The Biological Role of the Collagen Alpha-3 (VI) Chain and Its Cleaved C5 Domain Fragment Endotrophin in Cancer

References

• Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012;196(4):395–406. doi:10.1083/jcb.20110214722351925
   PubMed Web of Science ®Google Scholar
• Chen P, Cescon M, Bonaldo P. Collagen VI in cancer and its biological mechanisms. Trends Mol Med. 2013;19(7):410–417. doi:10.1016/j.molmed.2013.04.00123639582
   PubMed Web of Science ®Google Scholar
• Zanussi S, Doliana R, Segat D, Bonaldo P, Colombatti A. The human type VI collagen gene. mRNA and protein variants of the alpha 3 chain generated by alternative splicing of an additional 5-end exon. J Biol Chem. 1992;267(33):24082–24089.1339440
   PubMed Web of Science ®Google Scholar
• Demir E, Sabatelli P, Allamand V, et al. Mutations in COL6A3 cause severe and mild phenotypes of Ullrich congenital muscular dystrophy. Am J Hum Genet. 2002;70(6):1446–1458. doi:10.1086/34060811992252
   PubMed Web of Science ®Google Scholar
• Lamandé SR, Mörgelin M, Adams NE, Selan C, Allen JM. The C5 domain of the collagen VI alpha3(VI) chain is critical for extracellular microfibril formation and is present in the extracellular matrix of cultured cells. J Biol Chem. 2006;281(24):16607–16614. doi:10.1074/jbc.M51019220016613849
   PubMed Web of Science ®Google Scholar
• Bonaldo P, Russo V, Bucciotti F, Bressan GM, Colombatti A. Alpha 1 chain of chick type VI collagen. The complete cDNA sequence reveals a hybrid molecule made of one short collagen and three von Willebrand factor type A-like domains. J Biol Chem. 1989;264(10):5575–5580.2784434
   PubMed Web of Science ®Google Scholar
• Bonaldo P, Russo V, Bucciotti F, Doliana R, Colombatti A. Structural and functional features of the alpha 3 chain indicate a bridging role for chicken collagen VI in connective tissues. Biochemistry. 1990;29(5):1245–1254. doi:10.1021/bi00457a0212322559
   PubMed Web of Science ®Google Scholar
• Chu ML, Zhang RZ, Pan TC, et al. Mosaic structure of globular domains in the human type VI collagen alpha 3 chain: similarity to von Willebrand factor, fibronectin, actin, salivary proteins and aprotinin type protease inhibitors. EMBO J. 1990;9(2):385–393. doi:10.1002/j.1460-2075.1990.tb08122.x1689238
   PubMed Web of Science ®Google Scholar
• Doliana R, Bonaldo P, Colombatti A. Multiple forms of chicken alpha 3(VI) collagen chain generated by alternative splicing in type A repeated domains. J Cell Biol. 1990;111(5 Pt 1):2197–2205. doi:10.1083/jcb.111.5.21971977751
   PubMed Web of Science ®Google Scholar
• Bernardi P, Bonaldo P. Dysfunction of mitochondria and sarcoplasmic reticulum in the pathogenesis of collagen VI muscular dystrophies. Ann N Y Acad Sci. 2008;1147(1):303–311. doi:10.1196/annals.1427.00919076452
   PubMedGoogle Scholar
• Sabatelli P, Gara SK, Grumati P, et al. Expression of the collagen VI alpha5 and alpha6 chains in normal human skin and in skin of patients with collagen VI-related myopathies. J Invest Dermatol. 2011;131(1):99–107.20882040
   PubMed Web of Science ®Google Scholar
• Aigner T, Hambach L, Söder S, Schlötzer-Schrehardt U, Pöschl E. The C5 domain of Col6A3 is cleaved off from the Col6 fibrils immediately after secretion. Biochem Biophys Res Commun. 2002;290(2):743–748. doi:10.1006/bbrc.2001.622711785962
