The emerging and diverse roles of sirtuins in cancer: a clinical perspective

References

• ShoreDSquireMNasmythKACharacterization of two genes required for the position-effect control of yeast mating-type genesEMBO J1984312281728236098447
   PubMed Web of Science ®Google Scholar
• KaeberleinMMcVeyMGuarenteLThe SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanismsGenes Dev199913192570258010521401
   PubMed Web of Science ®Google Scholar
• TissenbaumHAGuarenteLIncreased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegansNature2001410682522723011242085
   PubMed Web of Science ®Google Scholar
• RoginaBHelfandSLSir2 mediates longevity in the fly through a pathway related to calorie restrictionProc Natl Acad Sci U S A200410145159981600315520384
   PubMed Web of Science ®Google Scholar
• HerranzDSerranoMSIRT1: recent lessons from mouse modelsNat Rev Cancer2010101281982321102633
   PubMed Web of Science ®Google Scholar
• HerranzDMunoz-MartinMCanameroMSirt1 improves healthy ageing and protects from metabolic syndrome-associated cancerNat Commun20101320975665
   PubMed Web of Science ®Google Scholar
• ViswanathanMGuarenteLRegulation of Caenorhabditis elegans lifespan by sir-2.1 transgenesNature20114777365E1E221938026
   PubMed Web of Science ®Google Scholar
• RizkiGIwataTNLiJThe evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXOPLoS Genet201179e100223521909281
   PubMed Web of Science ®Google Scholar
• BurnettCValentiniSCabreiroFAbsence of effects of Sir2 overexpression on lifespan in C. elegans and DrosophilaNature2011477736548248521938067
   PubMed Web of Science ®Google Scholar
• FryeRAPhylogenetic classification of prokaryotic and eukaryotic Sir2-like proteinsBiochem Biophys Res Commun2000273279379810873683
   PubMed Web of Science ®Google Scholar
• FryeRACharacterization of five human cDNAs with homology to the yeast SIR2 gene:Sir2-like proteins(sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activityBiochem Biophys Res Commun1999260127327910381378
   PubMed Web of Science ®Google Scholar
• ImaiSArmstrongCMKaeberleinMGuarenteLTranscriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseNature2000403677179580010693811
   PubMed Web of Science ®Google Scholar
• LandryJSuttonATafrovSTThe silencing protein SIR2 and its homologs are NAD-dependent protein deacetylasesProc Natl Acad Sci U S A200097115807581110811920
   PubMed Web of Science ®Google Scholar
• NorthBJMarshallBLBorraMTDenuJMVerdinEThe human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylaseMol Cell200311243744412620231
   PubMed Web of Science ®Google Scholar
• TannerKGLandryJSternglanzRDenuJMSilent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-riboseProc Natl Acad Sci U S A20009726141781418211106374
   PubMed Web of Science ®Google Scholar
• HaigisMCMostoslavskyRHaigisKMSIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cellsCell2006126594195416959573
   PubMed Web of Science ®Google Scholar
• LisztGFordEKurtevMGuarenteLMouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferaseJ Biol Chem200528022213132132015795229
   PubMed Web of Science ®Google Scholar
• BarberMFMichishita-KioiEXiYSIRT7 links H3K18 deacetylation to maintenance of oncogenic transformationNature2012487740511411822722849
   PubMed Web of Science ®Google Scholar
• MichishitaEMcCordRABoxerLDCell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6Cell Cycle20098162664266619625767
   PubMed Web of Science ®Google Scholar
• DuJZhouYSuXSirt5 is a NAD-dependent protein lysine demalonylase and desuccinylaseScience2011334605780680922076378
   PubMed Web of Science ®Google Scholar
• MichishitaEParkJYBurneskisJMBarrettJCHorikawaIEvolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteinsMol Biol Cell200516104623463516079181
   PubMed Web of Science ®Google Scholar
• TannoMSakamotoJMiuraTShimamotoKHorioYNucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1J Biol Chem200728296823683217197703
   PubMed Web of Science ®Google Scholar
• McBurneyMWYangXJardineKThe mammalian SIR2alpha protein has a role in embryogenesis and gametogenesisMol Cell Biol2003231385412482959
   PubMed Web of Science ®Google Scholar
• ChengHLMostoslavskyRSaitoSDevelopmental defects and p53 hyperacetylation in Sir2 homolog(SIRT1)-deficient miceProc Natl Acad Sci U S A200310019107941079912960381
   PubMed Web of Science ®Google Scholar
• SequeiraJBoilyGBazinetSsirt1-null mice develop an autoimmune-like conditionExp Cell Res2008314163069307418687325
   PubMed Web of Science ®Google Scholar
• ZhangJLeeSMShannonSThe type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in miceJ Clin Invest2009119103048305819729833
   PubMed Web of Science ®Google Scholar
• NorthBJVerdinEInterphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosisPLoS One200728e78417726514
   PubMed Web of Science ®Google Scholar
• VaqueroAScherMBLeeDHSirT2 is a histone deacetylase with preference for histone H4Lys 16 during mitosisGenes Dev200620101256126116648462
   PubMed Web of Science ®Google Scholar
• KimHSVassilopoulosAWangRHSIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activityCancer Cell201120448749922014574
   PubMed Web of Science ®Google Scholar
• OnyangoPCelicIMcCafferyJMBoekeJDFeinbergAPSIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondriaProc Natl Acad Sci U S A20029921136531365812374852
   PubMed Web of Science ®Google Scholar
• SchwerBNorthBJFryeRAOttMVerdinEThe human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylaseJ Cell Biol2002158464765712186850
