Update on the pharmacogenomics of pain management

References

• Institute of Medicine (US) Committee on Advancing Pain Research, Care and E. Relieving pain in America: a blueprint for transforming prevention, care, education, and research - PubMed - NCBI. Natl Acad Collect Rep Funded Natl Inst Heal. 2011. doi:10.7205/MILMED-D-16-00012
   Google Scholar
• IASP Group. Pain terms: a list with definitions and notes on usage. Recommended by the IASP subcommitee on taxonomy. Pain. 1979. doi:10.1016/0304-3959(79)90175-1
   Google Scholar
• Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009. doi:10.1146/annurev.neuro.051508.135531
   Web of Science ®Google Scholar
• Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet. 1999. doi:10.1016/S0140-6736(99)01307-0
   Web of Science ®Google Scholar
• Dahlhamer J, Lucas J, Zelaya C, et al. Prevalence of chronic pain and high-impact chronic pain among adults — United States, 2016. MMWR Morb Mortal Wkly Rep. 2018. doi:10.15585/mmwr.mm6736a2
   Web of Science ®Google Scholar
• Schappert SM, Burt CW. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001–02. Vital Health Stat. 2006;13 Available from: http://europepmc.org/abstract/MED/16471269.
   Google Scholar
• Dueñas M, Ojeda B, Salazar A, Mico JA, Failde I. A review of chronic pain impact on patients, their social environment and the health care system. J Pain Res. 2016. doi:10.2147/JPR.S105892
   Web of Science ®Google Scholar
• Hooten WM. Chronic pain and mental health disorders: shared neural mechanisms, epidemiology, and treatment. Mayo Clin Proc. 2016. doi:10.1016/j.mayocp.2016.04.029
   Web of Science ®Google Scholar
• Florence CS, Zhou C, Luo F, Xu L. The economic burden of prescription opioid overdose, abuse, and dependence in the United States, 2013. Med Care. 2016. doi:10.1097/MLR.0000000000000625
   Web of Science ®Google Scholar
• Paulozzi L, Baldwin G, Franklin G, et al. CDC grand rounds: prescription drug overdoses - a U.S. Epidemic. Morb Mortal Wkly Rep. Vol 61. 2012;[pii].
   Google Scholar
• Vogel F. Moderne Probleme der Humangenetik. Ergeb Inn Med Kinderheilkd. 1959. doi:10.1007/978-3-642-94744-5_2
   Google Scholar
• Relling MV, Evans WE. Pharmacogenomics in the clinic. Nature. 2015;526(7573):343–350. doi:10.1038/nature1581726469045
   PubMed Web of Science ®Google Scholar
• Vesell ES, Page JG. Genetic control of drug levels in man: antipyrine. Science (80-). 1968. doi:10.1126/science.161.3836.72
   Web of Science ®Google Scholar
• Price Evans DA, Manley KA, McKusick VA. Genetic control of isoniazid metabolism in man. Br Med J. 1960. doi:10.1136/bmj.2.5197.485
   Web of Science ®Google Scholar
• Blum M, Demierre A, Grant DM, Heim M, Meyer UA. Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc Natl Acad Sci. 1991. doi:10.1073/pnas.88.12.5237
   Web of Science ®Google Scholar
• Gonzalez FJ, Skodat RC, Kimura S, et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature. 1988. doi:10.1038/331442a0
   Web of Science ®Google Scholar
• Ingelman-Sundberg M, Evans WE. Unravelling the functional genomics of the human CYP2D6 gene locus. Pharmacogenetics. 2001. doi:10.1097/00008571-200110000-00002
   Google Scholar
• Crews KR, Gaedigk A, Dunnenberger HM, et al. Clinical pharmacogenetics implementation consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014;95(4):376–382. doi:10.1038/clpt.2013.25424458010
   PubMed Web of Science ®Google Scholar
• Matic M, De Wildt SN, Tibboel D, Van Schaik RHN. Analgesia and opioids: a pharmacogenetics shortlist for implementation in clinical practice. Clin Chem. 2017. doi:10.1373/clinchem.2016.264986
   Web of Science ®Google Scholar
• Van Driest SL, Shi Y, Bowton E, et al. Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing. Clin Pharmacol Ther. 2014. doi:10.1038/clpt.2013.229
   Web of Science ®Google Scholar
• Hoffman JM, Haidar CE, Wilkinson MR, et al. PG4KDS: A model for the clinical implementation of pre-emptive pharmacogenetics. Am J Med Genet Part C Semin Med Genet. 2014. doi:10.1002/ajmg.c.31391
