References
- SiegelRLMillerKDJemalACancer statistics, 2018CA Cancer J Clin201868173029313949
- WasonMSColonJdasSSensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS productionNanomedicine20139455856923178284
- Ben-JosefELawrenceTSZalupskiMMRadiotherapy for locally advanced pancreatic cancerJ Clin Oncol20072530486117947742
- FasihAElbazHAHüttemannMKonskiAAZielskeSPRadiosensitization of pancreatic cancer cells by metformin through the AMPK pathwayRadiat Res20141821505924909911
- RogersJLBayehLScheuermannTHDevelopment of inhibitors of the PAS-B domain of the HIF-2α transcription factorJ Med Chem20135641739174723363003
- StegemanHSpanPNKaandersJHBussinkJImproving chemoradiation efficacy by PI3-K/AKT inhibitionCancer Treat Rev201440101182119125312653
- TaiakinaDdal PraABristowRGIntratumoral hypoxia as the genesis of genetic instability and clinical prognosis in prostate cancerAdv Exp Med Biol201477218920424272360
- KoongACMehtaVKLeQTPancreatic tumors show high levels of hypoxiaInt J Radiat Oncol Biol Phys200048491992211072146
- TongWWTongGHChenXXZhengHCWangYZHIF2α is associated with poor prognosis and affects the expression levels of survivin and cyclin D1 in gastric carcinomaInt J Oncol201546123324225338835
- PutraACEguchiHLeeKLThe A Allele at rs13419896 of EPAS1 is associated with enhanced expression and poor prognosis for non-small cell lung cancerPLoS One2015108e013449626263511
- KrakstadCChekenyaMSurvival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeuticsMol Cancer2010913520515495
- TakasakiCKobayashiMIshibashiHAkashiTOkuboKExpression of hypoxia-inducible factor-1α affects tumor proliferation and antiapoptosis in surgically resected lung cancerMol Clin Oncol201652295300
- ArditoCMGrünerBMTakeuchiKKEGF receptor is required for KRAS-induced pancreatic tumorigenesisCancer Cell201222330431722975374
- ZhaoSWangYCaoLOuelletteMMFreemanJWExpression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cellsInt J Cancer201012792076208720473902
- SivekeJTEinwächterHSiposBLubeseder-MartellatoCKlöppelGSchmidRMConcomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMNCancer Cell200712326627917785207
- JoshiSKumarSPonnusamyMPBatraSKHypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survivalOncogene201635455882589227109098
- WangGWangJJFuXLGuangRToSTAdvances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review)Oncol Rep201737265767027959421
- KimSYYangEGRecent advances in developing inhibitors for hypoxia-inducible factor prolyl hydroxylases and their therapeutic implicationsMolecules20152011205512056826610437
- TaylorMSCharacterization and comparative analysis of the EGLN gene familyGene2001275112513211574160
- García-HerediaJMFelipe-AbrioBCanoDACarneroAGenetic modification of hypoxia signaling in animal models and its effect on cancerClin Transl Oncol20151729010225351170
- HuangJZhaoQMooneySMLeeFSSequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3J Biol Chem200227742397923980012181324
- TakeiAEkströmMMammadzadaPGene transfer of prolyl hydroxylase domain 2 inhibits hypoxia-inducible angiogenesis in a model of choroidal neovascularizationSci Rep201774254628186209
- JokilehtoTJaakkolaPMThe role of HIF prolyl hydroxylases in tumour growthJ Cell Mol Med201014475877020178464
- BruickRKMcknightSLA conserved family of prolyl-4-hydroxylases that modify HIFScience200129455451337134011598268
- EpsteinACGleadleJMMcneillLAC. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylationCell20011071435411595184
- de GeusSWLEskanderMFKasumovaGGStereotactic body radiotherapy for unresected pancreatic cancer: a nationwide reviewCancer2017123214158416728708929
- SemenzaGLHypoxia-inducible factors: mediators of cancer progression and targets for cancer therapyTrends Pharmacol Sci201233420721422398146
- DaiZJGaoJMaXBUp-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cellsJ Exp Clin Cancer Res2012312822453051
- WangGLiYYangZXuWYangYTanXROS mediated EGFR/MEK/ERK/HIF-1α loop regulates glucose metabolism in pancreatic cancerBiochem Biophys Res Commun2018500487387829702094
- GarvalovBKFossFHenzeATPHD3 regulates EGFR internalization and signalling in tumoursNat Commun20145557725420589
- DopesoHJiaoHKCuestaAMPHD3 controls lung cancer metastasis and resistance to EGFR inhibitors through TGFαCancer Res20187871805181929339541
- van ValenFKentrup-LardongVTruckenbrodBRübeCWinkelmannWJürgensWWRegulation of the release of tumour necrosis factor (TNF) alpha and soluble TNF receptor by gamma irradiation and interferon gamma in Ewing’s sarcoma/peripheral primitive neuroectodermal tumour cellsJ Cancer Res Clin Oncol199712352452529201246
- FujitaNGogateSSChibaKToyamaYShapiroIMRisbudMVProlyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signalingJ Biol Chem201228747399423995322948157
- SemenzaGLHIF-1 mediates the Warburg effect in clear cell renal carcinomaJ Bioenerg Biomembr200739323123417551816
- SemenzaGLRegulation of cancer cell metabolism by hypoxia-inducible factor 1Semin Cancer Biol2009191121619114105
- ToyoshimaMAnalysis of p53 dependent damage response in sperm-irradiated mouse embryosJ Radiat Res2009501111719218778
- ZhengLTangWWeiFRadiation-inducible protein RbAp48 contributes to radiosensitivity of cervical cancer cellsGynecol Oncol2013130360160823756179
- HubbiMEGilkesDMHuHKshitizAhmedISemenzaGLCyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progressionProc Natl Acad Sci U S A201411132E3325E333425071185