References
- LeeRCFeinbaumRLAmbrosVThe C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell1993758438548252621
- ScheelCWeinbergRACancer stem cells and epithelial-mesenchymal transition: concepts and molecular linksSemin Cancer Biol20122239640322554795
- AlisonMRLimSMNicholsonLJCancer stem cells: problems for therapy?J Pathol201122314716121125672
- GargMMicroRNAs, stem cells and cancer stem cellsWorld J Stem Cells20124627022993663
- LiYVecchiarelli-FedericoLMLiYJThe miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in miceBlood20121194486449822451425
- NorthcottPAFernandez-LAHaganJPThe miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursorsCancer Res2009693249325519351822
- TaguchiAYanagisawaKTanakaMIdentification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA clusterCancer Res2008685540554518632605
- ChenHCChenGHChenYHMicroRNA deregulation and pathway alterations in nasopharyngeal carcinomaBr J Cancer20091001002101119293812
- CalinGACroceCMMicroRNA signatures in human cancersNat Rev Cancer2006685786617060945
- YuFYaoHZhuPlet-7 regulates self renewal and tumorigenicity of breast cancer cellsCell20071311109112318083101
- YuFDengHYaoHLiuQSuFSongEMir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cellsOncogene2010294194420420498642
- ShimonoYZabalaMChoRWDownregulation of miRNA-200c links breast cancer stem cells with normal stem cellsCell200913859260319665978
- OkudaHXingFPandeyPRmiR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4Cancer Res2013731434144423384942
- LiuSPatelSHGinestierCMicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cellsPLoS Genet201286e100275122685420
- YuXYZhangZLiuJZhanBKongCZMicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25BOnco Targets Ther2013634935423596351
- HudsonRSYiMEspositoDMicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancerOncogene201332354139414722986525
- FanXChenXDengWZhongGCaiQLinTUp-regulated microRNA-143 in cancer stem cells differentiation promotes prostate cancer cells metastasis by modulating FNDC3B expressionBMC Cancer2013136123383988
- HuangSGuoWTangYRenDZouXPengXmiR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cellsOncol Rep2012281831183722948942
- HsiehISChangKCTsaiYTMicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathwayCarcinogenesis20133453053823188675
- SainiSMajidSShahryariVmiRNA-708 control of CD44(+) prostate cancer-initiating cellsCancer Res2012723618363022552290
- RyuSMcDonnellKChoiHSuppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migrationCancer Cell201323637623328481
- GalHPandiGKannerAAMIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cellsBiochem Biophys Res Commun2008376869018765229
- GuessousFAlvarado-VelezMMarcinkiewiczLOncogenic effects of miR-10b in glioblastoma stem cellsJ Neurooncol201311215316323307328
- WuNXiaoLZhaoXmiR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2FEBS Lett20125863831383922999819
- YingZLiYWuJLoss of miR-204 expression enhances glioma migration and stem cell-like phenotypeCancer Res20137399099923204229
- ChanXHNamaSGopalFTargeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomasCell Rep2012259160222921398
- LiuCKelnarKLiuBThe microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44Nat Med20111721121521240262
- JiQHaoXZhangMMicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cellsPLoS One20094e681619714243
- SunLWuZShaoYMicroRNA-34a suppresses cell proliferation and induces apoptosis in U87 glioma stem cellsTechnol Cancer Res Treat20121148349022568628
- YangSLiYGaoJMicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1Oncogene201332364294430323001043
- PagliucaAValvoCFabriziEAnalysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repressionOncogene EpubNovmber52012
- De VitoCRiggiNCornazSA TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcomaCancer Cell20122180782122698405
- TangMLinLCaiHTangJZhouZMicroRNA-145 downregulation associates with advanced tumor progression and poor prognosis in patients suffering osteosarcomaOnco Targets Ther2013683383823874105
- XiaHCheungWKNgSSLoss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cellsJ Biol Chem20122879962997122253443
- WangPChenLZhangJMethylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. OncogeneEpub January322013
- YuPNYanMDLaiHCDownregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cellsInt J Cancer Epub812013
- CittellyDMFinlay-SchultzJHoweENProgestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4Oncogene201332202555256422751119
- WangHGarzonRSunHNF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcomaCancer Cell20081436938118977326
- ZhangXZhaoXFiskusWCoordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomasCancer Cell20122250652323079660
- ZhangJLuoNLuoYPengZZhangTLiSmicroRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-MybInt J Oncol20124074775622025269
