Research Progress on Regulating LncRNAs of Hepatocellular Carcinoma Stem Cells

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.21492
   PubMed Web of Science ®Google Scholar
• Qin G, Dang M, Gao H, Wang H, Luo F, Chen R. Deciphering the protein-protein interaction network regulating hepatocellular carcinoma metastasis. Biochim Biophys Acta. 2017;1865(9):1114–1122. doi:10.1016/j.bbapap.2017.06.005
   Web of Science ®Google Scholar
• Batlle E, Clevers H. Cancer stem cells revisited. Nat Med. 2017;23(10):1124–1134. doi:10.1038/nm.4409
   PubMed Web of Science ®Google Scholar
• Nagano H, Ishii H, Marubashi S, et al. Novel therapeutic target for cancer stem cells in hepatocellular carcinoma. J Hepatobiliary Pancreat Sci. 2012;19(6):600–605. doi:10.1007/s00534-012-0543-5
   PubMed Web of Science ®Google Scholar
• Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem. 2012;81(1):145–166. doi:10.1146/annurev-biochem-051410-092902
   PubMed Web of Science ®Google Scholar
• Li X, Wu Z, Fu X, Han W. lncRNAs: insights into their function and mechanics in underlying disorders. Mutat Res Rev Mutat Res. 2014;762:1–21. doi:10.1016/j.mrrev.2014.04.002
   PubMed Web of Science ®Google Scholar
• Di Gesualdo F, Capaccioli S, Lulli M. A pathophysiological view of the long non-coding RNA world. Oncotarget. 2014;5(22):10976–10996. doi:10.18632/oncotarget.2770
   PubMedGoogle Scholar
• Amaral PP, Leonardi T, Han N, et al. Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci. Genome Biol. 2018;19(1):32. doi:10.1186/s13059-018-1405-5
   PubMedGoogle Scholar
• Geisler S, Coller J. RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol. 2013;14(11):699–712. doi:10.1038/nrm3679
   PubMed Web of Science ®Google Scholar
• Fernández-Ruiz I. Atherosclerosis: a new role for lncRNAs in atherosclerosis. Nat Rev Cardiol. 2018;15(4):195. doi:10.1038/nrcardio.2018.18
   PubMed Web of Science ®Google Scholar
• Wu Q, Guo L, Jiang F, Li L, Li Z, Chen F. Analysis of the miRNA–mRNA–lncRNA networks in ER+ and ER− breast cancer cell lines. J Cell Mol Med. 2015;19(12):2874–2887. doi:10.1111/jcmm.12681
   PubMed Web of Science ®Google Scholar
• Kapusta A, Kronenberg Z, Lynch VJ, et al. Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs. PLoS Genet. 2013;9(4):e1003470. doi:10.1371/journal.pgen.1003470
   PubMed Web of Science ®Google Scholar
• Wang C, Jiang X, Li X, et al. Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy. Stem Cell Res Ther. 2020;11(1):8. doi:10.1186/s13287-019-1528-y
   PubMed Web of Science ®Google Scholar
• Zou Z, Ma T, He X, et al. Long intergenic non-coding RNA 00324 promotes gastric cancer cell proliferation via binding with HuR and stabilizing FAM83B expression. Cell Death Dis. 2018;9(7):717. doi:10.1038/s41419-018-0758-8
   PubMed Web of Science ®Google Scholar
• Gao J, Dai C, Yu X, Yin XB, Zhou F. Long noncoding RNA LINC00324 exerts protumorigenic effects on liver cancer stem cells by upregulating fas ligand via PU box binding protein. FASEB J. 2020;34(4):5800–5817. doi:10.1096/fj.201902705RR
   PubMed Web of Science ®Google Scholar
• Leucci E, Vendramin R, Spinazzi M, et al. Melanoma addiction to the long non-coding RNA SAMMSON. Nature. 2016;531(7595):518–522. doi:10.1038/nature17161
   PubMed Web of Science ®Google Scholar
• Xiaopeng L. The Role and Molecular Mechanisms of Long Non-Coding RNA SAMMSON Maintains Self-Renewal in Human Liver Cancer Stem Cells. Nanchang University; 2019.