   Web of Science ®Google Scholar
• Weitzel KW, Aquilante CL, Johnson S, Kisor DF, Empey PE. Educational strategies to enable expansion of pharmacogenomics-based care. Am J Heal Pharm. 2016. doi:10.2146/ajhp160104
   Web of Science ®Google Scholar
• Tighe P, Buckenmaier CC, Boezaart AP, et al. Acute pain medicine in the United States: a status report. Pain Med (United States). 2015;16(9):1806–1826. doi:10.1111/pme.12760
   PubMed Web of Science ®Google Scholar
• Bonica JJ. Neurophysiologic and pathologic aspects of acute and chronic pain. Arch Surg. 1977;112(6):750–761. doi:10.1001/archsurg.1977.0137006008201416580
   PubMedGoogle Scholar
• Grichnik KP, Ferrante FM. The difference between acute and chronic pain. Mt Sinai J Med. (58):217–220. 1991.1875958
   PubMedGoogle Scholar
• Treede R-D, Rief W, Barke A, et al. A classification of chronic pain for ICD-11. Pain. 2015;156(6):1. doi:10.1097/j.pain.000000000000016025599292
   PubMed Web of Science ®Google Scholar
• Linley JE, Rose K, Ooi L, Gamper N. Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. Pflugers Arch Eur J Physiol. 2010;459(5):657–669. doi:10.1007/s00424-010-0784-620162302
   PubMed Web of Science ®Google Scholar
• Murnion BP. Neuropathic pain: current definition and review of drug treatment. Aust Prescr. 2018;41(3):60–63. doi:10.18773/austprescr.2018.02229921999
   PubMed Web of Science ®Google Scholar
• Gierthmühlen J, Baron R. Neuropathic pain. Semin Neurol. 2016;36(5):462–468. doi:10.1055/s-0036-158495027704502
   PubMed Web of Science ®Google Scholar
• Nersesyan H, Slavin KV. Current aproach to cancer pain management: availability and implications of different treatment options. Ther Clin Risk Manag. 2007;3(3):381–400. doi:10.1073/pnas.070575910418488078
   PubMed Web of Science ®Google Scholar
• Berg D, Gerlach H. Recent advances in understanding and managing sepsis. F1000Research. 2018;7:1570. doi:10.12688/f1000research.15758.1
   Google Scholar
• Nahin RL. Estimates of pain prevalence and severity in adults: United States, 2012. J Pain. 2015;16(8):769–780. doi:10.1016/j.jpain.2015.05.00226028573
   PubMed Web of Science ®Google Scholar
• Davies KA, Silman AJ, Macfarlane GJ, et al. The association between neighbourhood socio-economic status and the onset of chronic widespread pain: results from the EPIFUND study. Eur J Pain. 2009;13(6):635–640. doi:10.1016/j.ejpain.2008.07.00318782674
   PubMed Web of Science ®Google Scholar
• Roth RS, Punch MR, Bachman JE. Educational achievement and pain disability among women with chronic pelvic pain. J Psychosom Res. 2001;51(4):563–569. doi:10.1016/S0022-3999(01)00242-211595244
   PubMed Web of Science ®Google Scholar
• Brekke M, Hjortdahl P, Kvien TK. Severity of musculoskeletal pain: relations to socioeconomic inequality. Soc Sci Med. 2002;54(2):221–228. doi:10.1016/S0277-9536(01)00018-111824927
   PubMed Web of Science ®Google Scholar
• Wu MT, Pan HB, Lai PH, Chang JM, Tsai SH, Wu CW. CT of gastritis cystica polyposa. Abdom Imaging. 1994;19(1):8–10. doi:10.1007/BF021658528161914
   PubMedGoogle Scholar
• Østerås B, Sigmundsson H, Haga M. Perceived stress and musculoskeletal pain are prevalent and significantly associated in adolescents: an epidemiological cross-sectional study chronic disease epidemiology. BMC Public Health. 2015;15(1):1–10. doi:10.1186/s12889-015-2414-x25563658
   PubMed Web of Science ®Google Scholar
• Fischer S, Doerr JM, Strahler J, Mewes R, Thieme K, Nater UM. Stress exacerbates pain in the everyday lives of women with fibromyalgia syndrome-The role of cortisol and alpha-amylase. Psychoneuroendocrinology. 2016;63:68–77. doi:10.1016/j.psyneuen.2015.09.01826431802
   PubMed Web of Science ®Google Scholar
• Song TJ, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK. Anxiety and depression in tension-type headache: a population-based study. PLoS One. 2016;11(10):1–12. doi:10.1371/journal.pone.0165316
   Web of Science ®Google Scholar
• Coulbault L, Beaussier M, Verstuyft C, et al. Environmental and genetic factors associated with morphine response in the postoperative period. Clin Pharmacol Ther. 2006;79(4):316–324. doi:10.1016/j.clpt.2006.01.00716580900
