Omega-3PUFA Attenuates MNU-Induced Colorectal Cancer in Rats by Blocking PI3K/AKT/Bcl-2 Signaling

References

• Jideh B, Bourke MJ. Colorectal cancer screening reduces incidence, mortality and morbidity. Med J Aust. 2018;208(11):483–484. doi:10.5694/mja2.2018.208.issue-1129902408
   PubMed Web of Science ®Google Scholar
• Mansouri D. Lower morbidity and improved outcomes in patients with screen-detected colorectal cancer. Rev Esp Enferm Dig. 2017;109(7):483–484. doi:10.17235/reed.2017.5107/201728648086
   PubMed Web of Science ®Google Scholar
• Bailon-cuadrado M, Perez-saborido B, Sanchez-gonzalez J, et al. Prognostic Nutritional Index predicts morbidity after curative surgery for colorectal cancer. Cir Esp. 2019;97(2):71–80. doi:10.1016/j.ciresp.2018.08.01530583791
   PubMed Web of Science ®Google Scholar
• Giudetti AM, Cagnazzo R. Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. Prostaglandins Other Lipid Mediat. 2012;99(3–4):57–67. doi:10.1016/j.prostaglandins.2012.09.00623064030
   PubMed Web of Science ®Google Scholar
• Altenburg JD, Siddiqui RA. Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells. Mol Cancer Res. 2009;7(7):1013–1020. doi:10.1158/1541-7786.MCR-08-038519567784
   PubMed Web of Science ®Google Scholar
• Saedisomeolia A, Wood LG, Garg ML, et al. Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells. Br J Nutr. 2009;101(4):533–540. doi:10.1017/S000711450802579818631417
   PubMed Web of Science ®Google Scholar
• Sonestedt E, Ericson U, Gullberg B, et al. Do both heterocyclic amines and omega-6 polyunsaturated fatty acids contribute to the incidence of breast cancer in postmenopausal women of the Malmo diet and cancer cohort? Int J Cancer. 2008;123(7):1637–1643. doi:10.1002/ijc.2339418636564
   PubMed Web of Science ®Google Scholar
• Jia HJ, Zhang PJ, Liu YL, et al. Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer. World J Gastroenterol. 2016;22(8):2524–2532. doi:10.3748/wjg.v22.i8.252426937140
   PubMed Web of Science ®Google Scholar
• Serini S, Cassano R, Corsetto PA, et al. Omega-3 PUFA loaded in resveratrol-based solid lipid nanoparticles: physicochemical properties and antineoplastic activities in human colorectal cancer cells in vitro. Int J Mol Sci. 2018;19(2):586. doi:10.3390/ijms19020586
   PubMed Web of Science ®Google Scholar
• Corsetto PA, Colombo I, Kopecka J, et al. Omega-3 long chain polyunsaturated fatty acids as sensitizing agents and multidrug resistance revertants in cancer therapy. Int J Mol Sci. 2017;18(12):2770. doi:10.3390/ijms18122770
   PubMed Web of Science ®Google Scholar
• Zhu S, Lin G, Song C, et al. RA and omega-3 PUFA co-treatment activates autophagy in cancer cells. Oncotarget. 2017;8(65):109135–109150. doi:10.18632/oncotarget.2262929312596
   PubMedGoogle Scholar
• Aglago EK, Huybrechts I, Murphy N, et al. Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large european cohort. Clin Gastroenterol Hepatol. 2019;18:654–666.e6.31252190
   PubMed Web of Science ®Google Scholar
• Miccadei S, Masella R, Mileo AM, et al. Omega3 polyunsaturated fatty acids as immunomodulators in colorectal cancer: new potential role in adjuvant therapies. Front Immunol. 2016;7:486. doi:10.3389/fimmu.2016.0048627895640
   PubMed Web of Science ®Google Scholar
• Song M, Nishihara R, Wu K, et al. Marine omega-3 polyunsaturated fatty acids and risk of colorectal cancer according to microsatellite instability. J Natl Cancer Inst. 2015;107(4). doi:10.1093/jnci/djv007
   Google Scholar
• Huang Q, Wen J, Chen G, et al. Omega-3 polyunsaturated fatty acids inhibited tumor growth via preventing the decrease of genomic DNA methylation in colorectal cancer rats. Nutr Cancer. 2016;68(1):113–119. doi:10.1080/01635581.2016.111552626771229
   PubMed Web of Science ®Google Scholar
• Huang H, Jiang Y, Wang Y, et al. miR-5100 promotes tumor growth in lung cancer by targeting Rab6. Cancer Lett. 2015;362(1):15–24. doi:10.1016/j.canlet.2015.03.00425754817
   PubMed Web of Science ®Google Scholar
• Ghadban T, Reeh M, Bockhorn M, et al. Decentralized colorectal cancer care in Germany over the last decade is associated with high in-hospital morbidity and mortality. Cancer Manag Res. 2019;11:2101–2107. doi:10.2147/CMAR.S19786530881134
   PubMed Web of Science ®Google Scholar
