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Review

Molecularly targeted therapy for the treatment of head and neck cancer: a review of the ErbB family inhibitors

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Pages 1927-1943 | Published online: 04 Apr 2016

References

  • FerlayJSoerjomataramIDikshitRCancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Int J Cancer20151365E359E38625220842
  • American Cancer SocietyCancer Facts & Figures, 2014Atlanta, GAAmerican Cancer Society2014
  • ArgirisAKaramouzisMVRabenDFerrisRLHead and neck cancerLancet200837196251695170918486742
  • BlotWJMcLaughlinJKWinnDMSmoking and drinking in relation to oral and pharyngeal cancerCancer Res19884811328232873365707
  • GillisonMLChaturvediAKLowyDRHPV prophylactic vaccines and the potential prevention of noncervical cancers in both men and womenCancer200811310 Suppl3036304618980286
  • SturgisEMCinciripiniPMTrends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?Cancer200711071429143517724670
  • KleinGThe relationship of the virus to nasopharyngeal carcinomaEpsteinMAchongBThe Epstein-Barr VirusBerlin, GermanySpringer-Verlag1979339350
  • SeiwertTYCohenEEState-of-the-art management of locally advanced head and neck cancerBr J Cancer20059281341134815846296
  • National Comprehensive Cancer NetworkNCCN Clinical Practice Guidelines in Oncology™Head and Neck Cancers. Version 22014 Available from: http://www.nccn.org/professionals/physician_gls/PDF/head-and-neck.pdfAccessed September 22, 2014
  • GibsonMKLiYMurphyBRandomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trial of the Eastern Cooperative Oncology GroupJ Clin Oncol200523153562356715908667
  • ColevasADChemotherapy options for patients with metastatic or recurrent squamous cell carcinoma of the head and neckJ Clin Oncol200624172644265216763278
  • DassonvilleOFormentoJLFrancoualMExpression of epidermal growth factor receptor and survival in upper aerodigestive tract cancerJ Clin Oncol19931110187318788410112
  • Rubin GrandisJMelhemMFBarnesELTweardyDJQuantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neckCancer1996786128412928826952
  • SantiniJFormentoJLFrancoualMCharacterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomasHead Neck19911321321392022478
  • Rubin GrandisJMelhemMFGoodingWELevels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survivalJ Natl Cancer Inst199890118248329625170
  • AngKKBerkeyBATuXImpact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinomaCancer Res200262247350735612499279
  • XiaWLauYKZhangHZCombination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family membersClin Cancer Res19995124164417410632356
  • O-charoenratPRhys-EvansPHArcherDJEcclesSAC-erbB receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factorsOral Oncol2002381738011755824
  • BazleyLAGullickWJThe epidermal growth factor receptor familyEndocr Relat Cancer200512Suppl 1S17S2716113093
  • HynesNELaneHAERBB receptors and cancer: the complexity of targeted inhibitorsNat Rev Cancer20055534135415864276
  • EgloffAMGrandisJRTargeting epidermal growth factor receptor and SRC pathways in head and neck cancerSemin Oncol200835328629718544443
  • BaselgaJArteagaCLCritical update and emerging trends in epidermal growth factor receptor targeting in cancerJ Clin Oncol200523112445245915753456
  • GanlyITalbotSCarlsonDIdentification of angiogenesis/metastases genes predicting chemoradiotherapy response in patients with laryngopharyngeal carcinomaJ Clin Oncol200725111369137617416856
  • TakikitaMXieRChungJYMembranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinomaJ Transl Med2011912621801427
  • BarkerFGSimmonsMLChangSMEGFR overexpression and radiation response in glioblastoma multiformeInt J Radiat Oncol Biol Phys200151241041811567815
  • ErjalaKSundvallMJunttilaTTSignaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cellsClin Cancer Res200612134103411116818711
  • Schmidt-UllrichRKMikkelsenRBDentPRadiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylationOncogene19971510119111979294612
