332
Views
9
CrossRef citations to date
0
Altmetric
Review

Neuropathic cancer pain: What we are dealing with? How to manage it?

&
Pages 599-618 | Published online: 17 Apr 2014

References

  • MerskeyHBogdukNClassification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms2nd edSeattleIASP2012
  • BaranowskiABergerRBuffingtonTClassification of chronic painBaranowskiA4th ed2012 Available from: http://www.iasp-pain.org/PublicationsNews/Content.aspx?ItemNumber=1673&navItemNumber=677Accessed August 11, 2013
  • BjorgulKNovicoffWMSalehKJAmerican Society of Anesthesiologist Physical Status score may be used as a comorbidity index in hip fracture surgeryJ Arthroplasty201025Suppl 613413720537857
  • RiefWKaasaSJensenRNew proposals for the International Classification of Diseases-11 revision of pain diagnosesJ Pain201213430531622480770
  • PolomanoRCFarrarJTPain and neuropathy in cancer survivors. Surgery, radiation, and chemotherapy can cause pain; research could improve its detection and treatmentAm J Nurs2006106Suppl 3394716481851
  • ChongMSBajwaZHDiagnosis and treatment of neuropathic painJ Pain Symptom Manage200325Suppl 5S4S1112694987
  • TreedeRDJensenTSCampbellJNNeuropathic pain: redefinition and a grading system for clinical and research purposesNeurology200870181630163518003941
  • AuretKSchugSAPain management for the cancer patient – current practice and future developmentsBest Pract Res Clin Anaesthesiol201327454556124267557
  • SwarmRAAbernethyAPAnghelescuDLAdult cancer painJ Natl Compr Canc Netw2013118992102223946177
  • BaronRBinderAWasnerGNeuropathic pain: diagnosis, pathophysiological mechanisms, and treatmentLancet Neurol20109880781920650402
  • AttalNNeuropathic pain: mechanisms, therapeutic approach, and interpretation of clinical trialsContinuum201218116117522810075
  • WoolfCJSalterMWNeuronal plasticity: increasing the gain in painScience200028854721765176910846153
  • SiqueiraSRAlvesBMalpartidaHMTeixeiraMJSiqueiraJTAbnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgiaNeuroscience2009164257357719699781
  • Dib-HajjSDBlackJAWaxmanSGVoltage-gated sodium channels: therapeutic targets for painPain Med20091071260126919818036
  • BahiaPKSuzukiRBentonDCA functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processesJ Neurosci200525143489349815814779
  • TsudaMBeggsSSalterMWInoueKMicroglia and intractable chronic painGlia2013611556122740331
  • ChengKIWangHCChuangYTPersistent mechanical allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase activation in streptozotocin-induced diabetic ratsEur J Pain201418216217323868758
  • GoudasLCBlochRGialeli-GoudasMLauJCarrDBThe epidemiology of cancer painCancer Invest200523218219015813511
  • van den Beuken-van EverdingenMHde RijkeJMKesselsAGSchoutenHCvan KleefMPatijnJPrevalence of pain in patients with cancer: a systematic review of the past 40 yearsAnn Oncol20071891437144917355955
  • RaymentCHjermstadMJAassNNeuropathic cancer pain: prevalence, severity, analgesics and impact from the European Palliative Care Research Collaborative-Computerised Symptom Assessment studyPalliat Med201327871472123175513
  • FoleyKMAcute and chronic cancer pain syndromesHanksGChernyNIChristakisNAFallonMKaasaSPortenoyRKOxford Textbook of Palliative Medicine3rd edNew YorkOxford University Press2004298
  • BennettMIRaymentCHjermstadMAassNCaraceniAKaasaSPrevalence and aetiology of neuropathic pain in cancer patients: a systematic reviewPain2012153235936522115921
  • NealAJQianMYClinchASLeBHOrthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathyJ Clin Neurosci Epub10112013
  • PaiceJAMechanisms and management of neuropathic pain in cancerJ Support Oncol20031210712015352654
  • UrchCEDickensonAHNeuropathic pain in cancerEur J Cancer20084481091109618492553
