Geographic atrophy in patients with advanced dry age-related macular degeneration: current challenges and future prospects

References

• WongWLSuXLiXGlobal prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysisLancet Glob Health201422e106e11625104651
   PubMed Web of Science ®Google Scholar
• FerrisFLWilkinsonCPBirdAClinical classification of age-related macular degenerationOphthalmology2013120484485123332590
   PubMed Web of Science ®Google Scholar
• The Age-Related Eye Disease Study Research GroupThe Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study report number 6Am J Ophthalmol2001132566868111704028
   PubMed Web of Science ®Google Scholar
• KleinRKleinBEMossSEAge-related eye disease and survival. The Beaver Dam Eye StudyArch Ophthalmol199511333333397887847
   PubMedGoogle Scholar
• SunnessJSRubinGSZuckerbrodAApplegateCAFoveal-sparing scotomas in advanced dry age-related macular degenerationJ Vis Impair Blind20081021060061020224750
   PubMed Web of Science ®Google Scholar
• RudnickaARKapetanakisVVJarrarZIncidence of late-stage age-related macular degeneration in American whites: systematic review and meta-analysisAm J Ophthalmol2015160185.e8393.e8325857680
   PubMed Web of Science ®Google Scholar
• OwenCGFletcherAEDonoghueMRudnickaARHow big is the burden of visual loss caused by age related macular degeneration in the United Kingdom?Br J Ophthalmol200387331231712598445
   PubMed Web of Science ®Google Scholar
• OwenCGJarrarZWormaldRCookDGFletcherAERudnickaARThe estimated prevalence and incidence of late stage age related macular degeneration in the UKBr J Ophthalmol201296575275622329913
   PubMed Web of Science ®Google Scholar
• Age-related Eye Disease Study GroupA randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8Arch Ophthalmol2001119101417143611594942
   PubMedGoogle Scholar
• ChewEYClemonsTESangiovanniJPSecondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report no. 3JAMA Ophthalmol2014132214214924310343
   PubMed Web of Science ®Google Scholar
• GassJDDrusen and disciform macular detachment and degenerationArch Ophthalmol19739032062174738143
   PubMedGoogle Scholar
• SarksSHDrusen patterns predisposing to geographic atrophy of the retinal pigment epitheliumAust J Ophthalmol198210291977103872
   PubMedGoogle Scholar
• SarksJPSarksSHKillingsworthMCEvolution of geographic atrophy of the retinal pigment epitheliumEye19882Pt 55525772476333
   PubMed Web of Science ®Google Scholar
• SunnessJSThe natural history of geographic atrophy, the advanced atrophic form of age-related macular degenerationMol Vis199952510562649
   PubMed Web of Science ®Google Scholar
• SunnessJSGonzalez-BaronJApplegateCAEnlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degenerationOphthalmology199910691768177910485549
   PubMed Web of Science ®Google Scholar
• Schmitz-ValckenbergSFleckensteinMHelbHMCharbel IssaPSchollHPHolzFGIn-vivo imaging of foveal sparing in geographic atrophy secondary to age-related macular degenerationInvest Ophthalmol Vis Sci20095083915392119339734
   PubMed Web of Science ®Google Scholar
• MelethADMettuPAgronEChanges in retinal sensitivity in geographic atrophy progression as measured by microperimetryInvest Ophthalmol Vis Sci20115221119112620926818
   PubMed Web of Science ®Google Scholar
• SunnessJSApplegateCAHaselwoodDRubinGSFixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt diseaseOphthalmology19961039145814668841306
   PubMed Web of Science ®Google Scholar
• SunnessJSRubinGSApplegateCAVisual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuityOphthalmology199710410167716919331210
   PubMed Web of Science ®Google Scholar
