Optimal management of chronic osteomyelitis: current perspectives

References

• Mouzopoulos G, Kanakaris NK, Kontakis G, Obakponovwe O, Townsend R, Giannoudis PV. Management of bone infections in adults: the surgeon’s and microbiologist’s perspectives. Injury. 2011;42 Suppl 5: S18–S23.
   Google Scholar
• Masini BD, Waterman SM, Wenke JC, Owens BD, Hsu JR, Ficke JR. Resource utilization and disability outcome assessment of combat casualties from Operation Iraqi Freedom and Operation Enduring Freedom. J Orthop Trauma. 2009;23:261–266.
   PubMed Web of Science ®Google Scholar
• Kurtz SM, Lau E, Schmier J, Ong KL, Zhao K, Parvizi J. Infection burden for hip and knee arthroplasty in the United States. J Arthroplasty. 2008;23:984–991.
   PubMed Web of Science ®Google Scholar
• Schenker ML, Yannascoli S, Baldwin KD, Ahn J, Mehta S. Does timing of operative debridement affect infectious complications in open long fractures? A systematic review. J Bone Joint Surg Am. 2012;94:1057–1064.
   PubMedGoogle Scholar
• Lentino JR. Prosthetic joint infections: bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis. 2003;36:1157–1161.
   PubMed Web of Science ®Google Scholar
• Tice AD, Hoaglund PA, Shoultz DA. Risk factors and treatment outcomes in osteomyelitis. J Antimicrob Chemother. 2003;51:1261–1268.
   PubMed Web of Science ®Google Scholar
• Conterno LO, Turchi MD. Antibiotics for treating chronic osteomyelitis in adults. Cochrane Database Syst Rev. 2013;9:CD004439.
   Web of Science ®Google Scholar
• Gristina AG, Oga M, Webb LX, Hobgood CD. Adherent bacterial colonization in the pathogenesis of osteomyelitis. Science. 1985;228:990–993.
   PubMed Web of Science ®Google Scholar
• Ciampolini J, Harding KG. Pathophysiology of chronic bacterial osteomyelitis. Why do antibiotics fail so often? Postgrad Med J. 2000;76:479–483.
   PubMed Web of Science ®Google Scholar
• Aparna MS, Yadav S. Biofilms: microbes and disease. Braz J Infect Dis. 2008;12:526–530.
   PubMed Web of Science ®Google Scholar
• Zimmerli W, Moser C. Pathogenesis and treatment concepts of orthopaedic biofilm infections. FEMS Immunol Med Microbiol. 2012;65:158–168.
   PubMed Web of Science ®Google Scholar
• Cedric J, Jocelyne C. Impact of bacterial biofilm on the treatment of prosthetic joint infections. J Antimicrob Chemother. 2014;69 Suppl 1: i37–i40.
   Google Scholar
• Lew DP, Waldvogel FA. Osteomyelitis. Lancet. 2004;364:369–379.
   PubMed Web of Science ®Google Scholar
• Lazzarini L, Lipsky BA, Mader JT. Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials? Int J Infect Dis. 2005;9:127–138.
   PubMed Web of Science ®Google Scholar
• Calhoun JH, Manring MM. Adult osteomyelitis. Infect Dis Clin North Am. 2005;19:765–786.
   PubMed Web of Science ®Google Scholar
• Jorge LS, Chueire AG, Baptista AR: Osteomyelitis: a current challenge. Braz J Infect Dis. 2010;14:310–315.
   PubMed Web of Science ®Google Scholar
• Sheehy SH, Atkins BA, Bejon P, et al. The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical antimicrobial regimens. J Infect. 2010;60:338–343.
   PubMed Web of Science ®Google Scholar
• American Society of Plastic Surgeons. Evidence based clinical practice guideline: chronic wounds of the lower extremity. 2007. Available from: http://www.plasticsurgery.org/Documents/medical-professionals/health-policy/evidence-practice/Evidence-based-Clinical-Practice-Guideline-Chronic-Wounds-of-the-Lower-Extremity.pdf. Accessed April 22, 2015.
   Google Scholar
• Waldvogel FA, Medoff G, Swartz MN. Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. N Engl J Med. 1970;282:198–206.
   PubMed Web of Science ®Google Scholar
• Cierny G 3rd, Mader JT, Pennick JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res. 2003;414:7–24.
   Web of Science ®Google Scholar
• Cierny G 3rd. Chronic osteomyelitis: results of treatment. Instr Course Lect. 1990;39:495–508.
   PubMedGoogle Scholar
• Bowen TR, Widmaier JC. Host classification predicts infection after open fracture. Clin Orthop Relat Res. 2005;433:205–211.
   Google Scholar
• Pineda C, Espinosa R, Pena A. Radiographic imaging in osteomyelitis: the role of plain radiography, computed tomography, ultrasonography, magnetic resonance imaging and scintigraphy. Semin Plast Surg. 2009;23:80–89.