   PubMed Web of Science ®Google Scholar
• Fitzgerald J, Rich C, Zhou FH, Hansen U. Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI). J Biol Chem. 2008;283(29):20170–20180. doi:10.1074/jbc.M71013920018400749
   PubMed Web of Science ®Google Scholar
• Gara SK, Grumati P, Urciuolo A, et al. Three novel collagen VI chains with high homology to the alpha3 chain. J Biol Chem. 2008;283(16):10658–10670. doi:10.1074/jbc.M70954020018276594
   PubMed Web of Science ®Google Scholar
• Engel J, Furthmayr H, Odermatt E, et al. Structure and macromolecular organization of type VI collagen. Ann N Y Acad Sci. 1985;460:25–37. doi:10.1111/j.1749-6632.1985.tb51154.x3938630
   PubMed Web of Science ®Google Scholar
• Colombatti A, Bonaldo P, Ainger K, Bressan GM, Volpin D. Biosynthesis of chick type VI collagen. I. Intracellular assembly and molecular structure. J Biol Chem. 1987;262(30):14454–14460.3117786
   PubMed Web of Science ®Google Scholar
• Colombatti A, Mucignat MT, Bonaldo P. Secretion and matrix assembly of recombinant type VI collagen. J Biol Chem. 1995;270(22):13105–13111. doi:10.1074/jbc.270.22.131057768905
   PubMed Web of Science ®Google Scholar
• Colombatti A, Bonaldo P. Biosynthesis of chick type VI collagen. II. Processing and secretion in fibroblasts and smooth muscle cells. J Biol Chem. 1987;262(30):14461–14466.3667584
   PubMed Web of Science ®Google Scholar
• Chu ML, Pan TC, Conway D, et al. The structure of type VI collagen. Ann N Y Acad Sci. 1990;580:55–63. doi:10.1111/j.1749-6632.1990.tb17917.x2337306
   PubMedGoogle Scholar
• Heumuller SE, Talantikite M, Napoli M, et al. C-terminal proteolysis of the collagen VI alpha3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes. J Biol Chem. 2019;294(37):13769–13780. doi:10.1074/jbc.RA119.00864131346034
   PubMed Web of Science ®Google Scholar
• Fitzgerald J, Holden P, Hansen U. The expanded collagen VI family: new chains and new questions. Connect Tissue Res. 2013;54(6):345–350. doi:10.3109/03008207.2013.82286523869615
   PubMed Web of Science ®Google Scholar
• Sabatelli P, Gara SK, Grumati P, et al. Expression of the collagen VI α5 and α6 chains in normal human skin and in skin of patients with collagen VI-related myopathies. J Invest Dermatol. 2011;131(1):99–107. doi:10.1038/jid.2010.28420882040
   PubMed Web of Science ®Google Scholar
• Lamandé SR, Sigalas E, Pan TC, et al. The role of the alpha3(VI) chain in collagen VI assembly. Expression of an alpha3(VI) chain lacking N-terminal modules N10-N7 restores collagen VI assembly, secretion, and matrix deposition in an alpha3(VI)-deficient cell line. J Biol Chem. 1998;273(13):7423–7430. doi:10.1074/jbc.273.13.74239516440
   PubMed Web of Science ®Google Scholar
• Fitzgerald J, Mörgelin M, Selan C, et al. The N-terminal N5 subdomain of the alpha 3(VI) chain is important for collagen VI microfibril formation. J Biol Chem. 2001;276(1):187–193. doi:10.1074/jbc.M00817320011027693
   PubMed Web of Science ®Google Scholar
• Beecher N, Roseman AM, Jowitt TA, et al. Collagen VI, conformation of A-domain arrays and microfibril architecture. J Biol Chem. 2011;286(46):40266–40275. doi:10.1074/jbc.M111.26559521908605
   PubMed Web of Science ®Google Scholar