• SeddonJMReynoldsRMallerJFagernessJADalyMJRosnerBPrediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variablesInvest Ophthalmol Vis Sci20095052044205319117936
   PubMed Web of Science ®Google Scholar
• KleinMLFerrisFL3rdFrancisPJProgression of geographic atrophy and genotype in age-related macular degenerationOphthalmology201011781554155920381870
   PubMed Web of Science ®Google Scholar
• GrassmanFFauserSWeberBThe genetics of age-related macular degeneration (AMD) – novel targets for designing treatment options?Eur J Pharm Biochem Epub5162015
   Google Scholar
• LiuMMChanCCTuoJGenetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial geneticsHum Genomics201261132123244519
   PubMed Web of Science ®Google Scholar
• GrassmannFFleckensteinMChewEYClinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degenerationPLoS One2015105e012663625962167
   PubMed Web of Science ®Google Scholar
• CaireJRecaldeSVelazquez-VilloriaAGrowth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degenerationJAMA Ophthalmol2014132552853424557084
   PubMed Web of Science ®Google Scholar
• JohnsonLVOzakiSStaplesMKEricksonPAAndersonDHA potential role for immune complex pathogenesis in drusen formationExp Eye Res200070444144910865992
   PubMed Web of Science ®Google Scholar
• JohnsonLVLeitnerWPStapelsMKComplement activation and inflammatory processes in Drusen formation and age related macular degenerationExp Eye Res200173688789611846519
   PubMed Web of Science ®Google Scholar
• KeenanTDPickfordCEHolleyRJAge-dependent changes in heparan sulfate in human Bruch’s membrane: implications for age-related macular degenerationInvest Ophthalmol Vis Sci20145585370537925074778
   PubMed Web of Science ®Google Scholar
• BhuttoILuttyGUnderstanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complexMol Aspects Med201233429531722542780
   PubMed Web of Science ®Google Scholar
• HagemanGSLuthertPJVictor ChongNHJohnsonLVAndersonDHMullinsRFAn integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch’s membrane interface in aging and age-related macular degenerationProg Retin Eye Res200120670573211587915
   PubMed Web of Science ®Google Scholar
• AndersonDHMullinsRFHagemanGSA role for local inflammation in the formation of drusen in the aging eyeAm J Ophthalmol2002134341143112208254
   PubMed Web of Science ®Google Scholar
• MullinsRFSkeieJMMaloneEAKuehnMHMacular and peripheral distribution of ICAM-1 in the human choriocapillaris and retinaMol Vis20061222423516604055
   PubMed Web of Science ®Google Scholar
• BoraPSSohnJHCruzJMRole of complement and complement membrane attack complex in laser-induced choroidal neovascularizationJ Immunol2005174149149715611275
   PubMed Web of Science ®Google Scholar
• BoraNSKaliappanSJhaPComplement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor HJ Immunol200617731872187816849499
   PubMed Web of Science ®Google Scholar
• NozakiMRaislerBJSakuraiEDrusen complement components C3a and C5a promote choroidal neovascularizationProc Natl Acad Sci U S A200610372328233316452172
   PubMed Web of Science ®Google Scholar
• CurcioCAMessingerJDSloanKRMcGwinGMedeirosNESpaideRFSubretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis modelRetina201333226527623266879
   PubMed Web of Science ®Google Scholar
• ZanzotteraECMessingerJDAchTSmithRTCurcioCASubducted and melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epitheliumInvest Ophthalmol Vis Sci20155653269327826024109
   PubMed Web of Science ®Google Scholar
• CurcioCAMedeirosNEMillicanCLPhotoreceptor loss in age-related macular degenerationInvest Ophthalmol Vis Sci1996377123612498641827
   PubMed Web of Science ®Google Scholar