   Google Scholar
• Wu J, Zhu P, Lu T, et al. The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of hedgehog signaling. J Hepatol. 2019;70(5):918–929. doi:10.1016/j.jhep.2018.12.015
   PubMed Web of Science ®Google Scholar
• Qu L, Ding J, Chen C. Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA. Cancer Cell. 2016;29(5):653–668. doi:10.1016/j.ccell.2016.03.004
   PubMed Web of Science ®Google Scholar
• Yang C, Cai WC, Dong ZT, et al. lncARSR promotes liver cancer stem cells expansion via STAT3 pathway. Gene. 2019;687:73–81. doi:10.1016/j.gene.2018.10.087
   PubMed Web of Science ®Google Scholar
• Wang P, Mokhtari R, Pedrosa E, et al. CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells. Mol Autism. 2017;8(1):11. doi:10.1186/s13229-017-0124-1
   PubMedGoogle Scholar
• Zhang L, He X, Jin T, Gang L, Jin Z. Long non-coding RNA DLX6-AS1 aggravates hepatocellular carcinoma carcinogenesis by modulating miR-203a/MMP-2 pathway. Biomed Pharmacother. 2017;96:884–891. doi:10.1016/j.biopha.2017.10.056
   PubMed Web of Science ®Google Scholar
• Wu DM, Zheng ZH, Zhang YB, et al. Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells. J Exp Clin Cancer Res. 2019;38(1):237. doi:10.1186/s13046-019-1239-3
   PubMedGoogle Scholar
• Hosono Y, Niknafs YS, Prensner JR, et al. Oncogenic role of THOR, a conserved cancer/testis long non-coding RNA. Cell. 2017;171(7):1559–1572.e1520. doi:10.1016/j.cell.2017.11.040
   PubMed Web of Science ®Google Scholar
• Cheng Z, Lei Z, Yang P, et al. Long non-coding RNA THOR promotes liver cancer stem cells expansion via β-catenin pathway. Gene. 2019;684:95–103. doi:10.1016/j.gene.2018.10.051
   PubMed Web of Science ®Google Scholar
• Yang Y, Chen L, Gu J, et al. Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nat Commun. 2017;8(1):14421. doi:10.1038/ncomms14421
   PubMedGoogle Scholar
• Yang X, Wang CC, Lee WYW, Trovik J, Chung TKH, Kwong J. Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U. Cancer Lett. 2018;413:23–34. doi:10.1016/j.canlet.2017.10.028
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhu P, Luo J, et al. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO J. 2019;38(17):e101110. doi:10.15252/embj.2018101110
   PubMed Web of Science ®Google Scholar
• Guillou S, Beaumont J, Tamareille S, et al. Direct rivaroxaban-induced factor XA inhibition proves to be cardioprotective in rats. Shock. 2020;53(6):730–736. doi:10.1097/SHK.0000000000001412
   PubMed Web of Science ®Google Scholar
• Zhou L, Zhou X, Nie H, Xing R. Regulation of long non-coding RNA PVT1 on self-renewal of hepatocellular carcinoma stem cells through the activation of wnt signaling pathway. J China Pharm. 2019;22:1997–2002.
   Google Scholar
• Cheng Z. Long Non-Coding RNA NEAT1 Regulate the Self-Renewal of Liver Cancer Stem Cells via the Hippo Signal Pathway. The Second Military Medical University; 2019.
   Google Scholar
• Koyama S, Tsuchiya H, Amisaki M, et al. NEAT1 is required for the expression of the liver cancer stem cell marker CD44. Int J Mol Sci. 2020;21(6):1927. doi:10.3390/ijms21061927
   PubMed Web of Science ®Google Scholar
• Pu H, Zheng Q, Li H, et al. CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc. Oncotarget. 2015;6(38):40775–40798. doi:10.18632/oncotarget.5805
   PubMedGoogle Scholar
• Gui X, Li H, Li T, Pu H, Lu D. Long noncoding RNA CUDR regulates HULC and β-catenin to govern human liver stem cell malignant differentiation. Mol Ther. 2015;23(12):1843–1853. doi:10.1038/mt.2015.166
   PubMed Web of Science ®Google Scholar
• Li T, Zheng Q, An J, et al. SET1A cooperates with CUDR to promote liver cancer growth and hepatocyte-like stem cell malignant transformation epigenetically. Mol Ther. 2016;24(2):261–275. doi:10.1038/mt.2015.208
   PubMed Web of Science ®Google Scholar
• Kretz M, Webster DE, Flockhart RJ, et al. Suppression of progenitor differentiation requires the long noncoding RNA ANCR. Genes Dev. 2012;26(4):338–343. doi:10.1101/gad.182121.111
   PubMed Web of Science ®Google Scholar
• Yuan SX, Wang J, Yang F, et al. Long noncoding RNADANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1. Hepatology. 2016;63(2):499–511. doi:10.1002/hep.27893
   PubMed Web of Science ®Google Scholar
