Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation

References

• Williams DL, Isaacson BM. The 5 Hallmarks of Biomaterials Success: An Emphasis on Orthopaedics. Adv Biosci Biotechnol. 2014;5:283–293.
   Google Scholar
• Branemark PI. Vital microscopy of bone marrow in rabbit. Scand J Clin Lab Invest. 1959;11 Supp 38:S1–S82.
   Google Scholar
• Braånemark PI, Hansson BO, Adell R, et al. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl. 1977;16:1–132.
   Google Scholar
• Albrektsson T, Albrektsson B. Osseointegration of bone implants. A review of an alternative mode of fixation. Acta Orthop Scand. 1987;58(5):567–577.
   PubMed Web of Science ®Google Scholar
• Bloebaum RD, Bachus KN, Momberger NG, Hofmann AA. Mineral apposition rates of human cancellous bone at the interface of porous coated implants. J Biomed Mater Res. 1994;28(5):537–544.
   PubMed Web of Science ®Google Scholar
• Brånemark PI, Gröndahl K, Worthington P. Osseointegration and Autogenous Onlay Bone Grafts: Reconstruction of the Edentulous Atrophic Maxilla. Hanover Park, IL: Quintessence Publishing Co, Inc.; 2001.
   Google Scholar
• Brånemark PI, de Oliveira MF, editors. Craniofacial Prostheses: Anaplastology and Osseointegration. Hanover Park, IL: Quintessence Publishing Co, Inc.; 1997.
   Google Scholar
• Brånemark P-I, Rydevik BL, Skalak R, editors. Osseointegration in Skeletal Reconstruction and Joint Replacement: Proceedings of the Second International Workshop on Osseointegration in Skeletal Reconstruction and Joint Replacement, Rancho Santa Fe, CA, October 27–29, 1994. Hanover Park, IL: Quintessence Publishing Co, Inc.; 1997.
   Google Scholar
• Brånemark PI, Tolman DE, editors. Osseointegration in Craniofacial Reconstruction. Hanover Park, IL: Quintessence Publishing Co, Inc.; 1998.
   Google Scholar
• Brånemark P-I, Chien S, Grondahl H-G, Robinson K, editors. The Osseointegration book: from Calvarium to Calcaneus. Hanover Park, IL: Quintessence Publishing Co, Inc.; 2005.
   Google Scholar
• Worthington P, Brånemark PI. Advanced Osseointegration Surgery: Applications in the Maxillofacial Region. Hanover Park, IL: Quintessence Publishing Co, Inc.; 1992.
   Google Scholar
• Ellingsen JE, Lyngstadaas SP. Bio-Implant Interface: Improving Biomaterials and Tissue Reactions. Boca Raton, FL, London: CRC Press, Inc.; 2003.
   Google Scholar
• Jokstad A, editor. Osseointegration and Dental Implants. Hoboken, NJ: Wiley-Blackwell; 2009.
   Google Scholar
• Zarb GA, Albrektsson T, Baker G, Eckert SE, Stanford C, Tarnow DP, et al, editors. Osseointegration: On Continuing Synergies in Surgery, Prosthodontics, and Biomaterials. Hanover Park, IL: Quintessence Publishing Co, Inc.; 2008.
   Google Scholar
• Granström G. Craniofacial osseointegration. Oral Dis. 2007;13(3):261–269.
   Web of Science ®Google Scholar
• Gumieiro EH, Dib LL, Jahn RS, et al. Bone-anchored titanium implants for auricular rehabilitation: case report and review of literature. Sao Paulo Med J. 2009;127(3):160–165.
   Web of Science ®Google Scholar
• Goodman SB, Gómez Barrena E, Takagi M, Konttinen YT. Biocompatibility of total joint replacements: A review. J Biomed Mater Res A. 2009;90(2):603–618.
   PubMedGoogle Scholar
• Heath JC, Freeman MA, Swanson SA. Carcinogenic properties of wear particles from prostheses made in cobalt-chromium alloy. Lancet. 1971;1(7699):564–566.
   PubMed Web of Science ®Google Scholar
• Rae T. The haemolytic action of particulate metals (Cd, Cr, Co, Fe, Mo, Ni, Ta, Ti, Zn, Co-Cr alloy). J Pathol. 1978;125(2):81–89.
   Web of Science ®Google Scholar
• Rae T. The toxicity of metals used in orthopaedic prostheses. An experimental study using cultured human synovial fibroblasts. J Bone Joint Surg Br. 1981;63-B(3):435–440.
   Google Scholar
• Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52(2):155–170.