• KleinMLFerrisFLArmstrongJRetinal precursors and the development of geographic atrophy in age-related macular degenerationOphthalmology200811561026103117981333
   PubMed Web of Science ®Google Scholar
• Group CoA-rMDPTCRRisk factors for choroidal neovascularization and geographic atrophy in the complications of age-related macular degeneration prevention trialOphthalmology20081159147414791479.e14711476.e147118502512
   PubMed Web of Science ®Google Scholar
• YingGSMaguireMGDevelopment of a risk score for geographic atrophy in complications of the age-related macular degeneration prevention trialOphthalmology2011118233233820801521
   PubMed Web of Science ®Google Scholar
• DavisMDGangnonRELeeLYThe Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS report no. 17Arch Ophthalmol2005123111484149816286610
   PubMed Web of Science ®Google Scholar
• YingGSMaguireMGAlexanderJMartinRWAntoszykANDescription of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-Related Macular Degeneration Prevention trialArch Ophthalmol200912791147115119752423
   PubMedGoogle Scholar
• FerrisFLDavisMDClemonsTEA simplified severity scale for age-related macular degeneration: AREDS report no. 18Arch Ophthalmol2005123111570157416286620
   PubMed Web of Science ®Google Scholar
• MarsigliaMBodduSBearellySAssociation between geographic atrophy progression and reticular pseudodrusen in eyes with dry age-related macular degenerationInvest Ophthalmol Vis Sci201354127362736924114542
   PubMed Web of Science ®Google Scholar
• HolzFGStraussECSchmitz-ValckenbergSvan Lookeren CampagneMGeographic atrophy: clinical features and potential therapeutic approachesOphthalmology201412151079109124433969
   PubMed Web of Science ®Google Scholar
• KleinRMeuerSMKnudtsonMDIyengarSKKleinBEThe epidemiology of retinal reticular drusenAm J Ophthalmol2008145231732618045568
   PubMed Web of Science ®Google Scholar
• HolzFGSteinbergJSGöbelAFleckensteinMSchmitz-ValckenbergSFundus autofluorescence imaging in dry AMD: 2014 Jules Gonin lecture of the Retina Research FoundationGraefes Arch Clin Exp Ophthalmol2015253171625408425
   PubMed Web of Science ®Google Scholar
• SparrowJRDunckerTFundus autofluorescence and RPE lipofuscin in age-related macular degenerationJ Clin Med2014341302132125774313
   PubMedGoogle Scholar
• SparrowJRYoonKWuYYamamotoKInterpretations of fundus autofluorescence from studies of the bisretinoids of the retinaInvest Ophthalmol Vis Sci20105194351435720805567
   PubMed Web of Science ®Google Scholar
• FleckensteinMSchmitz-ValckenbergSLindnerMThe “diffuse-trickling” fundus autofluorescence phenotype in geographic atrophyInvest Ophthalmol Vis Sci20145552911292024699379
   PubMed Web of Science ®Google Scholar
• RudolfMVogtSDCurcioCAHistologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophyOphthalmology2013120482182823357621
   PubMed Web of Science ®Google Scholar
• SunnessJSApplegateCABresslerNMHawkinsBSDesigning clinical trials for age-related geographic atrophy of the macula: enrollment data from the geographic atrophy natural history studyRetina200727220421017290203
   PubMed Web of Science ®Google Scholar
• Garcia FilhoCAYehoshuaZGregoriGChange in drusen volume as a novel clinical trial endpoint for the study of complement inhibition in age-related macular degenerationOphthalmic Surg Lasers Imaging Retina2014451183124354307
   PubMed Web of Science ®Google Scholar
• CsakyKGRichmanEAFerrisFLIIIReport from the NEI/FDA Ophthalmic Clinical Trial Design and Endpoints SymposiumInvest Ophthalmol Vis Sci200849247948918234989
   PubMed Web of Science ®Google Scholar
• KleinRDavisMDMagliYLSegalPKleinBEHubbardLThe Wisconsin age-related maculopathy grading systemOphthalmology1991987112811341843453
   PubMed Web of Science ®Google Scholar
