173
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Outcomes of Severe Fungal Keratitis Using in vivo Confocal Microscopy and Early Therapeutic Penetrating Keratoplasty

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 2245-2254 | Published online: 12 Jul 2022

References

  • Brown L, Leck AK, Gichangi M, Burton MJ, Denning DW. The global incidence and diagnosis of fungal keratitis. Lancet Infect Dis. 2021;21:e49–e57. doi:10.1016/S1473-3099(20)30448-5
  • Gopinathan U, Sharma S, Garg P, Rao GN. Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade. Indian J Ophthalmol. 2009;57:273–279. doi:10.4103/0301-4738.53051
  • Khor W-B, Aung T, Saw S-M, et al. An outbreak of Fusarium keratitis associated with contact lens wear in Singapore. JAMA. 2006;295:2867–2873. doi:10.1001/jama.295.24.2867
  • Roth M, Holtmann C, Daas L, et al. Results From the German Fungal Keratitis Registry. Cornea. 2021;40:1453–1461. doi:10.1097/ICO.0000000000002705
  • Chang DC, Grant GB, O’Donnell K, et al. Multistate outbreak of Fusarium keratitis associated with use of a contact lens solution. JAMA. 2006;296:953–963. doi:10.1001/jama.296.8.953
  • Gaujoux T, Chatel MA, Chaumeil C, Laroche L, Borderie VM. Outbreak of contact lens-related Fusarium keratitis in France. Cornea. 2008;27(9):1018–1021. doi:10.1097/ICO.0b013e318173144d
  • Morgan PB, Efron N. A decade of contact lens prescribing trends in the United Kingdom (1996–2005). Contact Lens Anterior Eye. 2006;29:59–68. doi:10.1016/j.clae.2006.02.008
  • Alfaro Rangel R, Szentmáry N, Lepper S, et al. Perforierende Keratoplastiken mit großem Durchmesser sind meist auf eine sehr schwere infektiöse Keratitis zurückzuführen und können eine sekundäre Enukleation nicht immer verhindern. [Large-diameter penetrating keratoplasties are mostly due to very severe infectious keratitis and cannot always prevent secondary enucleation]. Klin Monbl Augenheilkd. 2021. German. doi:10.1055/a-1396-4787
  • Ams A-H, Bonifaz A, Ranque S, Sybren de Hoog G, Verweij PE, Meis JF. Current antifungal treatment of fusariosis. Int J Antimicrob Agents. 2018;51:326–332. doi:10.1016/j.ijantimicag.2017.06.017
  • Prajna NV, Krishnan T, Mascarenhas J, et al. The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole. JAMA Ophthalmol. 2013;131:422–429. doi:10.1001/jamaophthalmol.2013.1497
  • Behrens-Baumann W, Finis D, MacKenzie C, Roth M, Geerling G. Keratomykose - Therapiestandards und aktuelle Entwicklungen. [Keratomycosis - therapy standards and new developments]. Klin Monbl Augenheilkd. 2015;232:754–764. German. doi:10.1055/s-0035-1546032
  • Alfaro Rangel R, Szentmáry N, Lepper S, Daas L, Langenbucher A, Seitz B. 8.5/8.6-mm excimer laser-assisted penetrating keratoplasties in a tertiary corneal subspecialty referral center: indications and outcomes in 107 eyes. Cornea. 2020;39(806–811):806–811. doi:10.1097/ICO.0000000000002327
  • Küchle M, Seitz B, Langenbucher A, Naumann GO. Nonmechanical excimer laser penetrating keratoplasty for perforated or predescemetal corneal ulcers. Ophthalmology. 1999;106:2203–2209.
  • Nielsen SE, Nielsen E, Julian HO, et al. Incidence and clinical characteristics of fungal keratitis in a Danish population from 2000 to 2013. Acta Ophthalmol. 2015;93:54–58. doi:10.1111/aos.12440
  • Roth M, Daas L, Renner-Wilde A, et al. Das Deutsche Pilz-Keratitis-Register : Erste Ergebnisse einer multizentrischen Erhebung. [The German keratomycosis registry: initial results of a multicenter survey]. Ophthalmologe. 2019;116:957–966. German. doi:10.1007/s00347-019-0871-9
  • Tuft SJ, Tullo AB. Fungal keratitis in the United Kingdom 2003–2005. Eye. 2009;23:1308–1313. doi:10.1038/eye.2008.298
  • Walther G, Stasch S, Kaerger K, et al. Fusarium keratitis in Germany. J Clin Microbiol. 2017;55:2983–2995. doi:10.1128/JCM.00649-17
  • Hu J, Zhang J, Li Y, et al. A combination of intrastromal and intracameral injections of amphotericin b in the treatment of severe fungal keratitis. J Ophthalmol. 2016;2016:3436415. doi:10.1155/2016/3436415