   PubMed Web of Science ®Google Scholar
• NakamuraYOguraMTanakaDInagakiNLocalization of mouse mitochondrial SIRT proteins:shift of SIRT3 to nucleus by co-expression with SIRT5Biochem Biophys Res Commun2008366117417918054327
   PubMed Web of Science ®Google Scholar
• ScherMBVaqueroAReinbergDSirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stressGenes Dev200721892092817437997
   PubMed Web of Science ®Google Scholar
• LombardDBAltFWChengHLMammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylationMol Cell Biol200727248807881417923681
   PubMed Web of Science ®Google Scholar
• KimHSPatelKMuldoon-JacobsKSIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stressCancer Cell2010171415220129246
   PubMed Web of Science ®Google Scholar
• HirscheyMDShimazuTJingESIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndromeMol Cell201144217719021856199
   PubMed Web of Science ®Google Scholar
• FinleyLWCarracedoALeeJSIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilizationCancer Cell201119341642821397863
   PubMed Web of Science ®Google Scholar
• NasrinNWuXFortierESIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cellsJ Biol Chem201028542319953200220685656
   PubMed Web of Science ®Google Scholar
• AhujaNSchwerBCarobbioSRegulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferaseJ Biol Chem200728246335833359217715127
   PubMed Web of Science ®Google Scholar
• JeongSMXiaoCFinleyLWSIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolismCancer Cell201323445046323562301
   PubMed Web of Science ®Google Scholar
• YangHYangTBaurJANutrient-sensitive mitochondrial NAD+ levels dictate cell survivalCell200713061095110717889652
   PubMed Web of Science ®Google Scholar
• NakagawaTLombDJHaigisMCGuarenteLSIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycleCell2009137356057019410549
   PubMed Web of Science ®Google Scholar
• PengCLuZXieZThe first identification of lysine malonylation substrates and its regulatory enzymeMol Cell Proteomics20111012M111.01265821908771
   PubMed Web of Science ®Google Scholar
• ParkJChenYTishkoffDXSIRT5-mediated lysine desuccinylation impacts diverse metabolic pathwaysMol Cell201350691993023806337
   PubMed Web of Science ®Google Scholar
• MatsushitaNYonashiroROgataYDistinct regulation of mitochondrial localization and stability of two human Sirt5 isoformsGenes Cells201116219020221143562
   PubMed Web of Science ®Google Scholar
• MichishitaEMcCordRABerberESIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinNature2008452718649249618337721
   PubMed Web of Science ®Google Scholar
• JiangHKhanSWangYSIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysineNature2013496744311011323552949
   PubMed Web of Science ®Google Scholar
• MaoZTianXVan MeterMSirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescenceProc Natl Acad Sci U S A201210929118001180522753495
   PubMed Web of Science ®Google Scholar
• KimHSXiaoCWangRHHepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesisCell Metab201012322423620816089
   PubMed Web of Science ®Google Scholar
• KawaharaTLMichishitaEAdlerASSIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life spanCell20091361627419135889
   PubMed Web of Science ®Google Scholar
• ZhongLD’UrsoAToiberDThe histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alphaCell2010140228029320141841
   PubMed Web of Science ®Google Scholar
• McCordRAMichishitaEHongTSIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repairAging (Albany NY)20091110912120157594
   PubMedGoogle Scholar
• KaidiAWeinertBTChoudharyCJacksonSPHuman SIRT6 promotes DNA end resection through CtIP deacetylationScience201032959971348135320829486
   PubMed Web of Science ®Google Scholar
• XiaoCKimHSLahusenTSIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in miceJ Biol Chem201028547367763678420847051
   PubMed Web of Science ®Google Scholar
• SchwerBSchumacherBLombardDBNeural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesityProc Natl Acad Sci U S A201010750217902179421098266
   PubMed Web of Science ®Google Scholar
• MaoZHineCTianXSIRT6 promotes DNA repair under stress by activating PARP1Science201133260361443144621680843
   PubMed Web of Science ®Google Scholar
• TennenRIBuaDJWrightWEChuaKFSIRT6 is required for maintenance of telomere position effect in human cellsNat Commun2011243321847107
   PubMed Web of Science ®Google Scholar
• SundaresanNRVasudevanPZhongLThe sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-JunNat Med201218111643165023086477
   PubMed Web of Science ®Google Scholar
• DominyJEJrLeeYJedrychowskiMPThe deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesisMol Cell201248690091323142079
   PubMed Web of Science ®Google Scholar
• SebastianCZwaansBMSilbermanDMThe histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolismCell201215161185119923217706
   PubMed Web of Science ®Google Scholar
• MostoslavskyRChuaKFLombardDBGenomic instability and aging-like phenotype in the absence of mammalian SIRT6Cell2006124231532916439206
   PubMed Web of Science ®Google Scholar
• KanfiYNaimanSAmirGThe sirtuin SIRT6 regulates lifespan in male miceNature2012483738821822122367546
   PubMed Web of Science ®Google Scholar
• GrobARousselPWrightJEInvolvement of SIRT7 in resumption of rDNA transcription at the exit from mitosisJ Cell Sci2009122Pt 448949819174463
   PubMed Web of Science ®Google Scholar
