CD276 Promotes Vasculogenic Mimicry Formation in Hepatocellular Carcinoma via the PI3K/AKT/MMPs Pathway

References

• Gao J, Wang Z, Wang GJ, et al. Higher CYP2E1 activity correlates with hepatocarcinogenesis induced by diethylnitrosamine. J Pharmacol Exp Ther. 2018;365(2):398–407. doi:10.1124/jpet.117.24555529467309
   PubMed Web of Science ®Google Scholar
• Kudo M. Systemic therapy for hepatocellular carcinoma: 2017 update. Oncology. 2017;93(Suppl 1):135–146. doi:10.1159/00048124429258077
   PubMedGoogle Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.30620402
   PubMed Web of Science ®Google Scholar
• Hao CY. Angiogenesis blockade as therapy for hepatocellular carcinoma: progress and challenges. J Gastroenterol Hepatol. 2011;26(1):4–6.21175786
   PubMed Web of Science ®Google Scholar
• Plate KH, Scholz A, Dumont DJ. Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited. Acta Neuropathol. 2012;124(6):763–775.23143192
   PubMed Web of Science ®Google Scholar
• Folkman J. Proceedings: tumor angiogenesis factor. Cancer Res. 1974;34(8):2109–2113.4842257
   PubMed Web of Science ®Google Scholar
• Shen Y, Quan J, Wang M, et al. Tumor vasculogenic mimicry formation as an unfavorable prognostic indicator in patients with breast cancer. Oncotarget. 2017.
   Google Scholar
• Sun B, Zhang S, Zhang D, et al. Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma. Oncol Rep. 2006;16(4):693–698.16969481
   PubMed Web of Science ®Google Scholar
• Sun T, Zhao N, Zhao XL, et al. Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology. 2010;51(2):545–556. doi:10.1002/hep.2331119957372
   PubMed Web of Science ®Google Scholar
• Cao Z, Sun B, Zhao X, et al. The expression and functional significance of runx2 in hepatocellular carcinoma: its role in vasculogenic mimicry and epithelial-mesenchymal transition. Int J Mol Sci. 2017;18(3):500. doi:10.3390/ijms18030500
   PubMed Web of Science ®Google Scholar
• Folberg R, Maniotis AJ. Vasculogenic mimicry. APMIS. 2004;112(7–8):508–525. doi:10.1111/j.1600-0463.2004.apm11207-0810.x15563313
   PubMed Web of Science ®Google Scholar
• Sun B, Zhang D, Zhao N, Zhao X. Epithelial-to-endothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumors. Oncotarget. 2017;8(18):30502–30510. doi:10.18632/oncotarget.846127034014
   PubMedGoogle Scholar
• Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited. Annu Rev Immunol. 2005;23(1):515–548. doi:10.1146/annurev.immunol.23.021704.11561115771580
   PubMed Web of Science ®Google Scholar
• Picarda E, Ohaegbulam KC, Zang X. Molecular pathways: targeting B7-H3 (CD276) for human cancer immunotherapy. Clin Cancer Res. 2016;22(14):3425–3431. doi:10.1158/1078-0432.CCR-15-242827208063
   PubMed Web of Science ®Google Scholar
• Altan M, Pelekanou V, Schalper KA, et al. B7-H3 expression in NSCLC and its association with B7-H4, PD-L1 and tumor-infiltrating lymphocytes. Clin Cancer Res. 2017;23(17):5202–5209. doi:10.1158/1078-0432.CCR-16-310728539467
   PubMed Web of Science ®Google Scholar
• Mao Y, Chen L, Wang F, et al. Cancer cell-expressed B7-H3 regulates the differentiation of tumor-associated macrophages in human colorectal carcinoma. Oncol Lett. 2017;14(5):6177–6183.29113264
   PubMed Web of Science ®Google Scholar
• Xie C, Liu D, Chen Q, Yang C, Wang B, Wu H. Soluble B7-H3 promotes the invasion and metastasis of pancreatic carcinoma cells through the TLR4/NF-kappaB pathway. Sci Rep. 2016;6(1):27528. doi:10.1038/srep2752827273624
   PubMedGoogle Scholar
• Sun TW, Gao Q, Qiu SJ, et al. B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence. Cancer Immunol Immunother. 2012;61(11):2171–2182. doi:10.1007/s00262-012-1278-522729558
   PubMed Web of Science ®Google Scholar
• Dong P, Xiong Y, Yue J, Hanley SJB, Watari H. B7H3 as a promoter of metastasis and promising therapeutic target. Front Oncol. 2018;8:264.30035102
   PubMed Web of Science ®Google Scholar
• Flem-Karlsen K, Tekle C, Andersson Y, Flatmark K, Fodstad O, Nunes-Xavier CE. Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells. Pigment Cell Melanoma Res. 2017;30(5):467–476. doi:10.1111/pcmr.1259928513992
   PubMed Web of Science ®Google Scholar
• Li Y, Yang X, Wu Y, et al. B7-H3 promotes gastric cancer cell migration and invasion. Oncotarget. 2017;8(42):71725–71735. doi:10.18632/oncotarget.1784729069741
   PubMedGoogle Scholar
• Feng P, Zhang H, Zhang Z, et al. The interaction of MMP-2/B7-H3 in human osteoporosis. Clin Immunol. 2016;162:118–124. doi:10.1016/j.clim.2015.11.00926631755
   PubMed Web of Science ®Google Scholar
• Tekle C, Nygren MK, Chen YW, et al. B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes. Int J Cancer. 2012;130(10):2282–2290. doi:10.1002/ijc.2623821671471
   PubMed Web of Science ®Google Scholar
• Meng J, Chen S, Lei YY, et al. Hsp90beta promotes aggressive vasculogenic mimicry via epithelial-mesenchymal transition in hepatocellular carcinoma. Oncogene. 2019;38(2):228–243. doi:10.1038/s41388-018-0428-430087438
   PubMed Web of Science ®Google Scholar
• Cheng R, Cai XR, Ke K, Chen YL. Notch4 inhibition suppresses invasion and vasculogenic mimicry formation of hepatocellular carcinoma cells. J Huazhong Univ Sci Tech Med Sci. 2017;37(5):719–725.
