References
- SenRBaltimoreDMultiple nuclear factors interact with the immunoglobulin enhancer sequencesCell1986467057163091258 J Immunol2006177117485749617114415
- HaydenMSGhoshSNF-κB, the first quarter-century: remarkable progress and outstanding questionsGenes Dev201226320323422302935
- PerkinsNDThe diverse and complex roles of NF-κB subunits in cancerNat Rev Cancer201212212113222257950
- MonacoCAndreakosEKiriakidisSCanonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosisProc Natl Acad Sci U S A2004101155634563915064395
- BasakSKimHKearnsJDA fourth IkappaB protein within the NF-kappaB signaling moduleCell2007128236938117254973
- ChenJChenZJRegulation of NF-κB by ubiquitinationCurr Opin Immunol201325141223312890
- BasakSShihVFHoffmannAGeneration and activation of multiple dimeric transcription factors within the NF-kappaB signaling systemMol Cell Biol200828103139315018299388
- YuMQiXMorenoJLFarberDLKeeganADNF-κB signaling participates in both RANKL- and IL-4-induced macrophage fusion: receptor cross-talk leads to alterations in NF-κB pathwaysJ Immunol201118741797180621734075
- TianBNowakDEJamaluddinMWangSBrasierARIdentification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signalingJ Biol Chem200528017174351744815722553
- GilmoreTDIntroduction to NF-kappaB: players, pathways, perspectivesOncogene200625516680668417072321
- BasakSShihVFHoffmannAGeneration and activation of multiple dimeric transcription factors within the NF-kappaB signaling systemMol Cell Biol200828103139315018299388
- NovackDVRole of NF-κB in the skeletonCell Res201121116918221079651
- SchauerIGZhangJXingZInterleukin-1β promotes ovarian tumorigenesis through a p53/NF-κB-mediated inflammatory response in stromal fibroblastsNeoplasia201315440942023555186
- CaoYKarinMNF-kappaB in mammary gland development and breast cancerJ Mammary Gland Biol Neoplasia20038221522314635796
- NickolsJCValentineWKanwalSCarterBDActivation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formationNat Neurosci20036216116712514737
- LiYOhmsSJSunCFanJNF-κB controls Il2 and Csf2 expression during T cell development and activation processMol Biol Rep20134021685169223079711
- KailehMSenRNF-κB function in B lymphocytesImmunol Rev2012246125427122435560
- SnapperCMZelazowskiPRosasFRB cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switchingJ Immunol199615611831918598461
- GerondakisSBanerjeeAGrigoriadisGNF-κB subunit specificity in hemopoiesisImmunol Rev2012246127228522435561
- ThompsonCCloutierABosséYCysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expressionAm J Respir Cell Mol Biol200635669770416809637
- XanthouleaSCurfsDMHofkerMHde WintherMPNuclear factor kappa B signaling in macrophage function and atherogenesisCurr Opin Lipidol200516553654216148538
- KarinMNF-kappaB as a critical link between inflammation and cancerCold Spring Harb Perspect Biol200915a00014120066113
- DiDonatoJAMercurioFKarinMNF-κB and the link between inflammation and cancerImmunol Rev2012246137940022435567
- StaudtLMOncogenic activation of NF-kappaBCold Spring Harb Perspect Biol201026a00010920516126
- CarboneCMelisiDNF-κB as a target for pancreatic cancer therapyExpert Opin Ther Targets201216Suppl 2S1S1022443181
- OdqvistLSánchez-BeatoMMontes-MorenoSNIK controls classical and alternative NF-κB activation and is necessary for the survival of human T-cell lymphoma cellsClin Cancer Res20131992319233023536439
- AlbertiCPinciroliPValeriBLigand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancerOncogene201231374139414922158046
- KorkolopoulouPLevidouGTrigkaEAA comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinomaBJU Int201211011 Pt CE1237E124823107319
- ParajuliBLeeHGKwonSHSalinomycin inhibits Akt/NF-κB and induces apoptosis in cisplatin resistant ovarian cancer cellsCancer Epidemiol201337451251723545383
