Antiangiogenic effects of AA-PMe on HUVECs in vitro and zebrafish in vivo

References

• QuesadaARMunoz-ChapuliRMedinaMAAnti-angiogenic drugs: from bench to clinical trialsMed Res Rev20062648353016652370
   PubMed Web of Science ®Google Scholar
• CarmelietPAngiogenesis in life, disease and medicineNature200543893293616355210
   PubMed Web of Science ®Google Scholar
• FerraraNKerbelRSAngiogenesis as a therapeutic targetNature200543896797416355214
   PubMed Web of Science ®Google Scholar
• ZhongHBowenJPMolecular design and clinical development of VEGFR kinase inhibitorsCurr Top Med Chem200771379139317692027
   PubMed Web of Science ®Google Scholar
• FerraraNVascular endothelial growth factor: basic science and clinical progressEndocr Rev20042558161115294883
   PubMed Web of Science ®Google Scholar
• DongDFLiEXWangJBAnti-angiogenesis and anti-tumor effects of AdNT4-anginexCancer Lett200928521822419540664
   PubMed Web of Science ®Google Scholar
• SimoRCarrascoEGarcia-RamirezMHernandezCAngiogenic and antiangiogenic factors in proliferative diabetic retinopathyCurr Diabetes Rev20062719818220619
   PubMedGoogle Scholar
• PratheeshkumarPBudhrajaASonYOQuercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathwaysPLoS One20127e4751623094058
   PubMed Web of Science ®Google Scholar
• PotenteMGerhardtHCarmelietPBasic and therapeutic aspects of angiogenesisCell201114687388721925313
   PubMed Web of Science ®Google Scholar
• LiaoDJohnsonRSHypoxia: a key regulator of angiogenesis in cancerCancer Metastasis Rev20072628129017603752
   PubMed Web of Science ®Google Scholar
• FerraraNVEGF and the quest for tumour angiogenesis factorsNat Rev Cancer2002279580312360282
   PubMed Web of Science ®Google Scholar
• LinCWuMHDongJYQuercetin-42-O-beta-D-glucopyranoside (QODG) inhibits angiogenesis by suppressing VEGFR2-mediated signaling in zebrafish and endothelial cellsPLoS One20127e3170822348123
   PubMed Web of Science ®Google Scholar
• LiuBFaiaLHuMNussenblattRBPro-angiogenic effect of IFNgamma is dependent on the PI3K/mTOR/translational pathway in human retinal pigmented epithelial cellsMol Vis20101618419320157617
   PubMed Web of Science ®Google Scholar
• FerraraNGerberHPLeCouterJThe biology of VEGF and its receptorsNat Med2003966967612778165
   PubMed Web of Science ®Google Scholar
• FerraraNHillanKJGerberHPNovotnyWDiscovery and development of bevacizumab, an anti-VEGF antibody for treating cancerNat Rev Drug Discov2004339140015136787
   PubMed Web of Science ®Google Scholar
• Randrup HansenCGrimmDBauerJWehlandMMagnussonNEEffects and side effects of using sorafenib and sunitinib in the treatment of metastatic renal cell carcinomaInt J Mol Sci201718E46128230776
   PubMed Web of Science ®Google Scholar
• ShantakumarSNordstromBLDjousseLOccurrence of hepa-totoxicity with pazopanib and other anti-VEGF treatments for renal cell carcinoma: an observational study utilizing a distributed database networkCancer Chemother Pharmacol20167855956627438066
   PubMed Web of Science ®Google Scholar
• NobleMEEndicottJAJohnsonLNProtein kinase inhibitors: insights into drug design from structureScience20043031800180515031492
   PubMed Web of Science ®Google Scholar
• DongDKoBBaumeisterPVascular targeting and antiangio-genesis agents induce drug resistance effector GRP78 within the tumor microenvironmentCancer Res2005655785579115994954
   PubMed Web of Science ®Google Scholar
• JingYWangGGeYXuMGongZSynthesis, anti-tumor and anti-angiogenic activity evaluations of asiatic acid amino acid derivativesMolecules2015207309732425905607
   PubMed Web of Science ®Google Scholar
• SomboonwongJKankaisreMTantisiraBTantisiraMHWound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal studyBMC Complement Altern Med20121210322817824