  • ChristoPJMazloomdoostDCancer pain and analgesiaAnn N Y Acad Sci2008113827829818837907
  • WodarskiRClarkAKGristJMarchandFMalcangioMGabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic ratsEur J Pain200913880781118977160
  • Di Cesare MannelliLPaciniABonacciniLZanardelliMMelloTGhelardiniCMorphologic features and glial activation in rat oxaliplatin-dependent neuropathic painJ Pain201314121585160024135431
  • DemirIESchornSSchremmer-DanningerEPerineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitisPloS One201383e6052923555989
  • DemirIESchaferKHTieftrunkEFriessHCeyhanGONeural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals, and hypersensitivityActa Neuropathol2013125449150923417735
  • WangKDemirIED’HaeseJGThe neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancerCarcinogenesis201435110311324067900
  • MantyhPWClohisyDRKoltzenburgMHuntSPMolecular mechanisms of cancer painNat Rev Cancer20022320120911990856
  • DelaneyAFleetwood-WalkerSMColvinLAFallonMTranslational medicine: cancer pain mechanisms and managementBr J Anaesth20081011879418492671
  • ColvinLFallonMChallenges in cancer pain management – bone painEur J Cancer20084481083109018439817
  • CaraceniAMartiniCZeccaEBreakthrough pain characteristics and syndromes in patients with cancer pain. An international surveyPalliat Med200418317718315198130
  • WindebankAJGrisoldWChemotherapy-induced neuropathyJ Peripher Nerv Syst2008131274618346229
  • AntoineJCCamdessancheJPPeripheral nervous system involvement in patients with cancerLancet Neurol200761758617166804
  • KoikeHTanakaFSobueGParaneoplastic neuropathy: wide-ranging clinicopathological manifestationsCurr Opin Neurol201124550451021799410
  • SindicCJInfectious neuropathiesCurr Opin Neurol201326551051523945279
  • YawnBPGildenDThe global epidemiology of herpes zosterNeurology2013811092893023999562
  • FashnerJBellALHerpes zoster and postherpetic neuralgia: prevention and managementAm Fam Physician201183121432143721671543
  • GildenDNagelMACohrsRJMahalingamRThe variegate neurological manifestations of varicella zoster virus infectionCurr Neurol Neurosci Rep201313937423884722
  • KimSRKhanFTyringSKVaricella zoster: an update on current treatment options and future perspectivesExpert Opin Pharmacother2014151617124289750
  • AngaroneMEpidemiology and prevention of viral infections in patients with hematologic malignanciesInfect Disord Drug Targets2011111273321303338
  • WeitzmanDShavitOSteinMCohenRChodickGShalevVA population based study of the epidemiology of herpes zoster and its complicationsJ Infect201367546346923872209
  • HabelLARayGTSilverbergMJThe epidemiology of herpes zoster in patients with newly diagnosed cancerCancer Epidemiol Biomarkers Prev2013221829023118142
  • Garzón-RodríguezCGLyrasLGayosoLOCancer-related neuropathic pain in out-patient oncology clinics: a European surveyBMC Palliat Care20131214124200014
  • FairchildAUnder-treatment of cancer painCurr Opin Support Palliat Care201041111520040878
  • ShimozumaKOhashiYTakeuchiAFeasibility and validity of the Patient Neurotoxicity Questionnaire during taxane chemotherapy in a phase III randomized trial in patients with breast cancer: N-SAS BC 02Support Care Cancer200917121483149119330359
  • KuroiKShimozumaKOhashiYProspective assessment of chemotherapy-induced peripheral neuropathy due to weekly paclitaxel in patients with advanced or metastatic breast cancer (CSP-HOR 02 study)Support Care Cancer20091781071108019089463
  • GiglioPGilbertMRNeurologic complications of cancer and its treatmentCurr Oncol Rep2010121505920425608
  • KaleyTJDeangelisLMTherapy of chemotherapy-induced peripheral neuropathyBr J Haematol2009145131419170681
  • Farquhar-SmithPChemotherapy-induced neuropathic painCurr Opin Support Palliat Care2011511721192267
