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Review

Ocular Neuropathic Pain: An Overview Focusing on Ocular Surface Pains

ORCID Icon, ORCID Icon, , &
Pages 2843-2854 | Published online: 25 Sep 2020

References

  • Treede RD, Rief W, Barke A, et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases (ICD-11). Pain. 2019;160(1):19–27. doi:10.1097/j.pain.0000000000001384
  • Galor A, Levitt RC, Felix ER, Martin ER, Sarantopoulos CD. Neuropathic ocular pain: an important yet underevaluated feature of dry eye. Eye (Lond). 2015;29(3):301–312.
  • Lalisse S, Hua J, Lenoir M, Linck N, Rassendren F, Ulmann L. Sensory neuronal P2RX4 receptors controls BDNF signaling in inflammatory pain. Sci Rep. 2018;8(1):964. doi:10.1038/s41598-018-19301-5
  • Veluchamy A, Hebert HL, Meng W, Palmer CNA, Smith BH. Systematic review and meta-analysis of genetic risk factors for neuropathic pain. Pain. 2018;159(5):825–848. doi:10.1097/j.pain.0000000000001164
  • Korczeniewska OA, Husain S, Khan J, Eliav E, Soteropoulos P, Benoliel R. Differential gene expression in trigeminal ganglia of male and female rats following chronic constriction of the infraorbital nerve. Eur J Pain. 2018;22(5):875–888. doi:10.1002/ejp.1174
  • Vehof J, Sillevis Smitt-Kamminga N, Nibourg SA, Hammond CJ. Sex differences in clinical characteristics of dry eye disease. Ocul Surf. 2018;16(2):242–248. doi:10.1016/j.jtos.2018.01.001
  • Belmonte C, Aracil A, Acosta MC, Luna C, Gallar J. Nerves and sensations from the eye surface. Ocul Surf. 2004;2(4):248–253. doi:10.1016/S1542-0124(12)70112-X
  • Li W, Graham AD, Lin MC. Understanding ocular discomfort and dryness using the pain sensitivity questionnaire. PLoS One. 2016;11(5):e0154753. doi:10.1371/journal.pone.0154753
  • Galor A, Covington D, Levitt AE, et al. Neuropathic ocular pain due to dry eye is associated with multiple comorbid chronic pain syndromes. J Pain. 2016;17(3):310–318. doi:10.1016/j.jpain.2015.10.019
  • Brooks J, Tracey I. From nociception to pain perception: imaging the spinal and supraspinal pathways. J Anat. 2005;207(1):19–33. doi:10.1111/j.1469-7580.2005.00428.x
  • Reichling DB, Levine JD. Critical role of nociceptor plasticity in chronic pain. Trends Neurosci. 2009;32(12):611–618. doi:10.1016/j.tins.2009.07.007
  • Goyal S, Hamrah P. Understanding neuropathic corneal pain–gaps and current therapeutic approaches. Semin Ophthalmol. 2016;31(1–2):59–70. doi:10.3109/08820538.2015.1114853
  • Spierer O, Felix ER, McClellan AL, et al. Corneal mechanical thresholds negatively associate with dry eye and ocular pain symptoms. Invest Ophthalmol Vis Sci. 2016;57(2):617–625. doi:10.1167/iovs.15-18133
  • Ferrari G, Hajrasouliha AR, Sadrai Z, Ueno H, Chauhan SK, Dana R. Nerves and neovessels inhibit each other in the cornea. Invest Ophthalmol Vis Sci. 2013;54(1):813–820. doi:10.1167/iovs.11-8379
  • Rosenthal P, Borsook D, Moulton EA. Oculofacial pain: corneal nerve damage leading to pain beyond the eye. Invest Ophthalmol Vis Sci. 2016;57(13):5285–5287. doi:10.1167/iovs.16-20557
  • Belmonte C, Acosta MC, Merayo-Lloves J, Gallar J. What causes eye pain? Curr Ophthalmol Rep. 2015;3(2):111–121. doi:10.1007/s40135-015-0073-9
  • Meng ID, Kurose M. The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Exp Eye Res. 2013;117:79–87. doi:10.1016/j.exer.2013.08.011
  • Bushnell MC, Ceko M, Low LA. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci. 2013;14(7):502–511. doi:10.1038/nrn3516
  • Hofbauer RK, Rainville P, Duncan GH, Bushnell MC. Cortical representation of the sensory dimension of pain. J Neurophysiol. 2001;86(1):402–411. doi:10.1152/jn.2001.86.1.402
  • Foltz EL, White LE. Pain “relief” by frontal cingulumotomy. J Neurosurg. 1962;19:89–100. doi:10.3171/jns.1962.19.2.0089
  • Andreotti AM, Goiato MC, Pellizzer EP, et al. Phantom eye syndrome: a review of the literature. ScientificWorldJournal. 2014;2014:686493. doi:10.1155/2014/686493
  • Shtein RM. Post-LASIK dry eye. Expert Rev Ophthalmol. 2011;6(5):575–582. doi:10.1586/eop.11.56
  • Levitt AE, Galor A, Weiss JS, et al. Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders. Mol Pain. 2015;11:21. doi:10.1186/s12990-015-0020-7
  • Hirata H, Meng ID. Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease. Invest Ophthalmol Vis Sci. 2010;51(8):3969–3976. doi:10.1167/iovs.09-4744
  • Kovacs I, Luna C, Quirce S, et al. Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease. Pain. 2016;157(2):399–417. doi:10.1097/j.pain.0000000000000455
  • Belmonte C, Garcia-Hirschfeld J, Gallar J. Neurobiology of ocular pain. Prog Retin Eye Res. 1997;16(1):117–156. doi:10.1016/S1350-9462(96)00027-4
  • C.R. L. Glaucoma: is it a complex regional pain syndrome. 9ʹth Congress of European Glaucoma Society; September 12–17, 2010; Madrid2010.
