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Review

Bevacizumab in high-grade gliomas: a review of its uses, toxicity assessment, and future treatment challenges

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Pages 371-389 | Published online: 15 Apr 2013

References

  • WenPYKesariSMalignant gliomas in adultsN Engl J MedJul 312008359549250718669428
  • WrenschMMinnYChewTBondyMBergerMSEpidemiology of primary brain tumors: current concepts and review of the literatureNeuro Oncol1020024427829912356358
  • GiglioPVillanoJLNewly diagnosed high-grade gliomasCurr Treat Options Neurol7201012430932020842590
  • StuppRMasonWPvan den BentRadiotherapy plus concomitant and adjuvant temozolomide for glioblastomaN Engl J MedMar 1020053521098799615758009
  • StuppRHegiMEGilbertMRChakravartiAChemoradiotherapy in malignant glioma: standard of care and future directionsJ Clin OncolSep 10200725264127413617827463
  • StuppRHegiMEMasonWPEffects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialLancet Oncol5200910545946619269895
  • HegiMEDiserensACGodardSClinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomideClin Cancer ResMar 1520041061871187415041700
  • HegiMEDiserensACGorliaTMGMT gene silencing and benefit from temozolomide in glioblastomaN Engl J MedMar 10200535210997100315758010
  • HegiMELiuLHermanJGCorrelation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activityJ Clin OncolSep 1200826254189419918757334
  • ChamberlainMCEmerging clinical principles on the use of bevacizumab for the treatment of malignant gliomasCancerMay 28
  • WongETHessKRGleasonMJOutcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trialsJ Clin Oncol819991782572257810561324
  • FolkmanJTumor angiogensis: role in regulation of tumor growthSymp Soc Dev Biol197430043524600889
  • FolkmanJWhat is the evidence that tumors are angiogenesis dependent?J Natl Cancer InstJan 31990821461688381
  • GeigerTRPeeperDSMetastasis mechanismsBiochimica et biophysica acta [Research Support, Non-U.S. Gov’t Review]1220091796229330819683560
  • HanahanDWeinbergRAThe hallmarks of cancerCellJan 720001001577010647931
  • BergersGBenjaminLETumorigenesis and the angiogenic switchNature reviews Cancer. [Review]6200336401410
  • ParikhAAEllisLMThe vascular endothelial growth factor family and its receptors. Hematology/oncology clinics of North America. Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, PHSReview102004185951971vii
  • FolkmanJAngiogenesis: an organizing principle for drug discovery?Nat Rev Drug Discov420076427328617396134
  • JainRKNormalization of tumor vasculature: an emerging concept in antiangiogenic therapyScienceJan 720053075706586215637262
  • JainRKDudaDGClarkJWLoefflerJSLessons from phase III clinical trials on anti-VEGF therapy for cancerNat Clin Pract Oncol1200631244016407877
  • CalabreseCPoppletonHKocakMA perivascular niche for brain tumor stem cellsCancer Cell12007111698217222791
  • BaoSWuQSathornsumeteeSStem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factorCancer ResAug 15200666167843784816912155
  • SiemannDWShiWTargeting the tumor blood vessel network to enhance the efficacy of radiation therapySeminars in radiation oncology. [Research Support, U.S. Gov’t, P.H.S. Review]120031315361
  • MileticHNiclouSPJohanssonMBjerkvigRAnti-VEGF therapies for malignant glioma: treatment effects and escape mechanismsExpert Opin Ther Targets4200913445546819335067
  • LamszusKHeeseOWestphalMAngiogenesis-related growth factors in brain tumorsCancer treatment and research. [Review]2004117169190
  • TuettenbergJFriedelCVajkoczyPAngiogenesis in malignant glioma–a target for antitumor therapy?Critical reviews in oncology/hematology. [Review]92006593181193
  • PrestaLGChenHO’ConnorSJChisholmVMengYGKrummenLHumanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disordersCancer researchOct 1519975720459345999377574
  • ZondorSDMedinaPJBevacizumab: an angiogenesis inhibitor with efficacy in colorectal and other malignanciesThe Annals of pharmacotherapy. [Review]Jul-Aug2004387–812581264
