miR-939-5p Contributes to the Migration and Invasion of Pancreatic Cancer by Targeting ARHGAP4

References

• Wu J, Liu J, Wei X, et al. A feature-based analysis identifies COL1A2 as a regulator in pancreatic cancer. J Enzyme Inhib Med Chem. 2019;34:420–428. doi:10.1080/14756366.2018.148473430734598
   PubMed Web of Science ®Google Scholar
• Cao J, Zhang Y, Yang J, et al. NEAT1 regulates pancreatic cancer cell growth, invasion and migration though mircroRNA-335-5p/c-met axis. Am J Cancer Res. 2016;6:2361–2374.27822425
   PubMed Web of Science ®Google Scholar
• Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74:2913–2921. doi:10.1158/0008-5472.CAN-14-015524840647
   PubMed Web of Science ®Google Scholar
• Matsuno S, Egawa S, Fukuyama S, et al. Pancreatic cancer registry in Japan: 20 years of experience. Pancreas. 2004;28(3):219–230. doi:10.1097/00006676-200404000-0000215084961
   PubMed Web of Science ®Google Scholar
• Schnelldorfer T, Ware AL, Sarr MG, et al. Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible? Ann Surg. 2008;247:456–462. doi:10.1097/SLA.0b013e318161314218376190
   PubMed Web of Science ®Google Scholar
• Guo Q, Xiong Y, Song Y, Hua K, Gao S. ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K/AKT signaling pathway in cervical cancer. Gene. 2019;692:9–16. doi:10.1016/j.gene.2019.01.00430641218
   PubMed Web of Science ®Google Scholar
• Wu Y, Xu M, He R, Xu K, Ma Y. ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells. Oncol Rep. 2019;41(4):2281–2888. doi:10.3892/or.2019.703130816546
   PubMed Web of Science ®Google Scholar
• Dai X, Geng F, Dai J, Li M, Liu M. Rho GTPase activating protein 24 (ARHGAP24) regulates the anti-cancer activity of sorafenib against breast cancer MDA-MB-231 cells via the signal transducer and activator of transcription 3 (STAT3) signaling pathway. Med Sci Monit. 2018;24:8669–8677. doi:10.12659/MSM.91139430499465
   PubMed Web of Science ®Google Scholar
• Mao X, Tong J. ARHGAP30 suppressed lung cancer cell proliferation, migration, and invasion through inhibition of the Wnt/beta-catenin signaling pathway. Onco Targets Ther. 2018;11:7447–7457. doi:10.2147/OTT.S17525530425532
   PubMed Web of Science ®Google Scholar
• Vogt DL, Gray CD, Young WS 3rd, Orellana SA, Malouf AT. ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth. Mol Cell Neurosci. 2007;36:332–342. doi:10.1016/j.mcn.2007.07.00417804252
   PubMed Web of Science ®Google Scholar
• Huang L, Poke G, Gecz J, Gibson K. A novel contiguous gene deletion of AVPR2 and ARHGAP4 genes in male dizygotic twins with nephrogenic diabetes insipidus and intellectual disability. Am J Med Genet A. 2012;158a:2511–2518.22965914
   PubMed Web of Science ®Google Scholar
• Shen Y, Xu L, Ning Z, et al. ARHGAP4 regulates the cell migration and invasion of pancreatic cancer by the HDAC2/beta-catenin signaling pathway. Carcinogenesis. 2019;40:1405–1414. doi:10.1093/carcin/bgz06730958531
   PubMed Web of Science ®Google Scholar
• Shen Y, Chen G, Zhuang L, Xu L, Lin J, Liu L. ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1alpha signaling pathways. Onco Targets Ther. 2019;12:5003–5012. doi:10.2147/OTT.S20756031303760
   PubMed Web of Science ®Google Scholar
• Li H, He C, Wang X, Wang H, Nan G, Fang L. MicroRNA-183 affects the development of gastric cancer by regulating autophagy via MALAT1-miR-183-SIRT1 axis and PI3K/AKT/mTOR signals. Artif Cells Nanomed Biotechnol. 2019;47:3163–3171. doi:10.1080/21691401.2019.164290331352788
   PubMed Web of Science ®Google Scholar
• Liu J, Kong D, Sun D, Li J. Long non-coding RNA CCAT2 acts as an oncogene in osteosarcoma through regulation of miR-200b/VEGF. Artif Cells Nanomed Biotechnol. 2019;47:2994–3003. doi:10.1080/21691401.2019.164022931322006
   PubMed Web of Science ®Google Scholar
• Yonemori K, Kurahara H, Maemura K, Natsugoe S. MicroRNA in pancreatic cancer. J Hum Genet. 2017;62:33–40. doi:10.1038/jhg.2016.5927251005
   PubMed Web of Science ®Google Scholar
• Zhou J, Hui X, Mao Y, Fan L. Identification of novel genes associated with a poor prognosis in pancreatic ductal adenocarcinoma via a bioinformatics analysis. Biosci Rep. 2019;39(8). doi:10.1042/BSR20190625
   Google Scholar
• Su Q, Zhu EC, Qu YL, et al. Serum level of co-expressed hub miRNAs as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. J Cancer. 2018;9:3991–3999. doi:10.7150/jca.2769730410604
   PubMed Web of Science ®Google Scholar
