Cytoprotection “gone astray”: Nrf2 and its role in cancer

References

• KangKWLeeSJKimSGMolecular mechanism of nrf2 activation by oxidative stressAntioxid Redox Signal2005711–121664167316356128
   PubMed Web of Science ®Google Scholar
• OsburnWOKenslerTWNrf2 signaling: an adaptive response pathway for protection against environmental toxic insultsMutat Res20086591–2313918164232
   PubMed Web of Science ®Google Scholar
• KasparJWNitureSKJaiswalAKNrf2:INrf2 (Keap1) signaling in oxidative stressFree Radic Biol Med20094791304130919666107
   PubMed Web of Science ®Google Scholar
• SuzukiTMotohashiHYamamotoMToward clinical application of the Keap1-Nrf2 pathwayTrends Pharmacol Sci201334634034623664668
   PubMed Web of Science ®Google Scholar
• GiudiceAMontellaMActivation of the Nrf2-ARE signaling pathway: a promising strategy in cancer preventionBioessays200628216918116435293
   PubMed Web of Science ®Google Scholar
• LauAVilleneuveNFSunZWongPKZhangDDDual roles of Nrf2 in cancerPharmacol Res2008585–626227018838122
   PubMed Web of Science ®Google Scholar
• KwakMKKenslerTWTargeting NRF2 signaling for cancer chemopreventionToxicol Appl Pharmacol20102441667619732782
   PubMed Web of Science ®Google Scholar
• HayesJDMcMahonMChowdhrySDinkova-KostovaATCancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathwayAntioxid Redox Signal201013111713174820446772
   PubMed Web of Science ®Google Scholar
• SpornMBLibyKTNRF2 and cancer: the good, the bad and the importance of contextNat Rev Cancer201212856457122810811
   PubMed Web of Science ®Google Scholar
• JaramilloMCZhangDDThe emerging role of the Nrf2-Keap1 signaling pathway in cancerGenes Dev201327202179219124142871
   PubMed Web of Science ®Google Scholar
• SheltonPJaiswalAKThe transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?FASEB J201327241442323109674
   PubMed Web of Science ®Google Scholar
• ZhangDDThe Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancerAntioxid Redox Signal201013111623162620486759
   PubMed Web of Science ®Google Scholar
• DeNicolaGMKarrethFAHumptonTJOncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisNature2011475735410610921734707
   PubMed Web of Science ®Google Scholar
• CadenasEBiochemistry of oxygen toxicityAnnu Rev Biochem198958791102673022
   PubMed Web of Science ®Google Scholar
• HalliwellBGutteridgeJMFree Radicals in Biology and Medicine3rd edOxfordOxford University Press1999
   Google Scholar
• InoueMSatoEFNishikawaMMitochondrial generation of reactive oxygen species and its role in aerobic lifeCurr Med Chem200310232495250514529465
   PubMed Web of Science ®Google Scholar
• ConnerEMGrishamMBInflammation, free radicals, and antioxidantsNutrition19961242742778862535
   PubMed Web of Science ®Google Scholar
• PoliGLeonarduzziGBiasiFChiarpottoEOxidative stress and cell signallingCurr Med Chem20041191163118215134513
   PubMed Web of Science ®Google Scholar
• KnightJADiseases related to oxygen-derived free radicalsAnn Clin Lab Sci19952521111217785961
   PubMed Web of Science ®Google Scholar
• KlaunigJEKamendulisLMThe role of oxidative stress in carcinogenesisAnnu Rev Pharmacol Toxicol20044423926714744246
   PubMed Web of Science ®Google Scholar
• ReuterSGuptaSCChaturvediMMAggarwalBBOxidative stress, inflammation, and cancer: how are they linked?Free Radic Biol Med201049111603161620840865
   PubMed Web of Science ®Google Scholar
• ChoHYReddySPKleebergerSRNrf2 defends the lung from oxidative stressAntioxid Redox Signal200681–2768716487040
   PubMed Web of Science ®Google Scholar
• NguyenTNioiPPickettCBThe Nrf2-antioxidant response element signaling pathway and its activation by oxidative stressJ Biol Chem200928420132911329519182219
   PubMed Web of Science ®Google Scholar
• ChorleyBNCampbellMRWangXIdentification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alphaNucleic Acids Res201240157416742922581777
   PubMed Web of Science ®Google Scholar
• MalhotraDPortales-CasamarESinghAGlobal mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysisNucleic Acids Res201038175718573420460467
   PubMed Web of Science ®Google Scholar
• JohnsonCHPattersonADIdleJRGonzalezFJXenobiotic metabolomics: major impact on the metabolomeAnnu Rev Pharmacol Toxicol201252375621819238
   PubMed Web of Science ®Google Scholar
• IdleJRGonzalezFJMetabolomicsCell Metab20076534835117983580
   PubMed Web of Science ®Google Scholar
• WilliamsGMJeffreyAMOxidative DNA damage: endogenous and chemically inducedRegul Toxicol Pharmacol200032328329211162722
   PubMed Web of Science ®Google Scholar
• LiXSchulerMABerenbaumMRMolecular mechanisms of metabolic resistance to synthetic and natural xenobioticsAnnu Rev Entomol20075223125316925478
   PubMed Web of Science ®Google Scholar
• LewisDFHuman P450s in the metabolism of drugs: molecular modelling of enzyme-substrate interactionsExpert Opin Drug Metab Toxicol2005115816922648
   PubMedGoogle Scholar
• XuCLiCYKongANInduction of phase I, II and III drug metabolism/transport by xenobioticsArch Pharm Res200528324926815832810
   PubMed Web of Science ®Google Scholar
• HayesJDDinkova-KostovaATThe Nrf2 regulatory network provides an interface between redox and intermediary metabolismTrends Biochem Sci201439419921824647116
   PubMed Web of Science ®Google Scholar
• HirotsuYKatsuokaFFunayamaRNrf2-MafG heterodimers contribute globally to antioxidant and metabolic networksNucleic Acids Res20124020102281023922965115
   PubMed Web of Science ®Google Scholar
• MoiPChanKAsunisICaoAKanYWIsolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control regionProc Natl Acad Sci U S A19949121992699307937919
   PubMed Web of Science ®Google Scholar
• ItohKWakabayashiNKatohYKeap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domainGenes Dev199913176869887101
   PubMed Web of Science ®Google Scholar
• CullinanSBGordanJDJinJHarperJWDiehlJAThe Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligaseMol Cell Biol200424198477848615367669
   PubMed Web of Science ®Google Scholar
• KatohYIidaKKangMIEvolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasomeArch Biochem Biophys2005433234235015581590