  • BowersGReardonDHewittTThe relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cellsOncogene200120111388139711313882
  • ContessaJNHamptonJLammeringGIonizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cellsOncogene200221254032404112037685
  • DittmannKMayerCFehrenbacherBRadiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinaseJ Biol Chem200528035311823118916000298
  • DittmannKMayerCKehlbachRRodemannHPRadiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PKMol Cancer200876918789131
  • KavanaghBDLinPSChenPSchmidt-UllrichRKRadiation-induced enhanced proliferation of human squamous cancer cells in vitro: a release from inhibition by epidermal growth factorClin Cancer Res1995112155715629815956
  • AbholdELKiangARahimyEEGFR kinase promotes acquisition of stem cell-like properties: a potential therapeutic target in head and neck squamous cell carcinoma stem cellsPLoS One201272e3245922384257
  • BozecAPeyradeFFischelJLMilanoGEmerging molecular targeted therapies in the treatment of head and neck cancerExpert Opin Emerg Drugs200914229931019519286
  • ERBITUX® (cetuximab) injection, for intravenous infusion [package insert]Branchburg, NJImClone LLC2013
  • BonnerJAHarariPMGiraltJRadiotherapy plus cetuximab for squamous-cell carcinoma of the head and neckN Engl J Med2006354656757816467544
  • BonnerJAHarariPMGiraltJRadiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survivalLancet Oncol2010111212819897418
  • PignonJPle MaîtreAMaillardEBourhisJMeta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patientsRadiother Oncol200992141419446902
  • AngKKZhangQRosenthalDIRandomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522J Clin Oncol201432272940295025154822
  • LefebvreJLPointreauYRollandFInduction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II studyJ Clin Oncol201331785385923341517
  • BurtnessBGoldwasserMAFloodWMattarBForastiereAAPhase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group studyJ Clin Oncol200523348646865416314626
  • VermorkenJBMesiaRRiveraFPlatinum-based chemotherapy plus cetuximab in head and neck cancerN Engl J Med2008359111116112718784101
  • YangXDJiaXCCorvalanJRWangPDavisCGDevelopment of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapyCrit Rev Oncol Hematol2001381172311255078
  • VermorkenJBStohlmacher-WilliamsJDavidenkoICisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trialLancet Oncol201314869771023746666
  • ChungCIsaranuwatchaiWDi MaioMEconomic analysis of TORCH: erlotinib versus cisplatin and gemcitabine as first-line therapy for advanced non-small cell lung cancer (NSCLC)J Clin Oncol201331Suppl Abstract e19031
  • WirthLJDakhilSRKornekGPARTNER: a randomized phase II study of docetaxel/cisplatin (doc/cis) chemotherapy with or without panitumumab (pmab) as first-line treatment (tx) for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)J Clin Oncol201331Suppl Abstract 6029
  • GiraltJTrigoJMNuytsSPhase 2, randomized trial (CONCERT-2) of panitumumab (PMAB) plus radiotherapy (PRT) compared with chemoradiotherapy (CRT) in patients (PTS) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN) [Abstract 1016O]Ann Oncol201223Suppl 9ix334
  • SiuLLWaldronJNChenBEPhase III randomized trial of standard fractionation radiotherapy (SFX) with concurrent cisplatin (CIS) versus accelerated fractionation radiotherapy (AFX) with panitumumab (PMab) in patients (pts) with locoregionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN): NCIC Clinical Trials Group HN.6 trialJ Clin Oncol201533Suppl Abstract 6000
  • RingashJWaldronJNSiuLLQuality of life (QOL) in a phase III randomized trial of standard fractionation radiotherapy (SFX) with concurrent cisplatin (CIS) versus accelerated fractionation radiotherapy (AFX) with panitumumab (PMab) in patients (pts) with locoregionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN): NCIC Clinical Trials Group HN.6 (NCT00820248)J Clin Oncol201533Suppl Abstract 6053