• Keene DR, Engvall E, Glanville RW. Ultrastructure of type VI collagen in human skin and cartilage suggests an anchoring function for this filamentous network. J Cell Biol. 1988;107(5):1995–2006. doi:10.1083/jcb.107.5.19953182942
   PubMed Web of Science ®Google Scholar
• Allen JM, Zamurs L, Brachvogel B, et al. Mice lacking the extracellular matrix protein WARP develop normally but have compromised peripheral nerve structure and function. J Biol Chem. 2009;284(18):12020–12030. doi:10.1074/jbc.M80696820019279005
   PubMed Web of Science ®Google Scholar
• Cheng JS, Dubal DB, Kim DH, et al. Collagen VI protects neurons against Abeta toxicity. Nat Neurosci. 2009;12(2):119–121. doi:10.1038/nn.224019122666
   PubMed Web of Science ®Google Scholar
• Cheng IH, Lin YC, Hwang E, et al. Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/phosphatidylinositol 3-kinase signaling pathway. Neuroscience. 2011;183:178–188. doi:10.1016/j.neuroscience.2011.03.05721459131
   PubMed Web of Science ®Google Scholar
• Grumati P, Coletto L, Sabatelli P, et al. Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration. Nat Med. 2010;16(11):1313–1320. doi:10.1038/nm.224721037586
   PubMed Web of Science ®Google Scholar
• Bu D, Crewe C, Kusminski CM, et al. Human endotrophin as a driver of malignant tumor growth. JCI Insight. 2019;4:5.
   Web of Science ®Google Scholar
• Spencer M, Yao-Borengasser A, Unal R, et al. Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab. 2010;299(6):E1016–E1027. doi:10.1152/ajpendo.00329.201020841504
   PubMed Web of Science ®Google Scholar
• Iyengar P, Espina V, Williams TW, et al. Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest. 2005;115(5):1163–1176. doi:10.1172/JCI2342415841211
   PubMed Web of Science ®Google Scholar
• Park J, Scherer PE. Adipocyte-derived endotrophin promotes malignant tumor progression. J Clin Invest. 2012;122(11):4243–4256. doi:10.1172/JCI6393023041627
   PubMed Web of Science ®Google Scholar
• Sun K, Park J, Gupta OT, et al. Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. Nat Commun. 2014;5(1):3485. doi:10.1038/ncomms448524647224
   PubMedGoogle Scholar
• Park J, Scherer PE. Endotrophin - a novel factor linking obesity with aggressive tumor growth. Oncotarget. 2012;3(12):1487–1488. doi:10.18632/oncotarget.79623455368
   PubMedGoogle Scholar
• Mayer U, Pöschl E, Nischt R, et al. Recombinant expression and properties of the Kunitz-type protease-inhibitor module from human type VI collagen alpha 3(VI) chain. Eur J Biochem. 1994;225(2):573–580. doi:10.1111/j.1432-1033.1994.00573.x7525281
   PubMedGoogle Scholar
• Nanda A, Carson-Walter EB, Seaman S, et al. TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI). Cancer Res. 2004;64(3):817–820. doi:10.1158/0008-5472.CAN-03-240814871805
   PubMed Web of Science ®Google Scholar
• Huang Y, Li G, Wang K, et al. Collagen type VI alpha 3 chain promotes epithelial-mesenchymal transition in bladder cancer cells via transforming growth factor beta (TGF-beta)/smad pathway. Med Sci Monit. 2018;24:5346–5354. doi:10.12659/MSM.90981130066698
   PubMed Web of Science ®Google Scholar
• Thorsen K, Sorensen KD, Brems-Eskildsen AS, et al. Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Mol Cell Proteomics. 2008;7(7):1214–1224. doi:10.1074/mcp.M700590-MCP20018353764
