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Original Research

Identification of molecular target genes and key pathways in hepatocellular carcinoma by bioinformatics analysis

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Pages 1861-1869 | Published online: 04 Apr 2018

References

  • JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin2011612699021296855
  • El-SeragHBHepatocellular carcinomaN Engl J Med2011365121118112721992124
  • SanyalAJYoonSKLencioniRThe etiology of hepatocellular carcinoma and consequences for treatmentOncologist201015Suppl 4142221115577
  • SingalAGEl-SeragHBHepatocellular carcinoma from epidemiology to prevention: translating knowledge into practiceClin Gastroenterol Hepatol201513122140215126284591
  • LiuFLiHChangHWangJLuJIdentification of hepatocellular carcinoma-associated hub genes and pathways by integrated microarray analysisTumori2015101220621425768320
  • YinFShuLLiuXMicroarray-based identification of genes associated with cancer progression and prognosis in hepatocellular carcinomaJ Exp Clin Cancer Res201635112727567667
  • KulasingamVDiamandisEPStrategies for discovering novel cancer biomarkers through utilization of emerging technologiesNat Clin Pract Oncol200851058859918695711
  • ShangguanHTanSYZhangJRBioinformatics analysis of gene expression profiles in hepatocellular carcinomaEur Rev Med Pharmacol Sci201519112054206126125269
  • CritelliRMDe MariaNVillaEBiology of hepatocellular carcinomaDig Dis201533563564126398186
  • van MalensteinHvan PeltJVerslypeCMolecular classification of hepatocellular carcinoma anno 2011Eur J Cancer201147121789179721612914
  • HoshidaYToffaninSLachenmayerAVillanuevaAMinguezBLlovetJMMolecular classification and novel targets in hepatocellular carcinoma: recent advancementsSemin Liver Dis2010301355120175032
  • HuangXBLiJZhengLBioinformatics analysis reveals potential candidate drugs for HCCPathol Oncol Res201319225125823341104
  • Del VecchioFGalloFDi MarcoABioinformatics approach to predict target genes for dysregulated microRNAs in hepatocellular carcinoma: study on a chemically-induced HCC mouse modelBMC Bioinformatics20151640826652480
  • ShiKQLinZChenXJHepatocellular carcinoma associated microRNA expression signature: integrated bioinformatics analysis, experimental validation and clinical significanceOncotarget2015628250932510826231037
  • MakowskaZBoldanovaTAdametzDGene expression analysis of biopsy samples reveals critical limitations of transcriptome-based molecular classifications of hepatocellular carcinomaJ Pathol Clin Res201622809227499918
  • GhoshAGhoshADattaSHepatic miR-126 is a potential plasma biomarker for detection of hepatitis B virus infected hepatocellular carcinomaInt J Cancer2016138112732274426756996
  • BarrettTWilhiteSELedouxPNCBI GEO: archive for functional genomics data sets-updateNucleic Acids Res201341Database issueD991D99523193258
  • Huang daWShermanBTLempickiRASystematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesNat Protoc200941445719131956
  • BaderGDHogueCWAn automated method for finding molecular complexes in large protein interaction networksBMC Bioinformatics20034212525261
  • XiaoFZuoZCaiGKangSGaoXLiTmiRecords: an integrated resource for microRNA-target interactionsNucleic Acids Res200937Database issueD105D11018996891
  • WangWYHsuCCWangTYA gene expression signature of epithelial tubulogenesis and a role for ASPM in pancreatic tumor progressionGastroenterology201314551110112023896173
  • LinSYPanHWLiuSHASPM is a novel marker for vascular invasion, early recurrence, and poor prognosis of hepatocellular carcinomaClin Cancer Res200814154814482018676753
  • VangePBrulandTBeisvagVGenome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancerJ Pathol2015237444745926178168
  • Bruning-RichardsonABondJAlsiaryRASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survivalBr J Cancer2011104101602161021505456
