PD-1 blockade restores impaired function of ex vivo expanded CD8⁺ T cells and enhances apoptosis in mismatch repair deficient EpCAM⁺PD-L1⁺ cancer cells

References

• ErricoAMelanoma: CheckMate 067 – frontline nivolumab improves PFS alone or in combination with ipilimumabNat Rev Clin Oncol201512843526099982
   PubMedGoogle Scholar
• ValsecchiMECombined nivolumab and ipilimumab or monotherapy in untreated melanomaN Engl J Med2015373131270
   PubMed Web of Science ®Google Scholar
• YaqubFNivolumab for squamous-cell non-small-cell lung cancerLancet Oncol2015167e319
   PubMed Web of Science ®Google Scholar
• BorghaeiHPaz-AresLHornLNivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancerN Engl J Med2015373171627163926412456
   PubMed Web of Science ®Google Scholar
• ButtAQMillsKHImmunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccinesOncogene201433384623463124141774
   PubMedGoogle Scholar
• ByrneWLMillsKHLedererJAO’SullivanGCTargeting regulatory T cells in cancerCancer Res201171226915692022068034
   PubMed Web of Science ®Google Scholar
• JarnickiAGLysaghtJTodrykSMillsKHSuppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cellsJ Immunol2006177289690416818744
   PubMed Web of Science ®Google Scholar
• WherryEJKurachiMMolecular and cellular insights into T cell exhaustionNat Rev Immunol201515848649926205583
   PubMed Web of Science ®Google Scholar
• Twyman-Saint VictorCRechAJMaityARadiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancerNature2015520754737337725754329
   PubMed Web of Science ®Google Scholar
• WherryEJT cell exhaustionNat Immunol201112649249921739672
   PubMed Web of Science ®Google Scholar
• LegatASpeiserDEPircherHZehnDFuertes MarracoSAInhibitory receptor expression depends more dominantly on differentiation and activation than “exhaustion” of human CD8 T cellsFront Immunol2013445524391639
   PubMedGoogle Scholar
• JiangYLiYZhuBT-cell exhaustion in the tumor microenvironmentCell Death Dis20156e179226086965
   PubMed Web of Science ®Google Scholar
• TumehPCHarviewCLYearleyJHPD-1 blockade induces responses by inhibiting adaptive immune resistanceNature2014515752856857125428505
   PubMed Web of Science ®Google Scholar
• DonnemTHaldSMPaulsenEEStromal CD8+ T-cell density – a promising supplement to TNM staging in non-small cell lung cancerClin Cancer Res201521112635264325680376
   PubMed Web of Science ®Google Scholar
• LingAEdinSWikbergMLObergAPalmqvistRThe intratumoural subsite and relation of CD8(+) and FOXP3(+) T lymphocytes in colorectal cancer provide important prognostic cluesBr J Cancer2014110102551255924675384
   PubMed Web of Science ®Google Scholar
• MeiZLiuYLiuCTumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysisBr J Cancer201411061595160524504370
   PubMed Web of Science ®Google Scholar
• MellaMKauppilaJHKarihtalaPTumor infiltrating CD8+ T lymphocyte count is independent of tumor TLR9 status in treatment naive triple negative breast cancer and renal cell carcinomaOncoimmunology201546e100272626155410
   PubMedGoogle Scholar
• StumpfMHasenburgARienerMOIntraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytesBr J Cancer200910191513152119861998
   PubMed Web of Science ®Google Scholar
• HanSZhangCLiQTumour-infiltrating CD4(+) and CD8(+) lymphocytes as predictors of clinical outcome in gliomaBr J Cancer2014110102560256824691423
   PubMed Web of Science ®Google Scholar
• SharmaPShenYWenSCD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinomaProc Natl Acad Sci U S A2007104103967397217360461
   PubMed Web of Science ®Google Scholar
• LeDTUramJNWangHPD-1 blockade in tumors with mismatch-repair deficiencyN Engl J Med2015372262509252026028255
   PubMed Web of Science ®Google Scholar
• RestifoNPDudleyMERosenbergSAAdoptive immunotherapy for cancer: harnessing the T cell responseNat Rev Immunol201212426928122437939
   PubMed Web of Science ®Google Scholar
• WangXRiviereIManufacture of tumor- and virus-specific T lymphocytes for adoptive cell therapiesCancer Gene Ther2015222859425721207
   PubMed Web of Science ®Google Scholar
• JanelleVCarliCTailleferJOrioJDelisleJSDefining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in cultureJ Transl Med20151312325925868
   PubMed Web of Science ®Google Scholar
• FourcadeJSunZBenallaouaMUpregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patientsJ Exp Med2010207102175218620819923