- JinHLvSYangJUse of microRNA Let-7 to control the replication specificity of oncolytic adenovirus in hepatocellular carcinoma cellsPLoS One20116e2130721814544
- MengFGlaserSSFrancisHFunctional analysis of microRNAs in human hepatocellular cancer stem cellsJ Cell Mol Med20121616017321352471
- XiaHOoiLLHuiKMMiR-214 targets beta-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinomaPLoS One20127e4420622962603
- XuCXXuMTanLMicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/NanogJ Biol Chem2012287349703497822927443
- ShiLZhangSFengKMicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosisInt J Oncol20124011912921879257
- ZhangSWanYPanTMicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomideJ Mol Neurosci20124734635622528454
- HanMLiuMWangYAntagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTENPLoS One20127e3952022761812
- LiuXSempereLFGalimbertiFUncovering growth-suppressive MicroRNAs in lung cancerClin Cancer Res2009151177118319228723
- TakagiTIioANakagawaYNaoeTTanigawaNAkaoYDecreased expression of microRNA-143 and -145 in human gastric cancersOncology200977122119439999
- DengHGuoYSongHMicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancerGene2013518235135923333942
- La RoccaGBadinMShiBMechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathwayJ Cell Physiol200922048549119391107
- DyrskjotLOstenfeldMSBramsenJBGenomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitroCancer Res2009694851486019487295
- TongAWFulghamPJayCMicroRNA profile analysis of human prostate cancersCancer Gene Ther20091620621618949015
- WangSBianCYangZmiR-145 inhibits breast cancer cell growth through RTKNInt J Oncol2009341461146619360360
- YangYPChienYChiouGYInhibition of cancer stem celllike properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEIBiomaterials2012331462147622098779
- DynoodtPSpeeckaertRDe WeverOmiR-145 overexpression suppresses the migration and invasion of metastatic melanoma cellsInt J Oncol20134241443145123404256
- KatsushimaKShinjoKNatsumeAContribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cellsJ Biol Chem2012287273962740622736761
- LiuSTetzlaffMTCuiRXuXmiR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1Am J Pathol20121811823183522982443
- SinghSChitkaraDMehrazinRBehrmanSWWakeRWMahatoRIChemoresistance in prostate cancer cells is regulated by miRNAs and Hedgehog pathwayPLoS One20127e4002122768203
- LoWLYuCCChiouGYMicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cellsJ Pathol201122348249521294122
- ZhuYYuFJiaoYReduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5Clin Cancer Res2011177105711521953503
- QianPBanerjeeAWuZSLoss of SNAIL regulated miR-128-2 on chromosome 3p22.3 targets multiple stem cell factors to promote transformation of mammary epithelial cellsCancer Res2012726036605023019226
- GodlewskiJNowickiMOBroniszATargeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewalCancer Res2008689125913019010882
- GregoryPABertAGPatersonELThe miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Nat Cell Biol20081059360118376396
- ChenYSunYChenLmiRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signalingMol Med Rep2013751579158423546450
- PatersonELKazenwadelJBertAGKhew-GoodallYRuszkiewiczAGoodallGJDown-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progressionNeoplasia20131518019123441132
- CongNDuPZhangADownregulated microRNA-200a promotes EMT and tumor growth through the wnt/beta-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinomaOncol Rep2013291579158723381389
- ZhangLYLiuMLiXTangHmiR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-golgi intermediate compartment protein 3 (ERGIC3)J Biol Chem20132884035404723212913
- HeYCuiYWangWHypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinomaNeoplasia20111384185321969817
- XuXFanZKangLHepatitis B virus X protein represses miRNA-148a to enhance tumorigenesisJ Clin Invest2013123263064523321675
- YanYLuoYCWanHYMicroRNA-10a is involved in the metastatic process by regulating Eph tyrosine kinase receptor A4-mediated epithelial-mesenchymal transition and adhesion in hepatoma cellsHepatology20135766767722996586
- WongCCWongCMTungEKThe microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2Gastroenterology201114032233120951699
- JiangJGusevYAdercaIAssociation of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survivalClin Cancer Res20081441942718223217
- WangYLeeATMaJZProfiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific targetJ Biol Chem2008283132051321518319255
- LiBHanQZhuYYuYWangJJiangXDown-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting TwistFEBS J20122792393239822540680
- PapadimitriouEVasilakiEVorvisCDifferential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-beta and miR-24: role in epithelial-to-mesenchymal transitionOncogene2012312862287521986943
- MaLYoungJPrabhalaHmiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasisNat Cell Biol20101224725620173740
- GuoLChenCShiMStat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transitionOncogene Epub1142013
- SmithALIwanagaRDrasinDJThe miR-106b-25 cluster targets Smad7, activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancerOncogene2012315162517122286770
- LiangYJWangQYZhouCXMiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancerCarcinogenesis20133471372223250910
- HuntSJonesAVHinsleyEEWhawellSALambertDWMicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1FEBS Lett201158518719221112327
- ZhengFLiaoYJCaiMYThe putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2Gut20126127828921672940
- WardABalwierzAZhangJDRe-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancerOncogene2013321173118222508479
- CaoMSeikeMSoenoCMiR-23a regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cellsInt J Oncol20124186987522752005
- XuQSunQZhangJYuJChenWZhangZDownregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancerCarcinogenesis20133453954923188671
- HamadaSSatohKMiuraSmiR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 cateninJ Cell Physiol20132281255126323139153
- XiaHOoiLLHuiKMMicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancerHepatology20135862964123471579
- OishiNKumarMRRoesslerSTranscriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinomaHepatology2012561792180322707408
- PuhrMHoeferJSchaferGEpithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205Am J Pathol20121812188220123041061
- TucciPAgostiniMGrespiFLoss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancerProc Natl Acad Sci U S A2012109153121531722949650
- RuPSteeleRNewhallPPhillipsNJTothKRayRBmiRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signalingMol Cancer Ther2012111166117322402125
- LiuYNYinJJAbou-KheirWMiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanismsOncogene20133229630622370643
- ToyotaMSuzukiHSasakiYEpigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancerCancer Res2008684123413218519671
- VogtMMundingJGrünerMFrequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomasVirchows Arch201145831332221225432
- CorneyDCHwangCIMatosoAFrequent downregulation of miR-34 family in human ovarian cancersClin Cancer Res2010161119112820145172
- YuFJiaoYZhuYMicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cellsJ Biol Chem201228746547322074923
- SiemensHJackstadtRHuntenSmiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitionsCell Cycle2011104256427122134354
- YangDSunYHuLIntegrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancerCancer Cell20132318619923410973
- Wentz-HunterKKPotashkinJAThe role of miRNAs as key regulators in the neoplastic microenvironmentMol Biol Int2011201183987222091413
- ChouJLinJHBrenotAKimJWProvotSWerbZGATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expressionNat Cell Biol20131520121323354167
- SenguptaSden BoonJAChenIHMicroRNA 29c is downregulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteinsProc Natl Acad Sci U S A20081055874587818390668
- BroniszAGodlewskiJWallaceJAReprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320Nat Cell Biol20121415916722179046
- SchliekelmanMJGibbonsDLFacaVMTargets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancerCancer Res2011717670768221987723
- MusumeciMCoppolaVAddarioAControl of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancerOncogene2011304231424221532615
- WurdingerTTannousBASaydamOmiR-296 regulates growth factor receptor overexpression in angiogenic endothelial cellsCancer Cell20081438239318977327
- YangPLiQJFengYTGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinomaCancer Cell20122229130322975373
- DuddaJCSalaunBJiYMicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancerImmunity20133874275323601686
- HeSChuJWuLCMicroRNAs activate natural killer cells through Toll-like receptor signalingBlood20131214663467123580661
- MinSLiangXZhangMMultiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathwaysJ Immunol20131902437244623355742
- YangJZhangZChenCMicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogeneOncogene EpubJuly82013
- Hwang-VersluesWWChangPHWeiPCmiR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1Oncogene2011302463247421258409
- MaceTACollinsALWojcikSECroceCMLesinskiGBBloomstonMHypoxia induces the overexpression of microRNA-21 in pancreatic cancer cellsJ Surg Res2013184285586023726431
- YoshiokaYKosakaNOchiyaTKatoTMicromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteinsJ Biol Chem2012287341103411922896707
- ShenJXiaWKhotskayaYBEGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2Nature201349738338723636329
- ChenZLaiTCJanYHHypoxia-responsive miRNAs target argonaute 1 to promote angiogenesisJ Clin Invest20131231057106723426184