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OncoTargets and Therapy Volume 14, 2021 - Issue
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Case Report

PD-L1 Expressing Recurrent Clear Cell Carcinoma of the Vulva with Durable Partial Response to Pembrolizumab: A Case Report

Manavi Sachdeva1 Department of Medicine, National University Health System Singapore, Singapore, 119074, SingaporeView further author information
,
Natalie Y L Ngoi2 Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119228, SingaporeORCID Iconhttps://orcid.org/0000-0003-2071-0715View further author information
ORCID Icon,
Diana Lim3 Department of Pathology, National University Health System Singapore, Singapore, 119074, SingaporeView further author information
,
Michelle L M Poon2 Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119228, SingaporeView further author information
,
Yee Liang Thian4 Department of Diagnostic Imaging, National University Health System Singapore, Singapore, 119074, SingaporeView further author information
,
Yi Wan Lim2 Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119228, SingaporeORCID Iconhttps://orcid.org/0000-0003-4823-5151View further author information
ORCID Icon,
Siew Eng Lim2 Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119228, SingaporeView further author information
,
Pearl Tong5 Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, National University Hospital Singapore, Singapore, 119074, SingaporeView further author information
,
Jeffrey H Y Lum3 Department of Pathology, National University Health System Singapore, Singapore, 119074, SingaporeView further author information
,
Joseph Ng5 Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, National University Hospital Singapore, Singapore, 119074, SingaporeView further author information
,
Arunachalam Ilancheran5 Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, National University Hospital Singapore, Singapore, 119074, SingaporeView further author information
,
Efren J Domingo6 Department of Obstetrics and Gynecology, University of the Philippines College of Medicine, Philippine General Hospital, Manila, 1000, Metro Manila, PhilippinesView further author information
,
Jeffrey J H Low5 Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, National University Hospital Singapore, Singapore, 119074, SingaporeORCID Iconhttps://orcid.org/0000-0002-1992-7389View further author information
ORCID Icon &
David S P Tan2 Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119228, Singapore;7 Cancer Science Institute, National University of Singapore, Singapore, 117599, SingaporeCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9087-5262View further author information
ORCID Icon show all
Pages 3921-3928 | Published online: 29 Jun 2021

References

  • Buppasiri P, Kleebkaow P, Tharanon C, Aue-aungkul A, Kietpeerakool C. Clear cell carcinoma arising in vulvar endometriosis. Case Rep Pathol. 2018;2018:1–5. doi:10.1155/2018/4263104
  • Kojima N, Yoshida H, Uehara T, et al. Primary clear cell adenocarcinoma of the vulva: a case study with mutation analysis and literature review. Int J Surg Pathol. 2019;27(7):792–797. doi:10.1177/1066896919848823
  • Bolis GB, Maccio T. Clear cell adenocarcinoma of the vulva arising in endometriosis. A case report. Eur J Gynaecol Oncol. 2000;21(4):416–417.
  • Herghelegiu CG, Neacşu A, Oprescu ND, et al. Difficulties of clinical and histopathological diagnosis in advanced vulvar clear cell carcinoma. Rom J Morphol Embryol. 2018;59(4):1233–1237.
  • Messing MJ, Richardson MS, Smith MT, King L, Gallup DG. Metastatic clear-cell hidradenocarcinoma of the vulva. Gynecologic Oncology. 1993;48:264–268. doi:10.1006/gyno.1993.1045
  • Lim KC, Thompson IW, Wiener JJ. CASE REPORT A case of primary clear cell adenocarcinoma of Bartholin’s gland. BJOG. 2002;109:1305–1307.
  • Han MR, Shin S, Park HC, et al. Mutational signatures and chromosome alteration profiles of squamous cell carcinomas of the vulva. Exp Mol Med. 2018;50(2):e442–13. doi:10.1038/emm.2017.265
  • Wendel Naumann R, Hollebecque A, Meyer T, et al. Safety and efficacy of nivolumab monotherapy in recurrent or metastatic cervical, vaginal, or vulvar carcinoma: results from the phase I/II CheckMate 358 trial. J Clin Oncol. 2019;37(31):2825–2834. doi:10.1200/JCO.19.00739
  • Fu S, Shi N, Wheler J, et al. Characteristics and outcomes for patients with advanced vaginal or vulvar cancer referred to a Phase I clinical trials program: the MD Anderson cancer center experience. Gynecol Oncol Res Pract. 2015;2(1):1–6. doi:10.1186/s40661-015-0018-x
  • Witteveen PO, van der Velden J, Vergote I, et al. Phase II study on paclitaxel in patients with recurrent, metastatic or locally advanced vulvar cancer not amenable to surgery or radiotherapy: a study of the EORTC-GCG (European Organisation for Research and Treatment of Cancer - Gynaecological Cancer Gro). Ann Oncol. 2009;20(9):1511–1516. doi:10.1093/annonc/mdp043
  • Cormio G, Loizzi V, Gissi F, et al. Cisplatin and vinorelbine chemotherapy in recurrent vulvar carcinoma. Oncology. 2009;77(5):281–284. doi:10.1159/000259259
  • Wagenaar HC, Colombo N, Vergote I, et al. Bleomycin, methotrexate, and CCNU in locally advanced or recurrent, inoperable, squamous-cell carcinoma of the vulva: an EORTC gynaecological cancer cooperative group study. Gynecol Oncol. 2001;81(3):348–354. doi:10.1006/gyno.2001.6180
  • Sun LM, Lin CL, Lin MC, Liang JA, Kao CH. Radiotherapy-and chemotherapy-induced myelodysplasia syndrome: a nationwide population-based nested case-control study. Med (United States). 2015.

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