References
- HodisEWatsonIRKryukovGVA landscape of driver mutations in melanomaCell2012150225126322817889
- SmalleyKSUnderstanding melanoma signaling networks as the basis for molecular targeted therapyJ Invest Dermatol20101301283719571822
- ChapmanPBHauschildARobertCImproved survival with vemurafenib in melanoma with BRAF V600E mutationN Engl J Med2011364262507251621639808
- HauschildAGrobJDemidovLPhase III, randomized, open-label, multicenter trial (BREAK-3) comparing the BRAF kinase inhibitor dabrafenib (GSK2118436) with dacarbazine (DTIC) in patients with BRAFV600E-mutated melanomaAnnual Meeting Program, American Society of Clinical OncologyJune 1–5, 2012Chicago, IL, USA Abstract LBA 8500
- FlahertyKTRobertCHerseyPMETRIC Study GroupImproved survival with MEK inhibition in BRAF-mutated melanomaN Engl J Med2012367210711422663011
- KirkwoodJMBastholtLRobertCPhase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanomaClin Cancer Res201218255556722048237
- LoRussoPMKrishnamurthiSSRinehartJJPhase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancersClin Cancer Res20101661924193720215549
- FalchookGSLewisKDInfanteJRActivity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trialLancet Oncol201213878278922805292
- SullivanRJFlahertyKTResistance to BRAF-targeted therapy in melanomaEur J Cancer20134961297130423290787
- GregerJGEastmanSDZhangVCombinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutationsMol Cancer Ther201211490992022389471
- CorcoranRBDias-SantagataDBergethonKIafrateAJSettlemanJEngelmanJABRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutationSci Signal20103149ra8421098728
- LittleASBalmannoKSaleMJAmplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cellsSci Signal20114166ra1721447798
- PoulikakosPISolitDBResistance to MEK inhibitors: should we co-target upstream?Sci Signal20114166e16
- SuFVirosAMilagreCRAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitorsN Engl J Med2012366320721522256804
- FlahertyKTInfanteJRDaudACombined BRAF and MEK inhibition in melanoma with BRAF V600 mutationsN Engl J Med2012367181694170323020132
- GonzalezRRibasADaudAPhase IB Study of vemurafenib in combination with the MEK inhibitor, GDC-0973, in patients (pts) with unresectable or metastatic BRAFV600 mutated melanoma (BRIM7)Presented at: European Society for Medical Oncology CongressSeptember 28–October 2, 2012 Abstract LBA28_PR. Available from: http://abstracts.webges.com/esmo2012/myitinerary
- HooijkaasAIGadiotJvan der ValkMMooiWJBlankCUTargeting BRAF(V600E) in an inducible murine model of melanomaAm J Pathol2012181378579422796458
- HooijkaasAGadiotJMorrowMStewartRSchumacherTBlankCSelective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanomaOncoImmunology201216715
- DankortDCurleyDPCartlidgeRABraf(V600E) cooperates with Pten loss to induce metastatic melanomaNat Genet200941554455219282848
- GilmartinAGBleamMRGroyAGSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibitionClin Cancer Res2011175989100021245089
- TsaiJLeeJTWangWDiscovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activityProc Natl Acad Sci U S A200810583041304618287029
- BalagulaYBarth HustonKBusamKJLacoutureMEChapmanPBMyskowskiPLDermatologic side effects associated with the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886)Invest New Drugs20112951114112120978926
- DumesicPASchollFABarraganDIKhavariPAErk1/2 MAP kinases are required for epidermal G2/M progressionJ Cell Biol2009185340942219414607
- CichowskiKJännePADrug discovery: inhibitors that activateNature2010464728735835920237552
- BlankCUHooijkaasAIHaanenJBSchumacherTNCombination of targeted therapy and immunotherapy in melanomaCancer Immunol Immunother201160101359137121847631
- ParaisoKHFedorenkoIVCantiniLPRecovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapyBr J Cancer2010102121724173020531415
- FridayBBYuCDyGKBRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteinsCancer Res200868156145615318676837
- ByronSALochDCWellensCLSensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN statusMol Cancer2012117523039341
- ParaisoKHXiangYRebeccaVWPTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expressionCancer Res20117172750276021317224