  • Roberts CJ, MacLeod JD, Elkington AR. Ocular pain: a casualty study. The spectrum and prevalence of pain in acute eye disease. Eye (Lond). 1997;11(Pt 3):342–344. doi:10.1038/eye.1997.72
  • Albietz JM, Lenton LM, McLennan SG. Dry eye after LASIK: comparison of outcomes for Asian and Caucasian eyes. Clin Exp Optom. 2005;88(2):89–96. doi:10.1111/j.1444-0938.2005.tb06673.x
  • Wilker SC, Rucker JC, Newman NJ, Biousse V, Tomsak RL. Pain in ischaemic ocular motor cranial nerve palsies. Br J Ophthalmol. 2009;93(12):1657–1659. doi:10.1136/bjo.2008.155150
  • Thapa D, Ahuja V. Complex regional pain syndrome - I following eye injury. Indian J Anaesth. 2012;56(6):596–597. doi:10.4103/0019-5049.104596
  • Rasmussen ML, Prause JU, Toft PB. Phantom pain after eye amputation. Acta Ophthalmol. 2011;89(1):10–16. doi:10.1111/j.1755-3768.2010.02058.x
  • Shah-Desai SD, Tyers AG, Manners RM. Painful blind eye: efficacy of enucleation and evisceration in resolving ocular pain. Br J Ophthalmol. 2000;84(4):437–438. doi:10.1136/bjo.84.4.437
  • Park T, Choi G. Unilateral fronto-temporal headache with ocular pain caused by lens subluxation due to spontaneous zonulysis. Clin Exp Emerg Med. 2015;2(2):133–136. doi:10.15441/ceem.15.031
  • Rosenthal P, Borsook D. Ocular neuropathic pain. Br J Ophthalmol. 2016;100(1):128–134. doi:10.1136/bjophthalmol-2014-306280
  • McMonnies CW. The potential role of neuropathic mechanisms in dry eye syndromes. J Optom. 2017;10(1):5–13. doi:10.1016/j.optom.2016.06.002
  • Cho YK, Kim MS. Dry eye after cataract surgery and associated intraoperative risk factors. Korean J Ophthalmol. 2009;23(2):65–73. doi:10.3341/kjo.2009.23.2.65
  • Ambrósio R, Tervo T, Wilson SE. LASIK-associated dry eye and neurotrophic epitheliopathy: pathophysiology and strategies for prevention and treatment. J Refract Surg. 2008;24(4):396–407. doi:10.3928/1081597X-20080401-14
  • Wilson SE. Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. Ophthalmology. 2001;108(6):1082–1087. doi:10.1016/S0161-6420(01)00587-5
  • Wilson SE, Liang Q, Kim WJ. Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. Invest Ophthalmol Vis Sci. 1999;40(10):2185–2190.
