Combination of hyaluronic acid, carmellose, and osmoprotectants for the treatment of dry eye disease

References

• BjerrumKBKeratoconjunctivitis sicca and primary Sjögren’s syndrome in a Danish population aged 30–60 yearsActa Ophthalmol Scand19977532812869253975
   PubMedGoogle Scholar
• McCartyCABansalAKLivingstonPMStanislavskyYLTaylorHRThe epidemiology of dry eye in Melbourne, AustraliaOphthalmology19981056111411199627665
   PubMed Web of Science ®Google Scholar
• VersuraPCelliniMTorreggianiAProfazioVBernabiniBCaramazzaRDryness symptoms, diagnostic protocol and therapeutic management: a report on 1,200 patientsOphthalmic Res200133422122711464075
   PubMed Web of Science ®Google Scholar
• VisoERodriguez-AresMTGudeFPrevalence of and associated factors for dry eye in a Spanish adult population (the Salnes Eye Study)Ophthalmic Epidemiol2009161152119191177
   PubMed Web of Science ®Google Scholar
• YoungGChalmersRLNapierLHuntCKernJCharacterizing contact lens-related dryness symptoms in a cross-section of UK soft lens wearersCont Lens Anterior Eye2011342647020832350
   PubMed Web of Science ®Google Scholar
• ReitmeirPLinkohrBHeierMCommon eye diseases in older adults of southern Germany: results from the KORA-Age studyAge Ageing201746348148627974306
   PubMed Web of Science ®Google Scholar
• OsaeAEGehlsenUHorstmannJEpidemiology of dry eye disease in Africa: the sparse information, gaps and opportunitiesOcul Surf201715215916828065724
   PubMed Web of Science ®Google Scholar
• StapletonFAlvesMBunyaVYTFOS DEWS II epidemiology reportOcul Surf201715333436528736337
   PubMed Web of Science ®Google Scholar
• SchaumbergDASullivanDABuringJEDanaMRPrevalence of dry eye syndrome among US womenAm J Ophthalmol2003136231832612888056
   PubMed Web of Science ®Google Scholar
• 2007 Report of the International Dry Eye WorkShop (DEWS)Ocul Surf200751204
   Web of Science ®Google Scholar
• CraigJPNicholsKKAkpekEKTFOS DEWS II definition and classification reportOcul Surf201715327628328736335
   PubMed Web of Science ®Google Scholar
• SternMEGaoJSiemaskoKFBeuermanRWPflugfelderSCThe role of the lacrimal functional unit in the pathophysiology of dry eyeExp Eye Res200478340941615106920
   PubMed Web of Science ®Google Scholar
• Enríquez-de-SalamancaABoniniSCalongeMMolecular and cellular biomarkers in dry eye disease and ocular allergyCurr Opin Allergy Clin Immunol201212552353322895048
   PubMed Web of Science ®Google Scholar
• CalongeMEnríquez-de-SalamancaADieboldYDry eye disease as an inflammatory disorderOcul Immunol Inflamm201018424425320482396
   PubMed Web of Science ®Google Scholar
• BaudouinCAragonaPMessmerEMRole of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meetingOcul Surf201311424625824112228
   PubMed Web of Science ®Google Scholar
• ClouzeauCGodefroyDRianchoLRostèneWBaudouinCBrignole-BaudouinFHyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells in vitroMol Vis20121885186322529703
   PubMed Web of Science ®Google Scholar
• BronAJYokoiNGafneyETiffanyJMPredicted phenotypes of dry eye: proposed consequences of its natural historyOcul Surf200972789219383277
   PubMed Web of Science ®Google Scholar
• UbelsJLWilliamsKKLopez BernalDEdelhauserHFEvaluation of effects of a physiologic artificial tear on the corneal epithelial barrier: electrical resistance and carboxy fluorescein permeabilityAdv Exp Med Biol19943504414528030516
   PubMedGoogle Scholar
• NicholsKKPatient-reported symptoms in dry dye diseaseOcul Surf2006413714516900269
   PubMed Web of Science ®Google Scholar
• MiljanovićBDanaRSullivanDASchaumbergDAImpact of dry eye syndrome on vision-related quality of lifeAm J Ophthalmol2007143340941517317388
   PubMed Web of Science ®Google Scholar
• LeQZhouXGeLWuLHongJXuJImpact of dry eye syndrome on vision-related quality of life in a non-clinic-based general populationBMC Ophthalmol2012122222799274