   PubMed Web of Science ®Google Scholar
• Qiao J, Fang CY, Chen SX, et al. Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics. Oncotarget. 2015;6(30):29929–29946. doi:10.18632/oncotarget.496626338966
   PubMedGoogle Scholar
• Smith MJ, Culhane AC, Donovan M, et al. Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification. Br J Cancer. 2009;100(9):1452–1464. doi:10.1038/sj.bjc.660493119401702
   PubMed Web of Science ®Google Scholar
• Snezhkina AV, Krasnov GS, Zaretsky AR, et al. Differential expression of alternatively spliced transcripts related to energy metabolism in colorectal cancer. BMC Genomics. 2016;17(Suppl 14):1011. doi:10.1186/s12864-016-3351-528105922
   PubMedGoogle Scholar
• Cao W, Zhou D, Tang W, An H, Zhang Y. Discovery of plasma messenger RNA as novel biomarker for gastric cancer identified through bioinformatics analysis and clinical validation. PeerJ. 2019;7:e7025. doi:10.7717/peerj.702531249732
   PubMed Web of Science ®Google Scholar
• Xie X, Liu X, Zhang Q, Yu J. Overexpression of collagen VI alpha3 in gastric cancer. Oncol Lett. 2014;7(5):1537–1543. doi:10.3892/ol.2014.191024765172
   PubMed Web of Science ®Google Scholar
• Arafat H, Lazar M, Salem K, et al. Tumor-specific expression and alternative splicing of the COL6A3 gene in pancreatic cancer. Surgery. 2011;150(2):306–315. doi:10.1016/j.surg.2011.05.01121719059
   PubMed Web of Science ®Google Scholar
• Kang CY, Wang J, Axell-House D, et al. Clinical significance of serum COL6A3 in pancreatic ductal adenocarcinoma. J Gastrointest Surg. 2014;18(1):7–15. doi:10.1007/s11605-013-2326-y24002763
   PubMed Web of Science ®Google Scholar
• Lai KK, Shang S, Lohia N, et al. Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models. PLoS Genet. 2011;7(6):e1002147. doi:10.1371/journal.pgen.100214721731504
   PubMed Web of Science ®Google Scholar
• Lee C, Kim M, Lee JH, et al. COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease. J Pathol. 2019;247(1):99–109. doi:10.1002/path.517230246318
   PubMed Web of Science ®Google Scholar
• Yang J, Hou Z, Wang C, Wang H, Zhang H. Gene expression profiles reveal key genes for early diagnosis and treatment of adamantinomatous craniopharyngioma. Cancer Gene Ther. 2018;25(9–10):227–239. doi:10.1038/s41417-018-0015-429681617
   PubMed Web of Science ®Google Scholar
• Leivo I, Jee KJ, Heikinheimo K, et al. Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation. Cancer Genet Cytogenet. 2005;156(2):104–113. doi:10.1016/j.cancergencyto.2004.04.01615642389
   PubMedGoogle Scholar
• Gramann M, Wendler O, Haeberle L, Schick B. Prominent collagen type VI expression in juvenile angiofibromas. Histochem Cell Biol. 2009;131(1):155–164. doi:10.1007/s00418-008-0501-018797915
   PubMed Web of Science ®Google Scholar
• Fiscon G, Conte F, Paci P. SWIM tool application to expression data of glioblastoma stem-like cell lines, corresponding primary tumors and conventional glioma cell lines. BMC Bioinformatics. 2018;19(Suppl 15):436. doi:10.1186/s12859-018-2421-x30497369
   PubMedGoogle Scholar
• Schenck J, Fitzgerald JM. Analysis of COL6A3, COL6A5 and COL6A6 gene expression in breast and prostate tumors. Adv Clin Transl Res. 2018;2(2):100011.