   PubMedGoogle Scholar
• Santiago Restrepo C, Giménez CR, McCarthy K. Imaging of osteomyelitis and musculoskeletal soft tissue infections: current concepts. Rheum Dis Clin North Am. 2003;29:89–109.
   Web of Science ®Google Scholar
• Termaat MF, Raijmakers PG, Scholtein HJ, Bakker FC, Patka P, Haarman HJ. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. J Bone Joint Surg Am. 2005;87:2464–2471.
   PubMed Web of Science ®Google Scholar
• Lazzarini L, Mader JT, Calhoun JH. Osteomyelitis in long bones. J Bone Joint Surg Am. 2004;86-A:2305–2318.
   Web of Science ®Google Scholar
• Forsberg JA, Potter BK, Cierny G 3rd, Webb L. Diagnosis and management of chronic infection. J Am Acad Orthop Surg. 2011;19 Suppl 1: S8–S19.
   Google Scholar
• Perry CR, Pearson RL, Miller GA. Accuracy of cultures of material from swabbing of the superficial aspect of the wound and needle biopsy in the preoperative assessment of osteomyelitis. J Bone Joint Surg Am. 1991;73:745–749.
   Google Scholar
• Cierny G 3rd. Surgical treatment of osteomyelitis. Plast Reconstr Surg. 2011;127 Suppl 1:190S–204S.
   Google Scholar
• Salvana J, Rodner C, Browner BD, Livingston K, Schreiber J, Pesanti E. Chronic osteomyelitis: results obtained by an integrated team approach to management. Conn Med. 2005;69:195–202.
   PubMedGoogle Scholar
• Mader JT, Cantrell JS, Calhoun J. Oral ciprofloxacin therapy compared with standard parenteral antibiotic therapy for chronic osteomyelitis in adults. J Bone Joint Surg Am. 1990;72:104–110.
   PubMed Web of Science ®Google Scholar
• Fraimow HS. Systemic antimicrobial therapy in osteomyelitis. Semin Plast Surg. 2009;23:90–99.
   PubMedGoogle Scholar
• Mackintosh CL, White HA, Seaton RA. Outpatient parenteral antibiotic therapy (OPAT) for bone and joint infections: experience from a UK teaching hospital-based service. J Antimicrob Chemother. 2011;66:408–415.
   Web of Science ®Google Scholar
• Tice AD, Hoaglund PA, Shoultz DA. Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy. Am J Med. 2003;114:723–728.
   PubMed Web of Science ®Google Scholar
• Lai A, Tran T, Nguyen HM, Fleischmann J, Beenhouwer DO, Graber CJ. Outpatient parenteral antimicrobial therapy at large veterans administration medical center. Am J Manag Care. 2013;19:e317–e324.
   PubMed Web of Science ®Google Scholar
• Haidar R, Boghossain AD, Atiyeh B. Duration of post-surgical antibiotics in chronic osteomyelitis: empiric or evidence-based? Int J Infect Dis. 2010;14:e752–e758.
   PubMed Web of Science ®Google Scholar
• Spellberg B, Lipsky BA. Systemic antibiotic therapy for chronic osteomyelitis in adults. Clin Infect Dis. 2012;54:393–407.
   PubMed Web of Science ®Google Scholar
• Hatzenbuehler J, Pulling TJ. Diagnosis and management of osteomyelitis. Am Fam Physician. 2011;84:1027–1033.
   PubMed Web of Science ®Google Scholar
• Sendi P, Zimmerli W. Antimicrobial treatment concepts for orthopaedic device-related infection. Clin Microbiol Infect. 2012;18:1176–1184.
   PubMed Web of Science ®Google Scholar
• Tafer N, Belaieff W, Cuerel C, Zingg M, Hoffmeyer P, Uckay I. Optimal diagnosis, prevention, and management of periprosthetic joint infection. Orthop Res Rev. 2015;7:11–19.
   Google Scholar
• Buchholz HW, Engelbrecht H. [Depot effects of various antibiotics mixed with Palacos resins]. Chirurg. 1970;41:511–515. German.
   PubMed Web of Science ®Google Scholar
• Klemm K. [Gentamicin-PMMA-beads in treating bone and soft tissue infections (author’s transl)]. Zentralbl Chir. 1979;104:934–942. German.
   PubMed Web of Science ®Google Scholar
• Hoff SF, Fitzgerald RH Jr, Kelly PJ. The depot administration of penicillin G and gentamicin in acrylic bone cement. J Bone Joint Surg Am. 1981;63:798–804.
   PubMed Web of Science ®Google Scholar
• Kluin OS, van der Mei HC, Busscher HJ, Neut D. Biodegradable vs non-biodegradable antibiotic delivery devices in the treatment of osteomyelitis. Expert Opin Drug Deliv. 2013;10:341–351.
