High VCAM-1 Predicts Poor Prognosis and is Associated with Chemotherapy Resistance in Nasopharyngeal Carcinoma

References

• Chua MLK, Wee JTS, Hui EP, Chan ATC. Nasopharyngeal carcinoma. Lancet. 2016;387(10022):1012–1024. doi:10.1016/S0140-6736(15)00055-0
   PubMed Web of Science ®Google Scholar
• Colevas AD, Yom SS, Pfister DG, et al. NCCN guidelines insights: head and neck cancers, version 1.2018. J Nat Compr Cancer Network. 2018;16(5):479–490. doi:10.6004/jnccn.2018.0026
   PubMed Web of Science ®Google Scholar
• Chen YP, Chan ATC, Le QT, et al. Nasopharyngeal carcinoma. Lancet. 2019;394(10192):64–80. doi:10.1016/S0140-6736(19)30956-0
   PubMed Web of Science ®Google Scholar
• Bissey PA, Teng M, Law JH, et al. MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma. BMC Cancer. 2020;20(1):597. doi:10.1186/s12885-020-07081-z
   PubMed Web of Science ®Google Scholar
• Zhang P, Lu X, Shi Z, et al. miR-205-5p regulates epithelial-mesenchymal transition by targeting PTEN via PI3K/AKT signaling pathway in cisplatin-resistant nasopharyngeal carcinoma cells. Gene. 2019;710:103–113. doi:10.1016/j.gene.2019.05.058
   PubMed Web of Science ®Google Scholar
• Zhang R, Li SW, Liu L, et al. TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple. Oncogenesis. 2020;9(5):45. doi:10.1038/s41389-020-0229-9
   PubMed Web of Science ®Google Scholar
• Wei X, Nian J, Zheng J, et al. Inhibition of cyclin-dependent kinases by AT7519 enhances nasopharyngeal carcinoma cell response to chemotherapy. Cancer Chemother Pharmacol. 2020;85(5):949–957. doi:10.1007/s00280-020-04068-2
   PubMed Web of Science ®Google Scholar
• Zhang J, Xie T, Zhong X, et al. Melatonin reverses nasopharyngeal carcinoma cisplatin chemoresistance by inhibiting the Wnt/β-catenin signaling pathway. Aging. 2020;12(6):5423–5438. doi:10.18632/aging.102968
   PubMedGoogle Scholar
• Rice GE, Bevilacqua MP. An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science. 1989;246(4935):1303–1306. doi:10.1126/science.2588007
   PubMed Web of Science ®Google Scholar
• Cook-Mills JM, Marchese ME, Abdala-Valencia H. Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid Redox Signal. 2011;15(6):1607–1638. doi:10.1089/ars.2010.3522
   PubMed Web of Science ®Google Scholar
• Sharma R, Khaket TP, Dutta C, et al. Breast cancer metastasis: putative therapeutic role of vascular cell adhesion molecule-1. Cell Oncol. 2017;40(3):199–208. doi:10.1007/s13402-017-0324-x
   PubMed Web of Science ®Google Scholar
• Kong DH, Kim YK, Kim MR, et al. Emerging roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in immunological disorders and cancer. Int J Mol Sci. 2018;19:4. doi:10.3390/ijms19041057
   Web of Science ®Google Scholar
• Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature. 2005;436(7050):518–524. doi:10.1038/nature03799
   PubMed Web of Science ®Google Scholar
• Byrne GJ, Ghellal A, Iddon J, et al. Serum soluble vascular cell adhesion molecule-1: role as a surrogate marker of angiogenesis. J Natl Cancer Inst. 2000;92(16):1329–1336. doi:10.1093/jnci/92.16.1329
   PubMed Web of Science ®Google Scholar
• Ding YB, Chen GY, Xia JG, et al. Association of VCAM-1 overexpression with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma. World J Gastroenterol. 2003;9(7):1409–1414. doi:10.3748/wjg.v9.i7.1409
   PubMed Web of Science ®Google Scholar
• Zhang R, Qi F, Zhao F, et al. Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer. Cell Death Dis. 2019;10(4):273. doi:10.1038/s41419-019-1435-2
   PubMed Web of Science ®Google Scholar
• Kim MR, Jang JH, Park CS, et al. A human antibody that binds to the sixth Ig-like domain of VCAM-1 blocks lung cancer cell migration in vitro. Int J Mol Sci. 2017;18:3.
