miR-509-5p Downregulation Is Associated With Male Infertility And Acts As A Suppressor In Testicular Germ Cell Tumor Cells Through Targeting MDM2

References

• Kumar N, Singh AK. Trends of male factor infertility, an important cause of infertility: a review of literature. J Hum Reprod Sci. 2015;8(4):191–196. doi:10.4103/0974-1208.17037026752853
   PubMedGoogle Scholar
• Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015;13:37. doi:10.1186/s12958-015-0032-125928197
   PubMed Web of Science ®Google Scholar
• Weedin JW, Bennett RC, Fenig DM, Lamb DJ, Lipshultz LI. Early versus late maturation arrest: reproductive outcomes of testicular failure. J Urol. 2011;186(2):621–626. doi:10.1016/j.juro.2011.03.15621684558
   PubMed Web of Science ®Google Scholar
• Hung AJ, King P, Schlegel PN. Uniform testicular maturation arrest: a unique subset of men with nonobstructive azoospermia. J Urol. 2007;178(2):608–612. discussion 612. doi:10.1016/j.juro.2007.03.12517570432
   PubMed Web of Science ®Google Scholar
• Griswold MD. Spermatogenesis: the commitment to meiosis. Physiol Rev. 2016;96(1):1–17. doi:10.1152/physrev.00013.201526537427
   PubMed Web of Science ®Google Scholar
• Russell LD, Chiarini-Garcia H, Korsmeyer SJ, Knudson CM. Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol Reprod. 2002;66(4):950–958. doi:10.1095/biolreprod66.4.95011906913
   PubMed Web of Science ®Google Scholar
• Pareek TK, Joshi AR, Sanyal A, Dighe RR. Insights into male germ cell apoptosis due to depletion of gonadotropins caused by GnRH antagonists. Apoptosis. 2007;12(6):1085–1100. doi:10.1007/s10495-006-0039-317268770
   PubMed Web of Science ®Google Scholar
• Takagi S, Itoh N, Kimura M, Sasao T, Tsukamoto T. Spermatogonial proliferation and apoptosis in hypospermatogenesis associated with nonobstructive azoospermia. Fertil Steril. 2001;76(5):901–907. doi:10.1016/s0015-0282(01)02732-711704108
   PubMed Web of Science ®Google Scholar
• Steger K, Aleithe I, Behre H, Bergmann M. The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen. Mol Hum Reprod. 1998;4(3):227–233. doi:10.1093/molehr/4.3.2279570268
   PubMed Web of Science ®Google Scholar
• Reuter VE. Origins and molecular biology of testicular germ cell tumors. Mod Pathol. 2005;18(Suppl 2):S51–S60. doi:10.1038/modpathol.380030915761466
   PubMedGoogle Scholar
• Sheikine Y, Genega E, Melamed J, Lee P, Reuter VE, Ye H. Molecular genetics of testicular germ cell tumors. Am J Cancer Res. 2012;2(2):153–167.22432056
   PubMed Web of Science ®Google Scholar
• Bettegowda A, Wilkinson MF. Transcription and post-transcriptional regulation of spermatogenesis. Philosophical transactions of the Royal Society of London Series B. Biological Sciences. 2010;365(1546):1637–1651. doi:10.1098/rstb.2009.019620403875
   PubMed Web of Science ®Google Scholar
• Papaioannou MD, Nef S. microRNAs in the testis: building up male fertility. J Androl. 2010;31(1):26–33. doi:10.2164/jandrol.109.00812819875496
   PubMedGoogle Scholar
• Kotaja N. MicroRNAs and spermatogenesis. Fertil Steril. 2014;101(6):1552–1562. doi:10.1016/j.fertnstert.2014.04.02524882619
   PubMed Web of Science ®Google Scholar
• Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell. 2009;136(4):642–655. doi:10.1016/j.cell.2009.01.03519239886
   PubMed Web of Science ®Google Scholar
• Khazaie Y, Nasr Esfahani MH. MicroRNA and male infertility: a potential for diagnosis. Int J Fertil Steril. 2014;8(2):113–118.25083174
   PubMedGoogle Scholar
• Wienholds E, Koudijs MJ, van Eeden FJ, Cuppen E, Plasterk RHA. The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet. 2003;35(3):217–218. doi:10.1038/ng125114528306
   PubMed Web of Science ®Google Scholar
• Romero Y, Meikar O, Papaioannou MD, et al. Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects. PLoS One. 2011;6(10):e25241. doi:10.1371/journal.pone.002524121998645
   PubMed Web of Science ®Google Scholar
• Lian J, Tian H, Liu L, et al. Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. Cell Death Dis. 2010;1:e94. doi:10.1038/cddis.2010.7021368870