  • RoelofsRIHrusheskyWRoginJRosenbergLPeripheral sensory neuropathy and cisplatin chemotherapyNeurology19843479349386330613
  • AlbersJWChaudhryVCavalettiGDonehowerRCInterventions for preventing neuropathy caused by cisplatin and related compoundsCochrane Database Syst Rev20112CD00522821328275
  • ParkSBLinCSKrishnanAVGoldsteinDFriedlanderMLKiernanMCOxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathyBrain2009132Pt 102712272319745023
  • TaLEEspesetLPodratzJWindebankAJNeurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA bindingNeurotoxicology2006276992100216797073
  • DormannAJGrunewaldTWigginghausBHuchzermeyerHGemcitabine-associated autonomic neuropathyLancet199835191036449500323
  • ReevesBNDakhilSRSloanJAFurther data supporting that paclitaxel-associated acute pain syndrome is associated with development of peripheral neuropathy: North Central Cancer Treatment Group trial N08C1Cancer2012118205171517822415454
  • LeeJJSwainSMPeripheral neuropathy induced by microtubule-stabilizing agentsJ Clin Oncol200624101633164216575015
  • HausheerFHSchilskyRLBainSBerghornEJLiebermanFDiagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathySemin Oncol2006331154916473643
  • GradisharWJKrasnojonDCheporovSSignificantly longer progression-free survival with nab-paclitaxel compared with docetaxel as first-line therapy for metastatic breast cancerJ Clin Oncol200927223611361919470941
  • GradisharWJTjulandinSDavidsonNPhase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancerJ Clin Oncol200523317794780316172456
  • de BonoJSOudardSOzgurogluMPrednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trialLancet201037697471147115420888992
  • VerstappenCCKoeppenSHeimansJJDose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worseningNeurology20056461076107715781834
  • WeintraubMAddeMAVenzonDJSevere atypical neuropathy associated with administration of hematopoietic colony-stimulating factors and vincristineJ Clin Oncol19961439359408622042
  • LeghaSSVincristine neurotoxicity. Pathophysiology and managementMed Toxicol1986164214273540519
  • DeAngelisLMPosnerJBSide effects of chemotherapyNeurologic Complications of Cancer2nd edNew YorkOxford University Press2009447
  • MokhtarGMShaabanSYElbarbaryNSFayedWAA trial to assess the efficacy of glutamic acid in prevention of vincristine-induced neurotoxicity in pediatric malignancies: a pilot studyJ Pediatr Hematol Oncol201032859460020921909
  • ArgyriouAAMarmiroliPCavalettiGKalofonosHPEpothilone-induced peripheral neuropathy: a review of current knowledgeJ Pain Symptom Manage201142693194021621965
  • CortesJO’ShaughnessyJLoeschDEribulin monotherapy versus treatment of physician’s choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised studyLancet2011377976991492321376385
  • RajkumarSVRosinolLHusseinMMulticenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myelomaJ Clin Oncol200826132171217718362366
  • PlasmatiRPastorelliFCavoMNeuropathy in multiple myeloma treated with thalidomide: a prospective studyNeurology200769657358117679676
  • MurphyPTO’DonnellJRThalidomide induced impotence in male hematology patients: a common but ignored complication?Haematologica20079210144018024384
  • DimopoulosMAChenCSpencerALong-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myelomaLeukemia200923112147215219626046
  • RajkumarSVRichardsonPGHideshimaTAndersonKCProteasome inhibition as a novel therapeutic target in human cancerJ Clin Oncol200523363063915659509
  • GoyAYounesAMcLaughlinPPhase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin’s lymphomaJ Clin Oncol200523466767515613697
  • KobrinskyBJosephSOMuggiaFA phase I and pharmacokinetic study of oxaliplatin and bortezomib: activity, but dose-limiting neurotoxicityCancer Chemother Pharmacol20137251073107824048674
