84
Views
8
CrossRef citations to date
0
Altmetric
Original Research

Midazolam activates caspase, MAPKs and endoplasmic reticulum stress pathways, and inhibits cell cycle and Akt pathway, to induce apoptosis in TM3 mouse Leydig progenitor cells

, , , , , , & show all
Pages 1475-1490 | Published online: 15 Mar 2018

References

  • RevesJGFragenRJVinikHRGreenblattDJMidazolam: pharmacology and usesAnesthesiology19856233103243156545
  • LaegreidLClinical observations in children after prenatal benzodiazepine exposureDev Pharmacol Ther1990153–41861881983095
  • LaegreidLOlegårdRConradiNHagbergGWahlströmJAbrahamssonLCongenital malformations and maternal consumption of benzodiazepines: a case-control studyDev Med Child Neurol19903254324411972364
  • DolovichLRAddisAVaillancourtJMPowerJDKorenGEinarsonTRBenzodiazepine use in pregnancy and major malformations or oral cleft: meta-analysis of cohort and case-control studiesBMJ199831771628398439748174
  • SueharaTMorishitaJUekiMUenoMMaekawaNMizobuchiSEffects of sevoflurane exposure during late pregnancy on brain development of offspring micePaediatr Anaesth2016261525926645425
  • ZhangTShaoHXuKQKuangLTChenRFXiuHHMidazolam suppresses osteogenic differentiation of human bone marrow-derived mesenchymal stem cellsEur Rev Med Pharmacol Sci20141891411141824867522
  • ChenYCChenYHPanBSChangMMHuangBM2017. Functional study of Cordyceps sinensis and cordycepin in male reproduction – a reviewJ Food Drug Anal201725119720528911537
  • HabertRLejeuneHSaezJMOrigin, differentiation and regulation of fetal and adult Leydig cellsMol Cell Endocrinol20011791–2477411420130
  • ChenHGeRSZirkinBRLeydig cells: From stem cells to agingMol Cell Endocrinol20093061–291619481681
  • BraestrupCSquiresRSpecific benzodiazepine receptors in rat brain characterized by high-affinity (3H) diazepam bindingProc Natl Acad Sci U S A19777493805380920632
  • PapadopoulosVBrownASRole of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesisJ Steroid Biochem Mol Biol1995531–61031107626442
  • SoECChangYTHsingCHPoonPWLeuSFHuangBMThe effect of midazolam on mouse Leydig cell steroidogenesis and apoptosisToxicol Lett2010192216917819857560
  • SoECLinYXTsengCHMidazolam induces apoptosis in MA-10 mouse Leydig tumor cells through caspase activation and the involvement of MAPK signaling pathwayOncoTargets Ther20147211221
  • SoECChenYCWangSCMidazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cellsOncoTargets Ther2016925192533
  • WyllieAHGlucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activationNature198028457565555566245367
  • CerrettiDPKozloskyCJMosleyBMolecular cloning of the interleukin-1 beta converting enzymeScience19922565053971001373520
  • YuanJShahamSLedouxSEllisHMHorvitzHRThe C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzymeCell19937546416528242740
  • AshkenaziADixitVMDeath receptors: signaling and modulationScience19982815381130513089721089
  • LiPNijhawanDBudihardjoICytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeCell19979144794899390557
  • AhmadMSrinivasulaSMWangLCRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIPCancer Res19975746156199044836
  • YangXChangHYBaltimoreDAutoproteolytic activation of pro-caspases by oligomerizationMol Cell1998123193259659928
  • StennickeHRRyanCASalvesenGSReprieval from execution: the molecular basis of caspase inhibitionTrends Biochem Sci20022729410111852247
  • SrinivasulaSMAhmadMFernandes-AlnemriTAlnemriESAuto-activation of procaspase-9 by Apaf-1-mediated oligomerizationMol Cell1998179499579651578
  • GuptaSMolecular steps of tumor necrosis factor receptor-mediated apoptosisCurr Mol Med20011331732411899080
  • BoxemMCyclin-dependent kinases in C. elegansCell Div20061616759361
  • WangYJiPLiuJBroaddusRRXueFZhangWCentrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyMol Cancer20098819216791
  • JohnsonGLLapadatRMitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesScience200229856001911191212471242
  • LeeSHJaganathIBAtiyaNManikamRSekaranSDSuppression of ERK1/2 and hypoxia pathways by four Phyllanthus species inhibits metastasis of human breast cancer cellsJ Food Drug Anal201624485586528911625
  • SonYCheongYKKimNHChungHTKangDGPaeHOMitogen-activated protein kinases and reactive oxygen species: How can ROS activate MAPK pathways?J Signal Transduct2011201179263921637379
