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Original Research

DUB3 Facilitates Growth and Inhibits Apoptosis Through Enhancing Expression of EZH2 in Oral Squamous Cell Carcinoma

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Pages 1447-1460 | Published online: 18 Feb 2020

References

  • Yang MD, Chang WS, Tsai CW, et al. Inhibitory effects of AVEMAR on proliferation and metastasis of oral cancer cells. Nutr. Cancer. 2016;68(3):473–480. doi:10.1080/01635581.2016.115366827007465
  • Pan L, Yang H, Xu C, et al. ZNF750 inhibited the malignant progression of oral squamous cell carcinoma by regulating tumor vascular microenvironment. Biomed Pharmacother. 2018;105:566. doi:10.1016/j.biopha.2018.06.00129890464
  • Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90. doi:10.3322/caac.v61:221296855
  • Sieviläinen M, Almahmoudi R, Al‐Samadi A, et al. The prognostic value of immune checkpoints in oral squamous cell carcinoma. Oral Dis. 2018;25(6):1435–45.30315712
  • Warnakulasuriya S. Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival. Oral Oncol. 2010;46(6):407–410. doi:10.1016/j.oraloncology.2010.02.01520403722
  • Komander D, Rape M. The ubiquitin code. Annu Rev Biochem. 2012;81:203–229. doi:10.1146/annurev-biochem-060310-17032822524316
  • Chen X, Wu J, Chen Y, et al. Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma. Int J Biochem Cell Biol. 2016;79:350–359. doi:10.1016/j.biocel.2016.08.03827592452
  • Maspero E, Polo S, In vitro ubiquitination: self-ubiquitination, chain formation, and substrate ubiquitination assays. 2016.
  • Liu F, Fu Q, Li Y, et al. USP21 modulates Goosecoid function through deubiquitination. Biosci Rep. 2019;39(7):BSR20182148. doi:10.1042/BSR2018214831253698
  • Mj MG, Rascle A, Humbert M, et al. DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. J Bio Chem. 2004;279(14):13993–14000. doi:10.1074/jbc.M31129120014699124
  • Hu B, Deng T, Ma H, et al. Deubiquitinase DUB3 regulates cell cycle progression via stabilizing cyclin A for proliferation of non-small cell lung cancer cells. Cells. 2019;8(4):297. doi:10.3390/cells8040297
  • Zhang Q, Zhang Z, Du H, et al. DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer. Cell Death Differ. 2019;26(11):2300–13.30778200
  • Zhang S, Yuan J, Zheng R. Suppression of ubiquitin-specific peptidase 17 (USP17) inhibits tumorigenesis and invasion in non-small cell lung cancer cells. Oncol Res Featuring Preclinical Clin Cancer Ther. 2016;24(4):263–269. doi:10.3727/096504016X14666990347392
  • Wu Y, Wang Y, Lin Y, et al. Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation. Nat Commun. 2017;8:14228. doi:10.1038/ncomms1422828198361
  • Grunstein M. Histone acetylation in chromatin structure and transcription. Nature. 1997;389(6649):349–352. doi:10.1038/386649311776
  • Khoueiry P, Gahlawat AW, Petretich M, et al. BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity. Epigenetics Chromatin. 2019;12(1):39. doi:10.1186/s13072-019-0286-531266503
  • Chen R, Yik JH, Lew QJ, et al. Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer. Biomed Res Int. 2014;2014.
  • Denis GV, Green MR. A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. Genes Dev. 1996;10(3):261–271. doi:10.1101/gad.10.3.2618595877
  • Andrieu G, Tran AH, Strissel KJ, et al. BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling. Cancer Res. 2016;76(22):6555–6567. doi:10.1158/0008-5472.CAN-16-055927651315
  • Ba M, Long H, Yan Z, et al. BRD4 promotes gastric cancer progression through the transcriptional and epigenetic regulation of c‐MYC. J Cell Biochem. 2018;119(1):973–982. doi:10.1002/jcb.2626428681984
  • Hu Y, Zhou J, Ye F, et al. BRD4 inhibitor inhibits colorectal cancer growth and metastasis. Int J Mol Sci. 2015;16(1):1928–1948. doi:10.3390/ijms1601192825603177
  • Lou X, Zhu H, Ning L, et al. EZH2 regulates intestinal inflammation and necroptosis through the JNK signaling pathway in intestinal epithelial cells. Dig Dis Sci. 2019;64:1–10.30232636