  • Belmonte C. Eye dryness sensations after refractive surgery: impaired tear secretion or “phantom” cornea? J Refract Surg. 2007;23(6):598–602. doi:10.3928/1081-597X-20070601-11
  • Tran N, Graham AD, Lin MC. Ethnic differences in dry eye symptoms: effects of corneal staining and length of contact lens wear. Cont Lens Anterior Eye. 2013;36(6):281–288. doi:10.1016/j.clae.2013.06.001
  • Baudouin C, Irkec M, Messmer EM, et al. Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting. Acta Ophthalmol. 2018;96(2):111–119. doi:10.1111/aos.13436
  • Yoon SY, Bae SH, Shin YJ, et al. Low serum 25-hydroxyvitamin D levels are associated with dry eye syndrome. PLoS One. 2016;11(1):e0147847. doi:10.1371/journal.pone.0147847
  • Adatia FA, Michaeli-Cohen A, Naor J, Caffery B, Bookman A, Slomovic A. Correlation between corneal sensitivity, subjective dry eye symptoms and corneal staining in Sjogren’s syndrome. Can J Ophthalmol. 2004;39(7):767–771. doi:10.1016/S0008-4182(04)80071-1
  • Tuisku IS, Konttinen YT, Konttinen LM, Tervo TM. Alterations in corneal sensitivity and nerve morphology in patients with primary Sjogren’s syndrome. Exp Eye Res. 2008;86(6):879–885. doi:10.1016/j.exer.2008.03.002
  • Alhatem A, Cavalcanti B, Hamrah P. In vivo confocal microscopy in dry eye disease and related conditions. Semin Ophthalmol. 2012;27(5–6):138–148. doi:10.3109/08820538.2012.711416
  • Pflugfelder SC, Kinoshita S. Management and therapy of dry eye disease: report of the management and therapy subcommittee of the international dry eye workShop (2007). Ocul Surf. 2007;5(2):163–178.
  • Kim YJ, Ryu JS, Park SY, et al. Comparison of topical application of TSG-6, cyclosporine, and prednisolone for treating dry eye. Cornea. 2016;35(4):536–542. doi:10.1097/ICO.0000000000000756
  • Kanellopoulos AJ. Incidence and management of symptomatic dry eye related to LASIK for myopia, with topical cyclosporine A. Clin Ophthalmol. 2019;13:545–552. doi:10.2147/OPTH.S188521
  • Nichols KK, Foulks GN, Bron AJ, et al. The international workshop on meibomian gland dysfunction: executive summary. Invest Ophthalmol Vis Sci. 2011;52(4):1922–1929. doi:10.1167/iovs.10-6997a
  • Colin J. The role of NSAIDs in the management of postoperative ophthalmic inflammation. Drugs. 2007;67(9):1291–1308. doi:10.2165/00003495-200767090-00004
  • Higuchi A. Autologous serum and serum components. Invest Ophthalmol Vis Sci. 2018;59(14):DES121–DES129. doi:10.1167/iovs.17-23760
  • Jacobs DS. Diagnosis and treatment of ocular pain: the ophthalmologist’s perspective. Curr Ophthalmol Rep. 2017;5(4):271–275. doi:10.1007/s40135-017-0152-1
  • Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain. 2005;9(4):463–484.
  • Kawashima M, Uchino M, Yokoi N, et al. Associations between subjective happiness and dry eye disease: a new perspective from the Osaka study. PLoS One. 2015;10(4):e0123299. doi:10.1371/journal.pone.0123299
  • Sheha H, Tighe S, Hashem O, Hayashida Y. Update on cenegermin eye drops in the treatment of neurotrophic keratitis. Clin Ophthalmol. 2019;13:1973–1980. doi:10.2147/OPTH.S185184
  • Abidi A, Shukla P, Ahmad A. Lifitegrast: a novel drug for treatment of dry eye disease. J Pharmacol Pharmacother. 2016;7(4):194–198. doi:10.4103/0976-500X.195920
  • Ormonde S, Chou CY, Goold L, et al. Regulation of cennexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds. J Membrane Biol. 2012;245(7):381–388. doi:10.1007/s00232-012-9460-4
  • Nam KE, Kim JS, Hong BY, et al. Botulinum toxin type A injection for neuropathic pain in a patient with a brain tumor: a case report. Ann Rehabil Med. 2017;41(6):1088–1092. doi:10.5535/arm.2017.41.6.1088
  • Kuhnle MD, Ryan DS, Coe CD, et al. Oral gabapentin for photorefractive keratectomy pain. J Cataract Refract Surg. 2011;37(2):364–369. doi:10.1016/j.jcrs.2010.08.041
  • Matsuura M, Matsuura M, Ando F, Sahashi K, Torii Y, Hirose H. [The effect of stellate ganglion block on prolonged post-operative ocular pain]. Nippon Ganka Gakkai Zasshi. 2003;107(10):607–612.
  • Xavier TV, de Oliveira TR, Mendes TC. Treatment of patients with painful blind eye using stellate ganglion block. Braz J Anesthesiol. 2016;66(1):75–77. doi:10.1016/j.bjan.2012.12.009
  • Tolba R, Weiss AL, Denis DJ. Sphenopalatine ganglion block and radiofrequency ablation: technical notes and efficacy. Ochsner J. 2019;19(1):32–37. doi:10.31486/toj.18.0163