• FordEVoitRLisztGMaginCGrummtIGuarenteLMammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcriptionGenes Dev20062091075108016618798
   PubMed Web of Science ®Google Scholar
• VakhrushevaOSmolkaCGajawadaPSirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in miceCirc Res2008102670371018239138
   PubMed Web of Science ®Google Scholar
• RothMChenWYSorting out functions of sirtuins in cancerOncogene2013 [Epub]
   Google Scholar
• HiraikeHWada-HiraikeONakagawaSExpression of DBC1 is associated with nuclear grade and HER2 expression in breast cancerExp Ther Med2011261105110922977628
   PubMed Web of Science ®Google Scholar
• LeeHKimKRNohSJExpression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinomaHum Pathol201142220421321056897
   PubMed Web of Science ®Google Scholar
• WuMWeiWXiaoXExpression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancerMed Oncol20122953240324922661383
   PubMed Web of Science ®Google Scholar
• ChenWYWangDHYenRCTumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responsesCell2005123343744816269335
   PubMed Web of Science ®Google Scholar
• EadesGYaoYYangMmiR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cellsJ Biol Chem201128629259922600221596753
   PubMed Web of Science ®Google Scholar
• HollowayKRBarbieriAMalyarchukSSIRT1 positively regulates breast cancer associated human aromatase(CYP19A1) expressionMol Endocrinol201327348049023340254
   PubMedGoogle Scholar
• ZhangYZhangMDongHDeacetylation of cortactin by SIRT1 promotes cell migrationOncogene200928344546018850005
   PubMed Web of Science ®Google Scholar
• ChoiHKChoKBPhuongNTSIRT1-Mediated FoxO1 Deacetylation Is Essential for Multidrug Resistance-Associated Protein 2 Expression in Tamoxifen-Resistant Breast Cancer CellsMol Pharm2013 [Epub]
   Web of Science ®Google Scholar
• SuzukiKHayashiRIchikawaTSRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in miceOncol Rep20122761726173222470132
   PubMed Web of Science ®Google Scholar
• WangFChanCHChenKGuanXLinHKTongQDeacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradationOncogene201231121546155721841822
   PubMed Web of Science ®Google Scholar
• HuffmanDMGrizzleWEBammanMMSIRT1 is significantly elevated in mouse and human prostate cancerCancer Res200767146612661817638871
   PubMed Web of Science ®Google Scholar
• KojimaKOhhashiRFujitaYA role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cellsBiochem Biophys Res Commun2008373342342818573234
   PubMed Web of Science ®Google Scholar
• KangHSuhJYJungYSJungJWKimMKChungJHPeptide switch is essential for Sirt1 deacetylase activityMol Cell201144220321322017869
   PubMed Web of Science ®Google Scholar
• WangBHasanMKAlvaradoEYuanHWuHChenWYNAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress responseOncogene201130890792120956937
   PubMed Web of Science ®Google Scholar
• LovaasJDZhuLChiaoCYBylesVFallerDVDaiYSIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cellsProstate201373552253023038275
   PubMed Web of Science ®Google Scholar
• BylesVZhuLLovaasJDSIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasisOncogene201231434619462922249256
   PubMed Web of Science ®Google Scholar
• NakaneKFujitaYTerazawaRInhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cellsInt J Urol2012191717922050448
   PubMed Web of Science ®Google Scholar
• HerranzDMaraverACanameroMSIRT1 promotes thyroid carcinogenesis driven by PTEN deficiencyOncogene201332344052405622986535
   PubMed Web of Science ®Google Scholar
• NohSJBaekHAParkHSExpression of SIRT1 and cortactin is associated with progression of non-small cell lung cancerPathol Res Pract2013209636537023702379
   PubMed Web of Science ®Google Scholar
• TsengRCLeeCCHsuHSTzaoCWangYCDistinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patientsNeoplasia200911876377019649206
   PubMed Web of Science ®Google Scholar
• XieMLiuMHeCSSIRT1 regulates endothelial Notch signaling in lung cancerPLoS One201279e4533123028940
   PubMed Web of Science ®Google Scholar
• LiuGSuLHaoXSalermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cellsJ Cell Mol Med20121671618162821801305
   PubMed Web of Science ®Google Scholar
• MenssenAHydbringPKapelleKThe c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loopProc Natl Acad Sci U S A20121094E187E19622190494
   PubMed Web of Science ®Google Scholar
• KrieglLViethMKirchnerTMenssenAUp-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancerOncotarget20123101182119323045412
   PubMedGoogle Scholar
• NoshoKShimaKIraharaNSIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancerMod Pathol200922792293219430421
   PubMed Web of Science ®Google Scholar
• AkaoYNoguchiSIioAKojimaKTakagiTNaoeTDysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cellsCancer Lett2011300219720421067862
   PubMed Web of Science ®Google Scholar
• FengANZhangLHFanXSExpression of SIRT1 in gastric cardiac cancer and its clinicopathologic significanceInt J Surg Pathol201119674375021865267
   PubMed Web of Science ®Google Scholar
• ChaEJNohSJKwonKSExpression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinomaClin Cancer Res200915134453445919509139
   PubMed Web of Science ®Google Scholar
• ZhuHXiaLZhangYActivating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expressionPLoS One201272e3143122363646
   PubMed Web of Science ®Google Scholar
• ChenHCJengYMYuanRHHsuHCChenYLSIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosisAnn Surg Oncol20121962011201922146883
   PubMed Web of Science ®Google Scholar