  • Madani GK, Rad A, Molavi M, et al. Predicting the correlation of EZH2 and cancer stem cell markers in esophageal squamous cell carcinoma. J Gastrointest Cancer. 2018;49(4):437–441. doi:10.1007/s12029-017-9985-y28681114
  • Xu J, Wang Z, Lu W, et al. EZH2 promotes gastric cancer cells proliferation by repressing p21 expression. Pathol Res Pract. 2019;215:152374. doi:10.1016/j.prp.2019.03.00330952377
  • Zhou L, Wei E, Zhou B, et al. Anti-proliferative benefit of curcumol on human bladder cancer cells via inactivating EZH2 effector. Biomed Pharmacother. 2018;104:798–805. doi:10.1016/j.biopha.2018.05.10129852354
  • Shahabipour F, Caraglia M, Majeed M, et al. Naturally occurring anti-cancer agents targeting EZH2. Cancer Lett. 2017;400:325–335. doi:10.1016/j.canlet.2017.03.02028323035
  • Shih C, Chang Y, Huang W, et al. EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis. Oncogene. 2017;36(47):6542. doi:10.1038/onc.2017.26228759046
  • Tan T, Zimmermann M, Reichert AS. Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination. Biol Chem. 2016;397(7):637–647. doi:10.1515/hsz-2016-012527145142
  • McFarlane C, Kelvin AA, de la Vega M, et al. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. Cancer Res. 2010;70(8):3329–3339. doi:10.1158/0008-5472.CAN-09-415220388806
  • Yildirim N, Kocal GC, Isik Z, et al. Ubiquitin–proteasome axis, especially ubiquitin-specific protease-17 (USP17) gene family, is a potential target for epithelial–mesenchymal transition in high-grade serous ovarian cancer. Reprod Sci. 2019;26(6):794–805. doi:10.1177/193371911879918930198418
  • Song C, Liu W, Li J. USP17 is upregulated in osteosarcoma and promotes cell proliferation, metastasis, and epithelial–mesenchymal transition through stabilizing SMAD4. Tumor Bio. 2017;39(7):1010428317717138. doi:10.1177/1010428317717138
  • Burrows JF, Kelvin AA, McFarlane C, et al. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. J Bio Chem. 2009;284(14):9587–9595. doi:10.1074/jbc.M80721620019188362
  • Wang J, Cheng P, Pavlyukov MS, et al. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2017;127(8):3075–3089. doi:10.1172/JCI8909228737508
  • Yamagishi M, Uchimaru K. Targeting EZH2 in cancer therapy. Curr Opin Oncol. 2017;29(5):375–381. doi:10.1097/CCO.000000000000039028665819
  • Song H, Liu Y, Jin X, et al. Long non‐coding RNA LINC01535 promotes cervical cancer progression via targeting the miR‐214/EZH2 feedback loop. J Cell Mol Med. 2019;23:6098–6111. doi:10.1111/jcmm.v23.931273925
  • Di W, Weinan X, Xin L, et al. Long noncoding RNA SNHG14 facilitates colorectal cancer metastasis through targeting EZH2-regulated EPHA7. Cell Death Dis. 2019;10(7):514. doi:10.1038/s41419-019-1707-x31273190
  • Liu Y, Peng J, Sun T, et al. Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis. Proc National Acad Sci. 2017;114(19):E3796–E3805. doi:10.1073/pnas.1700909114
  • Shen G, Jiang M, Pu J. Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo. Biochem Biophys Res Commun. 2018;495(1):567–573. doi:10.1016/j.bbrc.2017.11.06229133261
  • Tan Y, Wang L, Du Y, et al. Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression. Int J Oncol. 2018;53(6):2503–2517. doi:10.3892/ijo.2018.457730272279
  • Zou Z, Huang B, Wu X, et al. Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA. Oncogene. 2014;33(18):2395. doi:10.1038/onc.2013.17923686307
  • Jin X, Yan Y, Wang D, et al. DUB3 promotes BET inhibitor resistance and cancer progression by deubiquitinating BRD4. Mol Cell. 2018;71(4):592–605. e4. doi:10.1016/j.molcel.2018.06.03630057199
  • Athamneh K, El Hasasna H, Al Samri H, et al. Rhus coriaria increases protein ubiquitination, proteasomal degradation and triggers non-canonical Beclin-1-independent autophagy and apoptotic cell death in colon cancer cells. Sci Rep. 2017;7(1):11633. doi:10.1038/s41598-017-11202-328912474
  • Wu X, Liu D, Tao D, et al. BRD4 regulates EZH2 transcription through upregulation of C-MYC and represents a novel therapeutic target in bladder cancer. Mol Cancer Ther. 2016;15(5):1029–1042. doi:10.1158/1535-7163.MCT-15-075026939702