• BirdACBresslerNMBresslerSBAn international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study GroupSurv Ophthalmol19953953673747604360
   PubMed Web of Science ®Google Scholar
• KleinRKleinBELintonKLPrevalence of age-related maculopathy. The Beaver Dam Eye StudyOphthalmology19929969339431630784
   PubMed Web of Science ®Google Scholar
• SunnessJSBresslerNMTianYAlexanderJApplegateCAMeasuring geographic atrophy in advanced age-related macular degenerationInvest Ophthalmol Vis Sci19994081761176910393046
   PubMed Web of Science ®Google Scholar
• LindbladASLloydPCClemonsTEChange in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26Arch Ophthalmol200912791168117419752426
   PubMedGoogle Scholar
• SchollHPDandekarSSPetoTWhat is lost by digitizing stereoscopic fundus color slides for macular grading in age-related maculopathy and degeneration?Ophthalmology2004111112513214711724
   PubMed Web of Science ®Google Scholar
• van LeeuwenRChakravarthyUVingerlingJRGrading of age-related maculopathy for epidemiological studies: is digital imaging as good as 35 mm film?Ophthalmology20031101540154412917169
   PubMed Web of Science ®Google Scholar
• DanisRPDomalpallyAChewEYMethods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 report number 2)Invest Ophthalmol Vis Sci20135474548455423620429
   PubMed Web of Science ®Google Scholar
• HubbardLDDanisRPNeiderMWBrightness, contrast, and color balance of digital versus film retinal images in the Age-Related Eye Disease Study 2Invest Ophthalmol Vis Sci20084983269328218421079
   PubMed Web of Science ®Google Scholar
• von RuckmannAFitzkeFWBirdACDistribution of fundus auto-fluorescence with a scanning laser ophthalmoscopeBr J Ophthalmol19957954074127612549
   PubMed Web of Science ®Google Scholar
• von RuckmannAFitzkeFWBirdACFundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscopeInvest Ophthalmol Vis Sci19973824784869040481
   PubMed Web of Science ®Google Scholar
• HolzFGBellmanCStaudtSSchuttFVolckerHEFundus autofluorescence and development of geographic atrophy in age-related macular degenerationInvest Ophthalmol Vis Sci20014251051105611274085
   PubMed Web of Science ®Google Scholar
• Schmitz-ValckenbergSJorzikJUnnebrinkKHolzFGAnalysis of digital scanning laser ophthalmoscopy fundus autofluorescence images of geographic atrophy in advanced age-related macular degenerationGraefes Arch Clin Exp Ophthalmol20022402737811933894
   PubMed Web of Science ®Google Scholar
• RamseyDJSunnessJSMalviyaPApplegateCHagerGDHandaJTAutomated image alignment and segmentation to follow progression of geographic atrophy in age-related macular degenerationRetina20143471296130724398699
   PubMed Web of Science ®Google Scholar
• Schmitz-ValckenbergSBrinkmannCKAltenFSemiautomated image processing method for identification and quantification of geographic atrophy in age-related macular degenerationInvest Ophthalmol Vis Sci201152107640764621873669
   PubMed Web of Science ®Google Scholar
• HolzFGBellmannCMargaritidisMSchuttFOttoTPVolckerHEPatterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degenerationGraefes Arch Clin Exp Ophthalmol199923721451529987631
   PubMed Web of Science ®Google Scholar
• Schmitz-ValckenbergSBindewald-WittichADolar-SzczasnyJCorrelation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMDInvest Ophthalmol Vis Sci20064762648265416723482
   PubMed Web of Science ®Google Scholar
• BearellySKhanifarAALedererDEUse of fundus autofluorescence images to predict geographic atrophy progressionRetina2011311818620890245
   PubMed Web of Science ®Google Scholar
• BindewaldABirdACDandekarSSClassification of fundus autofluorescence patterns in early age-related macular diseaseInvest Ophthalmol Vis Sci20054693309331416123434