  • HarveyRDOwonikokoTKLewisCMA phase 1 Bayesian dose selection study of bortezomib and sunitinib in patients with refractory solid tumor malignanciesBr J Cancer2013108476276523322195
  • CavalettiGJakubowiakAJPeripheral neuropathy during bortezomib treatment of multiple myeloma: a review of recent studiesLeuk Lymphoma20105171178118720497001
  • RichardsonPGDelforgeMBeksacMManagement of treatment-emergent peripheral neuropathy in multiple myelomaLeukemia201226459560822193964
  • ChaudhryVCornblathDRPolydefkisMFergusonABorrelloICharacteristics of bortezomib- and thalidomide-induced peripheral neuropathyJ Peripher Nerv Syst200813427528219192067
  • LawasutPChauhanDLaubachJNew proteasome inhibitors in myelomaCurr Hematol Malig Rep20127425826623065395
  • SiegelDSMartinTWangMA phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myelomaBlood2012120142817282522833546
  • DautRLCleelandCSFlaneryRCDevelopment of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseasesPain19831721972106646795
  • FishmanBPasternakSWallensteinSLHoudeRWHollandJCFoleyKMThe Memorial Pain Assessment Card. A valid instrument for the evaluation of cancer painCancer1987605115111583300951
  • BennettMIAttalNBackonjaMMUsing screening tools to identify neuropathic painPain2007127319920317182186
  • AttalNCruccuGBaronREFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revisionEur J Neurol20101791113118820402746
  • CleelandCSFarrarJTHausheerFHAssessment of cancer-related neuropathy and neuropathic painOncologist201015Suppl 2131820489192
  • CruccuGTruiniANeuropathic pain and its assessmentSurg Oncol201019314915420056406
  • BrzezińskiKChemotherapy-induced peripheral neuropathy. Part II. PreventionContemp Oncol (Pozn)201216325826123788891
  • RipamontiCISantiniDMaranzanoEBertiMRoilaFManagement of cancer pain: ESMO Clinical Practice GuidelinesAnn Oncol201223Suppl 7vii139vii15422997447
  • WalkerVAHoskinPJHanksGWWhiteIDEvaluation of WHO analgesic guidelines for cancer pain in a hospital-based palliative care unitJ Pain Symptom Manage1988331451492458415
  • World Health OrganizationScoping document for WHO guidelines for the pharmacological treatment of persisting pain in adults with medical illnesses2012 Available from: http://www.who.int/medicines/areas/quality_safety/Scoping_WHO_GLs_PersistPainAdults_webversion.pdfAccessed October 8, 2013
  • McNicolEStrasselsSAGoudasLLauJCarrDBNSAIDS or paracetamol, alone or combined with opioids, for cancer painCochrane Database Syst Rev20051CD00518015654708
  • NabalMLibradaSRedondoMJPigniABrunelliCCaraceniAThe role of paracetamol and nonsteroidal anti-inflammatory drugs in addition to WHO Step III opioids in the control of pain in advanced cancer. A systematic review of the literaturePalliat Med201226430531222126843
  • CaraceniAHanksGKaasaSUse of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPCLancet Oncol2012132e58e6822300860
  • LotschJOpioid metabolitesJ Pain Symptom Manage200529Suppl 5S10S2415907643
  • DuhmkeRMCornblathDDHollingsheadJRTramadol for neuropathic painCochrane Database Syst Rev20042CD00372615106216
  • MercadanteSPorzioGFerreraPTapentadol in cancer pain management: a prospective open-label studyCurr Med Res Opin201228111775177923057488
  • KingSForbesKHanksGWFerroCJChambersEJA systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment: a European Palliative Care Research Collaborative opioid guidelines projectPalliat Med201125552555221708859
  • GaertnerJSchiesslCCancer pain management: what’s new?Curr Pain Headache Rep201317432823456796
  • AhmedzaiSHNauckFBar-SelaGBosseBLeyendeckerPHoppMA randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer painPalliat Med2012261506021937568