• ChoiHNBaeJSJamiyandorjUExpression and role of SIRT1 in hepatocellular carcinomaOncol Rep201126250351021567102
   PubMed Web of Science ®Google Scholar
• PortmannSFahrnerRLechleiterAAntitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivoMol Cancer Ther201312449950823339189
   PubMed Web of Science ®Google Scholar
• ChenJZhangBWongNSirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growthCancer Res201171124138414921527554
   PubMed Web of Science ®Google Scholar
• WangHLiuHChenKSIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signalingOncol Rep201228131131822552445
   PubMed Web of Science ®Google Scholar
• JangKYNohSJLehwaldNSIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomasPLoS One201279e4511923024800
   PubMed Web of Science ®Google Scholar
• LouWChenQMaLOncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor modelJ Mol Med (Berl)201391671572523292172
   PubMed Web of Science ®Google Scholar
• BaeHJNohJHKimJKMicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinomaOncogene2013 [Epub]
   Google Scholar
• ZhaoGCuiJZhangJGSIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cellsGene Ther201118992092821677689
   PubMed Web of Science ®Google Scholar
• ZhangJGZhaoGQinQNicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathwaysPancreatology201313214014623561972
   PubMed Web of Science ®Google Scholar
• WautersESanchez-Arevalo LoboVJPinhoAVSirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancerCancer Res20137372357236723370328
   PubMed Web of Science ®Google Scholar
• XuJZhuWXuWUp-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherinCurr Mol Med201313338740023331011
   PubMed Web of Science ®Google Scholar
• JangKYKimKSHwangSHExpression and prognostic significance of SIRT1 in ovarian epithelial tumoursPathology200941436637119404850
   PubMed Web of Science ®Google Scholar
• BenayounBAGeorgesABL’HoteDTranscription factor FOXL2 protects granulosa cells from stress and delays cell cycle:role of its regulation by the SIRT1 deacetylaseHum Mol Genet20112091673168621289058
   PubMed Web of Science ®Google Scholar
• AllisonSJJiangMMilnerJOncogenic viral protein HPV E7 upregulates the SIRT1 longevity protein in human cervical cancer cellsAging (Albany NY)20091331632720157519
   PubMedGoogle Scholar
• MarshallGMLiuPYGherardiSSIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stabilityPLoS Genet201176e100213521698133
   PubMed Web of Science ®Google Scholar
• KimMJAhnKParkSHSIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3aFEBS Lett200958371183118819285077
   PubMed Web of Science ®Google Scholar
• ChangCJHsuCCYungMCEnhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expressionBiochem Biophys Res Commun2009380223624219166820
   PubMed Web of Science ®Google Scholar
• DixitDSharmaVGhoshSMehtaVSSenEInhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor(TNFalpha)-induced apoptosis through SIRT1 inhibitionCell Death Dis20123e27122318540
   PubMed Web of Science ®Google Scholar
• MaJXLiHChenXMExpression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitroNeuropathology201333171622537175
   PubMed Web of Science ®Google Scholar
• KozakoTAikawaAShojiTHigh expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cellsInt J Cancer201213192044205522322739
   PubMed Web of Science ®Google Scholar
• JangKYHwangSHKwonKSSIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphomaAm J Surg Pathol200832101523153118724249
   PubMed Web of Science ®Google Scholar
• BradburyCAKhanimFLHaydenRHistone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitorsLeukemia200519101751175916121216
   PubMed Web of Science ®Google Scholar
• HeltwegBGatbontonTSchulerADAntitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymesCancer Res20066684368437716618762
   PubMed Web of Science ®Google Scholar
• CeaMSonciniDFruscioneFSynergistic interactions between HDAC and sirtuin inhibitors in human leukemia cellsPLoS One201167e2273921818379
   PubMed Web of Science ®Google Scholar
• LiLWangLLiLActivation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinibCancer Cell201221226628122340598
   PubMed Web of Science ®Google Scholar
• YuanHWangZLiLActivation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesisBlood201211981904191422207735
   PubMed Web of Science ®Google Scholar
• WangZYuanHRothMStarkJMBhatiaRChenWYSIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cellsOncogene201332558959822410779
   PubMed Web of Science ®Google Scholar
• DicksonBCRiddleNDBrooksJSPashaTLZhangPJSirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiationHum Pathol20134461125113023332867
   PubMed Web of Science ®Google Scholar
• FiresteinRBlanderGMichanSThe SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growthPLoS One200834e202018414679
   PubMed Web of Science ®Google Scholar
• WangRHSenguptaKLiCImpaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant miceCancer Cell200814431232318835033
   PubMed Web of Science ®Google Scholar
• NoguchiALiXKubotaASIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patientsOral Surg Oral Med Oral Pathol Oral Radiol2013115338539223453030
   PubMed Web of Science ®Google Scholar
• KabraNLiZChenLSirT1 is an inhibitor of proliferation and tumor formation in colon cancerJ Biol Chem200928427182101821719433578
   PubMed Web of Science ®Google Scholar
• JangSHMinKWPaikSSJangKSLoss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinomaJ Clin Pathol201265873573922554968
   PubMed Web of Science ®Google Scholar