   PubMed Web of Science ®Google Scholar
• Rae T. Comparative laboratory studies on the production of soluble and particulate metal by total joint prostheses. Arch Orthop Trauma Surg. 1979;95(1–2):71–79.
   Web of Science ®Google Scholar
• Depprich R, Zipprich H, Ommerborn M, et al. Osseointegration of zirconia implants compared with titanium: an in vivo study. Head Face Med. 2008;4:30.
   Google Scholar
• Thomsen P, Larsson C, Ericson LE, Sennerby L, Lausmaa J, Kasemo B. Structure of the interface between rabbit cortical bone and implants of gold, zirconium and titanium. J Mater Sci Mater Med. 1997;8(11):653–665.
   Web of Science ®Google Scholar
• Agins HJ, Alcock NW, Bansal M, et al. Metallic wear in failed titanium-alloy total hip replacements. A histological and quantitative analysis. J Bone Joint Surg Am. 1988;70(3):347–356.
   PubMed Web of Science ®Google Scholar
• Tummler HP, Thull R, Schaldach M. The mechanism of repassivation and the concentration of corrosion products shown on TIALV. Proceedings of the World Congress on Medical Physics and Biomedical Engineering, 13th International Conference on Medical and Biological Engineering, and 6th International Conference on Medical Physics; September 5–11, 1982; Hamburg, Germany.
   Google Scholar
• Aaron RK, Herr HM, Ciombor DM, et al. Horizons in prosthesis development for the restoration of limb function. J Am Acad Orthop Surg. 2006;14(10 Spec No):S198–S204.
   Google Scholar
• Palmquist A, Omar OM, Esposito M, Lausmaa J, Thomsen P. Titanium oral implants: surface characteristics, interface biology and clinical outcome. J R Soc Interface. 2010;7 Suppl 5:S515–S527.
   Google Scholar
• Kieswetter K, Schwartz Z, Dean DD, Boyan BD. The role of implant surface characteristics in the healing of bone. Crit Rev Oral Biol Med. 1996;7(4):329–345.
   PubMedGoogle Scholar
• Meyer AE, Baier RE, Natiella JR, Meenaghan MA. Investigation of tissue/implant interactions during the first two hours of implantation. J Oral Implantol. 1988;14(3):363–379.
   Google Scholar
• Novaes AB, de Souza SL, de Barros RR, Pereira KK, Iezzi G, Piattelli A. Influence of implant surfaces on osseointegration. Braz Dent J. 2010;21(6):471–481.
   Google Scholar
• Bobyn JD, Pilliar RM, Cameron HU, Weatherly GC. The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone. Clin Orthop Relat Res. 1980;(150):263–270.
   Web of Science ®Google Scholar
• Boyan BD, Lohmann CH, Dean DD, Sylvia VL, Cochran DL, Schwartz Z. Mechanisms involved in osteoblast response to implant surface morphology. Annu Rev Mater Res. 2001;31:357–371.
   Web of Science ®Google Scholar
• Balshe AA, Assad DA, Eckert SE, Koka S, Weaver AL. A retrospective study of the survival of smooth- and rough-surface dental implants. Int J Oral Maxillofac Implants. 2009;24(6):1113–1118.
   Web of Science ®Google Scholar
• Pak HS, Yeo IS, Yang JH. A histomorphometric study of dental implants with different surface characteristics. J Adv Prosthodont. 2010;2(4):142–147.
   Web of Science ®Google Scholar
• Ritman EL, Bolander ME, Fitzpatrick LA, Turner RT. Micro-CT imaging of structure-to-function relationship of bone microstructure and associated vascular involvement. Technol Health Care. 1998; 6(5–6):403–412.
   Google Scholar
• Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrol. 2008;3 Suppl 3:S131–S139.
   Google Scholar
• Sela J, Gross UM, Kohavi D, et al. Primary mineralization at the surfaces of implants. Crit Rev Oral Biol Med. 2000;11(4):423–436.
   Google Scholar
• Behari J. Elements of bone biophysics. In: Behari J. Biophysical Bone Behaviour: Principles and Applications. Chichester: John Wiley & Sons, Ltd; 2009:1–52.
   Google Scholar
• Ross FP, Christiano AM. Nothing but skin and bone. J Clin Invest. 2006;116(5):1140–1149.
   Web of Science ®Google Scholar
• Wolff J. Das Gesetz der Transformation der Knochen, Hirschwald [The Law of Bone Remodeling]. Berlin: Springer-Verlag; 1892. German.
   Google Scholar
• Skedros JG, Baucom SL. Mathematical analysis of trabecular ‘trajectories’ in apparent trajectorial structures: the unfortunate historical emphasis on the human proximal femur. J Theor Biol. 2007;244(1):15–45.