  • DietrichJNordenADWenPYEmerging antiangiogenic treatments for gliomas—efficacy and safety issuesCurr Opin Neurol12200821673674419060566
  • CardonesARBanezLLVEGF inhibitors in cancer therapyCurrent pharmaceutical design. [Review]2006123387394
  • FerraraNHillanKJGerberHPNovotnyWDiscovery and development of bevacizumab, an anti-VEGF antibody for treating cancerNature reviews Drug discovery. [Review]5200435391400
  • FerraraNHillanKJNovotnyWBevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapyBiochemical and biophysical research communications. [Review]Jul 2920053332328335
  • Stark-VanceVBevacizumab and CPT-11 in the treatment of relapsed malignant glioma [abstract]Neuro Oncology [Abstract]20057369
  • VredenburghJJDesjardinsAHerndonJE2ndBevacizumab plus irinotecan in recurrent glioblastoma multiformeJ Clin OncolOct 20200725304722472917947719
  • FriedmanHSPradosMDWenPYBevacizumab alone and in combination with irinotecan in recurrent glioblastomaJ Clin OncolOct 1200927284733474019720927
  • CloughesyTJJVBDayADasHSFriedman and for the BRAIN InvestigatorsUpdated safety and survival of patients with relapsed glioblastoma treated with bevacizumab in the BRAIN studyJournal of Clinical Oncology 2010 ASCO Annual Meeting Proceedings (PostMeeting Edition). [Abstract]20102815
  • KreislTNKimLMooreKPhase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastomaJ Clin OncolFeb 10200927574074519114704
  • CohenMHShenYLKeeganPPazdurRFDA drug approval summary: Bevacizumab (Avastin (R)) as treatment of recurrent glioblastoma multiformeThe Oncologist20091411113119897538
  • BalanaCEtxanizOBugesCMartinezAApproval denied by the European Medicines Agency (EMA) for bevacizumab in the treatment of high-grade glioma recurrence: a good idea or a grave error?Clin Transl Oncol. [Letter]32011133209210
  • NarayanaAGolfinosJGFischerIFeasibility of using bevacizumab with radiation therapy and temozolomide in newly diagnosed high-grade gliomaInt J Radiat Oncol Biol PhysOct 1200872238338918793954
  • LaiATranANghiemphuPLPhase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiformeJournal of clinical oncology: Official journal of the American Society of Clinical Oncology [Clinical Trial, Phase II Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t] 10201129214214821135282
  • NarayanaAGruberDKunnakkatSA clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastomaJournal of neurosurgery. [Clinical Trial]20121162341345
  • ChinotOWickWMasonWOT3: Phase III trial of Bevacizumab added to standard radiotherapy and temozolomide for newly-diagnosed glioblastoma: mature progression-free survival and preliminary overall survival results in AVAGLIONeuro Oncology. [Abstract]2012146vi101vi105
  • LaiAFilkaEMcGibbonBNghiemphuPLGrahamCYongWHPhase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerabilityInt J Radiat Oncol Biol Phys20087151372138018355978
  • DesjardinsAReardonDAHerndonJE2ndMarcelloJQuinnJARichJNBevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas. Clinical cancer research: an official journal of the American Association for Cancer ResearchClinical Trial, Phase II, Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t2008142170687073
  • VredenburghJJDesjardinsAHerndonJE2ndDowellJMReardonDAQuinnJAPhase II trial of bevacizumab and irinotecan in recurrent malignant gliomaClin Cancer Res2007151341253125917317837
  • WickWKukerWBrain edema in neurooncology: radiological assessment and managementOnkologie. [Review]2004273261266
  • ChangSMParneyIFHuangWPatterns of care for adults with newly diagnosed malignant gliomaJAMA2005293555756415687310
  • DerrRLYeXIslasMUDesideriSSaudekCDGrossmanSAAssociation between hyperglycemia and survival in patients with newly diagnosed glioblastomaJournal of clinical oncology: official journal of the American Society of Clinical Oncology [Research Support, N.I.H., Extramural]20092771082108619139429
