Berberine Inhibits the Apoptosis-Induced Metastasis by Suppressing the iPLA2/LOX-5/LTB4 Pathway in Hepatocellular Carcinoma

References

• Tao YM, Liu Z, Liu HL. Dickkopf-1 (DKK1) promotes invasion and metastasis of hepatocellular carcinoma. Dig Liver Dis. 2013;45(3):251–257. doi:10.1016/j.dld.2012.10.02023266194
   PubMedGoogle Scholar
• Zhang Y, Shi ZL, Yang X, Yin ZF. Targeting of circulating hepatocellular carcinoma cells to prevent postoperative recurrence and metastasis. World J Gastroenterol. 2014;20(1):142–147. doi:10.3748/wjg.v20.i1.14224415867
   PubMed Web of Science ®Google Scholar
• Yang Y, Nagano H, Ota H, et al. Patterns and clinicopathologic features of extrahepatic recurrence of hepatocellular carcinoma after curative resection. Surgery. 2007;141(2):196–202. doi:10.1016/j.surg.2006.06.03317263976
   PubMed Web of Science ®Google Scholar
• Wang L, Yao M, Dong Z, Zhang Y, Yao D. Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring. Tumour Biol. 2014;35(1):9–20. doi:10.1007/s13277-013-1141-024006223
   PubMedGoogle Scholar
• Huang Q, Li F, Liu X, et al. Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med. 2011;17(7):860–866. doi:10.1038/nm.238521725296
   PubMed Web of Science ®Google Scholar
• Li F, Huang Q, Chen J, et al. Apoptotic cells activate the “phoenix rising” pathway to promote wound healing and tissue regeneration. Sci Signal. 2010;3(110):ra13. doi:10.1126/scisignal.200063420179271
   PubMed Web of Science ®Google Scholar
• Yom SS. Accelerated repopulation as a cause of radiation treatment failure in non-small cell lung cancer: review of current data and future clinical strategies. Semin Radiat Oncol. 2015;25(2):93–99. doi:10.1016/j.semradonc.2014.12.00225771413
   PubMed Web of Science ®Google Scholar
• Zhao Y, Cui L, Pan Y, et al. Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer. Cell Prolif. 2017;50(6):e12393. doi:10.1111/cpr.12393
   PubMed Web of Science ®Google Scholar
• Cui L, Zhao Y, Pan Y, et al. Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway. Onco Targets Ther. 2017;10:5817–5826. doi:10.2147/OTT.S15045629263678
   PubMed Web of Science ®Google Scholar
• Liaras K, Fesatidou M, Geronikaki A. Thiazoles and thiazolidinones as COX/LOX inhibitors. Molecules. 2018;23(3):685.
   PubMed Web of Science ®Google Scholar
• P JJ, Manju SL, Ethiraj KR, Elias G. Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: a structure-based approach. Eur J Pharm Sci. 2018;121:356–381. doi:10.1016/j.ejps.2018.06.00329883727
   PubMed Web of Science ®Google Scholar
• Fisher JC, Gander JW, Haley MJ, et al. Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor. Vasc Cell. 2011;3(1):22. doi:10.1186/2045-824X-3-2221978392
   PubMedGoogle Scholar
• Su JL, Shih JY, Yen ML, et al. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res. 2004;64(2):554–564. doi:10.1158/0008-5472.CAN-03-130114744769
   PubMed Web of Science ®Google Scholar
• Koehne CH, Dubois RN. COX-2 inhibition and colorectal cancer. Semin Oncol. 2004;31(2 Suppl 7):12–21. doi:10.1053/j.seminoncol.2004.03.041
   PubMed Web of Science ®Google Scholar
• Mandal P, Kundu BK, Vyas K, et al. Ruthenium(ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines. Dalton Trans. 2018;47(2):517–527. doi:10.1039/C7DT3637J29235601
   PubMed Web of Science ®Google Scholar
• Cox TR, Gartland A, Erler JT. Lysyl oxidase, a targetable secreted molecule involved in cancer metastasis. Cancer Res. 2016;76(2):188–192. doi:10.1158/0008-5472.CAN-15-230626732355
   PubMed Web of Science ®Google Scholar
• Cox TR, Rumney RMH, Schoof EM, et al. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature. 2015;522(7554):106–110. doi:10.1038/nature1449226017313
   PubMed Web of Science ®Google Scholar
• Matsuyama M, Yoshimura R, Tsuchida K, et al. Lipoxygenase inhibitors prevent urological cancer cell growth. Int J Mol Med. 2004;13(5):665–668.15067367
   PubMed Web of Science ®Google Scholar
• Tong WG, Ding XZ, Witt RC, Adrian TE. Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. Mol Cancer Ther. 2002;1(11):929–935.12481414
   PubMed Web of Science ®Google Scholar
• Ihara A, Wada K, Yoneda M, Fujisawa N, Takahashi H, Nakajima A. Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. J Pharmacol Sci. 2007;103(1):24–32. doi:10.1254/jphs.FP006065117220595
   PubMed Web of Science ®Google Scholar
• Li J, Li O, Kan M, et al. Berberine induces apoptosis by suppressing the arachidonic acid metabolic pathway in hepatocellular carcinoma. Mol Med Rep. 2015;12(3):4572–4577. doi:10.3892/mmr.2015.392626081696
   PubMed Web of Science ®Google Scholar
• Teschendorf P, Vogel P, Wippel A, et al. The effect of intracerebroventricular application of the caspase-3 inhibitor zDEVD-FMK on neurological outcome and neuronal cell death after global cerebral ischaemia due to cardiac arrest in rats. Resuscitation. 2008;78(1):85–91. doi:10.1016/j.resuscitation.2008.02.01018455860
   PubMed Web of Science ®Google Scholar
• Gdynia G, Grund K, Eckert A, et al. Basal caspase activity promotes migration and invasiveness in glioblastoma cells. Mol Cancer Res. 2007;5(12):1232–1240. doi:10.1158/1541-7786.MCR-07-034318171980
   PubMed Web of Science ®Google Scholar
• Zhao Y, He M, Cui L, et al. Chemotherapy exacerbates ovarian cancer cell migration and cancer stem cell-like characteristics through GLI1. Br J Cancer. 2020. doi:10.1038/s41416-020-0825-7
   Web of Science ®Google Scholar
• Miller BW, Morton JP, Pinese M, et al. Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Mol Med. 2015;7(8):1063–1076. doi:10.15252/emmm.20140482726077591
   PubMed Web of Science ®Google Scholar