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Original Research

Lung Carcinoma Cells Secrete Exosomal MALAT1 to Inhibit Dendritic Cell Phagocytosis, Inflammatory Response, Costimulatory Molecule Expression and Promote Dendritic Cell Autophagy via AKT/mTOR Pathway

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Pages 10693-10705 | Published online: 20 Oct 2020

References

  • Siegel R, Naishadham D, Jemal A. Cancer statistics for hispanics/ latinos, 2012. CA Cancer J Clin. 2012;62(5):283–298. doi:10.3322/caac.2115322987332
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7–30. doi:10.3322/caac.2133226742998
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. doi:10.1016/j.cell.2011.02.01321376230
  • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1–10. doi:10.1016/j.immuni.2013.07.01223890059
  • Marta R, Javier S, Alberto H, et al. Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer. Oncotarget. 2015;6(38):40575–40587. doi:10.18632/oncotarget.581826528758
  • Song X, Ding Y, Liu G, et al. Cancer cell-derived exosomes induce mitogen-activated protein kinase-dependent monocyte survival by transport of functional receptor tyrosine kinases. J Biol Chem. 2016;291(16):8453–8464. doi:10.1074/jbc.M116.71631626895960
  • Bruno S, Grange C, Deregibus MC, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol. 2009;20(5):1053. doi:10.1681/ASN.200807079819389847
  • Lai RC, Arslan F, Lee MM, et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010;4(3):214–222. doi:10.1016/j.scr.2009.12.00320138817
  • Young RS, Ponting CP, Lindsay MA, Griffiths-Jones S. Identification and function of long non-coding RNAs. Essays Biochem. 2013;54(54):113–126. doi:10.1042/bse054011323829531
  • Kornienko AE, Guenzl PM, Barlow DP, et al. Gene regulation by the act of long non-coding RNA transcription. BMC Biol. 2013;11(1):59. doi:10.1186/1741-7007-11-5923721193
  • Shi X, Sun M, Liu H, et al. Long non-coding RNAs: a new frontier in the study of human diseases. Cancer Lett. 2013;339(2):159–166. doi:10.1016/j.canlet.2013.06.01323791884
  • Mercer TR, Mattick JS. Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol. 2013;20(3):300. doi:10.1038/nsmb.248023463315
  • Wang F, Xie C, Zhao W, et al. Long non-coding RNA CARLo-5 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Clin Exper Med. 2015;17(1):1–11.26475621
  • Zhang Y, Zhang P, Wan X, et al. Downregulation of long non-coding RNA HCG11 predicts a poor prognosis in prostate cancer. Biomed Pharmacother. 2016;83:936–941. doi:10.1016/j.biopha.2016.08.01327522256
  • Gao X, Wen J, Gao P, Zhang G, Zhang G. Overexpression of the long non-coding RNA,linc-UBC1, is associated with poor prognosis and facilitates cell proliferation, migration, and invasion in colorectal cancer. Oncotargets Ther. 2017;10:1017–1026. doi:10.2147/OTT.S129343
  • Tian X, Xu G. Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis. BMJ Open. 2015;5(9):e008653. doi:10.1136/bmjopen-2015-008653
  • Zhang P, Zhou H, Lu K, et al. Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer. Oncotargets Ther. 2018;11:291–299. doi:10.2147/OTT.S155134
  • Zhang W, Zhou Y, Ding Y. Lnc-DC mediates the over-maturation of decidual dendritic cells and induces the increase in Th1 cells in preeclampsia. Am J Reprod Immunol. 2017;77(6):e12647. doi:10.1111/aji.12647
  • Wang P, Xue Y, Han Y, et al. The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation. Science. 2014;344(6181):310–313. doi:10.1126/science.125145624744378
  • Patel NA, Moss LD, Lee JY, et al. Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury. J Neuroinflamm. 2018;15(1):204. doi:10.1186/s12974-018-1240-3
  • Huang C, Han J, Wu Y, et al. Exosomal MALAT1 derived from oxidized low-density lipoprotein-treated endothelial cells promotes M2 macrophage polarization. Mol Med Rep. 2018. doi:10.3892/mmr.2018.8982
  • Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004;432(7020):1032–1036. doi:10.1038/nature0302915525940
  • Deretic V. Autophagy in innate and adaptive immunity. Trends Immunol. 2005;26(10):523–528. doi:10.1016/j.it.2005.08.00316099218
  • Chen J, Wang S, Jia S, et al. Integrated analysis of long non-coding RNA and mRNA expression profile in pancreatic cancer derived exosomes treated dendritic cells by microarray analysis. J Cancer. 2018;9(1):21–31. doi:10.7150/jca.2174929290766