   PubMed Web of Science ®Google Scholar
• Lu M, Tian H, Cao YX, et al. Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. Cell Death Dis. 2015;6:e1960. doi:10.1038/cddis.2015.26726539909
   PubMed Web of Science ®Google Scholar
• Zhang WB, Pan ZQ, Yang QS, et al. Tumor suppressive miR-509-5p contributes to cell migration, proliferation and antiapoptosis in renal cell carcinoma. Ir J Med Sci. 2013;182(4):621–627. doi:10.1007/s11845-013-0941-y23619562
   PubMed Web of Science ®Google Scholar
• Li X, Li Y, Wan L, Chen R, Chen F. miR-509-5p inhibits cellular proliferation and migration via targeting MDM2 in pancreatic cancer cells. Onco Targets Ther. 2017;10:4455–4464. doi:10.2147/OTT.S13037828979137
   PubMed Web of Science ®Google Scholar
• Song YH, Wang J, Nie G, et al. MicroRNA-509-5p functions as an anti-oncogene in breast cancer via targeting SOD2. Eur Rev Med Pharmacol Sci. 2017;21(16):3617–3625.28925482
   PubMed Web of Science ®Google Scholar
• Ludwig N, Leidinger P, Becker K, et al. Distribution of miRNA expression across human tissues. Nucleic Acids Res. 2016;44(8):3865–3877. doi:10.1093/nar/gkw11626921406
   PubMed Web of Science ®Google Scholar
• Bar-Shira Maymon B, Yogev L, Yavetz H, et al. Spermatogonial proliferation patterns in men with azoospermia of different etiologies. Fertil Steril. 2003;80(5):1175–1180. doi:10.1016/s0015-0282(03)02161-714607570
   PubMed Web of Science ®Google Scholar
• Wang P, Deng Y, Fu X. MiR-509-5p suppresses the proliferation, migration, and invasion of non-small cell lung cancer by targeting YWHAG. Biochem Biophys Res Commun. 2017;482(4):935–941. doi:10.1016/j.bbrc.2016.11.13627894843
   PubMed Web of Science ®Google Scholar
• Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell. 2003;115(7):787–798. doi:10.1016/s0092-8674(03)01018-314697198
   PubMed Web of Science ®Google Scholar
• Freedman DA, Wu L, Levine AJ. Functions of the MDM2 oncoprotein. Cell Mol Life Sci. 1999;55(1):96–107. doi:10.1007/s00018005027310065155
   PubMed Web of Science ®Google Scholar
• Bauer S, Muhlenberg T, Leahy M, et al. Therapeutic potential of Mdm2 inhibition in malignant germ cell tumours. Eur Urol. 2010;57(4):679–687. doi:10.1016/j.eururo.2009.06.01419560254
   PubMed Web of Science ®Google Scholar
• Schlatt S, Weinbauer GF. Immunohistochemical localization of proliferating cell nuclear antigen as a tool to study cell proliferation in rodent and primate testes. Int J Androl. 1994;17(4):214–222. doi:10.1111/j.1365-2605.1994.tb01245.x7995658
   PubMedGoogle Scholar
• Salama N, Tsuji M, Tamura M, Kagawa S. Proliferating cell nuclear antigen in testes of infertile men with varicocele–preliminary results of interrelationship with sperm count before and after varicocelectomy. Scand J Urol Nephrol. 2003;37(1):48–52. doi:10.1080/0036559031000869512745744
   PubMed Web of Science ®Google Scholar
• Tanaka H, Fujisawa M, Okada H, Arakawa S, Kamidono S. Assessment of germ-cell kinetics in the testes of patients with varicocele using image analysis of immunostained proliferating cell nuclear antigen. Br J Urol. 1996;78(5):769–771. doi:10.1046/j.1464-410x.1996.19619.x8976776
   PubMedGoogle Scholar
• Bieniek JM, Drabovich AP, Lo KC. Seminal biomarkers for the evaluation of male infertility. Asian J Androl. 2016;18(3):426–433. doi:10.4103/1008-682X.17578126975492
   PubMed Web of Science ®Google Scholar
• Huang C, Liu W, Ji GX, et al. Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population. Asian J Androl. 2012;14(5):691–694. doi:10.1038/aja.2012.3922773013
   PubMed Web of Science ®Google Scholar
• Gilbert D, Rapley E, Shipley J. Testicular germ cell tumours: predisposition genes and the male germ cell niche. Nat Rev Cancer. 2011;11(4):278–288. doi:10.1038/nrc302121412254
   PubMed Web of Science ®Google Scholar
• Hotaling JM, Walsh TJ. Male infertility: a risk factor for testicular cancer. Nat Rev Urol. 2009;6(10):550–556. doi:10.1038/nrurol.2009.17919724246
   PubMed Web of Science ®Google Scholar