  • FriedmanHSPradosMDWenPYBevacizumab alone and in combination with irinotecan in recurrent glioblastoma. Journal of clinical oncology: official journal of the American Society of Clinical OncologyClinical Trial, Phase II Multicenter Study, Randomized Controlled Trial. Research Support, Non-U.S. Govt2009272847334740
  • VredenburghJJCloughesyTSamantMCorticosteroid use in patients with glioblastoma at first or second relapse treated with bevacizumab in the BRAIN studyThe Oncologist [Clinical Trial, Phase II Multicenter Study Randomized Controlled Trial]201015121329133421147867
  • NordenADYoungGSSetayeshKBevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrenceNeurology2008701077978718316689
  • SemradTJO’DonnellRWunTEpidemiology of venous thromboembolism in 9489 patients with malignant gliomaJ Neurosurg42007106460160817432710
  • BrandesAAScelziESalmistraroGErmaniMCarolloCBertiFIncidence of risk of thromboembolism during treatment high-grade gliomas: a prospective studyEur J Cancer19973310159215969389920
  • JenkinsEOSchiffDMackmanNKeyNSVenous thromboembolism in malignant gliomasJ Thromb Haemost220108222121719912518
  • MarrasLCGeertsWHPerryJRThe risk of venous thromboembolism is increased throughout the course of malignant glioma: an evidence-based reviewCancer200089364064610931464
  • DrappatzJSchiffDKesariSNordenADWenPYMedical management of brain tumor patientsNeurol Clin1120072541035107117964025
  • NalluriSRChuDKeresztesRZhuXWuSRisk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysisJAMANov 192008300192277228519017914
  • GordonMSCunninghamDManaging patients treated with bevacizumab combination therapyOncology200569 Suppl 3253316301833
  • NghiemphuPLGreenRMPopeWBLaiACloughesyTFSafety of anticoagulation use and bevacizumab in patients with gliomaNeuro Oncol6200810335536018436627
  • NordenADBartolomeoJTanakaSSafety of concurrent bevacizumab therapy and anticoagulation in glioma patientsJ NeurooncolJun 262011
  • VerheulHMPinedoHMPossible molecular mechanisms involved in the toxicity of angiogenesis inhibitionNat Rev Cancer20077647548517522716
  • EskensFAVerweijJThe clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a reviewEur J Cancer200642183127313917098419
  • ChamberlainMCBevacizumab plus irinotecan in recurrent glioblastomaJ Clin OncolFeb 20200826610121013 author reply 318281677
  • NordenADDrappatzJCiampaASColon perforation during antiangiogenic therapy for malignant gliomaNeuro Oncol2009111929925
  • VredenburghJJDesjardinsAHerndonJE2ndPhase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clinical cancer research: an official journal of the American Association for Cancer ResearchClinical Trial, Phase II Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’tFeb 15200713412531259
  • ChamberlainMCBevacizumab and irinotecan for recurrent oligodendroglial tumorsNeurology74218120065257
  • SpecenierPBevacizumab in glioblastoma multiformeExpert review of anticancer therapy. [Review]2012121918
  • IwamotoFMAbreyLEBealKPatterns of relapse and prognosis after bevacizumab failure in recurrent glioblastomaNeurologyOct 13200973151200120619822869
  • BrandsmaDvan den BentMJPseudoprogression and pseudoresponse in the treatment of gliomasCurr Opin Neurol200922663363819770760
  • BrandesAAFranceschiETosoniAMGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patientsJ Clin Oncol200826132192219718445844
  • BatchelorTTSorensenAGdi TomasoEAZD2171, a panVEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patientsCancer Cell2007111839517222792
  • UllrichRBackesHLiHGlioma proliferation as assessed by 3’-fluoro-3’-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade glioma. Clinical cancer research: an official journal of the American Association for Cancer ResearchResearch Support, Non-U.S. Gov’t200814720492055
  • ChenWCloughesyTKamdarNImaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDGJ Nucl Med200546694595215937304
  • ChenWDelaloyeSSilvermanDHPredicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fuorothymidine positron emission tomography: a pilot studyJ Clin Oncol200725304714472117947718