   Web of Science ®Google Scholar
• Frost HM. Mechanical determinants of bone modeling. Metab Bone Dis Rel Res. 1982;4(4):217–229.
   Google Scholar
• Currey JD. The mechanical properties of bone. Clin Orthop Relat Res. 1970;(73):210–231.
   Web of Science ®Google Scholar
• Isaacson BM, Bloebaum RD. Bone bioelectricity: what have we learned in the past 160 years? J Biomed Mater Res A. 2010;95(4):1270–1279.
   PubMedGoogle Scholar
• Buckwalter JA, Glimcher MJ, Cooper RR, Recker R. Bone biology. J Bone Joint Surg. 1995;77:1276–1289.
   Google Scholar
• Dimitriou R, Babis GC. Biomaterial osseointegration enhancement with biophysical stimulation. J Musculoskelet Neuronal Interact. 2007;7(3):253–265.
   Google Scholar
• Currey JD. Mechanical properties of bone tissues with greatly differing functions. J Biomech. 1979;12(4):313–319.
   Web of Science ®Google Scholar
• Currey JD. Effects of differences in mineralization on the mechanical properties of bone. Philos Trans R Soc Lond B Biol Sci. 1984;304(1121):509–518.
   PubMed Web of Science ®Google Scholar
• Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg Br. 1960;42-B:28–30.
   Google Scholar
• Parfitt AM. Misconceptions (2): turnover is always higher in cancellous than in cortical bone. Bone. 2002;30(6):807–809.
   Web of Science ®Google Scholar
• Bloebaum RD, Bachus KN, Jensen JW, Hofmann AA. Postmortem analysis of consecutively retrieved asymmetric porous-coated tibial components. J Arthroplasty. 1997;12(8):920–929.
   Web of Science ®Google Scholar
• Eriksson AR, Albrektsson T. Temperature threshold levels for heat-induced bone tissue injury: a vital-microscopic study in the rabbit. J Prosthet Dent. 1983;50(1):101–107.
   PubMed Web of Science ®Google Scholar
• Rafel SS. Temperature changes during high-speed drilling on bone. J Oral Surg Anesth Hosp Dent Serv. 1962;20:475–477.
   Google Scholar
• Ling RS. Observations on the fixation of implants to the bony skeleton. Clin Orthop Relat Res. 1986;(210):80–96.
   Web of Science ®Google Scholar
• Abrahamsson I, Linder E, Lang NP. Implant stability in relation to osseointegration: an experimental study in the Labrador dog. Clin Oral Implants Res. 2009;20(3):313–318.
   Web of Science ®Google Scholar
• Collier JP, Mayor MB, Chae JC, Surprenant VA, Surprenant HP, Dauphinais LA. Macroscopic and microscopic evidence of prosthetic fixation with porous-coated materials. Clin Orthop Relat Res. 1988;(235):173–180.
   Web of Science ®Google Scholar
• Bobyn JD, Cameron HU, Abdulla D, Pilliar RM, Weatherly GC. Biologic fixation and bone modeling with an unconstrained canine total knee prosthesis. Clin Orthop Relat Res. 1982;(166):301–312.
   Web of Science ®Google Scholar
• Pilliar RM, Lee JM, Maniatopoulos C. Observations on the effect of movement on bone ingrowth into porous-surfaced implants. Clin Orthop Relat Res. 1986;(208):108–113.
   PubMed Web of Science ®Google Scholar
• Søballe K, Hansen ES, Brockstedt-Rasmussen H, Bünger C. Hydroxyapatite coating converts fibrous tissue to bone around loaded implants. J Bone Joint Surg Br. 1993;75(2):270–278.
   PubMedGoogle Scholar
• Cantoni T, Giovanni P. Implant treatment planning in fresh extraction sockets: use of a novel radiographic guide and CAD/CAM technology. Quintessence Int. 2009;40(9):773–781.
   Web of Science ®Google Scholar
• Valente F, Schiroli G, Sbrenna A. Accuracy of computer-aided oral implant surgery: a clinical and radiographic study. Int J Oral Maxillofac Implants. 2009;24(2):234–242.
   PubMed Web of Science ®Google Scholar
• Jeyapalina S, Beck JP, Bachus KN, Bloebaum RD. Cortical bone response to the presence of load-bearing percutaneous osseointegrated prostheses. Anat Rec (Hoboken). 2012;295(9):1437–1445.
   Google Scholar
• Bloebaum RD, Willie BM, Mitchell BS, Hofmann AA. Relationship between bone ingrowth, mineral apposition rate, and osteoblast activity. J Biomed Mater Res A. 2007;81(2):505–514.