  • Son CH, Bae JH, Shin DY, et al. Antitumor effect of dendritic cell loaded ex vivo and in vivo with tumor-associated antigens in lung cancer model. Immunol Invest. 2014;43(5):447–462. doi:10.3109/08820139.2014.88457624654594
  • Xiao L, Erb U, Zhao K, et al. Efficacy of vaccination with tumor-exosome loaded dendritic cells combined with cytotoxic drug treatment in pancreatic cancer. Oncoimmunology. 2017;6(6):e1319044. doi:10.1080/2162402X.2017.131904428680753
  • Jiang T, Chen X, Zhou W, et al. Immunotherapy with dendritic cells modified with tumor-associated antigen gene demonstrates enhanced antitumor effect against lung cancer. Transl Oncol. 2017;10(2):132–141. doi:10.1016/j.tranon.2016.12.00228129580
  • Tang Y, Xiao G, Chen Y, et al. LncRNA MALAT1 promotes migration and invasion of non-small-cell lung cancer by targeting miR-206 and activating Akt/mTOR signaling. Anticancer Drugs. 2018;1. doi:10.1097/CAD.000000000000065029099416
  • Wu J, Zhang H, Zheng Y, et al. The long noncoding RNA MALAT1 induces tolerogenic dendritic cells and regulatory T cells miR155/dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin/IL10Axis. Front Immunol. 2018;9. doi:10.3389/fimmu.2018.01847
  • Tripathi V, Ellis JD, Shen Z, et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell. 2010;39:925–938. doi:10.1016/j.molcel.2010.08.01120797886
  • Schmidt LH, Spieker T, Koschmieder S, et al. The long noncoding MALAT1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol. 2011;6:1984–1992. doi:10.1097/JTO.0b013e3182307eac22088988
  • Tano K, Mizuno R, Okada T, et al. MALAT1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes. FEBS Lett. 2010;584:4575–4580. doi:10.1016/j.febslet.2010.10.00820937273
  • Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009;19(2):43–51. doi:10.1016/j.tcb.2008.11.00319144520
  • Fang T, Lv H, Lv G, et al. Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer. Nat Commun. 2018;9(1):191. doi:10.1038/s41467-017-02583-029335551
  • Nabet BY, Qiu Y, Shabason JE, et al. Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer. Cell. 2017;170(2):352–366. doi:10.1016/j.cell.2017.06.03128709002
  • Rong L, Rong LI, Shaoying LI, et al. Immunosuppression of breast cancer cells mediated by transforming growth factor-β in exosomes from cancer cells. Oncol Lett. 2016;11(1):500. doi:10.3892/ol.2015.384126870240
  • Cheng L, Wang Y, Huang L. Exosomes from M1-polarized macrophages potentiate the cancer vaccine by creating a pro-inflammatory microenvironment in the lymph node. Mol Ther. 2017;25(7):1665. doi:10.1016/j.ymthe.2017.02.00728284981
  • Rao Q, Zuo B, Lu Z, et al. Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro. Hepatology. 2016;64(2):456–472. doi:10.1002/hep.2854926990897
  • Felzmann T, Katharina Gabriele H, Breuer SK, et al. Semi-mature IL-12 secreting dendritic cells present exogenous antigen to trigger cytolytic immune responses. Cancer Immunol Immunother. 2005;54(8):769–780. doi:10.1007/s00262-004-0637-215647926
  • Lee JJ, Foon KA, Mailliard RB, et al. Type 1-polarized dendritic cells loaded with autologous tumor are a potent immunogen against chronic lymphocytic leukemia. J Leukoc Biol. 2008;84(1):319–325. doi:10.1189/jlb.110773718426971
  • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392(6673):245–252. doi:10.1038/325889521319
  • Grewal IS, Foellmer HG, Grewal KD, et al. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science. 1996;273(5283):1864–1867. doi:10.1126/science.273.5283.18648791592
  • Stoll S, Delon J, Brotz TM, et al. Dynamic imaging of T cell-dendritic cell Interactions in lymph nodes. Science. 2002;296(5574):1873–1876. doi:10.1126/science.107106512052961
  • Gu CY, Zheng L, Wang Q. Research progress on mechanism and application of dendritic cells in the treatment of autoimmune diseases. Curr Immunol. 2005;25(3):253–255.
  • Prieto-Domínguez N, Ordóñez R, Fernández A, et al. Modulation of autophagy by sorafenib: effects on treatment response. Front Pharmacol. 2016;7. doi:10.3389/fphar.2016.00151
  • Sun SY. Enhancing perifosine’s anticancer efficacy by preventing autophagy. Autophagy. 2010;6(1):184–185. doi:10.4161/auto.6.1.1081620023422
  • Lin JF, Lin YC, Tsai TF, et al. Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells. Drug Des Dev Ther. 2016;1501. doi:10.2147/DDDT.S95900
  • Katheder NS, Khezri R, O’Farrell F, et al. Microenvironmental autophagy promotes tumour growth. Nature. 2017;541(7637):417–420. doi:10.1038/nature2081528077876