  • MarkmanBDienstmannRTaberneroJTargeting the PI3K/Akt/mTOR pathway – beyond rapalogsOncotarget20101753054321317449
  • HeinALOuelletteMMYanYRadiation-induced signaling pathways that promote cancer cell survival (review)Int J Oncol20144551813181925174607
  • ZhouCZhaoXMLiXFCurcumin inhibits AP-2gamma-induced apoptosis in the human malignant testicular germ cells in vitroActa Pharmacol Sin20133491192120023685957
  • LuoKCaoSSEndoplasmic reticulum stress in intestinal epithelial cell function and inflammatory bowel diseaseGastroenterol Res Pract2015201532879125755668
  • SandersonTHGallawayMKumarRUnfolding the unfolded protein response: unique insights into brain ischemiaInt J Mol Sci20151647133714225830481
  • LogueSEClearyPSaveljevaSSamaliANew directions in ER stress-induced cell deathApoptosis201318553754623430059
  • KaniaEPająkBOrzechowskiACalcium homeostasis and ER stress in control of autophagy in cancer cellsBiomed Res Int2015201535279425821797
  • KitamuraMEndoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus facesAm J Physiol Renal Physiol20082952F323F33418367660
  • HanESMullerFLPérezVIThe in vivo gene expression signature of oxidative stressPhysiol Genomics200834111212618445702
  • ReinhardtHCSchumacherBThe p53 network: cellular and systemic DNA damage responses in aging and cancerTrends Genet201228312813622265392
  • CmielováJRezáčováMp21Cip1/Waf1 protein and its function based on a subcellular localization [corrected]J Cell Biochem2011112123502350621815189
  • KamatoDBurchMLPivaTJTransforming growth factor-β signalling: role and consequences of Smad linker region phosphorylationCell Signal201325102017202423770288
  • MatherJPEstablishment and characterization of two distinct mouse testicular epithelial cell linesBiol Reprod19802312432526774781
  • GoldenbergRCFortesFSCristanchoJMModulation of gap junction mediated intercellular communication in TM3 Leydig cellsJ Endocrinol2003177232733512740021
  • GeigersederCDoepnerRFThalhammerAKriegerAMayerhoferAStimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABAReprod Biol Endocrinol200421315040802
  • GreenDRReedJCMitochondria and apoptosisScience19982815381130913129721092
  • van EngelandMRamaekersFCSchutteBReutelingspergerCPA novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in cultureCytometry19962421311398725662
  • LowryOHRosebroughNJFarrALRandallRJProtein measurement with the Folin phenol reagentJ Biol Chem1951193126527514907713
  • CreaghEMMartinSJCaspases: cellular demolition expertsBiochem Soc Trans200129Pt 669670211709057
  • TaylorRCCullenSPMartinSJApoptosis: controlled demolition at the cellular levelNat Rev Mol Cell Biol20089323124118073771
  • Paul-SamojednyMSuchanekRBorkowskaPKnockdown of AKT3 (PKBgamma) and PI3KCA suppresses cell viability and proliferation and induces the apoptosis of glioblastoma multiforme T98G cellsBiomed Res Int2014201476818124967401
  • OliveiraJBGuptaSDisorders of apoptosis: mechanisms for autoimmunity in primary immunodeficiency diseasesJ Clin Immunol200828S20S2818193340
  • LazebnikYAKaufmannSHDesnoyersSPoirierGGEarnshawWCCleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICENature199437164953463478090205
  • GhoriKO’DriscollJShortenGThe effect of midazolam on neutrophil mitogen-activated protein kinaseEur J Anaesthesiol201027656256520421794
  • VivancoISawyersCLThe phosphatidylinositol 3-Kinase AKT pathway in human cancerNat Rev Cancer20022748950112094235
  • ChongWSHyunCLParkMKMidazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injuryKorean J Anesthesiol201262216617122379573
  • HetzCMartinonFRodriguezDGlimcherLHThe unfolded protein response: integrating stress signals through the stress sensor IRE1alphaPhysiol Rev20119141219124322013210
  • KoromilasAERoles of the translation initiation factor eIF2alpha serine 51 phosphorylation in cancer formation and treatmentBiochim Biophys Acta20151849787188025497381
  • WangDLippardSJCellular processing of platinum anticancer drugsNat Rev Drug Discov20054430732015789122
  • ShityakovSSohajdaTPuskasIRoewerNForsterCBroscheitJAIonization states, cellular toxicity and molecular modeling studies of midazolam complexed with trimethyl-beta-cyclodextrinMolecules20141910168611687625338177