   Google Scholar
• Irish J, Virdi AS, Sena K, McNulty MA, Sumner DR. Implant placement increases bone remodeling transiently in a rat model. J Orthop Res. 2013;31(5):800–806.
   Web of Science ®Google Scholar
• Frost HM. Perspectives on artificial joint design. J Long Term Eff Med Implants. 1992;2(1):9–35.
   Web of Science ®Google Scholar
• Frost HM. The Utah paradigm of skeletal physiology: an overview of its insights for bone, cartilage and collagenous tissue organs. J Bone Miner Metab. 2000;18(6):305–316.
   Web of Science ®Google Scholar
• HM. A determinant of bone architecture. The minimum effective strain. Clin Orthop Relat Res. 1983(175):286–292.
   Google Scholar
• Frost HM. The regional acceleratory phenomenon: a review. Henry Ford Hosp Med J. 1983;31(1):3–9.
   PubMedGoogle Scholar
• Bourne GH, editor. The Biochemistry and Physiology of Bone. 2nd ed. New York, NY; London: Academic Press; 1972.
   Google Scholar
• Rhinelander FW. The normal circulation of bone and its response to surgical intervention. J Biomed Mater Res. 1974;8(1):87–90.
   Web of Science ®Google Scholar
• Cohen G, Campbell PM, Rossouw PE, Buschang PH. Effects of increased surgical trauma on rates of tooth movement and apical root resorption in foxhound dogs. Orthod Craniofac Res. 2010;13(3):179–190.
   Web of Science ®Google Scholar
• Meyer U, Joos U, Mythili J, et al. Ultrastructural characterization of the implant/bone interface of immediately loaded dental implants. Biomaterials. 2004;25(10):1959–1967.
   PubMed Web of Science ®Google Scholar
• Bloebaum RD, Bachus KN, Rubman MH, Dorr LD. Postmortem comparative analysis of titanium and hydroxyapatite porous-coated femoral implants retrieved from the same patient. A case study. J Arthroplasty. 1993;8(2):203–211.
   PubMedGoogle Scholar
• Hofmann AA, Bachus KN, Bloebaum RD. Comparative study of human cancellous bone remodeling to titanium and hydroxyapatite-coated implants. J Arthroplasty. 1993;8(2):157–166.
   PubMedGoogle Scholar
• Bloebaum RD, Mihalopoulus NL, Jensen JW, Dorr LD. Postmortem analysis of bone growth into porous-coated acetabular components. J Bone Joint Surg Am. 1997;79(7):1013–1022.
   PubMedGoogle Scholar
• Bloebaum RD, Bachus KN, Jensen JW, Scott DF, Hofmann AA. Porous-coated metal-backed patellar components in total knee replacement. A postmortem retrieval analysis. J Bone Joint Surg Am. 1998;80(4):518–528.
   Google Scholar
• Hagberg K, Brånemark R. Consequences of non-vascular trans-femoral amputation: a survey of quality of life, prosthetic use and problems. Prosthet Orthot Int. 2001;25(3):186–194.
   PubMed Web of Science ®Google Scholar
• Hofmann AA, Bloebaum RD, Bachus KN. Progression of human bone ingrowth into porous-coated implants. Rate of bone ingrowth in humans. Acta Orthop Scand. 1997;68(2):161–166.
   PubMed Web of Science ®Google Scholar
• Slaets E, Naert I, Carmeliet G, Duyck J. Early cortical bone healing around loaded titanium implants: a histological study in the rabbit. Clin Oral Implants Res. 2009;20(2):126–134.
   Web of Science ®Google Scholar
• Duyck J, Vandamme K, Geris L, et al. The influence of micro-motion on the tissue differentiation around immediately loaded cylindrical turned titanium implants. Arch Oral Biol. 2006;51(1):1–9.
   Web of Science ®Google Scholar
• Szmukler-Moncler S, Salama H, Reingewirtz Y, Dubruille JH. Timing of loading and effect of micromotion on bone-dental implant interface: review of experimental literature. J Biomed Mater Res. 1998;43(2):192–203.
   PubMed Web of Science ®Google Scholar
• Glauser R, Sennerby L, Meredith N, et al. Resonance frequency analysis of implants subjected to immediate or early functional occlusal loading. Successful vs failing implants. Clin Oral Implants Res. 2004;15(4):428–434.
   Web of Science ®Google Scholar
• Meredith N, Alleyne D, Cawley P. Quantitative determination of the stability of the implant-tissue interface using resonance frequency analysis. Clin Oral Implants Res. 1996;7(3):261–267.