   PubMed Web of Science ®Google Scholar
• LiMGongLSunXChapinWJAnxiety and depression in patients with dry eye syndromeCurr Eye Res20113611721174591
   PubMed Web of Science ®Google Scholar
• SutuCFukuokaHAfshariNAMechanisms and management of dry eye in cataract surgery patientsCurr Opin Ophthalmol2016271243026569526
   PubMed Web of Science ®Google Scholar
• KasetsuwanNSatitpitakulVChangulTJariyakosolSIncidence and pattern of dry eye after cataract surgeryPLoS One2013811e7865724265705
   PubMed Web of Science ®Google Scholar
• LevittAEGalorAWeissJSChronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent postoperative pain disordersMol Pain2015112125896684
   PubMed Web of Science ®Google Scholar
• BehrensADoyleJJSternLDysfunctional tear syndrome study group. Dysfunctional tear syndrome: a Delphi approach to treatment recommendationsCornea200625890090717102664
   PubMed Web of Science ®Google Scholar
• Mateo OrobiaAJBenítez del CastilloJMCalongeMProtocolo de prácticaclínicapreferente: Enfermedad de ojoseco. Adaptación del original: dry eye syndrome2013 Available from: https://www.aao.org/preferred-practice-pattern/dry-eye-syndrome-ppp-2013Accessed November 21, 2017
   Google Scholar
• GoaKLBenfieldPHyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healingDrugs19944735365667514978
   PubMed Web of Science ®Google Scholar
• KoganGSoltésLSternRGemeinerPHyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applicationsBiotechnol Lett2007291172517091377
   PubMed Web of Science ®Google Scholar
• IannittiTLodiDPalmieriBIntra-articular injections for the treatment of osteoarthritis: focus on the clinical use of hyaluronic acidDrugs R D2011111132721142290
   PubMedGoogle Scholar
• DaneMJvan den BergBMLeeDHA microscopic view on the renal endothelial glycocalyxAm J Physiol Renal Physiol20153089F956F96625673809
   PubMed Web of Science ®Google Scholar
• StridhSPalmFHansellPRenal interstitial hyaluronan: functional aspects during normal and pathological conditionsAm J Physiol Regul Integr Comp Physiol201230211R1235R124922513743
   PubMed Web of Science ®Google Scholar
• ChongBFBlankLMMclaughlinRNielsenLKMicrobial hyaluronic acid productionAppl Microbiol Biotechnol200566434135115599518
   PubMed Web of Science ®Google Scholar
• BalazsEAUltra-pure, high molecular wt. Hyaluronic acid- is non-antigenic and used as synthetic aq. Humour and synovial fluid, as nerve tissue and wound protector and drug carrierUnited States patent US41419731979227
   Google Scholar
• WidnerBBehrRVon DollenSHyaluronic acid production in Bacillus subtilisAppl Environ Microbiol20057173747375216000785
   PubMed Web of Science ®Google Scholar
• JinPKangZYuanPDuGChenJProduction of specific-molecular-weight hyaluronan by metabolically engineered Bacillus subtilis 168Metab Eng201635213026851304
   PubMed Web of Science ®Google Scholar
• GuillaumieFFurrerPFelt-BaeyensOComparative studies of various hyaluronic acids produced by microbial fermentation for potential topical ophthalmic applicationsJ Biomed Mater Res A20109241421143019358259
   PubMed Web of Science ®Google Scholar
• JiangDLiangJNoblePWHyaluronan in tissue injury and repairAnnu Rev Cell Dev Biol20072343546117506690
   PubMed Web of Science ®Google Scholar
• PauloinTDutotMJolyFWarnetJMRatPHigh molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cellsMol Vis20091557758319325714
   PubMed Web of Science ®Google Scholar
• PauloinTDutotMLiangHChavinierEWarnetJMRatPCorneal protection with high-molecular-weight hyaluronan against in vitro and in vivo sodium lauryl sulfate-induced toxic effectsCornea20092891032104119724206
   PubMed Web of Science ®Google Scholar