   Google Scholar
• Maekawa R, Sato S, Yamagata Y, et al. Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas. PLoS One. 2013;8(6):e66632. doi:10.1371/journal.pone.006663223818951
   PubMed Web of Science ®Google Scholar
• Hyman G, Manglik V, Rousch JM, Verma M, Kinkebiel D, Banerjee HN. Epigenetic approaches in glioblastoma multiforme and their implication in screening and diagnosis. Methods Mol Biol. 2015;1238:511–521.25421677
   PubMedGoogle Scholar
• Black DL. Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem. 2003;72(1):291–336. doi:10.1146/annurev.biochem.72.121801.16172012626338
   PubMedGoogle Scholar
• Maniatis T, Tasic B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature. 2002;418(6894):236–243. doi:10.1038/418236a12110900
   PubMed Web of Science ®Google Scholar
• Oltean S, Bates DO. Hallmarks of alternative splicing in cancer. Oncogene. 2014;33(46):5311–5318. doi:10.1038/onc.2013.53324336324
   PubMed Web of Science ®Google Scholar
• Stokes DG, Saitta B, Timpl R, Chu ML. Human alpha 3(VI) collagen gene. Characterization of exons coding for the amino-terminal globular domain and alternative splicing in normal and tumor cells. J Biol Chem. 1991;266(13):8626–8633.2022673
   PubMed Web of Science ®Google Scholar
• Dziadek M, Kazenwadel JS, Hendrey JA, Pan TC, Zhang RZ, Chu ML. Alternative splicing of transcripts for the alpha 3 chain of mouse collagen VI: identification of an abundant isoform lacking domains N7-N10 in mouse and human. Matrix Biol. 2002;21(3):227–241. doi:10.1016/S0945-053X(02)00009-412009329
   PubMed Web of Science ®Google Scholar
• Gardina PJ, Clark TA, Shimada B, et al. Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array. BMC Genomics. 2006;7(1):325. doi:10.1186/1471-2164-7-32517192196
   PubMedGoogle Scholar
• Henegar C, Tordjman J, Achard V, et al. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol. 2008;9(1):R14. doi:10.1186/gb-2008-9-1-r1418208606
   PubMed Web of Science ®Google Scholar
• Khan T, Muise ES, Iyengar P, et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol. 2009;29(6):1575–1591. doi:10.1128/MCB.01300-0819114551
   PubMed Web of Science ®Google Scholar
• Gesta S, Guntur K, Majumdar ID, et al. Reduced expression of collagen VI alpha 3 (COL6A3) confers resistance to inflammation-induced MCP1 expression in adipocytes. Obesity (Silver Spring). 2016;24(8):1695–1703. doi:10.1002/oby.2156527312141
   PubMed Web of Science ®Google Scholar
• Yang MY, Chaudhary A, Seaman S, et al. The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton. Biochim Biophys Acta. 2011;1813(1):39–49. doi:10.1016/j.bbamcr.2010.11.01321129411
   PubMed Web of Science ®Google Scholar
• Liu W, Li L, Ye H, Tao H, He H. Role of COL6A3 in colorectal cancer. Oncol Rep. 2018;39(6):2527–2536. doi:10.3892/or.2018.633129620224
   PubMed Web of Science ®Google Scholar
• Ao R, Guan L, Wang Y, Wang JN. Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k-Akt signaling pathway. J Cell Biochem. 2018;119(6):4420–4434. doi:10.1002/jcb.2652429143985
   PubMed Web of Science ®Google Scholar
• Guillen-Ahlers H, Buechler SA, Suckow MA, Castellino FJ, Ploplis VA. Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis. 2008;29(7):1421–1427. doi:10.1093/carcin/bgn12318499699
   PubMed Web of Science ®Google Scholar
• Cohen SM, Lippard SJ. Cisplatin: from DNA damage to cancer chemotherapy. Prog Nucleic Acid Res Mol Biol. 2001;67:93–130.11525387
   PubMed Web of Science ®Google Scholar