   PubMed Web of Science ®Google Scholar
• Scalici JM, Arapovic S, Saks EJ, et al. Mesothelium expression of vascular cell adhesion molecule-1 (VCAM-1) is associated with an unfavorable prognosis in epithelial ovarian cancer (EOC). Cancer. 2017;123(6):977–984. doi:10.1002/cncr.30415
   PubMed Web of Science ®Google Scholar
• Kim TK, Park CS, Na HJ, et al. Ig-like domain 6 of VCAM-1 is a potential therapeutic target in TNFα-induced angiogenesis. Exp Mol Med. 2017;49(2):e294. doi:10.1038/emm.2016.147
   PubMed Web of Science ®Google Scholar
• Kuai WX, Wang Q, Yang XZ, et al. Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells. World J Gastroenterol. 2012;18(9):979–985. doi:10.3748/wjg.v18.i9.979
   PubMed Web of Science ®Google Scholar
• Wang PC, Weng CC, Hou YS, et al. Activation of VCAM-1 and its associated molecule CD44 leads to increased malignant potential of breast cancer cells. Int J Mol Sci. 2014;15(3):3560–3579. doi:10.3390/ijms15033560
   PubMed Web of Science ®Google Scholar
• Becker PS, Kopecky KJ, Wilks AN, et al. Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia. Blood. 2009;113(4):866–874. doi:10.1182/blood-2007-12-124818
   PubMed Web of Science ®Google Scholar
• Liu CM, Sheen TS, Ko JY, Shun CT. Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer. Br J Cancer. 1999;79(2):360–362. doi:10.1038/sj.bjc.6690057
   PubMed Web of Science ®Google Scholar
• Cheng S, Li Z, He J, et al. Epstein-Barr virus noncoding RNAs from the extracellular vesicles of nasopharyngeal carcinoma (NPC) cells promote angiogenesis via TLR3/RIG-I-mediated VCAM-1 expression. Biochimica et biophysica acta. Mol Basis Dis. 2019;1865(6):1201–1213. doi:10.1016/j.bbadis.2019.01.015
   PubMed Web of Science ®Google Scholar
• Kurbacher CM, Cree IA, Bruckner HW, et al. Use of an ex vivo ATP luminescence assay to direct chemotherapy for recurrent ovarian cancer. Anticancer Drugs. 1998;9(1):51–57. doi:10.1097/00001813-199801000-00006
   PubMed Web of Science ®Google Scholar
• Zou R, Shi W, Tao J, et al. SIRT5 and post-translational protein modifications: a potential therapeutic target for myocardial ischemia-reperfusion injury with regard to mitochondrial dynamics and oxidative metabolism. Eur J Pharmacol. 2018;818:410–418. doi:10.1016/j.ejphar.2017.11.005
   PubMed Web of Science ®Google Scholar
• Nan J, Zhu W, Rahman MS, et al. Molecular regulation of mitochondrial dynamics in cardiac disease. Biochim Biophys Acta Mol Cell Res. 2017;1864(7):1260–1273. doi:10.1016/j.bbamcr.2017.03.006
   PubMed Web of Science ®Google Scholar
• Cerutti C, Ridley AJ. Endothelial cell-cell adhesion and signaling. Exp Cell Res. 2017;358(1):31–38. doi:10.1016/j.yexcr.2017.06.003
   PubMed Web of Science ®Google Scholar
• Wang L, Ding Y, Guo X, Zhao Q. Role and mechanism of vascular cell adhesion molecule-1 in the development of rheumatoid arthritis. Exp Ther Med. 2015;10(3):1229–1233. doi:10.3892/etm.2015.2635
   PubMed Web of Science ®Google Scholar
• Steinke JW, Borish L. Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res. 2001;2(2):66–70. doi:10.1186/rr40
   PubMed Web of Science ®Google Scholar
• Piotti G, Palmisano A, Maggiore U, Buzio C. Vascular endothelium as a target of immune response in renal transplant rejection. Front Immunol. 2014;5:505. doi:10.3389/fimmu.2014.00505
   PubMed Web of Science ®Google Scholar
• Baujat B, Audry H, Bourhis J, et al. Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys. 2006;64(1):47–56. doi:10.1016/j.ijrobp.2005.06.037
   PubMed Web of Science ®Google Scholar
• Blanchard P, Lee A, Marguet S, et al. Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis. Lancet Oncol. 2015;16(6):645–655. doi:10.1016/S1470-2045(15)70126-9
   PubMed Web of Science ®Google Scholar
• Zhang L, Huang Y, Hong S, et al. Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, Phase 3 trial. Lancet. 2016;388(10054):1883–1892. doi:10.1016/S0140-6736(16)31388-5
   PubMed Web of Science ®Google Scholar
• Bosse RC, Wasserstrom B, Meacham A, et al. Chemosensitizing AML cells by targeting bone marrow endothelial cells. Exp Hematol. 2016;44(5):363–377 e365. doi:10.1016/j.exphem.2016.02.003
   PubMed Web of Science ®Google Scholar
• Garmy-Susini B, Jin H, Zhu Y, et al. Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J Clin Invest. 2005;115(6):1542–1551. doi:10.1172/JCI23445
   PubMed Web of Science ®Google Scholar
• Carlson P, Dasgupta A, Grzelak CA, et al. Targeting the perivascular niche sensitizes disseminated tumor cells to chemotherapy. Nat Cell Biol. 2019;21(2):238–250. doi:10.1038/s41556-018-0267-0
   PubMed Web of Science ®Google Scholar