   PubMed Web of Science ®Google Scholar
• Klemm K. The use of antibiotic-containing bead chains in the treatment of chronic bone infections. Clin Microbiol Infect. 2001;7:28–31.
   PubMed Web of Science ®Google Scholar
• Chang W, Colangeli M, Colangeli S, Di Bella C, Gozzi E, Donati D. Adult osteomyelitis: debridement versus debridement plus Osteoset T pellets. Acta Orthop Belg. 2007;73:238–243.
   PubMed Web of Science ®Google Scholar
• Ikpeme IA, Oku EO, Ngim NE, Ilori IU, Abang IE. Comparison of the outcome of treatment of chronic osteomyelitis by surgical debridement with and without local antibiotic delivery system: experience from a Nigerian Teaching Hospital. Int J Clin Med. 2013;4:313–318.
   Google Scholar
• Masquelet AC, Begue T. The concept of induced membrane for reconstruction of long bone defects. Orthop Clin N Am. 2010;41:27–37.
   PubMed Web of Science ®Google Scholar
• Marais LC, Ferreira N. Bone transport through an induced membrane in the management of tibial bone defects resulting from chronic osteomyelitis. Strategies Trauma Limb Reconstr. 2015;10:27–33.
   PubMedGoogle Scholar
• McLaren AC. Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections. Clin Orthop Relat Res. 2004;427:101–106.
   PubMed Web of Science ®Google Scholar
• Gitelis S, Brebach GT. The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg (Hong Kong). 2002;10:53–60.
   PubMedGoogle Scholar
• McKee MD, Li-Band EA, Wild LM, Schemitsch EH. A prospective randomized clinical trial comparing on antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma. 2010;24:483–490.
   PubMed Web of Science ®Google Scholar
• Ferguson JY, Dudareva M, Riley ND, Stubbs D, Atkins BL, McNally MA. The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis: a series of 195 cases. Bone Joint J. 2014;96-B:829–836.
   Web of Science ®Google Scholar
• Tetsworth K, Cierny G 3rd. Osteomyelitis debridement techniques. Clin Orthop Relat Res. 1999;360:87–96.
   Google Scholar
• Sanders J, Mauffrey C. Long bone osteomyelitis in adults: fundamental concepts and current techniques. Orthopedics. 2013;36:368–375.
   PubMed Web of Science ®Google Scholar
• Simpson AH, Deakin M, Lathan JM. Chronic osteomyelitis. The effect of the extent of surgical resection on infection-free survival. J Bone Joint Surg Br. 2001;83:403–407.
   PubMedGoogle Scholar
• Trampuz A, Widmer AF. Infections associated with orthopedic implants. Curr Opin Infect Dis. 2006;19:349–356.
   PubMed Web of Science ®Google Scholar
• Verhelle N, Van Zele D, Liboutton L, Heymans O. How to deal with bone exposure and osteomyelitis: an overview. Acta Orthop Belg. 2003;69:481–494.
   PubMedGoogle Scholar
• Tan Y, Wang X, Li H, et al. The clinical efficacy of the vacuum-assisted closure therapy in the management of adult osteomyelitis. Arch Orthop Trauma Surg. 2011;131:255–259.
   Web of Science ®Google Scholar
• Gogia JS, Meehan JP, Di Cesare PE, Jamali AA. Local antibiotic therapy in osteomyelitis. Semin Plast Surg. 2009;23:100–107.
   PubMedGoogle Scholar
• Doi K, Kawakami F, Hiura Y, Oda T, Sakai K, Kawai S. One-stage treatment of infected bone defects of the tibia with skin loss by free vascularized osteocutaneous grafts. Microsurgery. 1995;16:704–712.
   Web of Science ®Google Scholar
• Rhomberg M, Frischhut B, Ninkovic M, Schwabegger AH. A single-stage operation in the treatment of chronic osteomyelitis of the lower extremity including reconstruction with free vascularized iliac bone graft and free-tissue transfer. Plast Reconstr Surg. 2003;111:2353–2361.
   Web of Science ®Google Scholar
• Dinh P, Hutchinson BK, Zalavaras C, Stevanovic MV. Reconstruction of osteomyelitis defects. Semin Plast Surg. 2009;23:108–118.
   PubMedGoogle Scholar
• Paley D, Herzenberg JE. Intramedullary infections treated with antibiotic cement rods: preliminary results in nine cases. J Orthop Trauma. 2002;16:723–729.
   Web of Science ®Google Scholar
• Marsh DR, Shah S, Elliott J, Kurdy N. The Ilizarov method in nonunion, malunion and infection of fractures. J Bone Joint Surg Br. 1997;79:273–279.