  • PaiceJAFerrellBThe management of cancer painCA Cancer J Clin201161315718221543825
  • MinozziSAmatoLDavoliMDevelopment of dependence following treatment with opioid analgesics for pain relief: a systematic reviewAddiction2013108468869822775332
  • FallonMHanksGChernyNPrinciples of control of cancer painBMJ200633275481022102416644831
  • GuindonJWalczakJSBeaulieuPRecent advances in the pharmacological management of painDrugs200767152121213317927280
  • KnotkovaHPappagalloMAdjuvant analgesicsMed Clin North Am200791111312417164107
  • FallonMTNeuropathic pain in cancerBr J Anaesth2013111110511123794652
  • DworkinRHO’ConnorABBackonjaMPharmacologic management of neuropathic pain: evidence-based recommendationsPain2007132323725117920770
  • HempenstallKNurmikkoTJJohnsonRWA’HernRPRiceASAnalgesic therapy in postherpetic neuralgia: a quantitative systematic reviewPLoS Med200527e16416013891
  • SaartoTWiffenPJAntidepressants for neuropathic pain: a Cochrane reviewJ Neurol Neurosurg Psychiatry201081121372137320543189
  • SindrupSHBachFWMadsenCGramLFJensenTSVenlafaxine versus imipramine in painful polyneuropathy: a randomized, controlled trialNeurology20036081284128912707430
  • RowbothamMCGoliVKunzNRLeiDVenlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled studyPain2004110369770615288411
  • DurandJPDeplanqueGMontheilVEfficacy of venlafaxine for the prevention and relief of oxaliplatin-induced acute neurotoxicity: results of EFFOX, a randomized, double-blind, placebo-controlled phase III trialAnn Oncol201223120020521427067
  • DurandJPGoldwasserFDramatic recovery of paclitaxel-disabling neurosensory toxicity following treatment with venlafaxineAnticancer Drugs200213777778012187335
  • KajdaszDKIyengarSDesaiahDDuloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studiesClin Ther200729Suppl2536254618164920
  • VevesABackonjaMMalikRAPainful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment optionsPain Med20089666067418828198
  • IrvingGAContemporary assessment and management of neuropathic painNeurology20056412 Suppl 3S21S2715999405
  • LunnMPHughesRAWiffenPJDuloxetine for treating painful neuropathy, chronic pain or fibromyalgiaCochrane Database Syst Rev20141CD00711524385423
  • AmrYMYousefAAEvaluation of efficacy of the perioperative administration of venlafaxine or gabapentin on acute and chronic postmastectomy painClin J Pain201026538138520473044
  • PiccoloJKolesarJMPrevention and treatment of chemotherapy-induced peripheral neuropathyAm J Health Syst Pharm2014711192524352178
  • SemenchukMRShermanSDavisBDouble-blind, randomized trial of bupropion SR for the treatment of neuropathic painNeurology20015791583158811706096
  • VadaloucaARaptisEMokaEZisPSykiotiPSiafakaIPharmacological treatment of neuropathic cancer pain: a comprehensive review of the current literaturePain Pract201212321925121797961
  • CaraceniAZeccaEBonezziCGabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study GroupJ Clin Oncol200422142909291715254060
  • TsavarisNKopteridesPKosmasCGabapentin monotherapy for the treatment of chemotherapy-induced neuropathic pain: a pilot studyPain Med2008981209121619067834
  • AraiYCMatsubaraTShimoKLow-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramineJ Anesth201024340741020217150
  • LossignolDAPlehiersBBodyJJGabapentin (Neurontin) and cancer pain: a pilot studyRev Med Brux2004255429435 French15584643
  • MishraSBhatnagarSGoyalGNRanaSPUpadhyaSPA comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled studyAm J Hosp Palliat Care201229317718221745832
  • YanPZButlerPMKurowskiDPerloffMDBeyond neuropathic pain: gabapentin use in cancer pain and perioperative painClin J Pain EpubNovemer252013
  • RossJRWaightCRileyJBroadleyKGabapentin: resistant neuropathic pain and malignancyPalliat Med200115434834912054154