- HoweENCochraneDRCittellyDMRicherJKmiR-200c targets a NF-κB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancerPLoS ONE2012711e4998723185507
- WangZBanerjeeSAhmadAActivated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathwaysPLoS ONE201166e2053721673986
- YuHMohanSNatarajanMRadiation-Triggered NF-κB Activation is Responsible for the Angiogenic Signaling Pathway and Neovascularization for Breast Cancer Cell Proliferation and GrowthBreast Cancer (Auckl)2012612513522872788
- PikarskyEPoratRMSteinINF-kappaB functions as a tumour promoter in inflammation-associated cancerNature2004431700746146615329734
- WangFHeWFanghuiPWangLFanQNF-κBP65 promotes invasion and metastasis of oesophageal squamous cell cancer by regulating matrix metalloproteinase-9 and epithelial-to-mesenchymal transitionCell Biol Int201337878078823504993
- KirillovaIChaissonMFaustoNTumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activationCell Growth Differ1999101281982810616907
- MeiraLBBugniJMGreenSLDNA damage induced by chronic inflammation contributes to colon carcinogenesis in miceJ Clin Invest200811872516252518521188
- LinEYNguyenAVRussellRGPollardJWColony-stimulating factor 1 promotes progression of mammary tumors to malignancyJ Exp Med2001193672774011257139
- PerkinsNDGilmoreTDGood cop, bad cop: the different faces of NF-kappaBCell Death Differ200613575977216410803
- HayflickLThe limited in vitro lifetime of human diploid cell strainsExp Cell Res19653761463614315085
- Ben-PorathIWeinbergRAThe signals and pathways activating cellular senescenceInt J Biochem Cell Biol200537596197615743671
- MalletteFAGaumont-LeclercMFFerbeyreGThe DNA damage signaling pathway is a critical mediator of oncogene-induced senescenceGenes Dev2007211434817210786
- AdamsPDHealing and hurting: molecular mechanisms, functions, and pathologies of cellular senescenceMol Cell200936121419818705
- CampisiJSenescent cells, tumor suppression, and organismal aging: good citizens, bad neighborsCell2005120451352215734683
- Ben-PorathIWeinbergRAWhen cells get stressed: an integrative view of cellular senescenceJ Clin Invest2004113181314702100
- KuilmanTMichaloglouCMooiWJPeeperDSThe essence of senescenceGenes Dev201024222463247921078816
- RyanKMPhillipsACVousdenKHRegulation and function of the p53 tumor suppressor proteinCurr Opin Cell Biol200113333233711343904
- LoweSWSherrCJTumor suppression by Ink4a-Arf: progress and puzzlesCurr Opin Genet Dev2003131778312573439
- Di MiccoRCicaleseAFumagalliMDNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalizationCell Cycle20087223601360619001874
- RufiniATucciPCelardoIMelinoGSenescence and aging: the critical roles of p53Oncogene2013
- DolesJStorerMCozzutoLRomaGKeyesWMAge-associated inflammation inhibits epidermal stem cell functionGenes Dev201226192144215322972935
- ChoudheryMSKhanMMahmoodRMehmoodAKhanSNRiazuddinSBone marrow derived mesenchymal stem cells from aged mice have reduced wound healing, angiogenesis, proliferation and anti-apoptosis capabilitiesCell Biol Int201236874775322352320
- VivarelliSWagstaffLPiddiniECell wars: regulation of cell survival and proliferation by cell competitionEssays Biochem201253698222928509
- XueWZenderLMiethingCSenescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasNature2007445712865666017251933
- KrieglLNeumannJViethMUp and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancerMod Pathol20112471015102221423154
- FavaroEBensaadKChongMGGlucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cellsCell Metab201216675176423177934
- YangDLiLLiuHInduction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cellsCell Death Differ201320223524722935614
- BiggersJWNguyenTDiXAutophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14Cancer Chemother Pharmacol201371244145523178952
- SalimHAkbarNSZongDmiRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescenceBr J Cancer201210781361137322929890
