ®Google Scholar
• Adam MA, Choudhury K, Dinan MA, et al. Minimally invasive versus open pancreaticoduodenectomy for cancer. Ann Surg. 2015;262(2):372–377. doi:10.1097/SLA.0000000000001055
   PubMed Web of Science ®Google Scholar
• Sharpe SM, Talamonti MS, Wang CE, et al. Early National experience with laparoscopic pancreaticoduodenectomy for ductal adenocarcinoma: a comparison of laparoscopic pancreaticoduodenectomy and open pancreaticoduodenectomy from the national cancer data base. J Am Coll Surg. 2015;221(1):175–184. doi:10.1016/j.jamcollsurg.2015.04.021
   PubMed Web of Science ®Google Scholar
• Zhang H, Wu X, Zhu F, et al. Systematic review and meta-analysis of minimally invasive versus open approach for pancreaticoduodenectomy. Surg Endosc. 2016;30(12):5173–5184. doi:10.1007/s00464-016-4864-3
   PubMed Web of Science ®Google Scholar
• de Rooij T, Lu MZ, Steen MW, et al. Minimally Invasive Versus Open Pancreatoduodenectomy. Ann Surg. 2016;264(2):257–267. doi:10.1097/SLA.0000000000001660
   PubMed Web of Science ®Google Scholar
• van Hilst J, de Rooij T, Bosscha K, et al. Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial. Lancet Gastroenterol Hepatol. 2019;4(3):199–207. doi:10.1016/S2468-1253(19)30004-4
   PubMed Web of Science ®Google Scholar
• Yu XZ, Li J, Fu DL, et al. Benefit from synchronous portal-superior mesenteric vein resection during pancreaticoduodenectomy for cancer: a meta-analysis. Eur J Surg Oncol. 2014;40(4):371–378. doi:10.1016/j.ejso.2014.01.010
   PubMed Web of Science ®Google Scholar
• Castleberry AW, White RR, De la Fuente SG, et al. The impact of vascular resection on early postoperative outcomes after pancreaticoduodenectomy: an analysis of the American college of surgeons national surgical quality improvement program database. Ann Surg Oncol. 2012;19(13):4068–4077. doi:10.1245/s10434-012-2585-y
   PubMed Web of Science ®Google Scholar
• Zettervall SL, Ju T, Holzmacher JL, et al. Arterial, but not venous, reconstruction increases 30-day morbidity and mortality in pancreaticoduodenectomy. J Gastrointestinal Surg. 2020;24(3):578–584. doi:10.1007/s11605-019-04211-2
   PubMed Web of Science ®Google Scholar
• Pastrana Del Valle J, Mahvi DA, Fairweather M, et al. The improvement in post-operative mortality following pancreaticoduodenectomy between 2006 and 2016 is associated with an improvement in the ability to rescue patients after major morbidity, not in the rate of major morbidity. HPB. 2021;23(3):434–443. doi:10.1016/j.hpb.2020.07.013
   PubMed Web of Science ®Google Scholar
• Amini N, Spolverato G, Kim Y, Pawlik TM. Trends in hospital volume and failure to rescue for pancreatic surgery. J Gastrointestinal Surg. 2015;19(9):1581–1592. doi:10.1007/s11605-015-2800-9
   PubMed Web of Science ®Google Scholar
• Gleeson EM, Pitt HA. Failure to rescue after the whipple. Adv Surg. 2022;56(1):1–11. doi:10.1016/j.yasu.2022.02.001
   PubMedGoogle Scholar
• Gleeson EM, Clarke JR, Morano WF, Shaikh MF, Bowne WB, Pitt HA. Patient-specific predictors of failure to rescue after pancreaticoduodenectomy. HPB. 2019;21(3):283–290. doi:10.1016/j.hpb.2018.07.022
   PubMed Web of Science ®Google Scholar
• Silber JH, Williams SV, Krakauer H, Schwartz S. Hospital and patient characteristics associated with death after surgery. Med Care. 1992;30(7):615–629. doi:10.1097/00005650-199207000-00004
   PubMed Web of Science ®Google Scholar
• Bundred JR, Kamarajah SK, Hammond JS, Wilson CH, Prentis J, Pandanaboyana S. Prehabilitation prior to surgery for pancreatic cancer: a systematic review. Pancreatology. 2020;20(6):1243–1250. doi:10.1016/j.pan.2020.07.411
   PubMed Web of Science ®Google Scholar
• Barberan-Garcia A, Ubré M, Roca J, et al. Personalised prehabilitation in high-risk patients undergoing elective major abdominal surgery. Ann Surg. 2018;267(1):50–56. doi:10.1097/SLA.0000000000002293
   PubMed Web of Science ®Google Scholar
• Ausania F, Senra P, Meléndez R, Caballeiro R, Ouviña R, Casal-Núñez E. Prehabilitation in patients undergoing pancreaticoduodenectomy: a randomized controlled trial. Revista Española de Enfermedades Digestivas. 2019;111. doi:10.17235/reed.2019.6182/2019
   PubMed Web of Science ®Google Scholar
• Smits FJ, Henry AC, Besselink MG, et al. Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial. Lancet. 2022;399(10338):1867–1875. doi:10.1016/S0140-6736(22)00182-9
   PubMed Web of Science ®Google Scholar