• LimJHLeeYMChunYSChenJKimJEParkJWSirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alphaMol Cell201038686487820620956
   PubMed Web of Science ®Google Scholar
• SimicPWilliamsEOBellELGongJJBonkowskiMGuarenteLSIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosisCell Rep2013341175118623583181
   PubMed Web of Science ®Google Scholar
• YuanJMinter-DykhouseKLouZA c-Myc-SIRT1 feedback loop regulates cell growth and transformationJ Cell Biol2009185220321119364925
   PubMed Web of Science ®Google Scholar
• ChoIRKohSSMalilasWSIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of beta-cateninBiochem Biophys Res Commun2012423227027522640743
   PubMed Web of Science ®Google Scholar
• SrisutteeRKohSSKimSJHepatitis B virus X (HBX) protein upregulates beta-catenin in a human hepatic cell line by sequestering SIRT1 deacetylaseOncol Rep201228127628222562294
   PubMed Web of Science ®Google Scholar
• SrisutteeRKohSSMalilasWSIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosisBiochem Biophys Res Commun20124291–2455023137540
   PubMed Web of Science ®Google Scholar
• HiratsukaMInoueTTodaTProteomics-based identification of differentially expressed genes in human gliomas:down-regulation of SIRT2 geneBiochem Biophys Res Commun2003309355856612963026
   PubMed Web of Science ®Google Scholar
• PetersCJReesJRHardwickRHOesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study GroupA 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardiaGastroenterology2010139619952004 e1520621683
   PubMed Web of Science ®Google Scholar
• HeXNieHHongYShengCXiaWYingWSIRT2 activity is required for the survival of C6 glioma cellsBiochem Biophys Res Commun2012417146847222166219
   PubMed Web of Science ®Google Scholar
• LiYMatsumoriHNakayamaYSIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosisGenes Cells2011161344521059157
   PubMed Web of Science ®Google Scholar
• ZuoQWuWLiXZhaoLChenWHDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactinOncol Rep201227381982422089141
   PubMed Web of Science ®Google Scholar
• LiuPYXuNMalyukovaAThe histone deacetylase SIRT2 stabilizes Myc oncoproteinsCell Death Differ201320350351423175188
   PubMed Web of Science ®Google Scholar
• DanLKlimenkovaOKlimiankouMThe role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cellsHaematologica201297455155922207684
   PubMed Web of Science ®Google Scholar
• LaiCCLinPMLinSFAltered expression of SIRT gene family in head and neck squamous cell carcinomaTumour Biol20133431847185423475622
   PubMedGoogle Scholar
• ZhangCZLiuLCaiMLow SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinomaPLoS One2012712e5170323272146
   PubMed Web of Science ®Google Scholar
• ZhangYYZhouLMSirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradationBiochem Biophys Res Commun20124231263122609775
   PubMed Web of Science ®Google Scholar
• SomeyaSYuWHallowsWCSirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restrictionCell2010143580281221094524
   PubMed Web of Science ®Google Scholar
• YuWDittenhafer-ReedKEDenuJMSIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox statusJ Biol Chem201228717140781408622416140
   PubMed Web of Science ®Google Scholar
• BellELEmerlingBMRicoultSJGuarenteLSirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS productionOncogene201130262986299621358671
   PubMed Web of Science ®Google Scholar
• InuzukaHGaoDFinleyLWAcetylation-dependent regulation of Skp2 functionCell2012150117919322770219
   PubMed Web of Science ®Google Scholar
• AshrafNZinoSMacintyreAAltered sirtuin expression is associated with node-positive breast cancerBr J Cancer20069581056106117003781
   PubMed Web of Science ®Google Scholar
• AlhazzaziTYKamarajanPJooNSirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancerCancer201111781670167821472714
   PubMed Web of Science ®Google Scholar
• KamarajanPAlhazzaziTYDanciuTD’silvaNJVerdinEKapilaYLReceptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesisCancer2012118235800581022674009
   PubMed Web of Science ®Google Scholar
• LiSBanckMMujtabaSZhouMMSugrueMMWalshMJp53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylasePLoS One201055e1048620463968
   PubMed Web of Science ®Google Scholar
• CsibiAFendtSMLiCThe mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4Cell2013153484085423663782
   PubMed Web of Science ®Google Scholar
• MarquardtJUFischerKBausKSIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patientsHepatology20135831054106423526469
   PubMed Web of Science ®Google Scholar
• YangBZwaansBMEckersdorffMLombardDBThe sirtuin SIRT6 deacetylates H3K56Ac in vivo to promote genomic stabilityCell Cycle20098162662266319597350
   PubMed Web of Science ®Google Scholar
• DasCLuciaMSHansenKCTylerJKCBP/p300-mediated acetylation of histone H3 on lysine 56Nature2009459724311311719270680
   PubMed Web of Science ®Google Scholar
• MinLJiYBakiriLLiver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivinNat Cell Biol201214111203121123041974
   PubMed Web of Science ®Google Scholar
• Van MeterMMaoZGorbunovaVSeluanovASIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cellsCell Cycle201110183153315821900744
   PubMed Web of Science ®Google Scholar
• WangJCKafeelMIAvezbakiyevBHistone deacetylase in chronic lymphocytic leukemiaOncology2011815–632532922237050
   PubMed Web of Science ®Google Scholar
• KhongkowMOlmosYGongCSIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancerCarcinogenesis20133471476148623514751
   PubMed Web of Science ®Google Scholar