• Chen GC, Qin LQ, Lu DB, et al. N-3 polyunsaturated fatty acids intake and risk of colorectal cancer: meta-analysis of prospective studies. Cancer Causes Control. 2015;26(1):133–141. doi:10.1007/s10552-014-0492-125416450
   PubMed Web of Science ®Google Scholar
• Ilag LL. Are long-chain polyunsaturated fatty acids the link between the immune system and the microbiome towards modulating cancer? Medicines (Basel). 2018;5(3):E102.30201858
   PubMedGoogle Scholar
• Michalak A, Mosinska P, Fichna J. Polyunsaturated fatty acids and their derivatives: therapeutic value for inflammatory, functional gastrointestinal disorders, and colorectal cancer. Front Pharmacol. 2016;7:459. doi:10.3389/fphar.2016.0045927990120
   PubMed Web of Science ®Google Scholar
• Khaddaj-mallat R, Morin C, Rousseau E. Novel n-3 PUFA monoacylglycerides of pharmacological and medicinal interest: anti-inflammatory and anti-proliferative effects. Eur J Pharmacol. 2016;792:70–77. doi:10.1016/j.ejphar.2016.10.03827818127
   PubMed Web of Science ®Google Scholar
• Nindrea RD, Aryandono T, Lazuardi L, et al. Association of dietary intake ratio of n-3/n-6 polyunsaturated fatty acids with breast cancer risk in western and asian countries: a meta-analysis. Asian Pac J Cancer Prev. 2019;20(5):1321–1327. doi:10.31557/APJCP.2019.20.5.132131127884
   PubMedGoogle Scholar
• Rahmani B, Hamedi Asl D, Naserpour Farivar T, et al. Omega-3 PUFA alters the expression level but not the methylation pattern of the WIF1 gene promoter in a pancreatic cancer cell line (MIA PaCa-2). Biochem Genet. 2019;57(4):477–486. doi:10.1007/s10528-018-9895-030649640
   PubMed Web of Science ®Google Scholar
• Luu HN, Cai H, Murff HJ, et al. A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk. Int J Cancer. 2018;143(9):2225–2237. doi:10.1002/ijc.v143.929905376
   PubMed Web of Science ®Google Scholar
• Gueraud F, Tache S, Steghens JP, et al. Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats. Free Radic Biol Med. 2015;83:192–200. doi:10.1016/j.freeradbiomed.2015.02.02325744414
   PubMed Web of Science ®Google Scholar
• Ahmed HH, Aglan HA, Zaazaa AM, et al. Quercetin confers tumoricidal activity through multipathway mechanisms in A N-methylnitrosourea rat model of colon cancer. Asian Pac J Cancer Prev. 2016;17(11):4991–4998. doi:10.22034/APJCP.2016.17.11.499128032729
   PubMedGoogle Scholar
• Perse M, Cerar A, Injac R, et al. N-methylnitrosourea induced breast cancer in rat, the histopathology of the resulting tumours and its drawbacks as a model. Pathol Oncol Res. 2009;15(1):115–121. doi:10.1007/s12253-008-9117-x18985443
   PubMed Web of Science ®Google Scholar
• Ahmed HH, El-abhar HS, Hassanin EAK, et al. Ginkgo biloba L. leaf extract offers multiple mechanisms in bridling N-methylnitrosourea - mediated experimental colorectal cancer. Biomed Pharmacother. 2017;95:387–393. doi:10.1016/j.biopha.2017.08.10328858737
   PubMed Web of Science ®Google Scholar
• Nasehi M, Torabinejad S, Hashemi M, et al. Effect of cholestasis and NeuroAid treatment on the expression of Bax, Bcl-2, Pgc-1alpha and Tfam genes involved in apoptosis and mitochondrial biogenesis in the striatum of male rats. Metab Brain Dis. 2019;35:183–192.31773435
   PubMed Web of Science ®Google Scholar
• Anantram A, Degani M. Targeting cancer’s Achilles’ heel: role of BCL-2 inhibitors in cellular senescence and apoptosis. Future Med Chem. 2019;11(17):2287–2312. doi:10.4155/fmc-2018-036631581912
   PubMed Web of Science ®Google Scholar
• Wang J, Li X. Chamaejasmine induces apoptosis in human non-small-cell lung cancer A549 cells through increasing the Bax/Bcl-2 ratio, caspase-3 and activating the Fas/FasL. Minerva Med. 2019. doi:10.23736/S0026-4806.19.06209-8
   Web of Science ®Google Scholar
• Liu S, Wang H, Mu J, et al. MiRNA-211 triggers an autophagy-dependent apoptosis in cervical cancer cells: regulation of Bcl-2. Naunyn Schmiedebergs Arch Pharmacol. 2019;393:359–370.31637455
   PubMed Web of Science ®Google Scholar
• Chen XY, Chen Y, Qu CJ, et al. Vitamin C induces human melanoma A375 cell apoptosis via Bax- and Bcl-2-mediated mitochondrial pathways. Oncol Lett. 2019;18(4):3880–3886. doi:10.3892/ol.2019.1068631516599
   PubMed Web of Science ®Google Scholar
• Qin XY, Wang YN, Liu HF, et al. Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis. Metallomics. 2019;12:92–103.