• McGuire WP, Hoskins WJ, Brady MF, et al. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med. 1996;334(1):1–6. doi:10.1056/NEJM1996010433401017494563
   PubMed Web of Science ®Google Scholar
• Ozols RF, Young RC. Chemotherapy of ovarian cancer. Semin Oncol. 1984;11(3):251–263.6435250
   PubMed Web of Science ®Google Scholar
• Kartalou M, Essigmann JM. Mechanisms of resistance to cisplatin. Mutat Res. 2001;478(1–2):23–43. doi:10.1016/S0027-5107(01)00141-511406167
   PubMed Web of Science ®Google Scholar
• Pinto AL, Lippard SJ. Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA. Biochim Biophys Acta. 1985;780(3):167–180. doi:10.1016/0304-419x(85)90001-03896310
   PubMedGoogle Scholar
• Kasahara K, Fujiwara Y, Nishio K, et al. Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin. Cancer Res. 1991;51(12):3237–3242.1645616
   PubMed Web of Science ®Google Scholar
• Gately DP, Howell SB. Cellular accumulation of the anticancer agent cisplatin: a review. Br J Cancer. 1993;67(6):1171–1176. doi:10.1038/bjc.1993.2218512802
   PubMed Web of Science ®Google Scholar
• DeClerck YA. Interactions between tumour cells and stromal cells and proteolytic modification of the extracellular matrix by metalloproteinases in cancer. Eur J Cancer. 2000;36(10):1258–1268. doi:10.1016/S0959-8049(00)00094-010882864
   PubMed Web of Science ®Google Scholar
• Sherman-Baust CA, Weeraratna AT, Rangel LB, et al. Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells. Cancer Cell. 2003;3(4):377–386. doi:10.1016/S1535-6108(03)00058-812726863
   PubMed Web of Science ®Google Scholar
• Park J, Morley TS, Scherer PE. Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours. EMBO Mol Med. 2013;5(6):935–948.23629957
   PubMed Web of Science ®Google Scholar
• Varma RR, Hector SM, Clark K, Greco WR, Hawthorn L, Pendyala L. Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10. Oncol Rep. 2005;14(4):925–932.16142353
   PubMed Web of Science ®Google Scholar
• Fiorillo M, Sanchez-Alvarez R, Sotgia F, Lisanti MP. The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling: implicating TIGAR in somatic resistance to endocrine therapy. Aging (Albany NY). 2018;10(12):4000–4023. doi:10.18632/aging.10169030573703
   PubMedGoogle Scholar
• Ge C, Wu M, Chen G, Yu G, Ji D, Wang S. Identification of molecular characteristics induced by radiotherapy in rectal cancer based on microarray data. Oncol Lett. 2017;13(4):2777–2783. doi:10.3892/ol.2017.575028454466
   PubMed Web of Science ®Google Scholar
• Ge W, Hu H, Cai W, et al. High-risk Stage III colon cancer patients identified by a novel five-gene mutational signature are characterized by upregulation of IL-23A and gut bacterial translocation of the tumor microenvironment. Int J Cancer. 2019;146:2027.31693169
   PubMed Web of Science ®Google Scholar
• Yu J, Wu WK, Li X, et al. Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. Gut. 2015;64(4):636–645. doi:10.1136/gutjnl-2013-30662024951259
   PubMed Web of Science ®Google Scholar
• Moller E, Mandahl N, Mertens F, Panagopoulos I. Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. Genes Chromosomes Cancer. 2008;47(1):21–25. doi:10.1002/gcc.2050117918257
   PubMed Web of Science ®Google Scholar
• West RB, Rubin BP, Miller MA, et al. A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. Proc Natl Acad Sci U S A. 2006;103(3):690–695. doi:10.1073/pnas.050732110316407111
   PubMed Web of Science ®Google Scholar
• Ho J, Peters T, Dickson BC, et al. Detection of CSF1 rearrangements deleting the 3ʹ UTR in tenosynovial giant cell tumors. Genes Chromosomes Cancer. 2020;59(2):96–105. doi:10.1002/gcc.2280731469468