• BauerIGrozioALasiglieDThe NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responsesJ Biol Chem201228749409244093723086953
   PubMed Web of Science ®Google Scholar
• De NigrisFCeruttiJMorelliCIsolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissuesBr J Cancer20028712147912454780
   PubMed Web of Science ®Google Scholar
• KimJKNohJHJungKHSirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125bHepatology20135731055106723079745
   PubMed Web of Science ®Google Scholar
• VakhrushevaOBraeuerDLiuZBraunTBoberESirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during agingJ Physiol Pharmacol200859Suppl 920121219261981
   PubMed Web of Science ®Google Scholar
• HubbiMEHuHKshitizNFGilkesDMSemenzaGLSirtuin-7 inhibits the activity of hypoxia-inducible factorsJ Biol Chem201328829207682077523750001
   PubMed Web of Science ®Google Scholar
• WangZChenWEmerging roles of SIRT1 in cancer drug resistanceGenes and Cancer201343–4829024019998
   PubMedGoogle Scholar
• LavuSBossOElliottPJLambertPDSirtuins – novel therapeutic targets to treat age-associated diseasesNat Rev Drug Discov200871084185318827827
   PubMed Web of Science ®Google Scholar
• CenYSirtuins inhibitors:the approach to affinity and selectivityBiochim Biophys Acta2010180481635164419931429
   PubMed Web of Science ®Google Scholar
• BruzzoneSParentiMDGrozioARejuvenating sirtuins: the rise of a new family of cancer drug targetsCurr Pharm Des201319461462323016857
   PubMed Web of Science ®Google Scholar
• MahajanSSLekoVSimonJABedalovASirtuin modulatorsHandb Exp Pharmacol201120624125521879453
   PubMedGoogle Scholar
• LainSHollickJJCampbellJDiscovery, in vivo activity, and mechanism of action of a small-molecule p53 activatorCancer Cell200813545446318455128
   PubMed Web of Science ®Google Scholar
• AmengualJEClark-GarveySKalacMSirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphomaBlood20131202725
   Web of Science ®Google Scholar
• ArrowsmithCHBountraCFishPVLeeKSchapiraMEpigenetic protein families:a new frontier for drug discoveryNat Rev Drug Discov201211538440022498752
   PubMed Web of Science ®Google Scholar
• FinninMSDonigianJRPavletichNPStructure of the histone deacetylase SIRT2Nat Struct Biol20018762162511427894
   PubMedGoogle Scholar
• JinLWeiWJiangYCrystal structures of human SIRT3 displaying substrate-induced conformational changesJ Biol Chem200928436243942440519535340
   PubMed Web of Science ®Google Scholar
• SchuetzAMinJAntoshenkoTStructural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suraminStructure200715337738917355872
   PubMed Web of Science ®Google Scholar
• PanPWFeldmanJLDevriesMKDongAEdwardsAMDenuJMStructure and biochemical functions of SIRT6J Biol Chem201128616145751458721362626
   PubMed Web of Science ®Google Scholar
• ZhaoXAllisonDCondonBThe 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibitionJ Med Chem201356396396923311358
   PubMed Web of Science ®Google Scholar
• DischJSEvindarGChiuCHDiscovery of thieno[3,2-d] pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3J Med Chem20135693666367923570514
   PubMed Web of Science ®Google Scholar
• PanMYuanHBrentMDingECMarmorsteinRSIRT1 contains N- and C-terminal regions that potentiate deacetylase activityJ Biol Chem201228742468247622157016
   PubMed Web of Science ®Google Scholar
• HubbardBPGomesAPDaiHEvidence for a common mechanism of SIRT1 regulation by allosteric activatorsScience201333961241216121923471411
   PubMed Web of Science ®Google Scholar
• HallowsWCLeeSDenuJMSirtuins deacetylate and activate mammalian acetyl-CoA synthetasesProc Natl Acad Sci U S A200610327102301023516790548
   PubMed Web of Science ®Google Scholar
• SundaresanNRPillaiVBWolfgeherDThe deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophySci Signal20114182ra4621775285
   PubMed Web of Science ®Google Scholar
• FuMLiuMSauveAAHormonal control of androgen receptor function through SIRT1Mol Cell Biol200626218122813516923962
   PubMed Web of Science ®Google Scholar
• YamamoriTDeRiccoJNaqviASIRT1 deacetylates APE1 and regulates cellular base excision repairNucleic Acids Res201038383284519934257
   PubMed Web of Science ®Google Scholar
• LeeIHCaoLMostoslavskyRA role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagyProc Natl Acad Sci U S A200810593374337918296641
   PubMed Web of Science ®Google Scholar
• NakahataYKaluzovaMGrimaldiBThe NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian controlCell2008134232934018662547
   PubMed Web of Science ®Google Scholar
• WuXKongXChenDSIRT1 links CIITA deacetylation to MHC II activationNucleic Acids Res201139229549955821890893
   PubMed Web of Science ®Google Scholar
• MaoBZhaoGLvXSirt1 deacetylates c-Myc and promotes c-Myc/Max associationInt J Biochem Cell Biol201143111573158121807113
   PubMed Web of Science ®Google Scholar
• JeongHCohenDECuiLSirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathwayNat Med201118115916522179316
   PubMed Web of Science ®Google Scholar
• LiuYDentinRChenDA fasting inducible switch modulates gluconeogenesis via activator/coactivator exchangeNature2008456721926927318849969
   PubMed Web of Science ®Google Scholar
• PengLYuanZLingHSIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activitiesMol Cell Biol201131234720473421947282
   PubMed Web of Science ®Google Scholar
• PradhanAKKuilaNSinghSChakrabortySEVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1Biochim Biophys Acta201118094–626927521555002
   PubMed Web of Science ®Google Scholar
• MattagajasinghIKimCSNaqviASIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthaseProc Natl Acad Sci U S A200710437148551486017785417
   PubMed Web of Science ®Google Scholar
• YuEJKimSHHeoKOuCYStallcupMRKimJHReciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor alpha activity and co-activator synergyNucleic Acids Res201139166932694321596782
   PubMed Web of Science ®Google Scholar
• DaitokuHHattaMMatsuzakiHSilent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activityProc Natl Acad Sci U S A200410127100421004715220471
   PubMed Web of Science ®Google Scholar
• BrunetASweeneyLBSturgillJFStress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseScience200430356662011201514976264
   PubMed Web of Science ®Google Scholar
• MottaMCDivechaNLemieuxMMammalian SIRT1 represses forkhead transcription factorsCell2004116455156314980222
   PubMed Web of Science ®Google Scholar
• van LoosdregtJVercoulenYGuichelaarTRegulation of Treg functionality by acetylation-mediated Foxp3 protein stabilizationBlood2010115596597419996091
   PubMed Web of Science ®Google Scholar
• KemperJKXiaoZPonugotiBFXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease statesCell Metab200910539240419883617
   PubMed Web of Science ®Google Scholar
• DioumEMChenRAlexanderMSRegulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1Science200932459321289129319498162
   PubMed Web of Science ®Google Scholar
• WesterheideSDAnckarJStevensSMJrSistonenLMorimotoRIStress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1Science200932359171063106619229036
   PubMed Web of Science ®Google Scholar
• JeongJJuhnKLeeHSIRT1 promotes DNA repair activity and deacetylation of Ku70Exp Mol Med200739181317334224
   PubMed Web of Science ®Google Scholar
• LiXZhangSBlanderGTseJGKriegerMGuarenteLSIRT1 deacetylates and positively regulates the nuclear receptor LXRMol Cell20072819110617936707
   PubMed Web of Science ®Google Scholar
• ZocchiLSassone-CorsiPSIRT1-mediated deacetylation of MeCP2 contributes to BDNF expressionEpigenetics20127769570022677942
   PubMed Web of Science ®Google Scholar
• FulcoMSchiltzRLIezziSSir2 regulates skeletal muscle differentiation as a potential sensor of the redox stateMol Cell2003121516212887892
   PubMed Web of Science ®Google Scholar
• YuanZZhangXSenguptaNLaneWSSetoESIRT1 regulates the function of the Nijmegen breakage syndrome proteinMol Cell200727114916217612497
   PubMed Web of Science ®Google Scholar
• YeungFHobergJERamseyCSModulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylaseEMBO J200423122369238015152190
   PubMed Web of Science ®Google Scholar
• LibertSPointerKBellELSIRT1 activates MAO-A in the brain to mediate anxiety and exploratory driveCell201114771459147222169038
   PubMed Web of Science ®Google Scholar
• ZhouYSchmitzKMMayerCYuanXAkhtarAGrummtIReversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencingNat Cell Biol20091181010101619578370
   PubMed Web of Science ®Google Scholar
• GuaraniVDeflorianGFrancoCAAcetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylaseNature2011473734623423821499261
   PubMed Web of Science ®Google Scholar
• BourasTFuMSauveAASIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1J Biol Chem200528011102641027615632193
   PubMed Web of Science ®Google Scholar
• LuoJNikolaevAYImaiSNegative control of p53 by Sir2alpha promotes cell survival under stressCell2001107213714811672522
   PubMed Web of Science ®Google Scholar
• VaziriHDessainSKNg EatonEhSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseCell2001107214915911672523
   PubMed Web of Science ®Google Scholar
• RajamohanSBPillaiVBGuptaMSIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1Mol Cell Biol200929154116412919470756
   PubMed Web of Science ®Google Scholar
• AsherGGatfieldDStratmannMSIRT1 regulates circadian clock gene expression through PER2 deacetylationCell2008134231732818662546
   PubMed Web of Science ®Google Scholar
• RodgersJTLerinCHaasWGygiSPSpiegelmanBMPuigserverPNutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Nature2005434702911311815744310
   PubMed Web of Science ®Google Scholar
• Akieda-AsaiSZaimaNIkegamiKSIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in MammalsPLoS One201057e1175520668706
   PubMed Web of Science ®Google Scholar
• IkenoueTInokiKZhaoBGuanKLPTEN acetylation modulates its interaction with PDZ domainCancer Res200868176908691218757404
   PubMed Web of Science ®Google Scholar
• DonmezGWangDCohenDEGuarenteLSIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10Cell2010142232033220655472
   PubMed Web of Science ®Google Scholar
• WongSWeberJDDeacetylation of the retinoblastoma tumour suppressor protein by SIRT1Biochem J2007407345146017620057
   PubMed Web of Science ®Google Scholar
• KumeSHanedaMKanasakiKSIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylationJ Biol Chem2007282115115817098745
   PubMed Web of Science ®Google Scholar
• PonugotiBKimDHXiaoZSIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolismJ Biol Chem201028544339593397020817729
   PubMed Web of Science ®Google Scholar
• NieYErionDMYuanZSTAT3 inhibition of gluconeogenesis is downregulated by SirT1Nat Cell Biol200911449250019295512
   PubMed Web of Science ®Google Scholar
• WangRHZhengYKimHSInterplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesisMol Cell2008321112018851829
   PubMed Web of Science ®Google Scholar
• VaqueroAScherMErdjument-BromageHTempstPSerranoLReinbergDSIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formationNature2007450716844044418004385