   PubMedGoogle Scholar
• Kang FB, Wang L, Jia HC, et al. B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway. Cancer Cell Int. 2015;15(1):45. doi:10.1186/s12935-015-0195-z25908926
   PubMedGoogle Scholar
• Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–W102. doi:10.1093/nar/gkx24728407145
   PubMed Web of Science ®Google Scholar
• Zhao X, Sun B, Liu T, et al. Long noncoding RNA n339260 promotes vasculogenic mimicry and cancer stem cell development in hepatocellular carcinoma. Cancer Sci. 2018;109(10):3197–3208. doi:10.1111/cas.1374030022558
   PubMed Web of Science ®Google Scholar
• Wang F, Wang G, Liu T, Yu G, Zhang G, Luan X. B7-H3 was highly expressed in human primary hepatocellular carcinoma and promoted tumor progression. Cancer Invest. 2014;32(6):262–271. doi:10.3109/07357907.2014.90982624787022
   PubMed Web of Science ®Google Scholar
• Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell. 2007;11(6):539–554. doi:10.1016/j.ccr.2007.04.01717560335
   PubMed Web of Science ®Google Scholar
• Seaman S, Zhu Z, Saha S, et al. Eradication of tumors through simultaneous ablation of CD276/B7-H3-positive tumor cells and tumor vasculature. Cancer Cell. 2017;31(4):501–515e508. doi:10.1016/j.ccell.2017.03.00528399408
   PubMed Web of Science ®Google Scholar
• Jiang B, Zhang T, Liu F, et al. The co-stimulatory molecule B7-H3 promotes the epithelial-mesenchymal transition in colorectal cancer. Oncotarget. 2016;7(22):31755–31771.27145365
   PubMedGoogle Scholar
• Xu L, Ding X, Tan H, Qian J. Correlation between B7-H3 expression and matrix metalloproteinases 2 expression in pancreatic cancer. Cancer Cell Int. 2013;13(1):81. doi:10.1186/1475-2867-13-8123947693
   PubMedGoogle Scholar
• Li K, Tay FR, Yiu CKY. The past, present and future perspectives of matrix metalloproteinase inhibitors. Pharmacol Ther. 2019;107465.31863819
   PubMed Web of Science ®Google Scholar
• Lu XS, Sun W, Ge CY, Zhang WZ, Fan YZ. Contribution of the PI3K/MMPs/Ln-5gamma2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas. Int J Oncol. 2013;42(6):2103–2115. doi:10.3892/ijo.2013.189723588386
   PubMed Web of Science ®Google Scholar
• Zhang JG, Zhang DD, Liu Y, et al. RhoC/ROCK2 promotes vasculogenic mimicry formation primarily through ERK/MMPs in hepatocellular carcinoma. Biochim Biophys Acta Mol Basis Dis. 2019;1865(6):1113–1125. doi:10.1016/j.bbadis.2018.12.00730779947
   PubMed Web of Science ®Google Scholar
• Zhu W, Sun W, Zhang JT, Liu ZY, Li XP, Fan YZ. Norcantharidin enhances TIMP2 antivasculogenic mimicry activity for human gallbladder cancers through downregulating MMP2 and MT1MMP. Int J Oncol. 2015;46(2):627–640. doi:10.3892/ijo.2014.275325405519
   PubMed Web of Science ®Google Scholar
• Hess AR, Seftor EA, Seftor RE, Hendrix MJ. Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. Cancer Res. 2003;63(16):4757–4762.12941789
   PubMed Web of Science ®Google Scholar
• Lin JX, Xie XS, Weng XF, et al. UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling. J Exp Clin Cancer Res. 2019;38(1):410. doi:10.1186/s13046-019-1416-431533855
   PubMed Web of Science ®Google Scholar
• Piperigkou Z, Manou D, Karamanou K, Theocharis AD. Strategies to target matrix metalloproteinases as therapeutic approach in cancer. Methods Mol Biol. 2018;1731:325–348.29318564
   PubMedGoogle Scholar
• Radisky ES, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J Mammary Gland Biol Neoplasia. 2010;15(2):201–212. doi:10.1007/s10911-010-9177-x20440544
   PubMed Web of Science ®Google Scholar