   PubMedGoogle Scholar
• Han CS, Wood MB, Bishop AT, Cooney WP 3rd. Vascularized bone transfer. J Bone Joint Surg Am. 1992;74:1441–9.
   Google Scholar
• Yajima H, Kobata Shigemetsu K, et al. Vascularized fibular grafting in the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis and infected nonunion. J Reconstr Microsurg. 2004;20:13–20.
   Web of Science ®Google Scholar
• Lê Thua TH, Pham DN, Boeckx W, De Mey A. Vascularized fibular transfer in longstanding and infected large bone defects. Acta Orthop Belg. 2014;80:50–55.
   PubMed Web of Science ®Google Scholar
• Papineau LJ, Allfageme A, Dalcourt JP, Pilon L. [Chronic osteomyelitis: open excision and grafting after saucerization (author’s transl)]. Int Orthop. 1979;3:165–176. French.
   PubMed Web of Science ®Google Scholar
• McNally MA, Small JO, Tofighi HG, Mollan RA. Two-stage management of chronic osteomyelitis of the long bones. The Belfast technique. J Bone Joint Surg Br. 1993;75:375–380.
   Google Scholar
• Hashmi MA, Norman P, Saleh M. The management of chronic osteomyelitis using the Lautenbach method. J Bone Joint Surg Br. 2004;86:269–275.
   PubMedGoogle Scholar
• Gokalp MA, Guner S, Ceylan MF, Doğan A, Sebik A. Results of treatment of chronic osteomyelitis by “gutter procedure and muscle flap transposition operation”. Eur J Orthop Surg Traumatol. 2014;24:415–419.
   Google Scholar
• Gill AL, Bell CN. Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM. 2004;97:385–395.
   PubMed Web of Science ®Google Scholar
• Kawashima M, Tamura H, Nagayoshi I, Takao K, Yoshida K, Yamaguchi T. Hyperbaric oxygen therapy in orthopedic conditions. Undersea Hyperb Med. 2004;31:155–162.
   Google Scholar
• Chen CY, Lin KP, Lu SH, Chen YJ, Lin CF. Adjuvant hyperbaric oxygen therapy in the treatment of hemodialysis patients with chronic osteomyelitis. Ren Fail. 2008;30:233–237.
   Web of Science ®Google Scholar
• Chen CE, Shih ST, Fu TH, Wang JW, Wang CJ. Hyperbaric oxygen therapy in the treatment of chronic refractory osteomyelitis: a preliminary report. Chang Gung Med J. 2003;26:114–121.
   Google Scholar
• Skeik N, Porten BR, Isaacson E, et al. Hyperbaric oxygen treatment outcome for different indications from a single center. Ann Vasc Surg. 2015;29:206–214.
   Web of Science ®Google Scholar
• Fang RC, Galiano RD. Adjunctive therapies in the treatment of osteomyelitis. Semin Plast Surg. 2009;23:141–147.
   PubMedGoogle Scholar
• Costerton JW. Biofilm theory can guide the treatment of device-related orthopaedic infections. Clin Orthop Relat Res. 2005;437:7–11.
   PubMed Web of Science ®Google Scholar
• Kazemzadeh-Narbat M, Kindrachuk J, Duan K, Jenssen H, Hancock RE, Wang R. Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections. Biomaterials. 2010;31:9519–9526.
   PubMed Web of Science ®Google Scholar
• Simchi A, Tamjid E, Pishbin F, Boccaccini AR. Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications. Nanomedicine. 2011;7:22–39.
   PubMed Web of Science ®Google Scholar
• Khoo X, O’Toole GA, Nair SA, Snyder BD, Kenan DJ, Grinstaff MW. Staphylococcus aureus resistance on titanium coated with multivalent PEGylated-peptides. Biomaterials. 2010;31:9285–9292.
   PubMed Web of Science ®Google Scholar
• Harro JM, Peters BM, O’May GA, et al. Vaccine development on Staphylococcus aureus: taking the biofilm phenotype into consideration. FEMS Immunol Med Microbiol. 2010;59:306–323.
   PubMed Web of Science ®Google Scholar
• Lattar SM, Noto Llana M, Denoël P, et al. Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis. Infect Immun. 2014;82:83–91.
   PubMed Web of Science ®Google Scholar
• Drago L, Romanò D, De Vecchi E, et al. Bioactive glass BAG-S53P4 for the adjunctive treatment of chronic osteomyelitis of the long bones: an in vitro and prospective clinical study. BMC Infect Dis. 2013;13:584.
   PubMed Web of Science ®Google Scholar
• Romanò CL, Logoluso N, Meani E, et al. A comparative study of the use of bioactive glass S53P4 and antibiotic-loaded calcium-based bone substitutes in the treatment of chronic osteomyelitis: a retrospective comparative study. Bone Joint J. 2014;96-B:845–850.
   Web of Science ®Google Scholar