   PubMed Web of Science ®Google Scholar
• KobayashiAKangMIWataiYOxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1Mol Cell Biol200626122122916354693
   PubMed Web of Science ®Google Scholar
• TongKIKobayashiAKatsuokaFYamamotoMTwo-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanismBiol Chem200638710–111311132017081101
   PubMed Web of Science ®Google Scholar
• RachakondaGXiongYSekharKRStamerSLLieblerDCFreemanMLCovalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3Chem Res Toxicol200821370571018251510
   PubMed Web of Science ®Google Scholar
• ZhangDDLoSCSunZHabibGMLiebermanMWHanninkMUbiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathwayJ Biol Chem200528034300913009915983046
   PubMed Web of Science ®Google Scholar
• VilleneuveNFTianWWuTUSP15 negatively regulates Nrf2 through deubiquitination of Keap1Mol Cell2013511687923727018
   PubMed Web of Science ®Google Scholar
• NitureSKKasparJWShenJJaiswalAKNrf2 signaling and cell survivalToxicol Appl Pharmacol20102441374219538984
   PubMed Web of Science ®Google Scholar
• HuangHCNguyenTPickettCBRegulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2Proc Natl Acad Sci U S A20009723124751248011035812
   PubMed Web of Science ®Google Scholar
• CullinanSBZhangDHanninkMArvisaisEKaufmanRJDiehlJANrf2 is a direct PERK substrate and effector of PERK-dependent cell survivalMol Cell Biol200323207198720914517290
   PubMed Web of Science ®Google Scholar
• ApopaPLHeXMaQPhosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cellsJ Biochem Mol Toxicol2008221637618273910
   PubMed Web of Science ®Google Scholar
• SunZChinYEZhangDDAcetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant responseMol Cell Biol200929102658267219273602
   PubMed Web of Science ®Google Scholar
• ChenZYeXTangNThe histone acetylranseferase [sic] hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancerBr J Pharmacol2014171133196321124571482
   PubMed Web of Science ®Google Scholar
• KawaiYGardunoLTheodoreMYangJArinzeIJAcetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localizationJ Biol Chem201128697629764021196497
   PubMed Web of Science ®Google Scholar
• KangSJRyooIGLeeYJKwakMKRole of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicityToxicol Appl Pharmacol20122581899822036727
   PubMed Web of Science ®Google Scholar
• YuRChenCMoYYActivation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanismJ Biol Chem200027551399073991310986282
   PubMed Web of Science ®Google Scholar
• YuRMandlekarSLeiWFahlWETanTHKongANp38 Mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogensJ Biol Chem200027542322232710644681
   PubMed Web of Science ®Google Scholar
• SakamotoKIwasakiKSugiyamaHTsujiYRole of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modificationsMol Biol Cell20092061606161719158375
   PubMed Web of Science ®Google Scholar
• JainAKJaiswalAKGSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2J Biol Chem200728222165021651017403689
   PubMed Web of Science ®Google Scholar
• BlankVSmall Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?J Mol Biol2008376491392518201722
   PubMed Web of Science ®Google Scholar
• MotohashiHShavitJAIgarashiKYamamotoMEngelJDThe world according to MafNucleic Acids Res19972515295329599224592
   PubMed Web of Science ®Google Scholar
• KannanMBSolovievaVBlankVThe small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectivesBiochim Biophys Acta20121823101841184622721719
   PubMed Web of Science ®Google Scholar
• BenkhelifaSProvotSNabaisEEychèneACalothyGFelder-SchmittbuhlMPPhosphorylation of MafA is essential for its transcriptional and biological propertiesMol Cell Biol200121144441445211416124
   PubMed Web of Science ®Google Scholar
• Sii-FeliceKPouponnotCGilletSMafA transcription factor is phosphorylated by p38 MAP kinaseFEBS Lett2005579173547355415963504
   PubMed Web of Science ®Google Scholar
• RoYTJangBKShinCYParkEUKimCGYangSIAkt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal functionJ Biomed Sci2010171820233453
   PubMed Web of Science ®Google Scholar
• TanigawaSLeeCHLinCSJun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasisCell Death Dis20134e92124232097
   PubMed Web of Science ®Google Scholar
• OyakeTItohKMotohashiHBach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 siteMol Cell Biol19961611608360958887638
   PubMed Web of Science ®Google Scholar
• HoshinoHKobayashiAYoshidaMOxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition elementJ Biol Chem200027520153701537610809773
   PubMed Web of Science ®Google Scholar
• DhakshinamoorthySJainAKBloomDAJaiswalAKBach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidantsJ Biol Chem200528017168911690015734732
   PubMed Web of Science ®Google Scholar
• JyrkkänenHKKuosmanenSHeinäniemiMNovel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2Biochem J2011440216717421812759
   PubMed Web of Science ®Google Scholar
• MitsuishiYTaguchiKKawataniYNrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogrammingCancer Cell2012221667922789539
   PubMed Web of Science ®Google Scholar
• NitureSKKhatriRJaiswalAKRegulation of Nrf2 – an updateFree Radic Biol Med201466364423434765
   PubMed Web of Science ®Google Scholar
• MitsuishiYMotohashiHYamamotoMThe Keap1-Nrf2 system in cancers: stress response and anabolic metabolismFront Oncol2012220023272301
   PubMedGoogle Scholar
• ZhangDDHanninkMDistinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stressMol Cell Biol200323228137815114585973
   PubMed Web of Science ®Google Scholar
• YamamotoTSuzukiTKobayashiAPhysiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activityMol Cell Biol20082882758277018268004
   PubMed Web of Science ®Google Scholar
• MageshSChenYHuLSmall molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsMed Res Rev201232468772622549716
   PubMed Web of Science ®Google Scholar
• KumarHKimISMoreSVKimBWChoiDKNatural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseasesNat Prod Rep201431110913924292194
   PubMed Web of Science ®Google Scholar
• LoSCHanninkMPGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondriaExp Cell Res200831481789180318387606