  • SchickUGujralDMRichardsTMHarringtonKJNuttingCMZalutumumab in head and neck cancerExpert Opin Biol Ther201212111912522171666
  • MachielsJPSubramanianSRuzsaAZalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: an open-label, randomised phase 3 trialLancet Oncol201112433334321377930
  • EriksenJGMaareCJohansenJDAHANCA 19: first results of a randomized phase III study of the importance of the EGFR-inhibitor zalutumumab for the outcome of primary curative radiotherapy for squamous cell carcinoma of the head and neckLate breaking abstract presented at: The European Cancer CongressSeptember 27–October 1, 2013Amsterdam, Netherlands Abstract 12
  • BolandWKBebbGNimotuzumab: a novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicityExpert Opin Biol Ther2009991199120619624281
  • TalaveraAFriemannRGomez-PuertaSNimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformationCancer Res200969145851585919584289
  • RodriguezMORiveroTCdel CastilloBRNimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neckCancer Biol Ther20109534334920448462
  • BasavarajCSierraPShivuJMelarkodeRMonteroENairPNimotuzumab with chemoradiation confers a survival advantage in treatment-naive head and neck tumors over expressing EGFRCancer Biol Ther201010767368120647773
  • BhatnagarARSinghDPSharmaRA comparative study of monoclonal antibody against EGFR (nimotuzumab) used in combination with chemoradiation versus chemoradiation alone in the treatment of locally advanced inoperable squamous cell carcinoma of the head and neckJ Clin Oncol201230Suppl Abstract e16012
  • KamathAVLuDGuptaPPreclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical doseCancer Chemother Pharmacol20126941063106922203367
  • SchaeferGHaberLCrockerLMA two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with mono-specific antibodiesCancer Cell201120447248622014573
  • HuangSLiCArmstrongEADual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiationCancer Res201373282483323172311
  • PedersenMWJacobsenHJKoefoedKSym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacyCancer Res201070258859720068188
  • MachielsJ-PHSpecenierPMKraussJSym004, a novel strategy to target EGFR with an antibody mixture, in patients with advanced SCCHN progressing after anti-EGFR monoclonal antibody: a proof of concept studyJ Clin Oncol201331Suppl Abstract 6002
  • AdamoVFranchinaTAdamoBGefitinib in lung cancer therapy: Clinical results, predictive markers of response and future perspectivesCancer Biol Ther20098320621219182534
  • StewartJSCohenEELicitraLPhase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neckJ Clin Oncol200927111864187119289630
  • ArgirisAGhebremichaelMGilbertJPhase III randomized, placebo-controlled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: an Eastern Cooperative Oncology Group trialJ Clin Oncol201331111405141423460714
  • CohenMHJohnsonJRChenYFSridharaRPazdurRFDA drug approval summary: erlotinib (Tarceva) tabletsOncologist200510746146616079312
  • Tarceva® (erlotinib tablets) [package insert]South San Francisco, CAGenentech, Inc2013
  • ThomasFRochaixPBenlyazidAPilot study of neoadjuvant treatment with erlotinib in nonmetastatic head and neck squamous cell carcinomaClin Cancer Res200713237086709218056187
  • HerchenhornDDiasFLViegasCMPhase I/II study of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neckInt J Radiat Oncol Biol Phys201078369670220421154
  • HainsworthJDSpigelDRGrecoFACombined modality treatment with chemotherapy, radiation therapy, bevacizumab, and erlotinib in patients with locally advanced squamous carcinoma of the head and neck: a phase II trial of the Sarah Cannon oncology research consortiumCancer J201117526727221952273
  • MartinsRGParvathaneniUBaumanJECisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trialJ Clin Oncol201331111415142123460709
  • SoulieresDSenzerNNVokesEEHidalgoMAgarwalaSSSiuLLMulticenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neckJ Clin Oncol2004221778514701768