• Guo W, Liu S, Cheng Y, et al. ICAM-1-related noncoding RNA in cancer stem cells maintains ICAM-1 expression in hepatocellular carcinoma. Clin Cancer Res. 2016;22(8):2041–2050. doi:10.1158/1078-0432.CCR-14-3106
   PubMed Web of Science ®Google Scholar
• Zhu P, Wang Y, Wu J, et al. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7(1):13608. doi:10.1038/ncomms13608
   PubMedGoogle Scholar
• Schraivogel D, Weinmann L, Beier D, et al. CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells. EMBO J. 2011;30(20):4309–4322. doi:10.1038/emboj.2011.301
   PubMed Web of Science ®Google Scholar
• Henrich KO, Bauer T, Schulte J, et al. CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells. Cancer Res. 2011;71(8):3142–3151. doi:10.1158/0008-5472.CAN-10-3014
   PubMed Web of Science ®Google Scholar
• Ha SY, Choi IH, Han J, et al. Pleural epithelioid hemangioendothelioma harboring CAMTA1 rearrangement. Lung Cancer. 2014;83(3):411–415. doi:10.1016/j.lungcan.2013.12.015
   PubMed Web of Science ®Google Scholar
• Ding LJ, Li Y, Wang SD. Long noncoding RNA lncCAMTA1 promotes proliferation and cancer stem cell-like properties of liver cancer by inhibiting CAMTA1. Int J Mol Sci. 2016;17(10):1617. doi:10.3390/ijms17101617
   PubMed Web of Science ®Google Scholar
• Zhu P, Wang Y, Huang G, et al. lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 2016;23(7):631–639. doi:10.1038/nsmb.3235
   PubMed Web of Science ®Google Scholar
• Wang Y, He L, Du Y, et al. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015;16(4):413–425. doi:10.1016/j.stem.2015.03.003
   PubMed Web of Science ®Google Scholar
• Li H, An J, Wu M, et al. LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. Oncotarget. 2015;6(29):27847–27864. doi:10.18632/oncotarget.4443
   PubMedGoogle Scholar
• Raveh E, Matouk IJ, Gilon M, Hochberg A. The H19 long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory. Mol Cancer. 2015;14(1):184. doi:10.1186/s12943-015-0458-2
   PubMedGoogle Scholar
• Yang ZW, Meng XX, Xu P. Central role of neutrophil in the pathogenesis of severe acute pancreatitis. J Cell Mol Med. 2015;19(11):2513–2520. doi:10.1111/jcmm.12639
   PubMed Web of Science ®Google Scholar
• Collins JF. Long noncoding RNAs and hepatocellular carcinoma. Gastroenterology. 2015;148(2):291–294. doi:10.1053/j.gastro.2014.12.011
   PubMed Web of Science ®Google Scholar
• Ding K, Liao Y, Gong D, Zhao X, Ji W. Effect of long non-coding RNA H19 on oxidative stress and chemotherapy resistance of CD133+ cancer stem cells via the MAPK/ERK signaling pathway in hepatocellular carcinoma. Biochem Biophys Res Commun. 2018;502(2):194–201. doi:10.1016/j.bbrc.2018.05.143
   PubMed Web of Science ®Google Scholar
• Wang X, Sun W, Shen W, et al. Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis. J Hepatol. 2016;64(6):1283–1294. doi:10.1016/j.jhep.2016.01.019
   PubMed Web of Science ®Google Scholar
• Zhong Y, Katavolos P, Nguyen T, et al. Tankyrase inhibition causes reversible intestinal toxicity in mice with a therapeutic index. Toxicol Pathol. 2016;44(2):267–278. doi:10.1177/0192623315621192
   PubMed Web of Science ®Google Scholar
• Mariotti L, Pollock K, Guettler S. Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding. Br J Pharmacol. 2017;174(24):4611–4636. doi:10.1111/bph.14038
   PubMed Web of Science ®Google Scholar
• Tian Y, Mok MT, Yang P, Cheng AS. Epigenetic activation of Wnt/β-catenin signaling in NAFLD-associated hepatocarcinogenesis. Cancers (Basel). 2016;8(8):8. doi:10.3390/cancers8080076
   PubMed Web of Science ®Google Scholar
• Dhanasekaran R, Bandoh S, Roberts LR. Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances. F1000Res. 2016;5:879. doi:10.12688/f1000research.6946.1
   Google Scholar
• Petrova R, Joyner AL. Roles for hedgehog signaling in adult organ homeostasis and repair. Development. 2014;141(18):3445–3457. doi:10.1242/dev.083691
   PubMed Web of Science ®Google Scholar
• Holtz AM, Griffiths SC, Davis SJ, Bishop B, Siebold C, Allen BL. Secreted HHIP1 interacts with heparan sulfate and regulates hedgehog ligand localization and function. J Cell Biol. 2015;209(5):739–757. doi:10.1083/jcb.201411024
   PubMed Web of Science ®Google Scholar
• Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. An essential role for Grk2 in hedgehog signalling downstream of smoothened. EMBO Rep. 2016;17(5):739–752. doi:10.15252/embr.201541532
   PubMed Web of Science ®Google Scholar
• Jeng KS, Jeng CJ, Jeng WJ, et al. Sonic hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma. Oncol Lett. 2019;18(5):4377–4384. doi:10.3892/ol.2019.10826
   PubMed Web of Science ®Google Scholar
• Tian F, Mysliwietz J, Ellwart J, Gamarra F, Huber RM, Bergner A. Effects of the hedgehog pathway inhibitor GDC-0449 on lung cancer cell lines are mediated by side populations. Clin Exp Med. 2012;12(1):25–30. doi:10.1007/s10238-011-0135-8
   PubMed Web of Science ®Google Scholar
• Siveen KS, Sikka S, Surana R, et al. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochim Biophys Acta. 2014;1845(2):136–154. doi:10.1016/j.bbcan.2013.12.005
   PubMed Web of Science ®Google Scholar
• Jung JW, Yoon SM, Kim S, et al. Bone morphogenetic protein-9 is a potent growth inhibitor of hepatocellular carcinoma and reduces the liver cancer stem cells population. Oncotarget. 2016;7(45):73754–73768. doi:10.18632/oncotarget.12062
   PubMedGoogle Scholar
• Alarmo EL, Kallioniemi A. Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis? Endocr Relat Cancer. 2010;17(2):R123–139. doi:10.1677/ERC-09-0273
   PubMed Web of Science ®Google Scholar
• Pickup MW, Owens P, Moses HL. TGF-β, bone morphogenetic protein, and activin signaling and the tumor microenvironment. Cold Spring Harb Perspect Biol. 2017;9(5):a022285. doi:10.1101/cshperspect.a022285
   PubMed Web of Science ®Google Scholar
• Kurtzeborn K, Kwon HN, Kuure S. MAPK/ERK signaling in regulation of renal differentiation. Int J Mol Sci. 2019;20(7):1779. doi:10.3390/ijms20071779
   PubMed Web of Science ®Google Scholar
• Chappell WH, Steelman LS, Long JM, et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget. 2011;2(3):135–164. doi:10.18632/oncotarget.240
   PubMedGoogle Scholar
• Steelman LS, Chappell WH, Abrams SL, et al. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY). 2011;3(3):192–222. doi:10.18632/aging.100296
   PubMedGoogle Scholar
• Johnson R, Halder G. The two faces of hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov. 2014;13(1):63–79. doi:10.1038/nrd4161
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhou D. Role of the transcriptional coactivators YAP/TAZ in liver cancer. Curr Opin Cell Biol. 2019;61:64–71. doi:10.1016/j.ceb.2019.07.006
   PubMed Web of Science ®Google Scholar
• Park JH, Shin JE, Park HW. The role of hippo pathway in cancer stem cell biology. Mol Cells. 2018;41(2):83–92. doi:10.14348/molcells.2018.2242
   PubMed Web of Science ®Google Scholar
• Pan D. The hippo signaling pathway in development and cancer. Dev Cell. 2010;19(4):491–505. doi:10.1016/j.devcel.2010.09.011
   PubMed Web of Science ®Google Scholar
• Steinway SN, Zañudo JG, Ding W. Network modeling of TGFβ signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint sonic hedgehog and Wnt pathway activation. Cancer Res. 2014;74(21):5963–5977. doi:10.1158/0008-5472.CAN-14-0225
   PubMed Web of Science ®Google Scholar
• Kim W, Khan SK, Yang Y. Interacting network of Hippo, Wnt/β-catenin and notch signaling represses liver tumor formation. BMB Rep. 2017;50(1):1–2. doi:10.5483/BMBRep.2017.50.1.196
   PubMed Web of Science ®Google Scholar
• Kim W, Khan SK, Gvozdenovic-Jeremic J, et al. Hippo signaling interactions with Wnt/β-catenin and notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127(1):137–152. doi:10.1172/JCI88486
   PubMed Web of Science ®Google Scholar
• Yuan YM, Ma N, Zhang EB, et al. BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis. Oncogene. 2019;38(48):7281–7293. doi:10.1038/s41388-019-0943-y
   PubMed Web of Science ®Google Scholar
• Kapil S, Sharma BK, Patil M, et al. The cell polarity protein scrib functions as a tumor suppressor in liver cancer. Oncotarget. 2017;8(16):26515–26531. doi:10.18632/oncotarget.15713
   PubMedGoogle Scholar
• Chung W, Kim M, de la Monte S, et al. Activation of signal transduction pathways during hepatic oncogenesis. Cancer Lett. 2016;370(1):1–9. doi:10.1016/j.canlet.2015.09.016
   PubMed Web of Science ®Google Scholar