117
Views
45
CrossRef citations to date
0
Altmetric
Original Research

Circ-PRKDC Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells by Regulating miR-375/FOXM1 Axis and Wnt/β-Catenin Pathway

, , & ORCID Icon
Pages 5939-5953 | Published online: 23 Jun 2020

References

  • Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. doi:10.3322/caac.2149230207593
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7–30. doi:10.3322/caac.2133226742998
  • Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, Phase 3 trial. Lancet Oncol. 2013;14:1208–1215. doi:10.1016/S1470-2045(13)70447-924120480
  • Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3(5):330–338. doi:10.1038/nrc107412724731
  • Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med. 2005;352(5):476–487. doi:10.1056/NEJMra04095815689586
  • Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014;56(1):55–66. doi:10.1016/j.molcel.2014.08.01925242144
  • Huang X, Li Z, Zhang Q, et al. Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression. Mol Cancer. 2019;18(1):71. doi:10.1186/s12943-019-0969-330927924
  • Zhou Y, Zheng X, Xu B, et al. Circular RNA hsa_circ_0004015 regulates the proliferation, invasion, and TKI drug resistance of non-small cell lung cancer by miR-1183/PDPK1 signaling pathway. Biochem Biophys Res Commun. 2019;508(2):527–535. doi:10.1016/j.bbrc.2018.11.15730509491
  • Abu N, Hon KW, Jeyaraman S, et al. Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer. Epigenomics. 2019;11(8):875–884. doi:10.2217/epi-2019-004231020847
  • Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014;15:509–524. doi:10.1038/nrm383825027649
  • Sun L, Fang Y, Wang X, et al. miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44. Theranostics. 2019;9:8409–8425. doi:10.7150/thno.3660531754405
  • Liang H, Xu Y, Zhang Q, et al. MiR-483-3p regulates oxaliplatin resistance by targeting FAM171B in human colorectal cancer cells. Artif Cells Nanomed Biotechnol. 2019;47:725–736. doi:10.1080/21691401.2019.156953030861353
  • Wang Y, Lieberman R, Pan J, et al. miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. Mol Cancer. 2016;15:70. doi:10.1186/s12943-016-0556-927832783
  • Fu H, Fu L, Xie C, et al. miR-375 inhibits cancer stem cell phenotype and tamoxifen resistance by degrading HOXB3 in human ER-positive breast cancer. Oncol Rep. 2017;37:1093–1099. doi:10.3892/or.2017.536028075453
  • Shen Y, Wang P, Li Y, et al. miR-375 is upregulated in acquired paclitaxel resistance in cervical cancer. Br J Cancer. 2013;109:92–99. doi:10.1038/bjc.2013.30823778521
  • Cui F, Wang S, Lao I, et al. miR-375 inhibits the invasion and metastasis of colorectal cancer via targeting SP1 and regulating EMT-associated genes. Oncol Rep. 2016;36:487–493. doi:10.3892/or.2016.483427222350
  • Katoh M, Katoh M. Human FOX gene family (Review). Int J Oncol. 2004;25:1495–1500.15492844
  • Halasi M, Gartel AL. Targeting FOXM1 in cancer. Biochem Pharmacol. 2013;85:644–652. doi:10.1016/j.bcp.2012.10.01323103567
  • Lin JZ, Wang WW, Hu TT, et al. FOXM1 contributes to docetaxel resistance in castration-resistant prostate cancer by inducing AMPK/mTOR-mediated autophagy. Cancer Lett. 2020;469:481–489. doi:10.1016/j.canlet.2019.11.01431738958
  • Liu C, Shi J, Li Q, et al. STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer. Clin Sci (Lond). 2019;133:645–663. doi:10.1042/CS2018081630782607
  • Li D, Ye L, Lei Y, et al. Downregulation of FoxM1 sensitizes nasopharyngeal carcinoma cells to cisplatin via inhibition of MRN-ATM-mediated DNA repair. BMB Rep. 2019;52:208–213. doi:10.5483/BMBRep.2019.52.3.249.30638177
  • Varghese V, Magnani L, Harada-Shoji N, et al. FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression. Sci Rep. 2019;9:1505. doi:10.1038/s41598-018-38017-030728402
  • Meng X, Fu R. miR-206 regulates 5-FU resistance by targeting Bcl-2 in colon cancer cells. Onco Targets Ther. 2018;11:1757–1765. doi:10.2147/OTT.S15909329636622
  • Gillet JP, Gottesman MM. Mechanisms of Multidrug Resistance in Cancer. Multi-Drug Resistance in Cancer. Springer; 2010:47–76.
  • Hua X, Sun Y, Chen J, et al. Circular RNAs in drug resistant tumors. Biomed Pharmacother. 2019;118:109233. doi:10.1016/j.biopha.2019.10923331351436
  • Liu YY, Zhang LY, Du WZ. Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through regulates ZEB1 expression by sponging miR-124-3p. Biosci Rep. 2019;39. doi:10.1042/BSR20193045.
  • Yan L, Liu G, Cao H, et al. Hsa_circ_0035483 sponges hsa-miR-335 to promote the gemcitabine-resistance of human renal cancer cells by autophagy regulation. Biochem Biophys Res Commun. 2019;519:172–178. doi:10.1016/j.bbrc.2019.08.09331492499
  • Jin C, Wang A, Liu L, et al. Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR-136/SH2B1 axis. J Cell Physiol. 2019;234:7247–7256. doi:10.1002/jcp.2748230370521
  • Kulcheski FR, Christoff AP, Margis R. Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol. 2016;238:42–51. doi:10.1016/j.jbiotec.2016.09.01127671698
  • Li X, Yang B, Ren H, et al. Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p. Cell Death Dis. 2019;10:953. doi:10.1038/s41419-019-2180-231844042
  • Yu W, Peng W, Sha H, et al. Hsa_circ_0003998 promotes chemoresistance via modulation of miR-326 in lung adenocarcinoma cells. Oncol Res. 2019;27:623–628. doi:10.3727/096504018X1542073482805830764896
  • Ward A, Balwierz A, Zhang JD, et al. Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene. 2013;32:1173–1182. doi:10.1038/onc.2012.12822508479
  • Xu X, Chen X, Xu M, et al. miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells. Aging (Albany NY). 2019;11:7357–7385. doi:10.18632/aging.10221431543507
  • Xu F, Ye ML, Zhang YP, et al. MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer. Cancer Sci. 2020;2:1–14. doi:10.1111/cas.14356
  • Liu X, Xie T, Mao X, et al. MicroRNA-149 increases the sensitivity of colorectal cancer cells to 5-Fluorouracil by targeting forkhead box transcription factor FOXM1. Cell Physiol Biochem. 2016;39:617–629. doi:10.1159/00044565327415661
  • Zhang H, Yan J, Lang X, et al. Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/beta-catenin signaling pathway. Oncol Lett. 2018;16:5856–5862. doi:10.3892/ol.2018.941030344736
  • Chen H, Liu S, Li M, et al. circ_0003418 inhibits tumorigenesis and cisplatin chemoresistance through Wnt/beta-Catenin pathway in hepatocellular carcinoma. Onco Targets Ther. 2019;12:9539–9549. doi:10.2147/OTT.S22950731807029