   PubMed Web of Science ®Google Scholar
• NitureSKJaiswalAKInhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosisJ Biol Chem201128652445424455622072718
   PubMed Web of Science ®Google Scholar
• KomatsuMKurokawaHWaguriSThe selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1Nat Cell Biol201012321322320173742
   PubMed Web of Science ®Google Scholar
• InamiYWaguriSSakamotoAPersistent activation of Nrf2 through p62 in hepatocellular carcinoma cellsJ Cell Biol2011193227528421482715
   PubMed Web of Science ®Google Scholar
• ChenWSunZWangXJDirect interaction between Nrf2 and p21 (Cip1/WAF1) upregulates the Nrf2-mediated antioxidant responseMol Cell200934666367319560419
   PubMed Web of Science ®Google Scholar
• ChowdhrySZhangYMcMahonMSutherlandCCuadradoAHayesJDNrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activityOncogene201332323765378122964642
   PubMed Web of Science ®Google Scholar
• RadaPRojoAIEvrard-TodeschiNStructural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/beta-TrCP axisMol Cell Biol201232173486349922751928
   PubMed Web of Science ®Google Scholar
• FaraonioRVergaraPDi MarzoDp53 Suppresses the Nrf2-dependent transcription of antioxidant response genesJ Biol Chem200628152397763978417077087
   PubMed Web of Science ®Google Scholar
• ChenWJiangTWangHDoes Nrf2 contribute to p53-mediated control of cell survival and death?Antioxid Redox Signal201217121670167522559194
   PubMed Web of Science ®Google Scholar
• KaloEKogan-SakinISolomonHMutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen speciesJ Cell Sci2012125Pt 225578558622899716
   PubMed Web of Science ®Google Scholar
• NitureSKJainAKSheltonPMJaiswalAKSrc subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expressionJ Biol Chem201128633288212883221690096
   PubMed Web of Science ®Google Scholar
• SunZZhangSChanJYZhangDDKeap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2Mol Cell Biol200727186334634917636022
   PubMed Web of Science ®Google Scholar
• YuMLiHLiuQNuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathwayCell Signal201123588389221262351
   PubMed Web of Science ®Google Scholar
• KimWDKimYWChoIJLeeCHKimSGE-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cellsJ Cell Sci2012125Pt 51284129522302998
   PubMed Web of Science ®Google Scholar
• BakinAVStourmanNVSekharKRSmad3-ATF3 signaling mediates TGF-beta suppression of genes encoding phase II detoxifying proteinsFree Radic Biol Med200538337538715629866
   PubMed Web of Science ®Google Scholar
• BrownSLSekharKRRachakondaGSasiSFreemanMLActivating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathwayCancer Res200868236436818199529
   PubMed Web of Science ®Google Scholar
• KratschmarDVCalabreseDWalshJSuppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cellsPLoS One201275e3677422606287
   PubMed Web of Science ®Google Scholar
• ZhouWLoSCLiuJHHanninkMLubahnDBERRβ: a potent inhibitor of Nrf2 transcriptional activityMol Cell Endocrinol20072781–2526217920186
   PubMed Web of Science ®Google Scholar
• YaoYBrodieAMDavidsonNEKenslerTWZhouQInhibition of estrogen signaling activates the NRF2 pathway in breast cancerBreast Cancer Res Treat2010124258559120623181
   PubMed Web of Science ®Google Scholar
• WangXJHayesJDHendersonCJWolfCRIdentification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alphaProc Natl Acad Sci U S A200710449195891959418048326
   PubMed Web of Science ®Google Scholar
• WangHLiuKGengMRXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2Cancer Res201373103097310823612120
   PubMed Web of Science ®Google Scholar
• BryanHKOlayanjuAGoldringCEParkBKThe Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulationBiochem Pharmacol201385670571723219527
   PubMed Web of Science ®Google Scholar
• Gañán-GómezIWeiYYangHBoyano-AdánezMCGarcía-ManeroGOncogenic functions of the transcription factor Nrf2Free Radic Biol Med20136575076423820265
   PubMed Web of Science ®Google Scholar
• SlocumSLKenslerTWNrf2: control of sensitivity to carcinogensArch Toxicol201185427328421369766
   PubMed Web of Science ®Google Scholar
• ChanKLuRChangJCKanYWNRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and developmentProc Natl Acad Sci U S A1996932413943139488943040
   PubMed Web of Science ®Google Scholar
• ChoHYKleebergerSRNrf2 protects against airway disordersToxicol Appl Pharmacol20102441435619646463
   PubMed Web of Science ®Google Scholar
• KudohKUchinamiHYoshiokaMSekiEYamamotoYNrf2 activation protects the liver from ischemia/reperfusion injury in miceAnn Surg2014260111812724368646
   PubMed Web of Science ®Google Scholar
• LiuMReddyNMHigbeeEMThe Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in miceKidney Int201485113414124088953
   PubMed Web of Science ®Google Scholar
• ShirasakiKTaguchiKUnnoMMotohashiHYamamotoMNF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in miceHepatology20145962371238224443206
   PubMed Web of Science ®Google Scholar
• ZhaoZChenYWangJAge-related retinopathy in NRF2-deficient micePLoS One201164e1945621559389
   PubMed Web of Science ®Google Scholar
• OsburnWOKarimBDolanPMIncreased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatmentInt J Cancer200712191883189117631644
   PubMed Web of Science ®Google Scholar
• KhorTOHuangMTKwonKHChanJYReddyBSKongANNrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitisCancer Res20066624115801158417178849
   PubMed Web of Science ®Google Scholar
• KhorTOHuangMTPrawanAIncreased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancerCancer Prev Res (Phila)20081318719119138955
   PubMed Web of Science ®Google Scholar
• IidaKItohKKumagaiYNrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesisCancer Res200464186424643115374950
   PubMed Web of Science ®Google Scholar
• LibyKTRoyceDBRisingsongRSynthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancerCancer Prev Res (Phila)20103111427143420959520
   PubMed Web of Science ®Google Scholar
• SawCLHuangMTLiuYKhorTOConneyAHKongANImpact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphaneMol Carcinog201150647948621557329
   PubMed Web of Science ®Google Scholar