  • NavarroASaldañaMTPérezCTorradesSRejasJPatient-reported outcomes in subjects with neuropathic pain receiving pregabalin: evidence from medical practice in primary care settingsPain Med201011571973120345618
  • WiffenPJDerrySMooreRALamotrigine for chronic neuropathic pain and fibromyalgia in adultsCochrane Database Syst Rev201312CD00604424297457
  • ZakrzewskaJMMcMillanRTrigeminal neuralgia: the diagnosis and management of this excruciating and poorly understood facial painPostgrad Med J201187102841041621493636
  • OkonTKetamine: an introduction for the pain and palliative medicine physicianPain Physician200710349350017525784
  • SindrupSHJensenTSEfficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug actionPain199983338940010568846
  • NoppersINiestersMAartsLSmithTSartonEDahanAKetamine for the treatment of chronic non-cancer painExpert Opin Pharmacother201011142417242920828267
  • HardyJQuinnSFazekasBRandomized, double-blind, placebo-controlled study to assess the efficacy and toxicity of subcutaneous ketamine in the management of cancer painJ Clin Oncol201230293611361722965960
  • JacksonKFrancoMWilliamLKetamine and cancer pain: the reports of my death have been greatly exaggeratedJ Clin Oncol201331101373137423423743
  • CrosbyVWilcockACorcoranRThe safety and efficacy of a single dose (500 mg or 1 g) of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancerJ Pain Symptom Manage2000191353910687324
  • SawynokJTopical analgesics for neuropathic pain: preclinical exploration, clinical validation, future developmentEur J Pain Epub9242013
  • ArgoffCEBarkinRLMcCarbergBStanosSPGalluzziKEArnstreinPMTopical analgesics in the management of acute and chronic painPostgrad Med20131254 Suppl 134124141026
  • RowbothamMCDaviesPSVerkempinckCGalerBSLidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgiaPain199665139448826488
  • GalerBSRowbothamMCPeranderJFriedmanETopical lidocaine patch relieves postherpetic neuralgia more effectively than a vehicle topical patch: results of an enriched enrollment studyPain199980353353810342414
  • MeierTWasnerGFaustMEfficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: a randomized, double-blind, placebo-controlled studyPain20031061–215115814581122
  • ConnollyIZaleonCMontagniniMManagement of severe neuropathic cancer pain: an illustrative case and reviewAm J Hosp Palliat Care2013301839022504863
  • JonesVMMooreKAPetersonDMCapsaicin 8% topical patch (Qutenza) – a review of the evidenceJ Pain Palliat Care Pharmacother2011251324121426216
  • HoySMTapentadol extended release: in adults with chronic painDrugs201272337539322316353
  • BuynakRShapiroDYOkamotoAEfficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo-and active-controlled Phase III studyExpert Opin Pharmacother201011111787180420578811
  • AfilaloMEtropolskiMSKuperwasserBEfficacy and safety of tapentadol extended release compared with oxycodone controlled release for the management of moderate to severe chronic pain related to osteoarthritis of the knee: a randomized, double-blind, placebo- and active-controlled phase III studyClin Drug Investig2010308489505
  • MerkerMDingesGKochTKrankePMorinAMUndesired side effects of tapentadol in comparison to oxycodone. A meta-analysis of randomized controlled comparative studiesSchmerz20122611626 German22366930
  • PortenoyRKGanae-MotanEDAllendeSNabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trialJ Pain201213543844922483680
  • PertweeRGCannabinoid pharmacology: the first 66 yearsBr J Pharmacol2006147Suppl 1S163S17116402100
  • WelchSPStevensDLAntinociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in miceJ Pharmacol Exp Ther1992262110181320680