   PubMed Web of Science ®Google Scholar
• Röser K, Johansson CB, Donath K, Albrektsson T. A new approach to demonstrate cellular activity in bone formation adjacent to implants. J Biomed Mater Res. 2000;51(2):280–291.
   Web of Science ®Google Scholar
• Nkenke E, Lehner B, Weinzierl K, et al. Bone contact, growth, and density around immediately loaded implants in the mandible of mini pigs. Clin Oral Implants Res. 2003;14(3):312–321.
   PubMed Web of Science ®Google Scholar
• Slaets E, Carmeliet G, Naert I, Duyck J. Early trabecular bone healing around titanium implants: a histologic study in rabbits. J Periodontol. 2007;78(3):510–517.
   Web of Science ®Google Scholar
• Piattelli A, Corigliano M, Scarano A, Costigliola G, Paolantonio M. Immediate loading of titanium plasma-sprayed implants: an histologic analysis in monkeys. J Periodontol. 1998;69(3):321–327.
   PubMed Web of Science ®Google Scholar
• Vandamme K, Naert I, Vander Sloten J, Puers R, Duyck J. Effect of implant surface roughness and loading on peri-implant bone formation. J Periodontol. 2008;79(1):150–157.
   Web of Science ®Google Scholar
• Peñarrocha M, Boronat A, Garcia B. Immediate loading of immediate mandibular implants with a full-arch fixed prosthesis: a preliminary study. J Oral Maxillofac Surg. 2009;67(6):1286–1293.
   Web of Science ®Google Scholar
• Hofmann AA, Evanich JD, Ferguson RP, Camargo MP. Ten- to 14-year clinical followup of the cementless Natural Knee system. Clin Orthop Relat Res. 2001;(388):85–94.
   Web of Science ®Google Scholar
• Eswaramoorthy V, Moonot P, Kalairajah Y, Biant LC, Field RE. The Metasul metal-on-metal articulation in primary total hip replacement: clinical and radiological results at ten years. J Bone Joint Surg Br. 2008;90(10):1278–1283.
   PubMedGoogle Scholar
• Rocci A, Martignoni M, Gottlow J. Immediate loading of Brånemark System TiUnite and machined-surface implants in the posterior mandible: a randomized open-ended clinical trial. Clin Implant Dent Relat Res. 2003;5 Suppl 1:S57–S63.
   Google Scholar
• Chaushu G, Chaushu S, Tzohar A, Dayan D. Immediate loading of single-tooth implants: immediate versus non-immediate implantation. A clinical report. Int J Oral Maxillofac Implants. 2001;16(2):267–272.
   PubMed Web of Science ®Google Scholar
• Ericsson I, Nilson H, Lindh T, Nilner K, Randow K. Immediate functional loading of Brånemark single tooth implants. An 18 months’ clinical pilot follow-up study. Clin Oral Implants Res. 2000;11(1):26–33.
   PubMed Web of Science ®Google Scholar
• Calandriello R, Tomatis M, Vallone R, Rangert B, Gottlow J. Immediate occlusal loading of single lower molars using Brånemark System Wide-Platform TiUnite implants: an interim report of a prospective open-ended clinical multicenter study. Clin Implant Dent Relat Res. 2003;5 Suppl 1:S74–S80.
   Google Scholar
• Calandriello R, Tomatis M, Rangert B. Immediate functional loading of Brånemark System implants with enhanced initial stability: a prospective 1- to 2-year clinical and radiographic study. Clin Implant Dent Relat Res. 2003;5 Suppl 1:S10–S20.
   Google Scholar
• Degidi M, Piattelli A. Immediate functional and non-functional loading of dental implants: a 2- to 60-month follow-up study of 646 titanium implants. J Periodontol. 2003;74(2):225–241.
   Web of Science ®Google Scholar
• Jeyapalina S, Beck JP, Bloebaum RD, Bachus KN. Progression of Bone Ingrowth and Attachment Strength for Stability of Percutaneous Osseointegrated Prostheses. Clin Orthop Relat Res. Epub 2013 Nov 21.
   Google Scholar
• Jeyapalina S, Beck JP, Bachus KN, Williams DL, Bloebaum RD. Efficacy of a porous-structured titanium subdermal barrier for preventing infection in percutaneous osseointegrated prostheses. J Orthop Res. 2012;30(8):1304–1311.
   Web of Science ®Google Scholar
• Shelton TJ, Beck JP, Bloebaum RD, Bachus KN. Percutaneous osseointegrated prostheses for amputees: Limb compensation in a 12-month ovine model. J Biomech. 2011;44(15):2601–2606.
   Web of Science ®Google Scholar
• Hansson S. The implant neck: smooth or provided with retention elements. A biomechanical approach. Clin Oral Implants Res. 1999;10(5):394–405.