• WuHZhangHWangCGenoprotective effect of hyaluronic acid against benzalkonium chloride-induced DNA damage in human corneal epithelial cellsMol Vis2011173364337022219631
   PubMed Web of Science ®Google Scholar
• WuCLChouHCLiJMHyaluronic acid-dependent protection against alkali-burned human corneal cellsElectrophoresis201334338839623161167
   PubMed Web of Science ®Google Scholar
• BalazsEAHyaluronan as an ophthalmic viscoelastic deviceCurr Pharm Biotechnol20089423623818691081
   PubMed Web of Science ®Google Scholar
• RahMJA review of hyaluronan and its ophthalmic applicationsOptometry2011821384321146792
   PubMedGoogle Scholar
• MisraSHascallVCMarkwaldRRGhatakSInteractions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and CancerFront Immunol2015620125999946
   PubMed Web of Science ®Google Scholar
• SaettoneMFMontiDTorraccaMTChetoniPMucoadhesive ophthalmic vehicles: evaluation of polymeric low-viscosity formulationsJ Ocul Pharmacol19941083928207347
   PubMedGoogle Scholar
• GreavesJLWilsonCGTreatment of diseases of the eye with mucoadhesive delivery systemsAdv Drug Delivery Rev199311349383
   Web of Science ®Google Scholar
• TorrasJAlarconSActualización en lágrimasartificialesAnn Oftalmol2016241319
   Google Scholar
• GirishKSKemparajuKThe magic glue hyaluronan and its eraser hyaluronidase: a biological overviewLife Sci2007801921194317408700
   PubMed Web of Science ®Google Scholar
• SternRAsariAASugaharaKNHyaluronan fragments: an information-rich systemEur J Cell Biol20068569971516822580
   PubMed Web of Science ®Google Scholar
• LitwiniukMKrejnerASpeyrerMSGautoARGrzelaTHyaluronic acid in inflammation and tissue regenerationWounds2016283788826978861
   PubMed Web of Science ®Google Scholar
• GarrettQSimmonsPAXuSCarboxymethyl cellulose binds to human corneal epithelial cells and is a modulator of corneal epithelial wound healingInvest Ophthalmol Vis Sci20074841559156717389485
   PubMed Web of Science ®Google Scholar
• GarrettQXuSSimmonsPACarboxymethyl cellulose stimulates rabbit corneal epithelial wound healingCurr Eye Res200833756757318600489
   PubMed Web of Science ®Google Scholar
• YaoKBaoYYeJEfficacy of 1% carboxymethyl cellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled studyBMC Ophthalmol2015152825880685
   PubMed Web of Science ®Google Scholar
• AheeJAKaufmanSCSamuelMABogoradDWeeCDecreased incidence of epithelial defects during laser in situ keratomileusis using intraoperative nonpreserved carboxymethylcellulose sodium 0.5% solutionJ Cataract Refract Surg2002281651165412231327
   PubMed Web of Science ®Google Scholar
• LentonLMAlbietzJMEffect of carmellose base artificial tears on the ocular surface in eyes after laser in situ keratomileusisJ Refract Surg199915S227S23110202728
   PubMed Web of Science ®Google Scholar
• CorralesRMLuoLChangEYPflugfelderSCEffects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cellsCornea200827557457918520508
   PubMed Web of Science ®Google Scholar
• HuaXSuZDengRLinJLiDQPflugfelderSCEffects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stressCurr Eye Res201540765766725271595
   PubMed Web of Science ®Google Scholar
• ChenWZhangXLiJWangYChenQHouCGarrettQEfficacy of osmoprotectants on prevention and treatment of murine dry eyeInvest Ophthalmol Vis Sci20135496287629723970467
   PubMed Web of Science ®Google Scholar
• SimmonsPAChang-LinJEChungQVehigeGWeltyDEffect of compatible solutes on transepithelial electrical resistance and uptake in primary rabbit corneal epithelial cell layers modelARVO20074813
   Google Scholar
• DengRSuZHuaXZhangZLiDQPflugfelderSCOsmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cellsMol Vis2014201243125225352733
   PubMed Web of Science ®Google Scholar
• PelusoGBarbarisiASavicaVCarnitine: an osmolyte that plays a metabolic roleJ Cell Biochem200080111011029749
   PubMed Web of Science ®Google Scholar