  • DesrochesJBouchardJFGendronLBeaulieuPInvolvement of cannabinoid receptors in peripheral and spinal morphine analgesiaNeuroscience2014261234224365460
  • BeijersAJJongenJLVreugdenhilGChemotherapy-induced neurotoxicity: the value of neuroprotective strategiesNeth J Med2012701182522271810
  • MijnhoutGSAlkhalafAKleefstraNBiloHJAlpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes?Neth J Med201068415816220421656
  • KalkanisJGWhitworthCRybakLPVitamin E reduces cisplatin ototoxicityLaryngoscope2004114353854215091231
  • KottschadeLASloanJAMazurczakMAThe use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase III clinical trialSupport Care Cancer201119111769177720936417
  • BergerASadoskyADukesEEdelsbergJOsterGClinical characteristics and patterns of healthcare utilization in patients with painful neuropathic disorders in UK general practice: a retrospective cohort studyBMC Neurol201212822394606
  • GilronIJensenTSDickensonAHCombination pharmacotherapy for management of chronic pain: from bench to bedsideLancet Neurol201312111084109524074723
  • ChaparroLEWiffenPJMooreRAGilronICombination pharmacotherapy for the treatment of neuropathic pain in adultsCochrane Database Syst Rev20127CD00894322786518
  • GattiASabatoAFOcchioniRColini BaldeschiGRealeCControlled-release oxycodone and pregabalin in the treatment of neuropathic pain: results of a multicenter Italian studyEur Neurol200961312913719092248
  • FinnerupNBOttoMMcQuayHJJensenTSSindrupSHAlgorithm for neuropathic pain treatment: an evidence based proposalPain2005118328930516213659
  • GarassinoMCPivaSLa VerdeNRandomised phase II trial (NCT00637975) evaluating activity and toxicity of two different escalating strategies for pregabalin and oxycodone combination therapy for neuropathic pain in cancer patientsPloS One201384e5998123577077
  • NishiharaMAraiYCYamamotoYCombinations of low-dose antidepressants and low-dose pregabalin as useful adjuvants to opioids for intractable, painful bone metastasesPain Physician2013165E547E55224077205
  • LazzariMSabatoAFCaldaruloCEffectiveness and tolerability of low-dose oral oxycodone/naloxone added to anticonvulsant therapy for noncancer neuropathic pain: an observational analysisCurr Med Res Opin Epub1252013
  • BhaskarAKInterventional management of cancer painCurr Opin Support Palliat Care2012611922246043
  • PlancarteRGuajardo-RosasJReyes-ChiqueteDManagement of chronic upper abdominal pain in cancer: transdiscal blockade of the splanchnic nervesReg Anesth Pain Med201035650050620975463
  • ZhangWYLiZSJinZDEndoscopic ultrasound-guided ethanol ablation therapy for tumorsWorld J Gastroenterol201319223397340323801831
  • HarshVViswanathanASurgical/radiological interventions for cancer painCurr Pain Headache Rep201317533123512723
  • FalcoFJPatelVBHayekSMIntrathecal infusion systems for long-term management of chronic non-cancer pain: an update of assessment of evidencePain Physician201316Suppl 2SE185SE21623615891
  • Sheinfeld GorinSKrebsPBadrHMeta-analysis of psychosocial interventions to reduce pain in patients with cancerJ Clin Oncol201230553954722253460
  • GarciaMKMcQuadeJHaddadRSystematic review of acupuncture in cancer care: a synthesis of the evidenceJ Clin Oncol201331795296023341529
  • MaaniCVShahMAHansenJJFowlerMMaaniEVMcGheeLLTranslational advances in pain and anesthesia for cancer patientsJ Surg Oncol2012105548849322441901
  • StamerUMStüberFCodeine and tramadol analgesic efficacy and respiratory effects are influenced by CYP2D6 genotypeAnaesthesia2007621212941295 author reply 1295–129617991273
  • StamerUMMusshoffFKobilayMMadeaBHoeftAStuberFConcentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypesClin Pharmacol Ther2007821414717361124
  • TurabiAPlunkettARThe application of genomic and molecular data in the treatment of chronic cancer painJ Surg Oncol2012105549450122441902