   PubMed Web of Science ®Google Scholar
• Hansson S. A conical implant-abutment interface at the level of the marginal bone improves the distribution of stresses in the supporting bone. An axisymmetric finite element analysis. Clin Oral Implants Res. 2003;14(3):286–293.
   PubMed Web of Science ®Google Scholar
• Pospula W, Noor TA, Al Rowaih A. Cementless Zweymüller hip replacement: a short-term follow-up in Al Razi Hospital, Kuwait. Med Princ Pract. 2005;14(4):255–259.
   Web of Science ®Google Scholar
• Vervest TM, Anderson PG, Van Hout F, Wapstra FH, Louwerse RT, Koetsier JW. Ten to twelve-year results with the Zweymüller cementless total hip prosthesis. J Arthroplasty. 2005;20(3):362–368.
   PubMed Web of Science ®Google Scholar
• Clohisy JC, Calvert G, Tull F, McDonald D, Maloney WJ. Reasons for revision hip surgery: a retrospective review. Clin Orthop Relat Res. 2004;(429):188–192.
   Web of Science ®Google Scholar
• Fehring TK, Odum S, Griffin WL, Mason JB, Nadaud M. Early failures in total knee arthroplasty. Clin Orthop Relat Res. 2001;(392):315–318.
   Web of Science ®Google Scholar
• Del Pozo J, Patel R. Clinical practice. Infection associated with prosthetic joints. N Engl J Med. 2009;361(8):787–794.
   PubMed Web of Science ®Google Scholar
• Craig MR, Poelstra KA, Sherrell JC, Kwon MS, Belzile EL, Brown TE. A novel total knee arthroplasty infection model in rabbits. J Orthop Res. 2005;23(5):1100–1104.
   PubMed Web of Science ®Google Scholar
• Mortazavi SM, Schwartzenberger J, Austin MS, Purtill JJ, Parvizi J. Revision total knee arthroplasty infection: incidence and predictors. Clin Orthop Relat Res. 2010;468(8):2052–2059.
   PubMed Web of Science ®Google Scholar
• Williams DL, Bloebaum RD. Observing the biofilm matrix of Staphylococcus epidermidis ATCC 35984 grown using the CDC biofilm reactor. Microsc Microanal. 2010;16(2):143–152.
   Web of Science ®Google Scholar
• Williams DL, Woodbury KL, Haymond BS, Parker AE, Bloebaum RD. A modified CDC biofilm reactor to produce mature biofilms on the surface of peek membranes for an in vivo animal model application. Curr Microbiol. 2011;62(6):1657–1663.
   PubMed Web of Science ®Google Scholar
• Fehring TK, Calton TF, Griffin WL. Cementless fixation in 2-stage reimplantation for periprosthetic sepsis. J Arthroplasty. 1999;14(2):175–181.
   Web of Science ®Google Scholar
• Masri BA, Panagiotopoulos KP, Greidanus NV, Garbuz DS, Duncan CP. Cementless two-stage exchange arthroplasty for infection after total hip arthroplasty. J Arthroplasty. 2007;22(1):72–78.
   PubMed Web of Science ®Google Scholar
• Toulson C, Walcott-Sapp S, Hur J, et al. Treatment of infected total hip arthroplasty with a 2-stage reimplantation protocol: update on “our institution’s” experience from 1989 to 2003. J Arthroplasty. 2009;24(7):1051–1060.
   Web of Science ®Google Scholar
• Norowski PA, Bumgardner JD. Biomaterial and antibiotic strategies for peri-implantitis: a review. J Biomed Mater Res B Appl Biomater. 2009;88(2):530–543.
   PubMed Web of Science ®Google Scholar
• Albrektsson T, Isidor F. Consensus report of session IV. In: Lang NP, Karring T, editors. Proceedings of the First European Workshop on Periodontology. London: Quintessence Publishing Co, Inc.; 1994; 365–369.
   Google Scholar
• Pontoriero R, Tonelli MP, Carnevale G, Mombelli A, Nyman SR, Lang NP. Experimentally induced peri-implant mucositis. A clinical study in humans. Clin Oral Implants Res. 1994;5(4):254–259.
   PubMed Web of Science ®Google Scholar
• Lindhe J, Meyle J; Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008;35(Suppl 8): S282–S285.
   PubMedGoogle Scholar
• Pye AD, Lockhart DEA, Dawson MP, Murray CA, Smith AJ. A review of dental implants and infection. J Hosp Infect. 2009;72(2):104–110.
   Web of Science ®Google Scholar
• Klinge B, Hultin M, Berglundh T. Peri-implantitis. Dent Clin North Am. 2005;49(3):661–676.