   PubMed Web of Science ®Google Scholar
• ShuklaARasikAMJainGKShankarRKulshresthaDKDhawanBNIn vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiaticaJ Ethnopharmacol19996511110350364
   PubMed Web of Science ®Google Scholar
• Soo LeeYJinD-QBeakS-MLeeE-SKimJ-AInhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytesEur J Pharmacol200347617317812969763
   PubMed Web of Science ®Google Scholar
• Mook-JungIShinJEYunSHProtective effects of asiaticoside derivatives against beta-amyloid neurotoxicityJ Neurosci Res19995841742510518115
   PubMed Web of Science ®Google Scholar
• JewSSYooCHLimDYStructure–activity relationship study of asiatic acid derivatives against beta amyloid (Aβ)-induced neurotoxicityBioorg Med Chem Lett20001011912110673093
   PubMed Web of Science ®Google Scholar
• LeeMKKimSRSungSHAsiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicityRes Commun Mol Pathol Pharmacol2000108758611758977
   PubMed Web of Science ®Google Scholar
• KrishnamurthyRGSenutMCZemkeDAsiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemiaJ Neurosci Res2009872541255019382233
   PubMed Web of Science ®Google Scholar
• TangLXHeRHYangGAsiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitroPLoS One20127e3135022363627
   PubMed Web of Science ®Google Scholar
• HsuYLKuoPLLinLTLinCCAsiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cellsJ Pharmacol Exp Ther200531333334415626723
   PubMed Web of Science ®Google Scholar
• ParkBCBosireKOLeeESLeeYSKimJAAsiatic acid induces apoptosis in SK-MEL-2 human melanoma cellsCancer Lett2005218819015639343
   PubMed Web of Science ®Google Scholar
• TangX-LYangX-YJungH-JAsiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascadeBiol Pharm Bull2009321399140519652380
   PubMed Web of Science ®Google Scholar
• ChoCWChoiDSCardoneMHKimCWSinskeyAJRhaCGlio-blastoma cell death induced by asiatic acidCell Biol Toxicol20062239340816897440
   PubMed Web of Science ®Google Scholar
• LeeYSJinD-QKwonEJAsiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cellsCancer Lett2002186839112183079
   PubMed Web of Science ®Google Scholar
• KavithaCVAgarwalCAgarwalRDeepGAsiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture modelsPLoS One20116e2274521826202
   PubMed Web of Science ®Google Scholar
• ZhaoDXQinCJFanXHLiYCGuBHInhibitory effects of quercetin on angiogenesis in larval zebrafish and human umbilical vein endothelial cellsEur J Pharmacol201472336036724239714
   PubMed Web of Science ®Google Scholar
• XuZLiYXiangQDesign and synthesis of novel xyloketal derivatives and their vasorelaxing activities in rat thoracic aorta and angiogenic activities in zebrafish angiogenesis screenJ Med Chem2010534642465320481602
   PubMed Web of Science ®Google Scholar
• LawsonNDWeinsteinBMIn vivo imaging of embryonic vascular development using transgenic zebrafishDev Biol200224830731812167406
   PubMed Web of Science ®Google Scholar
• YuXBTongYHanXQAnti-angiogenic activity of Herba Epimedii on zebrafish embryos in vivo and HUVECs in vitroPhytother Res2013271368137523147754
   PubMed Web of Science ®Google Scholar
• TruongLHarperSLTanguayRLEvaluation of embryotoxicity using the zebrafish modelMethods Mol Biol201169127127920972759
   PubMedGoogle Scholar
• MuXYPangSSunXZEvaluation of acute and developmental effects of difenoconazole via multiple stage zebrafish assaysEnviron Pollut201317514715723391686
   PubMed Web of Science ®Google Scholar
• HeMFHuangYHWuLWGeWShawPCButPPTriptolide functions as a potent angiogenesis inhibitorInt J Cancer201012626627819569053
   PubMed Web of Science ®Google Scholar
• LamHWLinHCLaoSCThe angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivoJ Cell Biochem200810319521117497682