   PubMed Web of Science ®Google Scholar
• PagansSPedalANorthBJSIRT1 regulates HIV transcription via Tat deacetylationPLoS Biol200532e4115719057
   PubMed Web of Science ®Google Scholar
• PengLLingHYuanZSIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60Mol Cell Biol201232142823283622586264
   PubMed Web of Science ®Google Scholar
• LiKCastaAWangRRegulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylationJ Biol Chem2008283127590759818203716
   PubMed Web of Science ®Google Scholar
• WangFMChenYJOuyangHJRegulation of unfolded protein response modulator XBP1s by acetylation and deacetylationBiochem J2011433124525220955178
   PubMed Web of Science ®Google Scholar
• FanWLuoJSIRT1 regulates UV-induced DNA repair through deacetylating XPAMol Cell201039224725820670893
   PubMed Web of Science ®Google Scholar
• MingMSheaCRGuoXRegulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum CProc Natl Acad Sci U S A201010752226232262821149730
   PubMed Web of Science ®Google Scholar
• SuzukiKKoikeTMammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice:a crucial role of tubulin deacetylationNeuroscience2007147359961217574768
   PubMed Web of Science ®Google Scholar
• JingEGestaSKahnCRSIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylationCell Metab20076210511417681146
   PubMed Web of Science ®Google Scholar
• SniderNTLeonardJMKwanRGriggsNWRuiLOmaryMBGlucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylationJ Cell Biol2013200324124723358244
   PubMed Web of Science ®Google Scholar
• RothgiesserKMErenerSWaibelSLuscherBHottigerMOSIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310J Cell Sci2010123Pt 244251425821081649
   PubMed Web of Science ®Google Scholar
• BlackJCMosleyAKitadaTWashburnMCareyMThe SIRT2 deacetylase regulates autoacetylation of p300Mol Cell200832344945518995842
   PubMed Web of Science ®Google Scholar
• BeirowskiBGustinJArmourSMSir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signalingProc Natl Acad Sci U S A201110843E952E96121949390
   PubMed Web of Science ®Google Scholar
• JiangWWangSXiaoMAcetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligaseMol Cell2011431334421726808
   PubMed Web of Science ®Google Scholar
• SerranoLMartinez-RedondoPMarazuela-DuqueAThe tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylationGenes Dev201327663965323468428
   PubMed Web of Science ®Google Scholar
• NarayanNLeeIHBorensteinRThe NAD-dependent deacetylase SIRT2 is required for programmed necrosisNature2012492742819920423201684
   PubMed Web of Science ®Google Scholar
• SchwerBBunkenborgJVerdinROAndersenJSVerdinEReversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2Proc Natl Acad Sci U S A200610327102241022916788062
   PubMed Web of Science ®Google Scholar
• ShulgaNWilson-SmithRPastorinoJGSirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondriaJ Cell Sci2010123Pt 689490220159966
   PubMed Web of Science ®Google Scholar
• HafnerAVDaiJGomesAPRegulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophyAging (Albany NY)201021291492321212461
   PubMedGoogle Scholar
• TsengAHShiehSSWangDLSIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damageFree Radic Biol Med201363C22223423665396
   PubMed Web of Science ®Google Scholar
• SchlickerCGertzMPapatheodorouPKachholzBBeckerCFSteegbornCSubstrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5J Mol Biol2008382379080118680753
   PubMed Web of Science ®Google Scholar
• SundaresanNRSamantSAPillaiVBRajamohanSBGuptaMPSIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70Mol Cell Biol200828206384640118710944
   PubMed Web of Science ®Google Scholar
• HirscheyMDShimazuTGoetzmanESIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylationNature2010464728512112520203611
   PubMed Web of Science ®Google Scholar
• PillaiVBSundaresanNRKimGExogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathwayJ Biol Chem201028553133314419940131
   PubMed Web of Science ®Google Scholar
• ShimazuTHirscheyMDHuaLSIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body productionCell Metab201012665466121109197
   PubMed Web of Science ®Google Scholar
• TaoRColemanMCPenningtonJDSirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stressMol Cell201040689390421172655
   PubMed Web of Science ®Google Scholar
• YangYCimenHHanMJNAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10J Biol Chem2010285107417742920042612
   PubMed Web of Science ®Google Scholar
• AhnBHKimHSSongSA role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasisProc Natl Acad Sci U S A200810538144471445218794531
   PubMed Web of Science ®Google Scholar
• HallowsWCYuWSmithBCSirt3 promotes the urea cycle and fatty acid oxidation during dietary restrictionMol Cell201141213914921255725
   PubMed Web of Science ®Google Scholar
• CimenHHanMJYangYTongQKocHKocECRegulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondriaBiochemistry201049230431120000467
   PubMed Web of Science ®Google Scholar
• FinleyLWHaasWDesquiret-DumasVSuccinate dehydrogenase is a direct target of sirtuin 3 deacetylase activityPLoS One201168e2329521858060
   PubMed Web of Science ®Google Scholar
• LaurentGGermanNJSahaAKSIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylaseMol Cell201350568669823746352
   PubMed Web of Science ®Google Scholar
• NakagawaTGuarenteLSirtuins at a glanceJ Cell Sci2011124Pt 683383821378304
   PubMed Web of Science ®Google Scholar