   Google Scholar
• Roos-Jansåker AM, Renvert S, Egelberg J. Treatment of peri-implant infections: a literature review. J Clin Periodontol. 2003;30(6):467–485.
   Web of Science ®Google Scholar
• Tanner A, Maiden MF, Lee K, Shulman LB, Weber HP. Dental implant infections. Clin Infect Dis. 1997;25 Suppl 2:S213–S217.
   Google Scholar
• Karoussis IK, Salvi GE, Heitz-Mayfield LJ, Brägger U, Hämmerle CH, Lang NP. Long-term implant prognosis in patients with and without a history of chronic periodontitis: a 10-year prospective cohort study of the ITI Dental Implant System. Clin Oral Implants Res. 2003;14(3):329–339.
   PubMed Web of Science ®Google Scholar
• Klinge B, Gustafsson A, Berglundh T. A systematic review of the effect of anti-infective therapy in the treatment of peri-implantitis. J Clin Periodontol. 2002;29 Suppl 3:S213–S225; discussion 232–233.
   Google Scholar
• Leonhardt A, Dahlén G, Renvert S. Five-year clinical, microbiological, and radiological outcome following treatment of peri-implantitis in man. J Periodontol. 2003;74(10):1415–1422.
   Web of Science ®Google Scholar
• Renvert S, Roos-Jansåker AM, Claffey N. Non-surgical treatment of peri-implant mucositis and peri-implantitis: a literature review. J Clin Periodontol. 2008;35(Suppl 8):S305–S315.
   Google Scholar
• Claffey N, Clarke E, Polyzois I, Renvert S. Surgical treatment of peri-implantitis. J Clin Periodontol. 2008;35(Suppl 8):S316–S332.
   Google Scholar
• Albrektsson T, Brånemark PI, Jacobsson M, Tjellström A. Present clinical applications of osseointegrated percutaneous implants. Plast Reconstr Surg. 1987;79(5):721–731.
   PubMedGoogle Scholar
• Hagberg K, Brånemark R. One hundred patients treated with osseointegrated transfemoral amputation prostheses – rehabilitation perspective. J Rehabil Res Dev. 2009;46(3):331–344.
   PubMed Web of Science ®Google Scholar
• Kang NV, Pendegrass C, Marks L, Blunn G. Osseocutaneous integration of an intraosseous transcutaneous amputation prosthesis implant used for reconstruction of a transhumeral amputee: case report. J Hand Surg Am. 2010;35(7):1130–1134.
   Google Scholar
• Aschoff HH, Clausen A, Hoffmeister T. [The endo-exo femur prosthesis – a new concept of bone-guided, prosthetic rehabilitation following above-knee amputation]. Z Orthop Unfall. 2009;147(5):610–615. German.
   Web of Science ®Google Scholar
• Tillander J, Hagberg K, Hagberg L, Brånemark R. Osseointegrated titanium implants for limb prostheses attachments: infectious complications. Clin Orthop Relat Res. 2010;468(10):2781–2788.
   PubMed Web of Science ®Google Scholar
• Gunterberg B, Brånemark PI, Brånemark R, Bergh P, Rydevik B. Osseointegrated prosthesis in lower limb amputation. The development of a new concept. In: Program and abstracts of the IXth World Congress of the International Society for Prosthetics and Orthotics; June 28–July 3, 1998; Amsterdam, The Netherlands.
   Google Scholar
• Aschoff HH, Kennon RE, Keggi JM, Rubin LE. Transcutaneous, distal femoral, intramedullary attachment for above-the-knee prostheses: an endo-exo device. J Bone Joint Surg Am. 2010;92 Suppl 2:S180–S186.
   Google Scholar
• Juhnke D-L. Über die Endo-Exo-Femurprothese: Erarbeitung von Konzepten für die Qualitätssicherung knochengeführter Oberschenkelprothesen durch ganganalytische Bestimmungen und Auswertung von Druckverläufen unter dem Fuß. Munchen, Germany: Medizinische Fakultät, Ludwig-Maximilians-Universitat München; 2010.
   Google Scholar
• Sullivan J, Uden M, Robinson KP, Sooriakumaran S. Rehabilitation of the trans-femoral amputee with an osseointegrated prosthesis: the United Kingdom experience. Prosthet Orthot Int. 2003;27(2):114–120.
   PubMed Web of Science ®Google Scholar
• Bragdon, CR, Nebergall AK, Antonellis A, Kärrkolm J, Brånemark R, Örjan B, Malchau H. RSA evaluation of an implant system for above the knee amputee patients. Oral presentation at the 4th International Conference on Advances in Orthopaedic Osseointegration; February 10, 2012; San Francisco, CA.