   PubMed Web of Science ®Google Scholar
• HolzFGBindewald-WittichAFleckensteinMDreyhauptJSchollHPSchmitz-ValckenbergSProgression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degenerationAm J Ophthalmol2007143346347217239336
   PubMed Web of Science ®Google Scholar
• Wolf-SchnurrbuschUEWittwerVVGhanemRBlue-light versus green-light autofluorescence: lesion size of areas of geographic atrophyInvest Ophthalmol Vis Sci201152139497950222110076
   PubMed Web of Science ®Google Scholar
• SpaideRFFundus autofluorescence and age-related macular degenerationOphthalmology2003110239239912578786
   PubMed Web of Science ®Google Scholar
• Schmitz-ValckenbergSFleckensteinMGobelAPEvaluation of autofluorescence imaging with the scanning laser ophthalmoscope and the fundus camera in age-related geographic atrophyAm J Ophthalmol2008146218319218514607
   PubMed Web of Science ®Google Scholar
• ParkSPSiringoFSPensecNComparison of fundus autofluorescence between fundus camera and confocal scanning laser ophth almoscope-based systemsOphthalmic Surg Lasers Imaging Retina201344653654324221461
   PubMed Web of Science ®Google Scholar
• WuZLuuCDAytonLNOptical coherence tomography-defined changes preceding the development of drusen-associated atrophy in age-related macular degenerationOphthalmology2014121122415242225109931
   PubMed Web of Science ®Google Scholar
• SimaderCSayeghRGMontuoroAA longitudinal comparison of spectral-domain optical coherence tomography and fundus autofluorescence in geographic atrophyAm J Ophthalmol20141583557566.e55124879944
   PubMed Web of Science ®Google Scholar
• NunesRPGregoriGYehoshuaZPredicting the progression of geographic atrophy in age-related macular degeneration with SD-OCT en face imaging of the outer retinaOphthalmic Surg Lasers Imaging Retina201344434435923883530
   PubMed Web of Science ®Google Scholar
• MoussaKLeeJYStinnettSSJaffeGJSpectral domain optical coherence tomography-determined morphologic predictors of the age-related macular degeneration-associated geographic atrophy progressionRetina20133381590159923538573
   PubMed Web of Science ®Google Scholar
• FleckensteinMSchmitz-ValckenbergSMartensCFundus autofluorescence and spectral-domain optical coherence tomography characteristics in a rapidly progressing form of geographic atrophyInvest Ophthalmol Vis Sci20115263761376621310912
   PubMed Web of Science ®Google Scholar
• HaririANittalaMGSaddaSROuter retinal tubulation as a predictor of the enlargement amount of geographic atrophy in age-related macular degenerationOphthalmology2015122240741325315664
   PubMed Web of Science ®Google Scholar
• CohenSYDuboisLNghiem-BuffetSRetinal pseudocysts in age-related geographic atrophyAm J Ophthalmol20101502211217.e21120537310
   PubMed Web of Science ®Google Scholar
• MonesJBiarnesMTrindadeFHyporeflective wedge-shaped band in geographic atrophy secondary to age-related macular degeneration: an underreported findingOphthalmology201211971412141922440276
   PubMed Web of Science ®Google Scholar
• ForteRQuerquesGQuerquesLLevezielNBenhamouNSouiedEHMultimodal evaluation of foveal sparing in patients with geographic atrophy due to age-related macular degenerationRetina201333348248923400084
   PubMed Web of Science ®Google Scholar
• YehoshuaZGarcia FilhoCAPenhaFMComparison of geographic atrophy measurements from the OCT fundus image and the sub-RPE slab imageOphthalmic Surg Lasers Imaging Retina201344212713223510038
   PubMed Web of Science ®Google Scholar
• SchacharIHZahidSComerGMQuantification of fundus autofluorescence to detect disease severity in nonexudative age-related macular degenerationJAMA Ophthalmol201313181009101523787960