• XuCHuangMTShenGInhibition of 7,12-dimethylbenz(a) anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2Cancer Res200666168293829616912211
   PubMed Web of Science ®Google Scholar
• YatesMSKwakMKEgnerPAPotent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1, 9(11)-dien-28-oyl]imidazoleCancer Res20066642488249416489057
   PubMed Web of Science ®Google Scholar
• McMahonMItohKYamamotoMThe Cap’n’Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymesCancer Res20016183299330711309284
   PubMed Web of Science ®Google Scholar
• Ramos-GomezMDolanPMItohKYamamotoMKenslerTWInteractive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in miceCarcinogenesis200324346146712663505
   PubMed Web of Science ®Google Scholar
• ShenGXuCHuRModulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcuminMol Cancer Ther200651395116432161
   PubMed Web of Science ®Google Scholar
• SussanTERangasamyTBlakeDJTargeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in miceProc Natl Acad Sci U S A2009106125025519104057
   PubMed Web of Science ®Google Scholar
• ZhengHWhitmanSAWuWTherapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathyDiabetes201160113055306622025779
   PubMed Web of Science ®Google Scholar
• Ramos-GomezMKwakMKDolanPMSensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient miceProc Natl Acad Sci U S A20019863410341511248092
   PubMed Web of Science ®Google Scholar
• CheungKLLeeJHKhorTONrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammationMol Carcinog2014531778422911891
   PubMed Web of Science ®Google Scholar
• SatohHMoriguchiTTaguchiKNrf2-deficiency creates a responsive microenvironment for metastasis to the lungCarcinogenesis201031101833184320513672
   PubMed Web of Science ®Google Scholar
• SchultzMAHaganSSDattaANrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cellsPLoS One201491e8720424466341
   PubMed Web of Science ®Google Scholar
• WangWKwokAMChanJYThe p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcriptionJ Biol Chem200728234246702467817609210
   PubMed Web of Science ®Google Scholar
• KunduJKSurhYJNrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesisPharm Res2010276999101320354764
   PubMed Web of Science ®Google Scholar
• LiuJGuXRobbinsDProtandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a modelPLoS One200944e528419384424
   PubMed Web of Science ®Google Scholar
• ZhaoCRGaoZHQuXJNrf2-ARE signaling pathway and natural products for cancer chemopreventionCancer Epidemiol201034552353320638930
   PubMed Web of Science ®Google Scholar
• AshrafianHCzibikGBellahceneMFumarate is cardioprotective via activation of the Nrf2 antioxidant pathwayCell Metab201215336137122405071
   PubMed Web of Science ®Google Scholar
• ChartoumpekisDVZirosPGPsyrogiannisAINrf2 represses FGF21 during long-term high-fat diet-induced obesity in miceDiabetes201160102465247321852674
   PubMed Web of Science ®Google Scholar
• JohnsonJAJohnsonDAKraftADThe Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegenerationAnn N Y Acad Sci20081147616919076431
   PubMed Web of Science ®Google Scholar
• LaPash DanielsCMAustinEVRockneyDEBeneficial effects of Nrf2 overexpression in a mouse model of Alexander diseaseJ Neurosci20123231105071051522855800
   PubMed Web of Science ®Google Scholar
• UrunoAFurusawaYYagishitaYThe Keap1-Nrf2 system prevents onset of diabetes mellitusMol Cell Biol201333152996301023716596
   PubMed Web of Science ®Google Scholar
• KenslerTWEgnerPAAgyemanASKeap1-nrf2 signaling: a target for cancer prevention by sulforaphaneTop Curr Chem201332916317722752583
   PubMed Web of Science ®Google Scholar
• CornblattBSYeLDinkova-KostovaATPreclinical and clinical evaluation of sulforaphane for chemoprevention in the breastCarcinogenesis20072871485149017347138
   PubMed Web of Science ®Google Scholar
• EgnerPAChenJGWangJBBioavailability of sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, ChinaCancer Prev Res (Phila)20114338439521372038
   PubMed Web of Science ®Google Scholar
• KenslerTWNgDCarmellaSGModulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, ChinaCarcinogenesis201233110110722045030
   PubMed Web of Science ®Google Scholar
• ZojaCBenigniARemuzziGThe Nrf2 pathway in the progression of renal diseaseNephrol Dial Transplant201429 Suppl 1i19i2423761459
   PubMed Web of Science ®Google Scholar
• ReddyNMPottetiHRMarianiTJBiswalSReddySPConditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammationAm J Respir Cell Mol Biol20114561161116821659655
   PubMed Web of Science ®Google Scholar
• TaguchiKMotohashiHYamamotoMMolecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolutionGenes Cells201116212314021251164
   PubMed Web of Science ®Google Scholar
• ListerANedjadiTKitteringhamNRNrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapyMol Cancer2011103721489257
   PubMed Web of Science ®Google Scholar
• SoiniYEskelinenMJuvonenPNuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinomaPathol Res Pract20142101353924189098
   PubMed Web of Science ®Google Scholar
• ArltASebensSKrebsSInhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activityOncogene201332404825483523108405
   PubMed Web of Science ®Google Scholar
• Garcia-ManeroGTambaroFPBekeleNBPhase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia or myelodysplastic syndromeJ Clin Oncol201230182204221022585696
   PubMed Web of Science ®Google Scholar
• ChenNYiXAbushahinNNrf2 expression in endometrial serous carcinomas and its precancersInt J Clin Exp Pathol201041859621228930
   PubMed Web of Science ®Google Scholar
• BarbanoRMuscarellaLAPasculliBAberrant Keap1 methylation in breast cancer and association with clinicopathological featuresEpigenetics20138110511223249627
   PubMed Web of Science ®Google Scholar
• Al SaatiTClercPHanounNOxidative stress induced by inactivation of TP53INP1 cooperates with KrasG12D to initiate and promote pancreatic carcinogenesis in the murine pancreasAm J Pathol201318261996200423578383
   PubMed Web of Science ®Google Scholar
• PetrelliAPerraACoraDMicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)Hepatology201459122824123857252
   PubMed Web of Science ®Google Scholar
• MaQHeXMolecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Pharmacol Rev20126441055108122966037
   PubMed Web of Science ®Google Scholar
• YooNJKimHRKimYRAnCHLeeSHSomatic mutations of the KEAP1 gene in common solid cancersHistopathology201260694395222348534
   PubMed Web of Science ®Google Scholar
• HastBECloerEWGoldfarbDCancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitinationCancer Res201474380881724322982
   PubMed Web of Science ®Google Scholar
• ShibataTOhtaTTongKICancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancyProc Natl Acad Sci U S A200810536135681357318757741
   PubMed Web of Science ®Google Scholar
• KimYROhJEKimMSOncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skinJ Pathol2010220444645119967722
   PubMed Web of Science ®Google Scholar
• SolisLMBehrensCDongWNrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic featuresClin Cancer Res201016143743375320534738
   PubMed Web of Science ®Google Scholar
• WangRAnJJiFJiaoHSunHZhouDHypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissuesBiochem Biophys Res Commun2008373115115418555005
   PubMed Web of Science ®Google Scholar
• HanadaNTakahataTZhouQMethylation of the KEAP1 gene promoter region in human colorectal cancerBMC Cancer2012126622325485
   PubMed Web of Science ®Google Scholar
• ZhangPSinghAYegnasubramanianSLoss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growthMol Cancer Ther20109233634620124447
   PubMed Web of Science ®Google Scholar
• YuSKhorTOCheungKLNrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP micePLoS One201051e857920062804
   PubMed Web of Science ®Google Scholar
• KhorTOHuangYWuTYShuLLeeJKongANPharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylationBiochem Pharmacol20118291073107821787756
   PubMed Web of Science ®Google Scholar
• DuWJiangYZhengZFeedback loop between p66(Shc) and Nrf2 promotes lung cancer progressionCancer Lett20133371586523689140
   PubMed Web of Science ®Google Scholar
• EadesGYangMYaoYZhangYZhouQmiR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cellsJ Biol Chem201128647407254073321926171
   PubMed Web of Science ®Google Scholar
• van JaarsveldMTHellemanJBoersmaAWmiR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cellsOncogene201332364284429323045278
   PubMed Web of Science ®Google Scholar
• YangMYaoYEadesGZhangYZhouQMiR-28 regulates Nrf2 expression through a Keap1-independent mechanismBreast Cancer Res Treat2011129398399121638050
   PubMed Web of Science ®Google Scholar
• YamamotoSInoueJKawanoTKozakiKOmuraKInazawaJThe impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumorsMol Cancer Res2014121586824307696
   PubMed Web of Science ®Google Scholar
• AdamJHatipogluEO’FlahertyLRenal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signalingCancer Cell201120452453722014577
   PubMed Web of Science ®Google Scholar
• KinchLGrishinNVBrugarolasJSuccination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2Cancer Cell201120441842022014567
   PubMed Web of Science ®Google Scholar
• KongBQiaCErkanMKleeffJMichalskiCWOverview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levelsFront Physiol2013424624062691
   PubMed Web of Science ®Google Scholar
• SatohHMoriguchiTTakaiJEbinaMYamamotoMNrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesisCancer Res201373134158416823610445
   PubMed Web of Science ®Google Scholar
• BauerAKHillT3rdAlexanderCMThe involvement of NRF2 in lung cancerOxid Med Cell Longev2013201374643223577226
   PubMed Web of Science ®Google Scholar
• YamadoriTIshiiYHommaSMolecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancersOncogene201231454768477722249257
   PubMed Web of Science ®Google Scholar
• BanerjeePBasuADattaDGasserMWaaga-GasserAMPalSThe heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signalJ Biol Chem201128638335803359021808062
   PubMed Web of Science ®Google Scholar
• FunesJMHendersonSKaufmanROncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survivalMol Cancer20141312024491031
   PubMed Web of Science ®Google Scholar
• NagyPVargaAPircsKHegedűsKJuhászGMyc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogasterPLoS Genet201398e100366423950728
   PubMed Web of Science ®Google Scholar
• LevySFormanHJC-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elementsIUBMB Life201062323724620232342
   PubMed Web of Science ®Google Scholar
• RomanoGThe role of the dysfunctional Akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug developmentScientifica (Cairo)2013201331718624381788
   PubMedGoogle Scholar
• GaoAMKeZPShiFSunGCChenHChrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathwayChem Biol Interact2013206110010823994249
   PubMed Web of Science ®Google Scholar
• DengXRuiWZhangFDingWPM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cellsCell Biol Toxicol201329314315723525690
   PubMed Web of Science ®Google Scholar
• StachelIGeismannCAdenKModulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stressJ Biol Chem201428941917192924311782
   PubMed Web of Science ®Google Scholar
• TaguchiKSakataKOhashiWImaizumiTImamuraJHattoriYTonic inhibition by G protein-coupled receptor kinase 2 of Akt/endothelial nitric oxide synthase signaling in human vascular endothelial cells under conditions of hyperglycemia with high insulin levelsJ Pharmacol Exp Ther2014349219920824570070
   PubMed Web of Science ®Google Scholar
• DeyNCrosswellHEDePThe protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migrationCancer Res20086861862187118339867
   PubMed Web of Science ®Google Scholar
• HuangWLvXLiuCThe N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibitionJ Biol Chem201228731262452625322692215
   PubMed Web of Science ®Google Scholar
• ChenQLiWWanYAmplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathwaysHepatology20125561820182922213475
   PubMed Web of Science ®Google Scholar
• LernerCBittoAPulliamDReduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblastsAging Cell201312696697723795962
   PubMed Web of Science ®Google Scholar
• ShibataTSaitoSKokubuASuzukiTYamamotoMHirohashiSGlobal downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathwayCancer Res201070229095910521062981