  • Roth M, Daas L, MacKenzie CR, et al. Development and assessment of a simulator for in vivo confocal microscopy in fungal and acanthamoeba keratitis. Curr Eye Res. 2020;45:1484–1489. doi:10.1080/02713683.2020.1772830
  • Farah CJ, Seitz B, Hamon L, Sourlis C, Daas L. Mischinfektionen bei kontaktlinsenassoziierter mykotischer Keratitis mit Pseudomonas oder Akanthamöben. [Coinfections in contact lens-associated mycotic keratitis with pseudomonas or acanthamoeba]. Ophthalmologe. 2020;118:940–943. German. doi:10.1007/s00347-020-01207-1
  • Hamon L, El Halabi M, Flockerzi FA, Seitz B, Daas L. Purpureocillium lilacinum : Atypischer Erreger einer mykotischen Keratitis bei einer immunkompetenten Patientin. [Purpureocillium lilacinum: atypical pathogen of mycotic keratitis in an immunocompetent patient]. Ophthalmologe. 2021. German. doi:10.1007/s00347-021-01325-4
  • Daas L, Bischoff-Jung M, Viestenz A, Seitz B, Viestenz A. Konfokale Mikroskopie als früher Rezidivmarker nach Keratoplastik infolge einer Fusarium-solani-Keratitis. [Confocal microscopy as an early relapse marker after keratoplasty due to Fusarium solani keratitis]. Ophthalmologe. 2017;114:66–69. German. doi:10.1007/s00347-016-0270-4
  • Das S, Samant M, Garg P, Vaddavalli PK, Vemuganti GK. Role of confocal microscopy in deep fungal keratitis. Cornea. 2009;28:11–13. doi:10.1097/ICO.0b013e318181cff7
  • Nielsen E, Heegaard S, Prause JU, Ivarsen A, Mortensen KL, Hjortdal J. Fungal keratitis-improving diagnostics by confocal microscopy. Case Rep Ophthalmol. 2013;4:303–310. doi:10.1159/000357558
  • Vaddavalli PK, Garg P, Sharma S, Sangwan VS, Rao GN, Thomas R. Role of confocal microscopy in the diagnosis of fungal and acanthamoeba keratitis. Ophthalmology. 2011;118:29–35. doi:10.1016/j.ophtha.2010.05.018
  • Said DG, Otri M, Miri A, Kailasanathan A, Khatib T, Dua HS. The challenge of fungal keratitis. Br J Ophthalmol. 2011;95:1623–1624. doi:10.1136/bjophthalmol-2011-301148
  • Yang JW, Lin HC, Hsiao CH, Chen PY. Therapeutic penetrating keratoplasty in severe infective keratitis using glycerol-preserved donor corneas. Cornea. 2012;31:1103–1106. doi:10.1097/ICO.0b013e31821c9ba2
  • Gao H, Song P, Echegaray JJ, et al. Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis. J Ophthalmol. 2014;2014:1–8. doi:10.1155/2014/209759
  • Xie L, Hu J, Shi W. Treatment failure after lamellar keratoplasty for fungal keratitis. Ophthalmology. 2008;115:33–36. doi:10.1016/j.ophtha.2007.03.072
  • Xie L, Zhai H, Shi W. Penetrating keratoplasty for corneal perforations in fungal keratitis. Cornea. 2007;26:158–162. doi:10.1097/01.ico.0000248381.24519.0d
  • Jain R, Bhutia KL, Mohan N, Gupta CKC, Ghai A. Outcome of therapeutic keratoplasty in hopeless microbial keratitis cases otherwise advised evisceration. Cornea. 2018;37:151–155. doi:10.1097/ICO.0000000000001432
  • Koçluk Y, Sukgen EA. Results of therapeutic penetrating keratoplasty for bacterial and fungal keratitis. Int Ophthalmol. 2017;37:1085–1093. doi:10.1007/s10792-016-0372-7
  • Laurik KL, Szentmáry N, Daas L, Langenbucher A, Seitz B. Early penetrating keratoplasty à chaud may improve outcome in therapy-resistant acanthamoeba keratitis. Adv Ther. 2019;36:2528–2540. doi:10.1007/s12325-019-01031-3
  • Chatterjee S, Agrawal D. Recurrence of infection in corneal grafts after therapeutic penetrating keratoplasty for microbial keratitis. Cornea. 2020;39:39–44. doi:10.1097/ICO.0000000000002044
  • Sharma N, Agarwal P, Sinha R, Titiyal JS, Velpandian T, Vajpayee RB. Evaluation of intrastromal voriconazole injection in recalcitrant deep fungal keratitis: case series. Br J Ophthalmol. 2011;95:1735–1737. doi:10.1136/bjo.2010.192815
  • Prakash G, Sharma N, Goel M, Titiyal JS, Vajpayee RB. Evaluation of intrastromal injection of voriconazole as a therapeutic adjunctive for the management of deep recalcitrant fungal keratitis. Am J Ophthalmol. 2008;146:56–59. doi:10.1016/j.ajo.2008.02.023