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Review

Potential use of custirsen to treat prostate cancer

Pages 785-797 | Published online: 25 Jun 2013

References

  • American Cancer SocietyCancer Facts and Figures2012Atlanta, GAAmerican Cancer Society2012
  • SiegelRDeSantisCVirgoKCancer treatment and survivorship statistics, 2012CA Cancer J Clin201262422024122700443 CA Cancer J Clin201262348
  • TannockIFde WitRBerryWRDocetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancerN Engl J Med20043511502151215470213
  • PetrylakDPTangenCMHussainMHDocetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancerN Engl J Med20043511513152015470214
  • National Comprehensive Cancer NetworkClinical Practice Guidelines in Oncology (NCCN Guideline®). Prostate Cancer Version 3Fort Washington, PANational Comprehensive Cancer Network2012
  • MachielsJPMazzeoFClausseMProspective randomized study comparing docetaxel, estramustine, and prednisone with docetaxel and prednisone in metastatic hormone-refractory prostate cancerJ Clin Oncol2008265261526818794543
  • SmallEDemkowTGerritsenWRA Phase III trial of GVAX immunotherapy for prostate cancer in combination with docetaxel versus docetaxel plus prednisone in symptomatic, castration-resistant prostate cancer (CRPC)Abstract 7 presented at the American Society of Clinical Oncology Genitourinary Cancers SymposiumFebruary 26–28, 2009Orlando, FL
  • KellyWKHalabiSCarducciMRandomized, double-blind, placebo-controlled Phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401J Clin Oncol2012301534154022454414
  • TannockIFizaziKIvanovSAflibercept versus placebo in combination with docetaxel/prednisone for first-line treatment of men with metastatic castration-resistant prostate cancer (mCRPC): results from the multinational Phase III trial (VENICE)J Clin Oncol201331Suppl 6Abstr 13
  • PetrylakDPFizaziKSternbergCA Phase 3 study to evaluate the efficacy and safety of docetaxel and prednisone (DP) with or without lenalidomide (LEN) in patients with castrate-resistant prostate cancer (CRPC): the MAINSAIL TrialAbstract LBA24 presented at the European Society for Molecular Oncology CongressJune 6–9, 2012Berlin, Germany
  • ArmstrongAJCreelPTurnbullJA Phase I–II study of docetaxel and atrasentan in men with castration-resistant metastatic prostate cancerClin Cancer Res2008146270627618829508
  • FizaziKHiganoCNelsonJPhase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan (ZD4054) in patients with metastatic castration-resistant prostate cancerJ Clin Oncol2013311740174723569308
  • ScherHIJiaXChiKRandomized, open-label Phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancerJ Clin Oncol2011292191219821483004
  • AraujoJCTrudelGCSaadFOverall survival (OS) and safety of dasatinib/docetaxel versus docetaxel in patients with metastatic castration-resistant prostate cancer (mCRPC): results from the randomized Phase III READY trialJ Clin Oncol201231Suppl 6Abstr LBA8
  • KantoffPWHiganoCSShoreNDSipuleucel-T immunotherapy for castration-resistant prostate cancerN Engl J Med201036341142220818862
  • de BonoJSOudardSOzgurogluMPrednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trialLancet20103761147115420888992
  • de BonoJSLogothetisCJMolinaAAbiraterone and increased survival in metastatic prostate cancerN Engl J Med20113641995200521612468
  • NilssonSFranzénLParkerCTwo-year survival follow-up of the randomized, double-blind, placebo-controlled Phase II study of radium-223 chloride in patients with castration-resistant prostate cancer and bone metastasesClin Genitourin Cancer201311202623021204
  • ScherIHFizaziKSaadFIncreased survival with enzalutamide in prostate cancer after chemotherapyN Engl J Med20123671187119722894553
  • GaestelMMolecular chaperones in signal transductionHandb Exp Pharmacol20061729310916610356
  • VabulasRMRaychaudhuriSHayer-HartlMHartlFUProtein folding in the cytoplasm and the heat shock responseCold Spring Harb Perspect Biol20102a00439021123396