  • SzetoMDChakrabortyGHadleyJQuantitative metrics of net proliferation and invasion link biological aggressiveness assessed by MRI with hypoxia assessed by FMISO-PET in newly diagnosed glioblastomasCancer research [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]20091569104502450919366800
  • ReardonDAGalanisEDeGrootJFClinical trial end points for high-grade glioma: the evolving landscapeNeuro-oncology. [Review]2011133353361
  • BatchelorTStanleyKAndersenJClinical trials in neuro-oncologyCurrent opinion in neurology. [Review]2001146689694
  • PradosMDSeiferheldWSandlerHMBucknerJCPhillipsTSchultzCPhase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404Int J Radiat Oncol Biol PhysMar 1520045841147115215001257
  • TherassePArbuckSGEisenhauerEANew guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaJournal of the National Cancer Institute. [Guideline Practice Guideline]2000923205216
  • EisenhauerEATherassePBogaertsJNew response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)European Journal of Cancer. [Practice Guideline]12009452228247
  • WarrenKEPatronasNAikinAAAlbertPSBalisFMComparison of one-, two-, and three-dimensional measurements of childhood brain tumorsJournal of the National Cancer Institute. [Comparative Study Evaluation Studies]2001931814011405
  • GalanisEBucknerJCMaurerMJValidation of neuroradiologic response assessment in gliomas: measurement by RECIST, two-dimensional, computer-assisted tumor area, and computer-assisted tumor volume methodsNeuro-oncology [Comparative Study Research Support, N.I.H., Extramural Validation Studies]2006215616516533757
  • WenPYMacdonaldDRReardonDAUpdated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working groupJ Clin Oncol201028111963197220231676
  • SorensenAGBatchelorTTWenPYZhangWTJainRKResponse criteria for gliomaNat Clin Pract Oncol200851163464418711427
  • van den BentMJVogelbaumMAWenPYMacdonaldDRChangSMEnd point assessment in gliomas: novel treatments limit usefulness of classical Macdonald’s CriteriaJ Clin Oncol200927182905290819451418
  • HensonJWUlmerSHarrisGJBrain tumor imaging in clinical trialsAJNR Am J Neuroradiol200829341942418272557
  • CairncrossJGMacdonaldDRPexmanJHIvesFJSteroid-induced CT changes in patients with recurrent malignant gliomaNeurology19883857247263362369
  • CairncrossJGPexmanJHRathboneMPDelMaestroRFPostoperative contrast enhancement in patients with brain tumorAnn Neurol19851765705724026227
  • UlmerSBragaTABarkerFG2ndLevMHGonzalezRGHensonJWClinical and radiographic features of peritumoral infarction following resection of glioblastomaNeurology2006146791668167017101902
  • KumarAJLeedsNEFullerGNMalignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatmentRadiology2000217237738411058631
  • HyltonNDynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. Journal of clinical oncology: official journal of the American Society of Clinical OncologyReview2006242032933298
  • BarrettTBrechbielMBernardoMChoykePLMRI of tumor angiogenesisJournal of magnetic resonance imaging: JMRI. [Research Support, N.I.H., Intramural Review]2007262235249
  • PopperlGKrethFWHermsJAnalysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods?Journal of nuclear medicine: official publication, Society of Nuclear Medicine. [Controlled Clinical Trial Research Support, Non-U.S. Gov’t]2006473393403
  • HidaKHidaYAminDNTumor-associated endothelial cells with cytogenetic abnormalitiesCancer research. [Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, P.H.S.]2004642282498255
  • CaoYZhongWSunYImprovement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistanceSeminars in cancer biology. [Research Support, Non-U.S. Gov’t Review]2009195338343
  • CasanovasOHicklinDJBergersGHanahanDDrug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumorsCancer Cell. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, P.H.S.]200584299309
  • ChamberlainMCBevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrenceNeurology2009728772773 author reply 3–419237713
  • ShojaeiFWuXMalikAKTumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cellsNature biotechnology2007258911920
  • ChamberlainMCRaizerJAntiangiogenic therapy for high-grade gliomasCNS Neurol Disord Drug Targets20098318419419601816
  • Paez-RibesMAllenEHudockJAntiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisCancer Cell200915322023119249680
  • LamszusKKunkelPWestphalMInvasion as limitation to anti-angiogenic glioma therapyActa neurochirurgica Supplement. [Review]200388169177
  • LefrancFBrotchiJKissRPossible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. Journal of clinical oncology: official journal of the American Society of Clinical OncologyReview2005231024112422
  • NakadaMNakadaSDemuthTTranNLHoelzingerDBBerensMEMolecular targets of glioma invasionCellular and molecular life sciences: CMLS. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Review]2007644458478
  • RubensteinJLKimJOzawaTAnti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooptionNeoplasia. [Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, P.H.S.]200024306314
  • RaoJSMolecular mechanisms of glioma invasiveness: the role of proteasesNat Rev Cancer20033748950112835669
  • JainRKXuLalphaPlGF: a new kid on the antiangiogenesis blockCell2007131344344517981110
  • BergersGHanahanDModes of resistance to anti-angiogenic therapyNat Rev Cancer2008859260318650835
  • BrastianosPKBatchelorTTVascular endothelial growth factor inhibitors in malignant gliomasTargeted oncology. [Review]201053167174
  • de GrootJFFullerGKumarAJTumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and miceNeuro Oncol201012323324220167811
  • ZunigaRMTorcuatorRJainRRebound tumour progression after the cessation of bevacizumab therapy in patients with recurrent high-grade gliomaJ Neurooncol201099223724220151176
  • QuantECNordenADDrappatzJMuzikanskyADohertyLLafrankieDRole of a second chemotherapy in recurrent malignant glioma patients who progress on bevacizumabNeuro Oncol200911555055519332770
  • TorcuatorRGThindRPatelMThe role of salvage reirradiation for malignant gliomas that progress on bevacizumabJ Neurooncol201097340140719838627
  • ReardonDAHerndonJE2ndPetersKBBevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patientsBritish journal of cancer 23201210791481148723037712
  • KathrynMFieldLCHelenWheelerAbstracts from the 16th Annual Scientific Meeting of the Society for Neuro-Oncology in Conjunction with the AANS/CNS Section on Tumors, November 17–20, 2011. Orange County, California: Lot-14. A randomized phase ii study of carboplatin and bevacizumab in recurrent glioblastoma multiforme (cabaret study)Neuro-Oncology [Abstract]2011133iii85iii91
  • ChamberlainMCJohnstonSSalvage chemotherapy with bevacizumab for recurrent alkylator-refractory anaplastic astrocytomaJ Neurooncol200991335936718953491
  • RaizerJJGrimmSChamberlainMCA phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomasCancer2010116225297530520665891
  • ChamberlainMCJohnstonSKSalvage therapy with single agent bevacizumab for recurrent glioblastomaJournal of neuro-oncology. [Clinical Trial]2010962259269
  • DesjardinsAReardonDAHerndonJE2ndBevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomasClin Cancer Res200814217068707318981004
  • GilbertMWangMAldapeKSorensenAMikkelsonTBoksteinFRTOG 0625: a randomized Phase II trial of bevacizumab with either irinotecan (CPT) or dose-dense temozolomide (TMZ) in recurrent glioblastoma (GBM)Neuro Oncol201012
  • NghiemphuPLLiuWLeeYBevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experienceNeurology200972141217122219349600
  • NarayanaAKellyPGolfinosJAntiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survivalJ Neurosurg2009110117318018834263
  • ZunigaRMTorcuatorRJainREfficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecanJ Neurooncol200991332933618953493
  • TaillibertSVincentLAGrangerBBevacizumab and irinotecan for recurrent oligodendroglial tumorsNeurology200972181601160619414728