   PubMed Web of Science ®Google Scholar
• GaikwadNWYangLRoganEGCavalieriELEvidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinonesFree Radic Biol Med200946225326218996184
   PubMed Web of Science ®Google Scholar
• AnsellPJLoSCNewtonLGRepression of cancer protective genes by 17β-estradiol: ligand-dependent interaction between human Nrf2 and estrogen receptor alphaMol Cell Endocrinol20052431–2273416198475
   PubMed Web of Science ®Google Scholar
• LoRMatthewsJThe aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cellsToxicol Appl Pharmacol2013270213914823583297
   PubMed Web of Science ®Google Scholar
• LamSSMakASYamJWCheungANNganHYWongASTargeting estrogen-related receptor alpha inhibits epithelial-to-mesenchymal transition and stem cell properties of ovarian cancer cellsMol Ther201422474375124419103
   PubMed Web of Science ®Google Scholar
• ZhangTLiangXShiLEstrogen receptor and PI3K/Akt signaling pathway involvement in S-(-)equol-induced activation of Nrf2/ARE in endothelial cellsPLoS One2013811e7907524260155
   PubMed Web of Science ®Google Scholar
• GorriniCGangBPBassiCEstrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathwayProc Natl Acad Sci U S A2014111124472447724567396
   PubMed Web of Science ®Google Scholar
• MontanoMMDengHLiuMSunXSingalRTranscriptional regulation by the estrogen receptor of antioxidative stress enzymes and its functional implicationsOncogene200423142442245314676828
   PubMed Web of Science ®Google Scholar
• ArltASchäferHKalthoffHThe ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancerOncogenesis20121e3523552468
   PubMed Web of Science ®Google Scholar
• WakabayashiNSlocumSLSkokoJJShinSKenslerTWWhen NRF2 talks, who’s listening?Antioxid Redox Signal201013111649166320367496
   PubMed Web of Science ®Google Scholar
• LiuGHQuJShenXNF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafKBiochim Biophys Acta20081783571372718241676
   PubMed Web of Science ®Google Scholar
• HealyZRLeeNHGaoXDivergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosisProc Natl Acad Sci U S A200510239140101401516172382
   PubMed Web of Science ®Google Scholar
• ChenCYJangJHLiMHSurhYJResveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cellsBiochem Biophys Res Commun20053314993100015882976
   PubMed Web of Science ®Google Scholar
• MannaSKMukhopadhyayAAggarwalBBResveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidationJ Immunol2000164126509651910843709
   PubMed Web of Science ®Google Scholar
• BalogunEForestiRGreenCJMotterliniRChanges in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cellsBiochem Biophys Res Commun2003308495095512927811
   PubMed Web of Science ®Google Scholar
• GanFFLingHAngXA novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathwaysToxicol Appl Pharmacol2013272385286223899529
   PubMed Web of Science ®Google Scholar
• KumarSSinghBKPrasadAKParmarVSBiswalSGhoshBEthyl 3′,4′,5′-trimethoxythionocinnamate modulates NF-κB and Nrf2 transcription factorsEur J Pharmacol20137001–3324123261968
   PubMed Web of Science ®Google Scholar
• RushworthSAZaitsevaLMurrayMYShahNMBowlesKMMacEwanDJThe high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistanceBlood2012120265188519823077289
   PubMed Web of Science ®Google Scholar
• ArltABauerISchafmayerCIncreased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)Oncogene200928453983399619734940
   PubMed Web of Science ®Google Scholar
• NitureSKJaiswalAKNrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistanceFree Radic Biol Med20135711913123275004
   PubMed Web of Science ®Google Scholar
• NitureSKJaiswalAKNrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosisJ Biol Chem2012287139873988622275372
   PubMed Web of Science ®Google Scholar
• RotblatBMelinoGKnightRANRF2 and p53: Januses in cancer?Oncotarget20123111272128323174755
   PubMed Web of Science ®Google Scholar
• VurusanerBPoliGBasagaHTumor suppressor genes and ROS: complex networks of interactionsFree Radic Biol Med201252171822019631
   PubMed Web of Science ®Google Scholar
• SuzukiSTanakaTPoyurovskyMVPhosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen speciesProc Natl Acad Sci U S A2010107167461746620351271
   PubMed Web of Science ®Google Scholar
• BensaadKTsurutaASelakMATIGAR, a p53-inducible regulator of glycolysis and apoptosisCell2006126110712016839880
   PubMed Web of Science ®Google Scholar
• AsherGLotemJKamaRSachsLShaulYNQO1 stabilizes p53 through a distinct pathwayProc Natl Acad Sci U S A20029953099310411867746
   PubMed Web of Science ®Google Scholar
• YouANamCWWakabayashiNYamamotoMKenslerTWKwakMKTranscription factor Nrf2 maintains the basal expression of Mdm2: an implication of the regulation of p53 signaling by Nrf2Arch Biochem Biophys2011507235636421211512
   PubMed Web of Science ®Google Scholar
• CapaccioneKMPineSRThe Notch signaling pathway as a mediator of tumor survivalCarcinogenesis20133471420143023585460
   PubMed Web of Science ®Google Scholar
• WakabayashiNSkokoJJChartoumpekisDVNotch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signalingMol Cell Biol201434465366324298019
   PubMed Web of Science ®Google Scholar
• KimJHThimmulappaRKKumarVNRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiationJ Clin Invest2014124273074124463449
   PubMed Web of Science ®Google Scholar
• ZhuJWangHSunQNrf2 is required to maintain the self-renewal of glioma stem cellsBMC Cancer20131338023937621
   PubMed Web of Science ®Google Scholar
• LiWLiuHZhouJSCaveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)J Biol Chem201228725209222093022547061
   PubMed Web of Science ®Google Scholar
• ZhengYMorrisASunkaraMLayneJToborekMHennigBEpigallocatechin-gallate stimulates NF-E2-related factor and heme oxygenase-1 via caveolin-1 displacementJ Nutr Biochem201223216316821447442
   PubMed Web of Science ®Google Scholar
• VolonteDLiuZMusillePMInhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescenceMol Biol Cell201324121852186223637463
   PubMed Web of Science ®Google Scholar
• CossetECGodetJEntz-WerleNInvolvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastomaInt J Cancer2012131360161121901744