  • RocchiPSoAKojimaSHeat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancerCancer Res2004646595660215374973
  • ZoubeidiAChiKGleaveMTargeting the cytoprotective chaperone, clusterin, for treatment of advanced cancerClin Cancer Res2010161088109320145158
  • JonesSEJomaryCClusterinInt J Biochem Cell Biol20023442743111906815
  • LiHLiuSZhuXYangSXiangJChenHClusterin immunoexpression and its clinical significance in patients with non-small cell lung cancerLung201018842343120614220
  • MiyakeHGleaveMKamidonoSHaraIOverexpression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrenceUrology20025915015411796313
  • RosenbergMESilkensenJClusterin: physiologic and pathophysiologic considerationsInt J Biochem Cell Biol1995276336457648419
  • YuJTTanLThe role of clusterin in Alzheimer’s disease: pathways, pathogenesis, and therapyMol Neurobiol20124531432622274961
  • NizardPTetleySLe DréanYStress-induced retrotranslocation of clusterin/ApoJ into the cytosolTraffic2007855456517451556
  • HumphreysDTCarverJAEasterbrook-SmithSBWilsonMRClusterin has chaperone-like activity similar to that of small heat shock proteinsJ Biol Chem19992746875688110066740
  • KumitaJRPoonSCaddyGLThe extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar speciesJ Mol Biol200736915716717407782
  • WyattARYerburyJJBerghoferPClusterin facilitates in vivo clearance of extracellular misfolded proteinsCell Mol Life Sci2011683919393121505792
  • ZhangQZhouWKunduSThe leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitroBJU Int20069845246016879694
  • ZhangHKimJKEdwardsCAClusterin inhibits apoptosis by interacting with activated BaxNat Cell Biol2005790991516113678
  • ZoubeidiAEttingerSBeraldiEClusterin facilitates COMMD1 and I-kappa B degradation to enhance NF-kappa B activity in prostate cancer cellsMol Cancer Res2010811913020068069
  • ShiotaMZardanATakeuchiAClusterin mediates TGF-β-induced epithelial-mesenchymal transition and metastasis via Twist 1 in prostate cancer cellsCancer Res2012725261527222896337
  • KevansDFoleyJTenniswoodMHigh clusterin expression correlates with a poor outcome in stage II colorectal cancersCancer Epidemiol Biomarkers Prev20091839339919155441
  • KurahashiTMuramakiMYamanakaKHaraIMiyakeHExpression of the secreted form of clusterin protein in renal cell carcinoma as a predictor of disease extensionBJU Int20059689589916153225
  • RedondoMVillarETorres-MuñozJTellezTMorellMPetitoCKOverexpression of clusterin in human breast carcinomaAm J Pathol200015739339910934144
  • SteinbergJOyasuRLangSIntracellular levels of SGP-2 (clusterin) correlate with tumor grade in prostate cancerClin Cancer Res19973170717119815554
  • XieDLauSHShamJSUpregulated expression of cytoplasmic clusterin in human ovarian carcinomaCancer200510327728315578711
  • CochraneDRWangZMuramakiMGleaveMENelsonCCDifferential regulation of clusterin and its isoforms by androgens in prostate cellsJ Biol Chem20072822278228717148459
  • JulyLVAkbariMZellwegerTJonesECGoldenbergSLGleaveMEClusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapyProstate20025017918811813210
  • PattersonSGWeiSChenXNovel role of Stat1 in the development of docetaxel resistance in prostate tumor cellsOncogene2006256113612216652143
  • SoweryRDHadaschikBASoAIClusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapyBJU Int200810238939718336596
  • MiyakeHNelsonCRenniePSGleaveMETestosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancerCancer Res20006017017610646870
  • MiyakeHNelsonCRenniePSGleaveMEAcquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft modelsCancer Res2000602547255410811138
  • ZellwegerTKiyamaSChiKOverexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour modelBJU Int20039246346912930442
  • GleaveMEMoniaBPAntisense therapy for cancerNat Rev Cancer2005546847915905854
  • BedikianAYMillwardMPehambergerHBcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study GroupJ Clin Oncol2006244738474516966688
  • Chanan-KhanAANiesvizkyRHohlRJPhase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myelomaLeuk Lymphoma20095055956519373653