  • HoferSElandtKGreilRClinical outcome with bevacizumab in patients with recurrent high-grade glioma treated outside clinical trialsActa oncologica. [Evaluation Studies Multicenter Study Research Support, Non-U.S. Gov’t]2011505630635
  • ChauffertBFeuvretLBonnetainFRandomized multicenter phase II trial of irinotecan and bevacizumab as neoadjuvant and adjuvant to temozolomide-based chemoradiation versus chemoradiation for unresectable glioblastoma: Interim results of the TEMAVIR study from the ANOCEF groupASCO Meeting Abstracts201129152029
  • HofandKFHSSørensenMSchultzHRandomized phase ii study of neoadjuvant bevacizumab and irinotecan versus bevacizumab and temozolomide followed by concomitant chemoradiotherapy in newly diagnosed primary glioblastoma multiformeNeuro-Oncology. [Abstract]2011133iii51
  • LouEReardonDAPetersKUpfront bevacizumab with temozolomide or with temozolomide and irinotecan for unresectable or multifocal glioblastomaJ Clin Oncol292011 (suppl; abstr 2055)
  • VredenburghJJDesjardinsAReardonDAPetersKBHerndonJE2ndMarcelloJThe addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastomaClinical cancer research: an official journal of the American Association for Cancer Research201117124119412421531816
  • OmuroAMPBealKKarimiSCorreaDChanTADeAngelisLMPhase II study of bevacizumab (BEV), temozolomide (TMZ), and hypofractionated stereotactic radiotherapy (HFSRT) for newly diagnosed glioblastoma (GBM)J Clin Oncol201129152028
  • MacdonaldDRCascinoTLScholdSCJrCairncrossJGResponse criteria for phase II studies of supratentorial malignant gliomaJ Clin Oncol7199087127712802358840
  • WenPYMacdonaldDRReardonDACloughesyTFSorensenAGGalanisEUpdated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working groupJournal of clinical oncology : official journal of the American Society of Clinical Oncology201028111963177220231676
  • ChaSNeuroimaging in neuro-oncologyNeurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics. [Review]7200963465477
  • LawMYoungRJBabbJSPeccerelliNChheangSGruberMLGliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imagingRadiology. [Research Support, N.I.H., Extramural]20082472490498
  • AkellaNSTwiegDBMikkelsenTAssessment of brain tumor angiogenesis inhibitors using perfusion magnetic resonance imaging: quality and analysis results of a phase I trial. Journal of magnetic resonance imaging : JMRIClinical Trial Clinical Trial, Phase I Multicenter Study Research Support, U.S. Gov’t, P.H.S.2004206913922
  • BarajasRFJrChangJSSegalMRDifferentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imagingRadiology2009253248649619789240
  • SorensenAGBatchelorTTZhangWTChenPJYeoPWangMA “vascular normalization index” as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patientsCancer Res200969135296530019549889
  • CaoYTsienCINageshVSurvival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT [corrected]International journal of radiation oncology, biology, physics. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]2006643876885
  • GerstnerERBatchelorTTImaging and response criteria in gliomasCurrent opinion in oncology. [Research Support, Non-U.S. Gov’t Review]2010226598603
  • PopeWBLaiAMehtaRKimHJQiaoJYoungJRApparent diffusion coefficient histogram analysis stratifes progression-free survival in newly diagnosed bevacizumab-treated glioblastomaAJNR. [Research Support, Non-U.S. Gov’t]2011325882889
  • AhluwaliaMSWenPYAntiangiogenic therapy for patients with glioblastoma: current challenges in imaging and future directionsExpert review of anticancer therapy [Editorial]201111565365621554035
  • EllingsonBMMalkinMGRandSDVolumetric analysis of functional diffusion maps is a predictive imaging biomarker for cytotoxic and anti-angiogenic treatments in malignant gliomasJournal of neuro-oncology [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]201110219510320798977
  • WeybrightPSundgrenPCMalyPDifferentiation between brain tumor recurrence and radiation injury using MR spectroscopyAJR200518561471147616304000