   PubMed Web of Science ®Google Scholar
• GreenDRLevineBTo be or not to be? How selective autophagy and cell death govern cell fateCell20141571657524679527
   PubMed Web of Science ®Google Scholar
• LauAWangXJZhaoFA noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62Mol Cell Biol201030133275328520421418
   PubMed Web of Science ®Google Scholar
• IchimuraYWaguriSSouYSPhosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagyMol Cell201351561863124011591
   PubMed Web of Science ®Google Scholar
• JainALamarkTSjøttemEp62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcriptionJ Biol Chem201028529225762259120452972
   PubMed Web of Science ®Google Scholar
• BrayKMathewRLauAAutophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibitionPLoS One201277e4183122848625
   PubMed Web of Science ®Google Scholar
• ParkSHKimJHChiGYInduction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen speciesToxicol Lett2012212325226122721804
   PubMed Web of Science ®Google Scholar
• RaoVAKleinSRBonarSJThe antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinoneJ Biol Chem201028545344473445920805228
   PubMed Web of Science ®Google Scholar
• ZhouYWangHDZhuLKnockdown of Nrf2 enhances autophagy induced by temozolomide in U251 human glioma cell lineOncol Rep201329139440023128449
   PubMed Web of Science ®Google Scholar
• LiSLiJShenCtert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activationBiochim Biophys Acta201418411223324055888
   PubMed Web of Science ®Google Scholar
• KimTHHurEGKangSJNRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1αCancer Res20117162260227521278237
   PubMed Web of Science ®Google Scholar
• JiXWangHZhuJCorrelation of Nrf2 and HIF-1α in glioblastoma and their relationships to clinicopathologic features and survivalNeurol Res201335101044105024070025
   PubMed Web of Science ®Google Scholar
• JiXWangHZhuJKnockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1αInt J Cancer2014135357458424374745
   PubMed Web of Science ®Google Scholar
• ShenHYangYXiaSRaoBZhangJWangJBlockage of Nrf2 suppresses the migration and invasion of esophageal squamous cell carcinoma cells in hypoxic microenvironmentDis Esophagus Epub9132013
   Web of Science ®Google Scholar
• KwakMKKenslerTWInduction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathwayBiochem Biophys Res Commun200634541350135716723119
   PubMed Web of Science ®Google Scholar
• KwakMKWakabayashiNGreenlawJLYamamotoMKenslerTWAntioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathwayMol Cell Biol200323238786879414612418
   PubMed Web of Science ®Google Scholar
• SchaedlerSKrauseJHimmelsbachKHepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2J Biol Chem201028552410744108620956535
   PubMed Web of Science ®Google Scholar
• PickeringAMLinderRAZhangHFormanHJDaviesKJNrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stressJ Biol Chem201228713100211003122308036
   PubMed Web of Science ®Google Scholar
• HöhnTJGruneTThe proteasome and the degradation of oxidized proteins: Part III – Redox regulation of the proteasomal systemRedox Biol2014238839424563857
   PubMed Web of Science ®Google Scholar
• ChenJReganRFIncreasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injuryCurr Neurovasc Res20052318919616181113
   PubMed Web of Science ®Google Scholar
• RenSSmithMJLouroIDThe p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanomaOncogene200019111419142710723133
   PubMed Web of Science ®Google Scholar
• RhoJHQinSWangJYRoehrlMHProteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancerJ Proteome Res2008772959297218549262
   PubMed Web of Science ®Google Scholar
• HuZPanXFWuFQSynergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemiaPLoS One200947e625719606213
   PubMed Web of Science ®Google Scholar
• SebensSBauerIGeismannCInflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protectionJ Biol Chem201128647409114092121990354
   PubMed Web of Science ®Google Scholar
• DuZXYanYZhangHYProteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cellsJ Clin Endocrinol Metab2011965E763E77121346076
   PubMed Web of Science ®Google Scholar
• EbertBKisielaMMalatkovaPEl-HawariYMaserERegulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cellsBiochemistry201049398499851120806931
   PubMed Web of Science ®Google Scholar
• KraftDCDeocarisCCWadhwaRRattanSIPreincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblastsAnn N Y Acad Sci2006106742042416804021
   PubMed Web of Science ®Google Scholar
• RushworthSABowlesKMMacEwanDJHigh basal nuclear levels of Nrf2 in acute myeloid leukemia reduces sensitivity to proteasome inhibitorsCancer Res20117151999200921212410
   PubMed Web of Science ®Google Scholar
• KochASteffenJKrügerETCF11 at the crossroads of oxidative stress and the ubiquitin proteasome systemCell Cycle20111081200120721412055
   PubMed Web of Science ®Google Scholar
• GorowiecMRBorthwickLAParkerSMKirbyJASaretzkiGCFisherAJFree radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanismFree Radic Biol Med20125261024103222240154
   PubMed Web of Science ®Google Scholar
• OkitaYKamoshidaASuzukiHTransforming growth factor-beta induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 geneJ Biol Chem201328828206582066723737527
   PubMed Web of Science ®Google Scholar
• OhCJKimJYChoiYKDimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta/Smad signalingPLoS One2012710e4587023056222
   PubMed Web of Science ®Google Scholar
• ChoiHKPokharelYRLimSCInhibition of liver fibrosis by solubilized coenzyme Q10: role of Nrf2 activation in inhibiting transforming growth factor-β1 expressionToxicol Appl Pharmacol2009240337738419647758
   PubMed Web of Science ®Google Scholar
• RachakondaGSekharKRJowharDIncreased cell migration and plasticity in Nrf2-deficient cancer cell linesOncogene201029253703371420440267
   PubMed Web of Science ®Google Scholar
• PanHWangHZhuLMaoLQiaoLSuXThe role of Nrf2 in migration and invasion of human glioma cell U251World Neurosurg2013803–436337022120303
   PubMed Web of Science ®Google Scholar
• ZhangLWangNZhouSYeWJingGZhangMPropofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2J Exp Clin Cancer Res2012316622901367