• GarrettQXuSSimmonsPAVehigeJFlanaganJLWillcoxMDExpression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epitheliumInvest Ophthalmol Vis Sci200849114844484918641280
   PubMed Web of Science ®Google Scholar
• XuSFlanaganJLSimmonsPAVehigeJWillcoxMDGarrettQTransport of L-carnitine in human corneal and conjunctival epithelial cellsMol Vis2010161823183121045919
   PubMed Web of Science ®Google Scholar
• HuaXDengRLiJProtective effects of L-Carnitine against oxidative injury by hyperosmolarity in human corneal epithelial cellsInvest Ophthalmol Vis Sci20155695503551126284556
   PubMed Web of Science ®Google Scholar
• SimmonsPABeardBJVehigeJGOptimizing viscosity of ophthalmic solutions with the combination of two polymersPresented at: the 7th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical RelevanceSeptember 18–21, 2013Taormina, Italy
   Google Scholar
• SheYLiJXiaoBEvaluation of a novel artificial tear in the prevention and treatment of dry eye in an animal modelJ Ocul Pharmacol Ther201531952553026322539
   PubMed Web of Science ®Google Scholar
• SimmonsPALiuHCarlisle-WilcoxCVehigeJGEfficacy and safety of two new formulations of artificial tears in subjects with dry eye disease: a 3-month, multicenter, active-controlled, randomized trialClin Ophthalmol2015966567525931807
   PubMed Web of Science ®Google Scholar
• MencucciRBoccaliniCCaputoRFavuzzaEEffect of a hyaluronic acid and carboxymethyl cellulose ophthalmic solution on ocular comfort and tear-film instability after cataract surgeryJ Cataract Refract Surg20154181699170426432128
   PubMed Web of Science ®Google Scholar
• LabetoulleMChiambarettaFShirlawALeabackRBaudouinCOsmoprotectants, carboxymethylcellulose and hyaluronic acid multi-ingredient eye drop: a randomized controlled trial in moderate to severe dry eyeEye (Lond)201731101409141628452989
   PubMed Web of Science ®Google Scholar
• MateoAJDel PradoEBlascoARole of a hyaluronic acid and carboxymethylcellulose ophthalmic solution on maintenance of tear film homeostasis in moderate to severe dry eye patientsPresented at: the international Symposium on Ocular Pharmacology & Therapeutics (ISOPT)December 1–3; 2016Rome Available from: http://www.isoptclinical.com/Events/Display/ISOPT2016?Page=ProgramAccessed November 21, 2017
   Google Scholar
• SimmonsPAragonaPWangHWangTProperties Of Hyaluronic Acid–Based Eye DropsPresented at: the international Symposium on Ocular Pharmacology & Therapeutics (ISOPT)December 1–3; 2016Rome Available from: http://www.isoptclinical.com/Events/Display/ISOPT2016?Page=ProgramAccessed November 21, 2017
   Google Scholar
• SimmonsPAragonaPWangHWangTPhysiochemical Properties Of Hyaluronic Acid-based Eye DropsPresented at: the 8th International Conference on the Tear Film & Ocular Surface (TFOS): Basic Science and Clinical RelevanceSeptember 7–10; 2016Montpellier, France
   Google Scholar
• GouveiaSMTiffanyJMHuman tear viscosity: an interactive role for proteins and lipidsBiochim Biophys Acta20051753215516316236563
   PubMed Web of Science ®Google Scholar
• ZhangLMKongTAqueous polysaccharide blends based on hydroxypropyl guar gum and carboxymethyl cellulose: synergistic viscosity and thixotropic propertiesColloid Polym Sci20062852145151
   Web of Science ®Google Scholar
• HuanYZhangSVardhanabhutiBInfluence of the molecular weight of carboxymethylcellulose on properties and stability of whey protein-stabilized oil-in-water emulsionsJ Dairy Sci20169953305331526947286
   PubMed Web of Science ®Google Scholar
• GhicaMVHîrjăuMLupuleasaDDinu-PîrvuCEFlow and thixotropic parameters for rheological characterization of hydrogelsMolecules2016216 pii: E786
   Web of Science ®Google Scholar
• JonesLDownieLEKorbDTFOS DEWS II management and therapy reportOcul Surf201715357562828736343
   PubMed Web of Science ®Google Scholar