   Google Scholar
• Hacking SA, Bobyn JD, Toh K, Tanzer M, Krygier JJ. Fibrous tissue ingrowth and attachment to porous tantalum. J Biomed Mater Res. 2000;52(4):631–638.
   Web of Science ®Google Scholar
• Brånemark PI, Albrektsson T. Titanium implants permanently penetrating human skin. Scand J Plast Reconstr Surg. 1982;16(1):17–21.
   PubMed Web of Science ®Google Scholar
• Vandamme K, Naert I, Geris L, Sloten JV, Puers R, Duyck J. Histodynamics of bone tissue formation around immediately loaded cylindrical implants in the rabbit. Clin Oral Implants Res. 2007;18(4):471–480.
   Web of Science ®Google Scholar
• Uhthoff HK, Germain JP. The reversal of tissue differentiation around screws. Clin Orthop Relat Res. 1977;(123):248–252.
   Web of Science ®Google Scholar
• Albrektsson T, Johansson C. Osteoinduction, osteoconduction and osseointegration. Eur Spine J. 2001;10 Suppl 2:S96–S101.
   Google Scholar
• Morinaga K, Kido H, Sato A, Watazu A, Matsuura M. Chronological changes in the ultrastructure of titanium-bone interfaces: analysis by light microscopy, transmission electron microscopy, and micro-computed tomography. Clin Implant Dent Relat Res. 2009;11(1):59–68.
   Web of Science ®Google Scholar
• Stoppie N, van der Waerden JP, Jansen JA, Duyck J, Wevers M, Naert IE. Validation of microfocus computed tomography in the evaluation of bone implant specimens. Clin Implant Dent Relat Res. 2005;7(2):87–94.
   Web of Science ®Google Scholar
• Huja SS, Roberts WE. Mechanism of osseointegration: characterization of supporting bone with indentation testing and backscattered imaging. Semin Orthod. 2004;10(2):162–173.
   Google Scholar
• Tuan HS, Hutmacher DW. Application of micro CT and computation modeling in bone tissue engineering. Comput Aided Des. 2005;37(11):1151–1161.
   Web of Science ®Google Scholar
• Yip G, Schneider P, Roberts EW. Micro-computed tomography: high resolution imaging of bone and implants in three dimensions. Semin Orthod. 2004;10(2):174–187.
   Google Scholar
• Huang HM, Chiu CL, Yeh CY, Lee SY. Factors influencing the resonance frequency of dental implants. J Oral Maxillofac Surg. 2003;61(10):1184–1188.
   Web of Science ®Google Scholar
• Pattijn V, Jaecques SV, De Smet E, et al. Resonance frequency analysis of implants in the guinea pig model: influence of boundary conditions and orientation of the transducer. Med Eng Phys. 2007;29(2):182–190.
   Web of Science ®Google Scholar
• Pattijn V, Van Lierde C, Van der Perre G, Naert I, Vander Sloten J. The resonance frequencies and mode shapes of dental implants: Rigid body behaviour versus bending behaviour. A numerical approach. J Biomech. 2006;39(5):939–947.
   Web of Science ®Google Scholar
• Schliephake H, Sewing A, Aref A. Resonance frequency measurements of implant stability in the dog mandible: experimental comparison with histomorphometric data. Int J Oral Maxillofac Surg. 2006;35(10):941–946.
   Web of Science ®Google Scholar
• Veltri M, Balleri B, Goracci C, Giorgetti R, Balleri P, Ferrari M. Soft bone primary stability of 3 different miniscrews for orthodontic anchorage: a resonance frequency investigation. Am J Orthod Dentofacial Orthop. 2009;135(5):642–648.
   Web of Science ®Google Scholar
• Isaacson BM, Vance RE, Chou TG, Bloebaum RD, Bachus KN, Webster JB. Effectiveness of resonance frequency in predicting orthopedic implant strength and stability in an in vitro osseointegration model. J Rehabil Res Dev. 2009;46(9):1109–1120.
   Google Scholar
• Bloebaum RD, Rubman MH, Hofmann AA. Bone ingrowth into porous-coated tibial components implanted with autograft bone chips. Analysis of ten consecutively retrieved implants. J Arthroplasty. 1992;7(4):483–493.
   PubMedGoogle Scholar
• Bloebaum RD, Rhodes DM, Rubman MH, Hofmann AA. Bilateral tibial components of different cementless designs and materials. Microradiographic, backscattered imaging, and histologic analysis. Clin Orthop Relat Res. 1991179–1991187.
   Google Scholar