   PubMed Web of Science ®Google Scholar
• JiXJChenSHZhuLKnockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft modelOncol Rep201330115716423673813
   PubMed Web of Science ®Google Scholar
• HanahanDWeinbergRAHallmarks of cancer: the next generationCell2011144564667421376230
   PubMed Web of Science ®Google Scholar
• HayesJDAshfordMLNrf2 orchestrates fuel partitioning for cell proliferationCell Metab201216213914122883227
   PubMed Web of Science ®Google Scholar
• ShimizuTTolcherAWPapadopoulosKPThe clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancerClin Cancer Res20121882316232522261800
   PubMed Web of Science ®Google Scholar
• SinghAHappelCMannaSKTranscription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesisJ Clin Invest201312372921293423921124
   PubMed Web of Science ®Google Scholar
• MaXZhangJLiuSHuangYChenBWangDNrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancerCancer Chemother Pharmacol201269248549421842204
   PubMed Web of Science ®Google Scholar
• JiangTChenNZhaoFHigh levels of Nrf2 determine chemoresistance in type II endometrial cancerCancer Res201070135486549620530669
   PubMed Web of Science ®Google Scholar
• DuongHQYiYWKangHJInhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabineInt J Oncol201444395996924366069
   PubMed Web of Science ®Google Scholar
• AkhdarHLoyerPRauchCCorluAGuillouzoAMorelFInvolvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cellsEur J Cancer200945122219222719524433
   PubMed Web of Science ®Google Scholar
• HuXFYaoJGaoSGNrf2 overexpression predicts prognosis and 5-FU resistance in gastric cancerAsian Pac J Cancer Prev20131495231523524175806
   PubMedGoogle Scholar
• GaoAMKeZPWangJNYangJYChenSYChenHApigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathwayCarcinogenesis20133481806181423563091
   PubMed Web of Science ®Google Scholar
• SinghAWuHZhangPHappelCMaJBiswalSExpression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotypeMol Cancer Ther2010982365237620682644
   PubMed Web of Science ®Google Scholar
• WangXJLiYLuoLOxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugsFree Radic Biol Med201470687724556415
   PubMed Web of Science ®Google Scholar
• EmminkBLVerheemAVan HoudtWJThe secretome of colon cancer stem cells contains drug-metabolizing enzymesJ Proteomics201391849623835434
   PubMed Web of Science ®Google Scholar
• MahaffeyCMZhangHRinnaAHollandWMackPCFormanHJMultidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinomaFree Radic Biol Med200946121650165719345732
   PubMed Web of Science ®Google Scholar
• NishinakaTMiuraTOkumuraMNakaoFNakamuraHTeradaTRegulation of aldo-keto reductase AKR1B10 gene expression: involvement of transcription factor Nrf2Chem Biol Interact20111911–318519121277289
   PubMed Web of Science ®Google Scholar
• NaHKSurhYJOncogenic potential of Nrf2 and its principal target protein heme oxygenase-1Free Radic Biol Med20146735336524200599
   PubMed Web of Science ®Google Scholar
• ZhouSYeWShaoQZhangMLiangJNrf2 is a potential therapeutic target in radioresistance in human cancerCrit Rev Oncol Hematol201388370671524126138
   PubMed Web of Science ®Google Scholar
• ManandharSLeeSKwakMKEffect of stable inhibition of NRF2 on doxorubicin sensitivity in human ovarian carcinoma OV90 cellsArch Pharm Res201033571772620512470
   PubMed Web of Science ®Google Scholar
• TanKPKosugeKYangMItoSNRF2 as a determinant of cellular resistance in retinoic acid cytotoxicityFree Radic Biol Med200845121663167318845239
   PubMed Web of Science ®Google Scholar
• TarumotoTNagaiTOhmineKAscorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell lineExp Hematol200432437538115050748
   PubMed Web of Science ®Google Scholar
• KweonMHAdhamiVMLeeJSMukhtarHConstitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallateJ Biol Chem200628144337613377216950787
   PubMed Web of Science ®Google Scholar
• LimoncielAJenningsPA review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicityToxins (Basel)20146137137924448208
   PubMed Web of Science ®Google Scholar
• RenDVilleneuveNFJiangTBrusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanismProc Natl Acad Sci U S A201110841433143821205897
   PubMed Web of Science ®Google Scholar
• CuendetMGillsJJPezzutoJMBrusatol-induced HL-60 cell differentiation involves NF-κB activationCancer Lett20042061435015019158
   PubMed Web of Science ®Google Scholar
• WruckCJClaussenMFuhrmannGLuteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathwayJ Neural Transm Suppl200772576717982879
   PubMedGoogle Scholar
• LinCWWuMJLiuIYSuJDYenJHNeurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expressionJ Agric Food Chem20105874477448620302373
   PubMed Web of Science ®Google Scholar
• PanduranganAKAnanda SadagopanSKDharmalingamPGanapasamSLuteolin, a bioflavonoid inhibits azoxymethane-induced colorectal cancer through activation of Nrf2 signalingToxicol Mech Methods2014241132024024667
   PubMed Web of Science ®Google Scholar
• LeeSLimMJKimMHAn effective strategy for increasing the radiosensitivity of human lung cancer cells by blocking Nrf2-dependent antioxidant responsesFree Radic Biol Med201253480781622684019
   PubMed Web of Science ®Google Scholar
• BoettlerUSommerfeldKVolzNCoffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expressionJ Nutr Biochem201122542644020655719
   PubMed Web of Science ®Google Scholar
• van DijkAEOlthofMRMeeuseJCSeebusEHeineRJvan DamRMAcute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose toleranceDiabetes Care20093261023102519324944
   PubMed Web of Science ®Google Scholar
• OlthofMRvan DijkAEDeaconCFHeineRJvan DamRMAcute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormonesNutr Metab (Lond)201181021299855
   PubMed Web of Science ®Google Scholar
• ZhongYZhangFSunZDrug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense responseMol Carcinog2013521082483422593043
   PubMed Web of Science ®Google Scholar
• SharmaPKVarshneyR2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defenseFree Radic Res201246121446145722946929
   PubMed Web of Science ®Google Scholar