   Web of Science ®Google Scholar
• Zhang C, Yu H, Shen Y, et al. Polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway. Arch Med Sci. 2015;11(5):1081–1094. doi:10.5114/aoms.2015.5486526528354
   PubMed Web of Science ®Google Scholar
• Wei Z, Lyu B, Hou D, et al. Mir-5100 mediates proliferation, migration and invasion of oral squamous cell carcinoma cells via targeting SCAI. J Invest Surg. 2019; 1–8. doi:10.1080/08941939.2019.1637484
   Web of Science ®Google Scholar
• Zhang JJ, Xu WR, Chen B, et al. The up-regulated lncRNA DLX6-AS1 in colorectal cancer promotes cell proliferation, invasion and migration via modulating PI3K/AKT/mTOR pathway. Eur Rev Med Pharmacol Sci. 2019;23(19):8321–8331. doi:10.26355/eurrev_201910_1914331646562
   PubMed Web of Science ®Google Scholar
• Wen S, Sun L, An R, et al. A combination of Citrus reticulata peel and black tea inhibits migration and invasion of liver cancer via PI3K/AKT and MMPs signaling pathway. Mol Biol Rep. 2019;47:507–519.31673889
   PubMed Web of Science ®Google Scholar
• Chen T, Yu Q, Xin L, et al. Circular RNA circC3P1 restrains kidney cancer cell activity by regulating miR-21/PTEN axis and inactivating PI3K/AKT and NF- kB pathways. J Cell Physiol. 2019;235:4001–4010.31643094
   PubMed Web of Science ®Google Scholar
• Wei X, Jia Y, Lou H, et al. Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway. Oncol Rep. 2019;42(6):2768–2776. doi:10.3892/or.2019.737031638241
   PubMed Web of Science ®Google Scholar
• Jia X, Wen Z, Sun Q, et al. Apatinib suppresses the proliferation and apoptosis of gastric cancer cells via the PI3K/Akt signaling pathway. J BUON. 2019;24(5):1985–1991.31786865
   PubMed Web of Science ®Google Scholar
• Wu YJ, Lin SH, Din ZH, et al. Sinulariolide inhibits gastric cancer cell migration and invasion through downregulation of the EMT process and suppression of FAK/PI3K/AKT/mTOR and MAPKs signaling pathways. Mar Drugs. 2019;17(12):668. doi:10.3390/md17120668
   PubMed Web of Science ®Google Scholar
• Zhang XQ, Yao C, Bian WH, et al. Effects of Astragaloside IV on treatment of breast cancer cells execute possibly through regulation of Nrf2 via PI3K/AKT/mTOR signaling pathway. Food Sci Nutr. 2019;7(11):3403–3413. doi:10.1002/fsn3.115431762993
   PubMed Web of Science ®Google Scholar
• Yang JH, Yu K, Si XK, et al. Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway. J Cancer. 2019;10(25):6431–6438. doi:10.7150/jca.3269131772676
   PubMed Web of Science ®Google Scholar
• Reddy D, Kumavath R, Ghosh P, et al. Lanatoside C induces G2/M cell cycle arrest and suppresses cancer cell growth by attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways. Biomolecules. 2019;9(12):792. doi:10.3390/biom9120792
   PubMed Web of Science ®Google Scholar
• Zhang L, Jiang B, Zhu N, et al. Mitotic checkpoint kinase Mps1/TTK predicts prognosis of colon cancer patients and regulates tumor proliferation and differentiation via PKCalpha/ERK1/2 and PI3K/Akt pathway. Med Oncol. 2019;37(1):5. doi:10.1007/s12032-019-1320-y31720873
   PubMed Web of Science ®Google Scholar