   PubMed Web of Science ®Google Scholar
• WuZLuuCDAytonLNFundus autofluorescence characteristics of nascent geographic atrophy in age-related macular degenerationInvest Ophthalmol Vis Sci20155631546155225678689
   PubMed Web of Science ®Google Scholar
• SchutzeCBolzMSayeghRLesion size detection in geographic atrophy by polarization-sensitive optical coherence tomography and correlation to conventional imaging techniquesInvest Ophthalmol Vis Sci201354173974523258154
   PubMed Web of Science ®Google Scholar
• PanorgiasAZawadzkiRJCappsAGHunterAAMorseLSWernerJSMultimodal assessment of microscopic morphology and retinal function in patients with geographic atrophyInvest Ophthalmol Vis Sci20135464372438423696601
   PubMed Web of Science ®Google Scholar
• GochoKSardaVFalahSAdaptive optics imaging of geographic atrophyInvest Ophthalmol Vis Sci20135453673368023620431
   PubMed Web of Science ®Google Scholar
• HwangJCChanJWChangSSmithRTPredictive value of fundus autofluorescence for development of geographic atrophy in age-related macular degenerationInvest Ophthalmol Vis Sci20064762655266116723483
   PubMed Web of Science ®Google Scholar
• BatiogluFGedik OguzYDemirelSOzmertEGeographic atrophy progression in eyes with age-related macular degeneration: role of fundus autofluorescence patterns, fellow eye and baseline atrophy areaOphthalmic Res2014522535924993093
   PubMed Web of Science ®Google Scholar
• SunnessJSMargalitESrikumaranDThe long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and implications for interventional clinical trialsOphthalmology2007114227127717270676
   PubMed Web of Science ®Google Scholar
• DomalpallyADanisRPWhiteJCircularity index as a risk factor for progression of geographic atrophyOphthalmology2013120122666267124206616
   PubMed Web of Science ®Google Scholar
• KleinRMeuerSMKnudtsonMDKleinBEThe epidemiology of progression of pure geographic atrophy: the Beaver Dam Eye studyAm J Ophthalmol2008146569269918672224
   PubMed Web of Science ®Google Scholar
• BiarnesMAriasLAlonsoJIncreased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN studyAm J Ophthalmol20151602345353.e525982972
   PubMed Web of Science ®Google Scholar
• YehoshuaZde Amorim Garcia FilhoCANunesRPComparison of geographic atrophy growth rates using different imaging modalities in the COMPLETE studyOphthalmic Surg Lasers Imaging Retina201546441342225970861
   PubMed Web of Science ®Google Scholar
• DreyhauptJMansmannUPritschMDolar-SzczasnyJBindewaldAHolzFGModelling the natural history of geographic atrophy in patients with age-related macular degenerationOphthalmic Epidemiol200512635336216283987
   PubMed Web of Science ®Google Scholar
• FeuerWJYehoshuaZGregoriGSquare root transformation of geographic atrophy area measurements to eliminate dependence of growth rates on baseline lesion measurements: a reanalysis of Age-Related Eye Disease Study report no. 26JAMA Ophthalmol2013131111011123307222
   PubMed Web of Science ®Google Scholar
• LeeSChenTTBarberCLAutocrine VEGF signaling is required for vascular homeostasisCell2007130469170317719546
   PubMed Web of Science ®Google Scholar
• Saint-GeniezMKuriharaTSekiyamaEMaldonadoAED’AmorePAAn essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillarisProc Natl Acad Sci U S A200910644187511875619841260
   PubMed Web of Science ®Google Scholar
• NishijimaKNgYSZhongLVascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injuryAm J Pathol20071711536717591953
   PubMed Web of Science ®Google Scholar
• RosenfeldPJShapiroHTuomiLCharacteristics of patients losing vision after 2 years of monthly dosing in the phase III ranibizumab clinical trialsOphthalmology2011118352353020920825