   PubMed Web of Science ®Google Scholar
• LuXLXuZLYaoXLMarine cyclotripeptide X-13 promotes angiogenesis in zebrafish and human endothelial cells via PI3K/Akt/eNOS signaling pathwaysMar Drugs2012101307132022822374
   PubMed Web of Science ®Google Scholar
• LuXLLuoDYaoXLdl-3n-Butylphthalide promotes angio-genesis via the extracellular signal-regulated kinase 1/2 and phosphati-dylinositol 3-kinase/Akt-endothelial nitric oxide synthase signaling pathwaysJ Cardiovasc Pharmacol20125935236222286127
   PubMed Web of Science ®Google Scholar
• SinghRPDhanalakshmiSAgarwalCAgarwalRSilibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapyOncogene2005241188120215558015
   PubMed Web of Science ®Google Scholar
• ParngCSengWLSeminoCMcGrathPZebrafish: a preclinical model for drug screeningAssay Drug Dev Technol20021414815090155
   PubMed Web of Science ®Google Scholar
• van MoorselaarRJVoestEEAngiogenesis in prostate cancer: its role in disease progression and possible therapeutic approachesMol Cell Endocrinol200219723925012431818
   PubMed Web of Science ®Google Scholar
• ZacharyISignaling mechanisms mediating vascular protective actions of vascular endothelial growth factorAm J Physiol Cell Physiol2001280C1375C138611350732
   PubMed Web of Science ®Google Scholar
• RobertsDMKearneyJBJohnsonJHRosenbergMPKumarRBautchVLThe vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formationAm J Pathol20041641531153515111299
   PubMed Web of Science ®Google Scholar
• MatsumotoTBohmanSDixeliusJVEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesisEMBO J2005242342235315962004
   PubMed Web of Science ®Google Scholar
• TakahashiTYamaguchiSChidaKShibuyaMA single autophos-phorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cellsEMBO J2001202768277811387210
   PubMed Web of Science ®Google Scholar
• PangXYiZZhangJCelastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathwayCancer Res2010701951195920160026
   PubMed Web of Science ®Google Scholar
• EdirisingheIYangSRYaoHVEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunctionFASEB J2008222297231018263699
   PubMed Web of Science ®Google Scholar
• CrawfordTNAlfaroDV3rdKerrisonJBJablonEPDiabetic retinopathy and angiogenesisCurr Diabetes Rev2009581319199892
   PubMedGoogle Scholar
• AlbiniASpornMBThe tumour microenvironment as a target for chemopreventionNat Rev Cancer2007713914717218951
   PubMed Web of Science ®Google Scholar
• CarmelietPJainRKAngiogenesis in cancer and other diseasesNature200040724925711001068
   PubMed Web of Science ®Google Scholar
• JingYWangGGeYXuMTangSGongZAA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cellsOnco Targets Ther201691605162127073325
   PubMed Web of Science ®Google Scholar
• JainRKdi TomasoEDudaDGLoefflerJSSorensenAGBatchelorTTAngiogenesis in brain tumoursNat Rev Neurosci2007861062217643088
   PubMed Web of Science ®Google Scholar
• GuQWangDWangXBasic fibroblast growth factor inhibits radiation-induced apoptosis of HUVECs. I. The PI3K/AKT pathway and induction of phosphorylation of BADRadiat Res200416169270215161350
   PubMed Web of Science ®Google Scholar
• Gingis-VelitskiSZetserAFlugelmanMYVlodavskyIIlanNHeparanase induces endothelial cell migration via protein kinase B/Akt activationJ Biol Chem2004279235362354115044433
   PubMed Web of Science ®Google Scholar
• KandaSMiyataYKanetakeHSmithgallTENon-receptor proteintyrosine kinases as molecular targets for antiangiogenic therapy (review)Int J Mol Med20072011312117549397
   PubMed Web of Science ®Google Scholar
• AmorosoFCapeceMRotondoAThe P2X7 receptor is a key modulator of the PI3K/GSK3beta/VEGF signaling network: evidence in experimental neuroblastomaOncogene2015345240525125619831
   PubMed Web of Science ®Google Scholar