   PubMed Web of Science ®Google Scholar
• Willumsen N, Bager C, Karsdal MA. Matrix metalloprotease generated fragments of type VI collagen have serum biomarker potential in cancer - a proof of concept study. Transl Oncol. 2019;12(5):693–698. doi:10.1016/j.tranon.2019.02.00430856553
   PubMed Web of Science ®Google Scholar
• Martianov I, Cler E, Duluc I, et al. TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3. PLoS One. 2014;9(2):e87365. doi:10.1371/journal.pone.008736524498316
   PubMed Web of Science ®Google Scholar
• Gadd S, Huff V, Walz AL, et al. A children’s oncology group and TARGET initiative exploring the genetic landscape of WILMS tumor. Nat Genet. 2017;49(10):1487–1494. doi:10.1038/ng.394028825729
   PubMed Web of Science ®Google Scholar
• Sun S, Henriksen K, Karsdal MA, et al. Collagen Type III and VI Turnover in Response to Long-Term Immobilization. PLoS One. 2015;10(12):e0144525. doi:10.1371/journal.pone.014452526641456
   PubMed Web of Science ®Google Scholar
• Juhl P, Bay-Jensen AC, Karsdal M, Siebuhr AS, Franchimont N, Chavez J. Serum biomarkers of collagen turnover as potential diagnostic tools in diffuse systemic sclerosis: a cross-sectional study. PLoS One. 2018;13(12):e0207324. doi:10.1371/journal.pone.020732430507931
   PubMed Web of Science ®Google Scholar
• Rasmussen DGK, Hansen TW, von Scholten BJ, et al. Higher collagen vi formation is associated with all-cause mortality in patients with type 2 diabetes and microalbuminuria. Diabetes Care. 2018;41(7):1493–1500. doi:10.2337/dc17-239229643059
   PubMed Web of Science ®Google Scholar
• Karsdal MA, Henriksen K, Genovese F, et al. Serum endotrophin identifies optimal responders to PPARgamma agonists in type 2 diabetes. Diabetologia. 2017;60(1):50–59. doi:10.1007/s00125-016-4094-127631136
   PubMed Web of Science ®Google Scholar
• Stolz D, Leeming DJ, Kristensen JHE, et al. Systemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD. Chest. 2017;151(1):47–59. doi:10.1016/j.chest.2016.08.144027575358
   PubMed Web of Science ®Google Scholar
• Bihlet AR, Karsdal MA, Sand JM, et al. Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD. Respir Res. 2017;18(1):22. doi:10.1186/s12931-017-0509-x28103932
   PubMedGoogle Scholar
• Sand JM, Martinez G, Midjord AK, Karsdal MA, Leeming DJ, Lange P. Characterization of serological neo-epitope biomarkers reflecting collagen remodeling in clinically stable chronic obstructive pulmonary disease. Clin Biochem. 2016;49(15):1144–1151. doi:10.1016/j.clinbiochem.2016.09.00327614218
   PubMed Web of Science ®Google Scholar
• Sand JM, Knox AJ, Lange P, et al. Accelerated extracellular matrix turnover during exacerbations of COPD. Respir Res. 2015;16(1):69. doi:10.1186/s12931-015-0225-326062683
   PubMedGoogle Scholar
• Kehlet SN, Høye A, Boisen MK, et al. Prognostic evaluation of a new class of liquid biopsy biomarkers in patients with metastatic colorectal cancer: using the tumor microenvironment as a source of protein biomarkers. 2018;36(15_suppl):3588.
   Google Scholar
• Cescon M, Gattazzo F, Chen P, Bonaldo P. Collagen VI at a glance. J Cell Sci. 2015;128(19):3525–3531. doi:10.1242/jcs.16974826377767
   PubMed Web of Science ®Google Scholar
• Furthmayr H, Wiedemann H, Timpl R, Odermatt E, Engel J. Electron-microscopical approach to a structural model of intima collagen. Biochem J. 1983;211(2):303–311. doi:10.1042/bj2110303
   Google Scholar