  • WangFChangYLiJStrong correlation between ASPM gene expression and HCV cirrhosis progression identified by co-expression analysisDige Liver Dis20174917076
  • HeBYinJGongSBioinformatics analysis of key genes and pathways for hepatocellular carcinoma transformed from cirrhosisMedicine (Baltimore)20179625e693828640074
  • KollareddyMDzubakPZhelevaDHajduchMAurora kinases: structure, functions and their association with cancerBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub20081521273318795071
  • CarmenaMEarnshawWCThe cellular geography of aurora kinasesNat Rev Mol Cell Biol200341184285414625535
  • KamadaKYamadaYHiraoTAmplification/overexpression of Aurora-A in human gastric carcinoma: potential role in differentiated type gastric carcinogenesisOncol Rep200412359359915289843
  • JengYMPengSYLinCYHsuHCOverexpression and amplification of Aurora-A in hepatocellular carcinomaClin Cancer Res20041062065207115041727
  • RojanalaSHanHMunozRMThe mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancerMol Cancer Ther20043445145715078988
  • YuCTHsuJMLeeYCTsouAPChouCKHuangCYPhosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-AMol Cell Biol200525145789580015987997
  • TsouAPYangCWHuangCYIdentification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinomaOncogene200322229830712527899
  • KleinAFlugelDKietzmannTTranscriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1Mol Biol Cell20081993667367518562694
  • GaoPWangRShenJJHypoxia-inducible enhancer/alpha-fetoprotein promoter-driven RNA interference targeting STK15 suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cellsCancer Sci200899112209221718803637
  • ParkSHYuGRKimWHMoonWSKimJHKimDGNF-Y-dependent cyclin B2 expression in colorectal adenocarcinomaClin Cancer Res200713385886717289878
  • ShubbarEKovacsAHajizadehSElevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcomeBMC Cancer201313123282137
  • LeiCYWangWZhuYTFangWYTanWLThe decrease of cyclin B2 expression inhibits invasion and metastasis of bladder cancerUrol Oncol2016345237.e1e10
  • NamHJvan DeursenJMCyclin B2 and p53 control proper timing of centrosome separationNat Cell Biol201416653854924776885
  • AlonsoASasinJBottiniNProtein tyrosine phosphatases in the human genomeCell2004117669971115186772
  • BlotJChartrainIRoghiCPhilippeMTassanJPCell cycle regulation of pEg3, a new Xenopus protein kinase of the KIN1/PAR-1/MARK familyDev Biol2002241232733811784115
  • XiaHKongSNChenJMELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrenceCancer Lett20163831859327693640
  • LiCXueCYangQLowBCLiouYCNuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection forceNat Commun201671059726839278
  • IyerJMogheSFurukawaMTsaiMYWhat’s Nu(SAP) in mitosis and cancer?Cell Signal201123699199821111812
  • SubramanianRWilson-KubalekEMArthurCPInsights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding proteinCell2010142343344320691902
  • WangSMOoiLLHuiKMUpregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinomaClin Cancer Res201117186040605121825042
  • IsaacsRJDaviesSLSandriMIRedwoodCWellsNJHicksonIDPhysiological regulation of eukaryotic topoisomerase IIBiochim Biophys Acta199814001–31211379748535
  • WongNYeoWWongWLTOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistanceInt J Cancer2009124364465219003983
  • PanvichianRTantiwetrueangdetAAngkathunyakulNLeelaudomlipiSTOP2A amplification and overexpression in hepatocellular carcinoma tissuesBiomed Res Int2015201538160225695068
  • ChistiakovDASobeninIAOrekhovANBobryshevYVHuman miR-221/222 in physiological and atherosclerotic vascular remodelingBiomed Res Int2015201535451726221589
  • GarofaloMQuintavalleCRomanoGCroceCMCondorelliGmiR221/222 in cancer: their role in tumor progression and response to therapyCurr Mol Med2012121273322082479
  • WongQWChingAKChanAWMiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signalingClin Cancer Res201016386787520103675