• Fornari F, Ferracin M, Trere D, et al. Circulating microRNAs, miR-939, miR-595, miR-519d and miR-494, identify cirrhotic patients with HCC. PLoS One. 2015;10:e0141448. doi:10.1371/journal.pone.014144826509672
   PubMed Web of Science ®Google Scholar
• Chen Y, Guo Y, Yan W. lncRNA RP5-916L7.2 correlates with advanced tumor stage, and promotes cells proliferation while inhibits cells apoptosis through targeting miR-328 and miR-939 in tongue squamous cell carcinoma. Clin Biochem. 2019;67:24–32. doi:10.1016/j.clinbiochem.2019.02.01330825424
   PubMed Web of Science ®Google Scholar
• Zhang JX, Xu Y, Gao Y, et al. Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway. Mol Cancer. 2017;16:18. doi:10.1186/s12943-017-0586-y28114937
   PubMed Web of Science ®Google Scholar
• Han X, Du C, Chen Y, et al. Overexpression of miR-939-3p predicts poor prognosis and promotes progression in lung cancer. Cancer Biomark. 2019;25:325–332. doi:10.3233/CBM-19027131322549
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liu X, Li Q, Zhang Y. lncRNA LINC00460 promoted colorectal cancer cells metastasis via miR-939-5p sponging. Cancer Manag Res. 2019;11:1779–1789. doi:10.2147/CMAR.S19245230863183
   PubMed Web of Science ®Google Scholar
• Tang M, Jiang L, Lin Y, et al. Platelet microparticle-mediated transfer of miR-939 to epithelial ovarian cancer cells promotes epithelial to mesenchymal transition. Oncotarget. 2017;8:97464–97475. doi:10.18632/oncotarget.v8i5729228624
   PubMedGoogle Scholar
• Kusama T, Mukai M, Endo H, et al. Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis. Cancer Sci. 2006;97:848–853. doi:10.1111/j.1349-7006.2006.00242.x16776779
   PubMed Web of Science ®Google Scholar
• Xuehu X, Yuandong X, Zhu Z, Shuling L, Xiaobing W, Liu X. Expression and clinical significance of ARHGAP4 in colorectal cancer. J Pract Med. 2017;33:705–708.
   Google Scholar
• Belvedere R, Saggese P, Pessolano E, Memoli D, Bizzarro V, Rizzo F. miR-196a is able to restore the aggressive phenotype of annexin A1 knock-out in pancreatic cancer cells by CRISPR/Cas9 genome editing. Int J Mol Sci. 2018;19:pii: E1967.
   Web of Science ®Google Scholar
• Sun J, Jiang Z, Li Y, Wang K, Chen X, Liu G. Downregulation of miR-21 inhibits the malignant phenotype of pancreatic cancer cells by targeting VHL. Onco Targets Ther. 2019;12:7215–7226. doi:10.2147/OTT.S21153531564905
   PubMed Web of Science ®Google Scholar
• Qiu Z, Wang X, Shi Y, Da M. miR-129-5p suppresses proliferation, migration, and induces apoptosis in pancreatic cancer cells by targeting PBX3. Acta Biochim Biophys Sin. 2019;51:997–1007. doi:10.1093/abbs/gmz09631518383
   PubMedGoogle Scholar
• Wang J, Guo J, Fan H. MiR-155 regulates the proliferation and apoptosis of pancreatic cancer cells through targeting SOCS3. Eur Rev Med Pharmacol Sci. 2019;23:5168–5175. doi:10.26355/eurrev_201906_1818131298410
   PubMed Web of Science ®Google Scholar
• Yang C, Humphries B, Li Y, et al. Abstract 1468: miR-200b targets ARHGAP18 and suppresses triple negative breast cancer metastasis. Cancer Res. 2017;77:1468.
   Web of Science ®Google Scholar
• Li B, Wang L, Li Z, et al. miR-3174 contributes to apoptosis and autophagic cell death defects in gastric cancer cells by targeting ARHGAP10. Mol Ther Nucleic Acids. 2017;9:294–311. doi:10.1016/j.omtn.2017.10.00829246308
   PubMedGoogle Scholar
• Fang Y, Zhu X, Wang J, et al. MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5. Oncotarget. 2015;6:13164–13175. doi:10.18632/oncotarget.v6i1525961434
   PubMedGoogle Scholar
• Ying X, Li-ya Q, Feng Z, Yin W, Ji-hong L. MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression. Biomed Pharmacother. 2015;71:64–69. doi:10.1016/j.biopha.2015.02.02025960217
   PubMed Web of Science ®Google Scholar
• Di Modica M, Regondi V, Sandri M, et al. Breast cancer-secreted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers. Cancer Lett. 2017;384:94–100. doi:10.1016/j.canlet.2016.09.01327693459
   PubMed Web of Science ®Google Scholar
• Usuba W, Urabe F, Yamamoto Y, et al. Circulating miRNA panels for specific and early detection in bladder cancer. Cancer Sci. 2019;110:408–419. doi:10.1111/cas.1385630382619
   PubMed Web of Science ®Google Scholar
• He TL, Zhang YJ, Jiang H, Li XH, Zhu H, Zheng KL. The c-Myc-LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer. Med Oncol. 2015;32:187. doi:10.1007/s12032-015-0633-826021472
   PubMed Web of Science ®Google Scholar
• Sun Q, Chen X, Ma J, et al. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A. 2011;108:4129–4134. doi:10.1073/pnas.101476910821325052
   PubMed Web of Science ®Google Scholar