  • ISIS Pharmaceuticals Available from: http://ir.isispharm.com/phoenix.zhtml?c=222170&p=irol-newsArticle_pf&ID=1290234&highlightAccessed January 8, 2013
  • ZellwegerTMiyakeHCooperSAntitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy)ethyl chemistryJ Pharmacol Exp Ther200129893494011504787
  • MoniaBPLesnikEAGonzalezCEvaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expressionJ Biol Chem199326814514145228390996
  • HenrySSteckerKBrooksDMonteithDConklinBBennettCFChemically modified oligonucleotides exhibit decreased immune stimulation in miceJ Pharmacol Exp Ther200029246847910640282
  • ChiKNHotteSJEllardSA randomized Phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC)J Clin Oncol201230SupplAbstr 4514
  • ChiKNHotteSJEllardSA randomized Phase II study of OGX-427 plus prednisone versus prednisone alone in patients with chemotherapy-naive metastatic castration-resistant prostate cancerJ Clin Oncol201230Suppl 5Abstr 121
  • SoAIBlackPCChiKNA Phase I trial of intravesical antisense oligonucleotide targeting heat shock protein 27 (OGX-427) for the treatment of non-muscle-invasive bladder cancerJ Clin Oncol201230Suppl 5Abstr 286
  • TalbotDCRansonMDaviesJTumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose studyClin Cancer Res2010166150615821041181
  • CaoCShinoharaETLiHClusterin as a therapeutic target for radiation sensitization in a lung cancer modelInt J Radiat Oncol Biol Phys2005631228123616253777
  • SoASinnemannSHuntsmanDFazliLGleaveMKnockdown of the cytoprotective chaperone, clusterin, chemosensitizes human breast cancer cells both in vitro and in vivoMol Cancer Ther200541837184916373699
  • GleaveMMiyakeHUse of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancerWorld J Urol200523384615770517
  • JulyLVBeraldiESoANucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivoMol Cancer Ther2004322323215026542
  • MuramakiMSoAHayashiNChemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterinBJU Int200910338439019007378
  • ChiKNEisenhauerEFazliLA Phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancerJ Natl Cancer Inst2005971287129616145049
  • ChiKNGoldenbergLKollmannsbergerCMurrayNFazliLGleaveMEA Phase II neoadjuvant study of OGX-011, a 2′methoxyethyl phosphorothioate antisense to clusterin, in patients with prostate cancer prior to prostatectomyAbstract 167 presented at the American Society of Clinical Oncology Genitourinary Cancers SymposiumFebruary 14–16, 2008San Francisco, CA
  • ChiKNHotteSJYuEYRandomized Phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancerJ Clin Oncol2010284247425420733135
  • SaadFHotteSNorthSRandomized Phase II trial of custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel: CUOG Trial P-06Clin Cancer Res2011175765577321788353
  • ChiKNSiuLLHirteHA Phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancerClin Cancer Res20081483383918245546
  • BertholdDRPondGRdeWit REisenbergerMTannockifTAX 327 InvestigatorsSurvival and PSA response of patients in the TAX 327 study who crossed over to receive docetaxel after mitoxantrone or vice versaAnn Oncol2008191749175318487550
  • JankovicBBeardsleyEChiKNRechallenge with docetaxel as second-line chemotherapy in patients with metastatic hormone refractory prostate cancer (HRPC) after previous docetaxel: a population based analysisAbstract 196 presented at the American Society of Clinical Oncology Genitourinary Cancers SymposiumFebruary 14–16, 2008San Francisco, CA
  • NemunaitisJHolmlundJTKraynakMPhase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancerJ Clin Oncol1999173586359510550158
  • WatersJSWebbACunninghamDPhase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin’s lymphomaJ Clin Oncol2000181812182310784621
  • ChiKNDe BonoJSHiganoCSSYNERGY: a randomized Phase III study comparing first-line docetaxel/prednisone to docetaxel/prednisone plus custirsen in metastatic castrate-resistant prostate cancer (mCRPC)J Clin Oncol2011SupplAbstr TPS180