- VaughanSJatPSDeciphering the role of nuclear factor-κB in cellular senescenceAging (Albany NY)201131091391921990145
- BernardDQuatannensBBegueAVandenbunderBAbbadieCAntiproliferative and antiapoptotic effects of crel may occur within the same cells via the up-regulation of manganese superoxide dismutaseCancer Res20016162656266411289144
- BernardDSlomiannyCVandenbunderBAbbadieCcRel induces mitochondrial alterations in correlation with proliferation arrestFree Radic Biol Med200131894395311595379
- HardyKMansfieldLMackayATranscriptional networks and cellular senescence in human mammary fibroblastsMol Biol Cell200516294395315574883
- AdlerASSinhaSKawaharaTLZhangJYSegalEChangHYMotif module map reveals enforcement of aging by continual NF-kappaB activityGenes Dev200721243244325718055696
- RovillainEMansfieldLCaetanoCActivation of nuclear factor-kappa B signalling promotes cellular senescenceOncogene201130202356236621242976
- LiuKFengTLiuJZhongMZhangSSilencing of the DEK gene induces apoptosis and senescence in CaSki cervical carcinoma cells via the up-regulation of NF-κB p65Biosci Rep201232332333222390170
- CampisiJAndersenJKKapahiPMelovSCellular senescence: a link between cancer and age-related degenerative disease?Semin Cancer Biol201121635435921925603
- RodierFCampisiJFour faces of cellular senescenceJ Cell Biol2011192454755621321098
- FreundAPatilCKCampisiJp38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotypeEMBO J20113081536154821399611
- TilstraJSRobinsonARWangJNF-κB inhibition delays DNA damage-induced senescence and aging in miceJ Clin Invest201212272601261222706308
- OsorioFGBárcenaCSoria-VallesCNuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory responseGenes Dev201226202311232423019125
- ZhangGLiJPurkayasthaSHypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRHNature2013497744821121623636330
- HinzMStilmannMArslanSÇKhannaKKDittmarGScheidereitCA cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activationMol Cell2010401637420932475
- LeeYKChaHJHongMYoonYLeeHAnSRole of NF-κB-p53 crosstalk in ultraviolet A-induced cell death and G1 arrest in human dermal fibroblastsArch Dermatol Res20123041737921947322
- PoltzRNaumannMDynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic interventionBMC Syst Biol2012612522979979
- BoldersonERichardDJZhouBBKhannaKKRecent advances in cancer therapy targeting proteins involved in DNA double-strand break repairClin Cancer Res200915206314632019808869
- DeorukhkarAKrishnanSTargeting inflammatory pathways for tumor radiosensitizationBiochem Pharmacol201080121904191420599771
- CusackJCLiuRBaldwinASInducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activationCancer Res20006092323233010811101
- LiuYHawkinsOESuYTargeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescenceEMBO Mol Med20135114916623180582
- OhannaMGiulianoSBonetCSenescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)Genes Dev201125121245126121646373
- ChienYScuoppoCWangXControl of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivityGenes Dev201125202125213621979375
- OrjaloAVBhaumikDGenglerBKScottGKCampisiJCell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine networkProc Natl Acad Sci U S A200910640170311703619805069
- AcostaJCO’LoghlenABanitoAChemokine signaling via the CXCR2 receptor reinforces senescenceCell200813361006101818555777
- TchkoniaTZhuYvan DeursenJCampisiJKirklandJLCellular senescence and the senescent secretory phenotype: therapeutic opportunitiesJ Clin Invest2013123396697223454759
- MoiseevaODeschênes-SimardXSt-GermainEMetformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activationAging Cell201312348949823521863
- EwaldJDesotelleJAlmassiNJarrardDDrug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivoBr J Cancer20089871244124918349844
- KuilmanTMichaloglouCVredeveldLCOncogene-induced senescence relayed by an interleukin-dependent inflammatory networkCell200813361019103118555778