  • WolfeDMataMFinkDJTargeted drug delivery to the peripheral nervous system using gene therapyNeurosci Lett20125272858922565023
  • XuJMSongSTFengFYCobrotoxin-containing analgesic compound to treat chronic moderate to severe cancer pain: results from a randomized, double-blind, cross-over study and from an open-label studyOncol Rep20061651077108417016596
  • WallaceMSKosekPSStaatsPFisherRSchultzDMLeongMPhase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic painPain Med20089327128118366507
  • WallaceMSCharapataSGFisherRIntrathecal ziconotide in the treatment of chronic nonmalignant pain: a randomized, double-blind, placebo-controlled clinical trialNeuromodulation200692758622151630
  • StaatsPSYearwoodTCharapataSGIntrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trialJAMA20042911637014709577
  • EllisDJDissanayakeSMcGuireDContinuous intrathecal infusion of ziconotide for treatment of chronic malignant and nonmalignant pain over 12 months: a prospective, open-label studyNeuromodulation2008111404922150990
  • HannonHEAtchisonWDOmega-conotoxins as experimental tools and therapeutics in pain managementMar Drugs201311368069923470283
  • MarcilJWalczakJSGuindonJNgocAHLuSBeaulieuPAntinociceptive effects of tetrodotoxin (TTX) in rodentsBr J Anaesth200696676176816675510
  • PatelMKGonzalezMIBramwellSPinnockRDLeeKGabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cordBr J Pharmacol200013081731173410952660
  • HagenNALapointeBOng-LamMA multicentre open-label safety and efficacy study of tetrodotoxin for cancer painCurr Oncol2011183e109e11621655148
  • HagenNAFisherKMLapointeBAn open-label, multi-dose efficacy and safety study of intramuscular tetrodotoxin in patients with severe cancer-related painJ Pain Symptom Manage200734217118217662911
  • HagenNAdu SouichPLapointeBTetrodotoxin for moderate to severe cancer pain: a randomized, double blind, parallel design multicenter studyJ Pain Symptom Manage200835442042918243639
  • WangXMHamzaMWuTXDionneRAUpregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: correlation to clinical painPain2009142327528319233564
  • UceylerNKafkeWRiedigerNElevated proinflammatory cytokine expression in affected skin in small fiber neuropathyNeurology201074221806181320513817
  • WangXMLehkyTJBrellJMDorseySGDiscovering cytokines as targets for chemotherapy-induced painful peripheral neuropathyCytokine20125913922537849
  • GinhouxFGreterMLeboeufMFate mapping analysis reveals that adult microglia derive from primitive macrophagesScience2010330600584184520966214
  • NimmerjahnAKirchhoffFHelmchenFResting microglial cells are highly dynamic surveillants of brain parenchyma in vivoScience200530857261314131815831717
  • TsudaMTozaki-SaitohHInoueKPurinergic system, microglia and neuropathic painCurr Opin Pharmacol2012121747922036170
  • ChengKIWangHCChuangYTPersistent mechanical allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase activation in streptozotocin-induced diabetic ratsEur J Pain201418216217323868758
  • KolesnickRThe therapeutic potential of modulating the ceramide/sphingomyelin pathwayJ Clin Invest200211013812093880
  • SalveminiDDoyleTKressMNicolGTherapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in painTrends Pharmacol Sci201334211011823318139
  • BennettGJPathophysiology and animal models of cancer-related painful peripheral neuropathyOncologist201015Suppl 291220489191
  • DworkinRHBackonjaMRowbothamMCAdvances in neuropathic pain: diagnosis, mechanisms, and treatment recommendationsArch Neurol200360111524153414623723
  • McNicolEHorowicz-MehlerNFiskRAManagement of opioid side effects in cancer-related and chronic noncancer pain: a systematic reviewJ Pain20034523125614622694