  • SiuLLSoulieresDChenEXPhase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Princess Margaret Hospital phase II consortium and National Cancer Institute of Canada Clinical Trials Group StudyJ Clin Oncol200725162178218317538162
  • KimESKiesMSGlissonBSFinal results of a phase II study of erlotinib, docetaxel and cisplatin in patients with recurrent/metastatic head and neck cancerJ Clin Oncol20072518S Abstract 6013
  • KondoNTsukudaMIshiguroYAntitumor effects of lapatinib (GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinomaOncol Rep201023495796320204279
  • TYKERB® (lapatinib) tablets [package insert]Research Triangle Park, NCGlaxoSmithKline2012
  • Del CampoJMHittRSebastianPEffects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neckBr J Cancer2011105561862721829197
  • de SouzaJADavisDWZhangYA phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neckClin Cancer Res20121882336234322371453
  • LalamiYSpecenierPMAwadaAEORTC 24051: unexpected side effects in a phase I study of TPF induction chemotherapy followed by chemoradiation with lapatinib, a dual EGFR/ErbB2 inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell carcinomaRadiother Oncol2012105223824022989664
  • HarringtonKJTemamSD’CruzAFinal analysis: a randomized, blinded, placebo (P)-controlled phase III study of adjuvant postoperative lapatinib (L) with concurrent chemotherapy and radiation therapy (CH-RT) in high-risk patients with squamous cell carcinoma of the head and neck (SCCHN)J Clin Oncol2014325s Abstract 6005
  • LiDAmbrogioLShimamuraTBIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer modelsOncogene200827344702471118408761
  • SolcaFDahlGZoephelATarget binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blockerJ Pharmacol Exp Ther2012343234235022888144
  • MachielsJPHaddadRIFayetteJAfatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trialLancet Oncol201516558359425892145
  • CohenEEWFayetteLJGaulerTCBiomarker analysis in recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients (pts) treated with second-line afatinib versus methotrexate (MTX): LUX-Head & Neck 1 (LUX-H&N1)J Clin Oncol201533Suppl Abstract 6023
  • SeiwertTYFayetteJCupissolDA randomized, phase II study of afatinib versus cetuximab in metastatic or recurrent squamous cell carcinoma of the head and neckAnn Oncol20142591813182024928832
  • GonzalesAJHookKEAlthausIWAntitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitorMol Cancer Ther2008771880188918606718
  • Abdul RazakARSoulieresDLaurieSAA phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neckAnn Oncol201324376176923108949
  • WedgeSROgilvieDJDukesMZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administrationCancer Res200262164645465512183421
  • CAPRELSA® (vandetanib) tablets [prescribing information]Wilmington, DEAstraZeneca Pharmaceuticals LP2011
  • LimayeSRileySZhaoSA randomized phase II study of docetaxel with or without vandetanib in recurrent or metastatic squamous cell carcinoma of head and neck (SCCHN)Oral Oncol201349883584123727257
  • HansenARSiuLLEpidermal growth factor receptor targeting in head and neck cancer: have we been just skimming the surface?J Clin Oncol201331111381138323460713
  • KimuraHSakaiKAraoTShimoyamaTTamuraTNishioKAntibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptorCancer Sci20079881275128017498200
  • KalyankrishnaSGrandisJREpidermal growth factor receptor biology in head and neck cancerJ Clin Oncol200624172666267216763281
  • DebTBSuLWongLEpidermal growth factor (EGF) receptor kinase-independent signaling by EGFJ Biol Chem200127618155541556011279155
  • GusenbauerSVlaicuPUllrichAHGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitorsOncogene201332333846385623045285
  • WeihuaZTsanRHuangWCSurvival of cancer cells is maintained by EGFR independent of its kinase activityCancer Cell200813538539318455122
  • TanXThapaNSunYAndersonRAA kinase-independent role for EGF receptor in autophagy initiationCell20151601–214516025594178
  • DienstmannRBranaIRodonJTaberneroJToxicity as a biomarker of efficacy of molecular targeted therapies: focus on EGFR and VEGF inhibiting anticancer drugsOncologist201116121729174022135123
