32
Views
5
CrossRef citations to date
0
Altmetric
Original Research

Silencing of estrogen receptor β promotes the invasion and migration of osteosarcoma cells through activating Wnt signaling pathway

, , , &
Pages 6779-6788 | Published online: 22 Aug 2019

References

  • Jackson TM, Bittman M, Granowetter L. Pediatric malignant bone tumors: a review and update on current challenges, and emerging drug targets. Curr Prob Pediatr Adolesc Health Care. 2016;46:213–228. doi:10.1016/j.cppeds.2016.04.002
  • Mirabello L, Troisi R. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the surveillance, epidemiology, and end results program. Cancer. 2010;115:1531–1543. doi:10.1002/cncr.24121
  • Mialou V, Philip T, Kalifa C, et al. Metastatic osteosarcoma at diagnosis: prognostic factors and long-term outcome–the French pediatric experience. Cancer. 2010;104:1100–1109. doi:10.1002/cncr.21263
  • Siegel HJ, Pressey JG. Current concepts on the surgical and medical management of osteosarcoma. Expert Rev Anticancer Ther. 2014;8:1257. doi:10.1586/14737140.8.8.1257
  • Guillette TC, Jackson TW, Belcher SM. Duality of estrogen receptor β action in cancer progression. Curr Opin Pharmacol. 2018;41:66–73. doi:10.1016/j.coph.2018.05.00129772419
  • Johan H, Karin E, Karolina L, et al. Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. Cancer Res. 2009;69:6100–6106. doi:10.1158/0008-5472.CAN-09-050619602591
  • Sreenivasan P, Hema P, Vaishali K, et al. Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res. 2004;64:423. doi:10.1158/0008-5472.CAN-03-244614729654
  • Shan Y, Wang X, Chan FL. Overexpression of estrogen receptor-related receptor β (ERRβ) suppresses the cell proliferation and tumor growth of androgen-dependent and -independent prostate cancer cells via induction of p21Cip1/Waf1. Cancer Res. 2006;66:779.
  • Yang M, Bing L, Jin L, et al. Estrogen receptor β exhibited anti-tumor effects on osteosarcoma cells by regulating integrin, IAP, NF-kB/BCL-2 and PI3K/Akt signal pathway. J Bone Oncol. 2017;9:S2212137417300933. doi:10.1016/j.jbo.2017.09.005
  • Zhou Y, Ming J, Xu Y, et al. ERβ1 inhibits the migration and invasion of breast cancer cells through upregulation of E-cadherin in a Id1-dependent manner. Biochem Biophys Res Commun. 2015;457:141–147. doi:10.1016/j.bbrc.2014.12.03825514034
  • Li H, Tu Z, An L, et al. Inhibitory effects of ERβ on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells–prognostication for the use of ERβ-selective therapy. Pharm Biol. 2012;50:839–849. doi:10.3109/13880209.2011.63750622486657
  • Thomas C, Rajapaksa G, Nikolos F, et al. ERβ1 represses basal-like breast cancer epithelial to mesenchymal transition by destabilizing EGFR. Breast Cancer Res. 2012;14:R148. doi:10.1186/bcr316923158001
  • Nusse R, Clevers H. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169:985. doi:10.1016/j.cell.2017.05.01628575679
  • Zhao S, Kurenbekova L, Gao Y, et al. NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 2015;34:5069. doi:10.1038/onc.2014.46225579177
  • Fan Z, Anmin C, Jianfeng C, et al. SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. Asian Pac J Cancer Prev. 2011;12:239–245.21517265
  • Chaudhary SC, Tripti S, Talwelkar SS, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res. 2014;7:186. doi:10.1158/1940-6207.CAPR-13-0276
  • Livak KJ. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))Method. METHODS. 2001;25(4):402–408. doi:10.1006/meth.2001.126211846609
  • Warner M, Huang B, Gustafsson JA. Estrogen receptor β as a pharmaceutical target. Trends Pharmacol Sci. 2017;38:92. doi:10.1016/j.tips.2017.07.00327979317
  • Alnakhle H, Burns PA, Cummings M, et al. Estrogen receptor β1 expression is regulated by miR-92 in breast cancer. Cancer Res. 2010;70:4778–4784. doi:10.1158/0008-5472.CAN-09-410420484043
  • Lazennec G. Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis. Cancer Lett. 2006;231:151–157. doi:10.1016/j.canlet.2005.01.02116399219
  • Daniels G, Gellert LL, Melamed J, et al. Decreased expression of stromal estrogen receptor α and β in prostate cancer. Am J Transl Res. 2014;6:140–146.24489993
  • Campbellthompson M, Lynch IJ, Bhardwaj B. Expression of Estrogen Receptor (ER) subtypes and ERβ isoforms in colon cancer. Cancer Res. 2001;61:632–640.11212261
  • Thomas C, Rajapaksa G, Nikolos F, et al. Abstract 1384: Estrogen receptor beta inhibits migration and invasion of breast cancer cells by regulating E-cadherin levels. Cancer Res. 2011;71:1384.
  • Tu Z, Ma Y, Tian J, et al. Estrogen receptor β potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells. J Cancer Res Clin Oncol. 2012;138:1091–1103. doi:10.1007/s00432-011-1145-322398780
  • Hui L, Zhenzhen T, Lianxiao A, et al. Inhibitory effects of ERβ on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells–prognostication for the use of ERβ-selective therapy. Pharm Biol. 2012;50:839–849. doi:10.3109/13880209.2011.63750622486657
  • Kim JH, Pyun JA, Lee KJ, et al. Study on association between single nucleotide polymorphisms of MMP7, MMP8, MMP9 genes and development of gastric cancer and lymph node metastasis. Korean J Gastroenterol. 2011;58:245. doi:10.4166/kjg.2011.58.5.24522113040
  • Hsu TI, Lin SC, Lu PS, et al. MMP7-mediated cleavage of nucleolin at Asp255 induces MMP9 expression to promote tumor malignancy. Oncogene. 2015;34:826. doi:10.1038/onc.2014.46224632608
  • Pinton G, Thomas W, Bellini P, et al. Estrogen receptor β exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib. Plos One 2010;5:e14110.
  • Zhao C, Dahlmanwright K, Gustafsson JA. Estrogen receptor β: an overview and update. Nucl Recept Signal. 2008;4:e003.
  • Dey P, Ström A, Gustafsson JÅ. Estrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene. 2013;33:4213–4225. doi:10.1038/onc.2013.38424077289