References
- JemalASiegelRXuJWardECancer statisticsCA Cancer J Clin201060527730020610543
- KyleRARajkumarSVMultiple myelomaN Engl J Med2004351181860187315509819
- LaubachJPSchlossmanRLMitsiadesCSAndersonKCRichardsonPGThalidomide, lenalidomide and bortezomib in the management of newly diagnosed multiple myelomaExpert Rev Hematol201141516021322778
- van de DonkNWLokhorstHMDimopoulosMTreatment of relapsed and refractory multiple myeloma in the era of novel agentsCancer Treat Rev201137426628320863623
- SinghalSMehtaJDesikanRAntitumor activity of thalidomide in refractory multiple myelomaN Engl J Med1999341211565157110564685
- AndersonKCLenalidomide and thalidomide: mechanisms of action-similarities and differencesSemin Hematol2005424 Suppl 4S3S816344099
- HoffmannMKasserraCReyesJAbsorption, metabolism and excretion of [14C] pomalidomide in humans following oral administrationCancer Chemother Pharmacol201371248950123203815
- RajkumarSVKyleRAAngiogenesis in multiple myelomaSemin Oncol200128656056411740809
- ReddyNHernandez-IlizaliturriFJDeebGImmunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivoBr J Haematol20081401364517995965
- DredgeKMarriottJBMacdonaldCDNovel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effectsBr J Cancer200287101166117212402158
- VaccaAScavelliCMontefuscoVThalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myelomaJ Clin Oncol200523235334534615939924
- DredgeKHorsfallRRobinsonSPOrally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitroMicrovasc Res2005691–2566315797261
- HideshimaTChauhanDShimaYThalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapyBlood20009692943295011049970
- MitsiadesNMitsiadesCSPoulakiVApoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implicationsBlood200299124525453012036884
- NogueiraACNeubertRHelgeHNeubertDThalidomide and the immune system. 3. Simultaneous up- and down-regulation of different integrin receptors on human white blood cellsLife Sci199455277927516993
- DaviesFERajeNHideshimaTThalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myelomaBlood200198121021611418482
- ZhuDCorralLGFlemingYWSteinBImmunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activationCancer Immunol Immunother200857121849185918392823
- ZhuYXBraggioEShiCXCereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomideBlood2011118184771477921860026
- ZhuYXKortuemKMStewartAKMolecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myelomaLeuk Lymphoma201354468368722966948
- PrattGGoodyearOMossPImmunodeficiency and immunotherapy in multiple myelomaBr J Haematol2007138556357917686051
- RacanelliVLeonePFrassanitoMAAlterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myelomaBlood201011561185119320008301
- GoodyearOCPrattGMcLarnonADifferential pattern of CD4+ and CD8+ T-cell immunity to MAGE-A1/A2/A3 in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myelomaBlood200811283362337218658027
- DredgeKMarriottJBTodrykSMProtective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunityJ Immunol2002168104914491911994441
- LuLPayvandiFWuLThe anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditionsMicrovasc Res2009772788618805433
- Escoubet-LozachLLinILJensen-PergakesKPomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanismCancer Res200969187347735619738071
- El-DeiryWSTokinoTVelculescuVEWAF1, a potential mediator of p53 tumor suppressionCell19937548178258242752
- Lopez-GironaAMendyDItoTCereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomideLeukemia201226112326233522552008
- ScheySAFieldsPBartlettJBPhase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myelomaJ Clin Oncol200422163269327615249589
- StreetlyMJGyertsonKDanielYZeldisJBKazmiMScheySAAlternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulationBr J Haematol20081411415118324965
- BladéJSamsonDReeceDCriteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantationMyeloma Subcommittee of the EBMT. European Group for Blood and Marrow TransplantBr J Haematol19981025111511239753033
- RichardsonPGSiegelDBazRPhase I study of pomalidomide MTD, safety and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomibBlood2013121111961196723243282
- RichardsonPGWellerELonialSLenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myelomaBlood2010116567968620385792
- DimopoulosMAKastritisEChristoulasDTreatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapiesLeukemia201024101769177820739955
- RichardsonPGHofmeisterCCSiegelDMM-005: a phase 1, multicenter, open-label, dose-escalation study to determine the maximum tolerated dose for the combination of pomalidomide, bortezomib, and low-dose dexamethasone in subjects with relapsed or refractory multiple myelomaPaper presented at: 54th Annual Meeting of the American Society of HematologyDecember 8–11, 2012Atlanta, GA, USA
- BazRShainKHAlsinaMOral weekly cyclophosphamide in combination with pomalidomide and dexamethasone for relapsed and refractory myeloma: report of the dose escalation cohortPaper presented at: 54th Annual Meeting of the American Society of HematologyDecember 8–11, 2012Atlanta, GA, USA
- BerensonJRHilgerJDKleinLMA Phase 1/2 Study of pomalidomide, dexamethasone and pegylated liposomal doxorubicin for patients with relapsed/refractory multiple myelomaPaper presented at: 54th Annual Meeting of the American Society of HematologyDecember 8–11, 2012Atlanta, GA, USA
- LacyMQHaymanSRGertzMAPomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myelomaJ Clin Oncol200927305008501419720894
- DurieBGHarousseauJLMiguelJSInternational uniform response criteria for multiple myelomaLeukemia20062091467147316855634
- LacyMQHaymanSRGertzMAPomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)Leukemia201024111934193920827286
- JagannathSHofmeisterCCSiegelDSPomalidomide (POM) with Low-Dose Dexamethasone (LoDex) in Patients (Pts) with Relapsed and Refractory Multiple Myeloma Who Have Received Prior Therapy with Lenalidomide (LEN) and Bortezomib (BORT): Updated Phase 2 Results and Age Subgroup AnalysisPaper presented at: 54th Annual Meeting of the American Society of HematologyDecember 8–11, 2012Atlanta, GA, USA
- LacyMQAllredJBGertzMAPomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory diseaseBlood2011118112970297521690557
- LeleuXAttalMArnulfBIntergroupe Francophone du MyélomePomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide-refractory multiple myeloma: Intergroupe Francophone du Myelome 2009-02Blood2013121111968197523319574
- ShortKDRajkumarSVLarsonDIncidence of extramedullary disease in patients with multiple myeloma in the era of novel therapy, and the activity of pomalidomide on extramedullary myelomaLeukemia201125690690821350560
- DimopoulosMALacyMQMoreauPPomalidomide in combination with low-dose dexamethasone: demonstrates a significant progression free survival and overall survival advantage, in relapsed/refractory mm: a phase 3, multicenter, randomized, open-label studyPaper presented at: 54th Annual Meeting of the American Society of HematologyDecember 8–11, 2012Atlanta, GA, USA