  • CohenEEKaneMAListMAPhase II trial of gefitinib 250 mg daily in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neckClin Cancer Res200511238418842416322304
  • SolomonBMJatoiARash from EGFR inhibitors: opportunities and challenges for palliationCurr Oncol Rep200810430430818778556
  • LauxIJainASinghSAgusDBEpidermal growth factor receptor dimerization status determines skin toxicity to HER-kinase targeted therapiesBr J Cancer2006941859216306877
  • SalamaJKHaddadRIKiesMSClinical practice guidance for radiotherapy planning after induction chemotherapy in locoregionally advanced head-and-neck cancerInt J Radiat Oncol Biol Phys200975372573319362781
  • MesiaRRuedaAVeraRAdjuvant therapy with cetuximab for locally advanced squamous cell carcinoma of the oropharynx: results from a randomized, phase II prospective trialAnn Oncol201324244845323041591
  • MarurSLeeJ-WCmelakAECOG 1308: a phase II trial of induction chemotherapy followed by cetuximab with low dose versus standard dose IMRT in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx (OP)J Clin Oncol201230Suppl Abstract 5566
  • MarurSLiSCmelakAE 1308: a phase II trial of induction chemotherapy (IC) followed by cetuximab with low dose versus standard dose IMRT in patients with human papilloma virus (HPV)-associated resectable squamous cell carcinoma of the oropharynx (OPSCC)J Clin Oncol201331Suppl Abstract 6005
  • MassarelliEHaddadRILeeJJWeekly paclitaxel, carboplatin, cetuximab (PCC), and cetuximab, docetaxel, cisplatin, and fluorouracil (C-TPF), followed by risk-based local therapy in previously untreated, locally advanced head and neck squamous cell carcinoma (LAHN-SCC)J Clin Oncol201533Suppl Abstract 6001
  • GuigayJFayetteJDilliesAFCetuximab, docetaxel, and cisplatin (TPEx) as first-line treatment in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): final results of phase II trial GORTEC 2008-03J Clin Oncol201230Suppl Abstract 5505
  • HittRIrigoyenACortes-FunesHGrauJJGarcia-SaenzJACruz-HernandezJJPhase II study of the combination of cetuximab and weekly paclitaxel in the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of head and neckAnn Oncol20122341016102221865152
  • BaselgaJTrigoJMBourhisJPhase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neckJ Clin Oncol200523245568557716009950
  • KnoedlerMDietzAGaulerTCCetuximab, fluorouracil (5-FU), cisplatin, and docetaxel as first-line treatment in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): interim results of a randomized phase II clinical trial (CeFCiD)J Clin Oncol201331Suppl Abstract e17021
  • VermorkenJBLicitraLStohlmacher-WilliamsJPhase II study of pemetrexed in combination with cisplatin and cetuximab in recurrent or metastatic squamous cell carcinoma of the head and neckEur J Cancer201349132877288323726971
  • HerbstRSArquetteMShinDMPhase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neckJ Clin Oncol200523245578558716009949
  • FuryMGShermanELisaDA randomized phase II study of cetuximab every 2 weeks at either 500 or 750 mg/m2 for patients with recurrent or metastatic head and neck squamous cell cancerJ Natl Compr Canc Netw201210111391139823138167
  • VermorkenJBTrigoJHittROpen-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapyJ Clin Oncol200725162171217717538161
  • CrombetTOsorioMCruzTUse of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patientsJ Clin Oncol20042291646165415117987
  • HarringtonKBerrierARobinsonMRandomised phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative diseaseEur J Cancer20134971609161823265705
  • WaldronJNParulekarWO’SullivanBA phase III study of standard fractionation radiotherapy with concurrent high-dose cisplatin versus accelerated fractionation radiotherapy (RT) with panitumumab in patients with locally advanced stage III and IV squamous cell carcinoma of the head and neck (SCCHN) (NCIC Clinical Trials Group HN.6)J Clin Oncol201230Suppl Abstract TPS5600