   PubMed Web of Science ®Google Scholar
• YuanZSotsky KentTWeberTKDifferential expression of DOC-1 in microsatellite-unstable human colorectal cancerOncogene200322406304631013679870
   PubMedGoogle Scholar
• OikonomouEKothonidisKTaoufikENewly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivoBr J Cancer2007971738417551494
   PubMedGoogle Scholar
• Dons’koiBVChernyshovVPOsypchukDVMeasurement of NK activity in whole blood by the CD69 up-regulation after co-incubation with K562, comparison with NK cytotoxicity assays and CD107a degranulation assayJ Immunol Methods20113721–218719521839083
   PubMed Web of Science ®Google Scholar
• Hardtke-WolenskiMKrausLSchmetzCExchange of cytosolic content between T cells and tumor cells activates CD4 T cells and impedes cancer growthPloS One2013810e7855824205259
   PubMedGoogle Scholar
• DemmersMWBaanCCvan BeelenEIjzermansJNWeimarWRowshaniATDifferential effects of activated human renal epithelial cells on T-cell migrationPloS One201385e6491623717673
   PubMedGoogle Scholar
• TrickettAKwanYLT cell stimulation and expansion using anti-CD3/CD28 beadsJ Immunol Methods20032751–225125512667688
   PubMed Web of Science ®Google Scholar
• TeschnerDWenzelGDistlerEIn vitro stimulation and expansion of human tumour-reactive CD8+ cytotoxic T lymphocytes by anti-CD3/CD28/CD137 magnetic beadsScand J Immunol201174215516421517928
   PubMedGoogle Scholar
• LiuMFWengCTWengMYVariable increased expression of program death-1 and program death-1 ligands on peripheral mononuclear cells is not impaired in patients with systemic lupus erythematosusJ Biomed Biotechnol2009200940613619759858
   PubMedGoogle Scholar
• Couzin-FrankelJBreakthrough of the year 2013. Cancer immunotherapyScience201334261651432143324357284
   PubMed Web of Science ®Google Scholar
• RosenbergSARestifoNPAdoptive cell transfer as personalized immunotherapy for human cancerScience20153486230626825838374
   PubMed Web of Science ®Google Scholar
• MeleroIBermanDMAznarMAKormanAJGraciaJLHaanenJEvolving synergistic combinations of targeted immunotherapies to combat cancerNat Rev Cancer201515845747226205340
   PubMed Web of Science ®Google Scholar
• MaudeSLFreyNShawPAChimeric antigen receptor T cells for sustained remissions in leukemiaN Engl J Med2014371161507151725317870
   PubMed Web of Science ®Google Scholar
• PodrazilMHorvathRBechtEPhase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancerOncotarget2015620181921820526078335
   PubMed Web of Science ®Google Scholar
• FinnOJImmuno-oncology: understanding the function and dysfunction of the immune system in cancerAnn Oncol201223Suppl 8viii6viii922918931
   PubMed Web of Science ®Google Scholar
• HanahanDWeinbergRAHallmarks of cancer: the next generationCell2011144564667421376230
   PubMed Web of Science ®Google Scholar
• MahnkeKSkorokhodAGrabbeSEnkAHOpening a niche for therapy: local lymphodepletion helps the immune system to fight melanomaJ Invest Dermatol201413471794179624924759
   PubMedGoogle Scholar
• FourcadeJKudelaPSunZPD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patientsJ Immunol200918295240524919380770
   PubMed Web of Science ®Google Scholar
• LongAHHasoWMShernJF4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptorsNat Med201521658159025939063
   PubMed Web of Science ®Google Scholar
• PengWLiuCXuCPD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokinesCancer Res201272205209521822915761
   PubMed Web of Science ®Google Scholar
• LugliATzankovAZlobecITerraccianoLMDifferential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair statusMod Pathol200821111403141218587323
   PubMedGoogle Scholar
• DudleyJCLinMTLeDTEshlemanJRMicrosatellite instability as a biomarker for PD-1 blockadeClin Cancer Res201622481382026880610
   PubMed Web of Science ®Google Scholar
• ChangHNLiuBYQiYKBlocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapyAngew Chem Int Ed Engl20155440117601176426259671
   PubMed Web of Science ®Google Scholar
• ZhanMMHuXQLiuXXRuanBFXuJLiaoCFrom monoclonal antibodies to small molecules: the development of inhibitors targeting the PD-1/PD-L1 pathwayDrug Discov Today20162161027103627094104
   PubMed Web of Science ®Google Scholar
• SuSHuBShaoJCRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patientsSci Rep201662007026818188
   PubMed Web of Science ®Google Scholar