   PubMed Web of Science ®Google Scholar
• BhisitkulRBMendesTSRofaghaSMacular atrophy progression and 7-year vision outcomes in subjects from the ANCHOR, MARINA, and HORIZON studies: the SEVEN-UP studyAm J Ophthalmol20151595915924.e91225640411
   PubMed Web of Science ®Google Scholar
• GrunwaldJEDanielEHuangJRisk of geographic atrophy in the comparison of age-related macular degeneration treatments trialsOphthalmology2014121115016124084496
   PubMed Web of Science ®Google Scholar
• GrunwaldJEPistilliMYingGSGrowth of geographic atrophy in the comparison of age-related macular degeneration treatments trialsOphthalmology2015122480981625542520
   PubMed Web of Science ®Google Scholar
• TanakaEChaikitmongkolVBresslerSBBresslerNMVision-threatening lesions developing with longer-term follow-up after treatment of neovascular age-related macular degenerationOphthalmology2015122115316125283060
   PubMed Web of Science ®Google Scholar
• DoDVPieramiciDJvan Lookeren CampagneMA phase Ia dose-escalation study of the anti-factor D monoclonal antibody fragment FCFD4514S in patients with geographic atrophyRetina201434231332023842100
   PubMed Web of Science ®Google Scholar
• RohrerBGuoYKunchithapauthamKGilkesonGSEliminating complement factor D reduces photoreceptor susceptibility to light-induced damageInvest Ophthalmol Vis Sci200748115282528917962484
   PubMed Web of Science ®Google Scholar
• WilliamsDFMAHALO Phase II study: Safety, tolerability and activity of lampalizumab (anti-factor D) in patients with geographic atrophyPaper presented at: American Society of Retinal SpecialistsAugust 27, 2013Toronto, Ontario, Canada
   Google Scholar
• PatelHREichenbaumDGeographic atrophy: clinical impact and emerging treatmentsOphthalmic Surg Lasers Imaging Retina201546181325559503
   PubMed Web of Science ®Google Scholar
• YehoshuaZde Amorim Garcia FilhoCANunesRPSystemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE studyOphthalmology2014121369370124289920
   PubMed Web of Science ®Google Scholar
• WongWTDresnerSForooghianFTreatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trialInvest Ophthalmol Vis Sci20135442941295023548622
   PubMed Web of Science ®Google Scholar
• ZhouHZhaoXJohnsonEJSerum carotenoids and risk of age-related macular degeneration in a Chinese population sampleInvest Ophthalmol Vis Sci20115274338434421508112
   PubMed Web of Science ®Google Scholar
• PetrouPACunninghamDShimelKIntravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trialInvest Ophthalmol Vis Sci201556133033825525171
   PubMed Web of Science ®Google Scholar
• RaduRAMataNLNusinowitzSLiuXSievingPATravisGHTreatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt’s macular degenerationProc Natl Acad Sci U S A200310084742474712671074
   PubMed Web of Science ®Google Scholar
• MataNLLichterJBVogelRHanYBuiTVSingermanLJInvestigation of oral fenretinide for treatment of geographic atrophy in age-related macular degenerationRetina201333349850723023528
   PubMed Web of Science ®Google Scholar
• ZhouJJangYPKimSRSparrowJRComplement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epitheliumProc Natl Acad Sci U S A200610344161821618717060630
   PubMed Web of Science ®Google Scholar
• RaduRAHanYBuiTVReductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseasesInvest Ophthalmol Vis Sci200546124393440116303925
   PubMed Web of Science ®Google Scholar
• KubotaRAl-FayoumiSMallikaarjunSPatilSBavikCChandlerJWPhase 1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in healthy volunteersRetina201434360360924056528
   PubMed Web of Science ®Google Scholar
• KubotaRBomanNLDavidRMallikaarjunSPatilSBirchDSafety and effect on rod function of ACU-4429, a novel small-molecule visual cycle modulatorRetina201232118318821519291
   PubMed Web of Science ®Google Scholar
• TanitoMLiFElliottMHDittmarMAndersonREProtective effect of TEMPOL derivatives against light-induced retinal damage in ratsInvest Ophthalmol Vis Sci20074841900190517389526
   PubMed Web of Science ®Google Scholar
• WongWTKamWCunninghamDTreatment of geographic atrophy by the topical administration of OT-551: results of a phase II clinical trialInvest Ophthalmol Vis Sci201051126131613920574018
   PubMed Web of Science ®Google Scholar
• ChewEYClemonsTEAgrónELong-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35Ophthalmology2013120816041611.e160423582353
   PubMed Web of Science ®Google Scholar
• JohnsonLVLeitnerWPRivestAJStaplesMKRadekeMJAndersonDHThe Alzheimer’s A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degenerationProc Natl Acad Sci U S A20029918118301183512189211
   PubMed Web of Science ®Google Scholar
• DingJDJohnsonLVHerrmannRAnti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degenerationProc Natl Acad Sci U S A201110828E279E28721690377
   PubMed Web of Science ®Google Scholar
• DamicoFMGasparinFScolariMRPedralLSTakahashiBSNew approaches and potential treatments for dry age-related macular degenerationArq Bras Oftalmol2012751717622552424
   PubMed Web of Science ®Google Scholar
• LaiRKChunTHassonDLeeSMehrbodFWheelerLAlpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the ratVis Neurosci200219217518512385629
   PubMed Web of Science ®Google Scholar
• TattonWChenDChalmers-RedmanRWheelerLNixonRTattonNHypothesis for a common basis for neuroprotection in glaucoma and Alzheimer’s disease: anti-apoptosis by alpha-2-adrenergic receptor activationSurv Ophthalmol200348Suppl 1S25S3712852432
   PubMed Web of Science ®Google Scholar
• AllerganSafety and efficacy of brimonidine intravitreal implant in patients with geographic atrophy due to age-related macular degeneration (AMD) [updated: March 13, 2013]. Available from: https://clini-caltrials.gov/ct2/show/results/NCT00658619?sect=X870156&term=NCT00658619&rank=1#outcome2. NLM identifier: NCT00658619Accessed October 8, 2015
   Google Scholar
• LaVailMMYasumuraDMatthesMTProtection of mouse photoreceptors by survival factors in retinal degenerationsInvest Ophthalmol Vis Sci19983935926029501871
   PubMed Web of Science ®Google Scholar
• TaoWWenRGoddardMBEncapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosaInvest Ophthalmol Vis Sci200243103292329812356837
   PubMed Web of Science ®Google Scholar
• SievingPACarusoRCTaoWCiliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implantsProc Natl Acad Sci U S A2006103103896390116505355
   PubMed Web of Science ®Google Scholar
• ZhangKHopkinsJHeierJSCiliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degenerationProc Natl Acad Sci U S A2011108156241624521444807
   PubMed Web of Science ®Google Scholar
• MuYZhaoMSuGStem cell-based therapies for age-related macular degeneration: current status and prospectsInt J Clin Exp Med20147113843385225550892
   PubMed Web of Science ®Google Scholar
• LundRDWangSKlimanskayaIHuman embryonic stem cell-derived cells rescue visual function in dystrophic RCS ratsCloning Stem Cells20068318919917009895
   PubMedGoogle Scholar
• SchwartzSDHubschmanJPHeilwellGEmbryonic stem cell trials for macular degeneration: a preliminary reportLancet2012379981771372022281388
   PubMed Web of Science ®Google Scholar
• SchwartzSDRegilloCDLamBLHuman embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt’s macular dystrophy: follow-up of two open-label phase 1/2 studiesLancet2015385996750951625458728
   PubMed Web of Science ®Google Scholar