   PubMed Web of Science ®Google Scholar
• Periasamy S, Poovathai R, Pondiyadanar S. Influences of gender on postoperative morphine consumption. J Clin Diagnostic Res. 2014;8(12):GC04–GC07. doi:10.7860/JCDR/2014/10770.5319
   Google Scholar
• Elsbernd A. Zum Verh??ltnis von pflegerischem Wissen, pflegerischer Handlungsfreiheit und den Grenzen des Gehorsams der individuellen Pflegeperson. Pflege. 1994;7(2):105–116. doi:10.1002/npr2.120038018806
   PubMedGoogle Scholar
• Bair MJ, Robinson RL, Katon W, Kroenke K. Depression and pain comorbidity. Arch Intern Med. 2003;163(20):2433. doi:10.1001/archinte.163.20.243314609780
   PubMed Web of Science ®Google Scholar
• Nielsen CS, Stubhaug A, Price DD, Vassend O, Czajkowski N, Harris JR. Individual differences in pain sensitivity: genetic and environmental contributions. Pain. 2008;136(1–2):21–29. doi:10.1016/j.pain.2007.06.00817692462
   PubMed Web of Science ®Google Scholar
• James S. Human pain and genetics: some basics. Br J Pain. 2013;7(4):171–178. doi:10.1177/204946371350640826516521
   PubMedGoogle Scholar
• Campbell CM, Edwards RR. Ethnic differences in pain and pain management. Pain Manag. 2012;2(3):219–230. doi:10.2217/pmt.12.723687518
   PubMedGoogle Scholar
• Green CR, Anderson KO, Baker TA, et al. The unequal burden of pain: confronting racial and ethnic disparities in pain. Pain Med. 2003;4(3):277–294. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12974827. Accessed May 1, 2019. doi:10.1046/j.1526-4637.2003.03034.x12974827
   PubMed Web of Science ®Google Scholar
• Reyes-Gibby CC, Aday LA, Todd KH, Cleeland CS, Anderson KO. Pain in aging community-dwelling adults in the United States: non-Hispanic whites, non-Hispanic blacks, and Hispanics. J Pain. 2007;8(1):75–84. doi:10.1016/j.jpain.2006.06.00216949874
   PubMed Web of Science ®Google Scholar
• Mossey JM. Defining racial and ethnic disparities in pain management. Clin Orthop Relat Res. 2011;469(7):1859–1870. doi:10.1007/s11999-011-1770-921249483
   PubMed Web of Science ®Google Scholar
• Jimenez N, Garroutte E, Kundu A, Morales L, Buchwald D. A review of the experience, epidemiology, and management of pain among American Indian, Alaska Native, and Aboriginal Canadian peoples. J Pain. 2011;12(5):511–522. doi:10.1016/j.jpain.2010.12.00221330217
   PubMed Web of Science ®Google Scholar
• Chan A, Malhotra C, Do YK, Malhotra R, Østbye T. Self reported pain severity among multiethnic older Singaporeans: does adjusting for reporting heterogeneity matter? Eur J Pain. 2011;15(10):1094–1099. doi:10.1016/j.ejpain.2011.05.00621646030
   PubMed Web of Science ®Google Scholar
• Zhu X, Wong F, Bensoussan A, Lo SK, Zhou C, Yu J. Are there any cross-ethnic differences in menstrual profiles? A pilot comparative study on Australian and Chinese women with primary dysmenorrhea. J Obstet Gynaecol Res. 2010;36(5):1093–1101. doi:10.1111/j.1447-0756.2010.01250.x20846252
   PubMed Web of Science ®Google Scholar
• Sjölander P. What is known about the health and living conditions of the indigenous people of northern Scandinavia, the Sami? Glob Health Action. 2011;4(1):8457. doi:10.3402/gha.v4i0.8457
   PubMed Web of Science ®Google Scholar
• Shakur H, Roberts I, Fawole B, et al. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet. 2017;389(10084):2105–2116. doi:10.1016/S0140-6736(17)30638-428456509
   PubMed Web of Science ®Google Scholar
• Bates MS, Rankin-Hill L. Control, culture and chronic pain. Soc Sci Med. 1994;39(5):629–645. Accessed May 1, 2019. doi:10.1016/0277-9536(94)90020-5.7973863
   PubMed Web of Science ®Google Scholar
• Zhang J-M, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 2007. doi:10.1097/AIA.0b013e318034194e
   Google Scholar
• Si HB, Yang TM, Zeng Y, et al. Correlations between inflammatory cytokines, muscle damage markers and acute postoperative pain following primary total knee arthroplasty. BMC Musculoskelet Disord. 2017. doi:10.1186/s12891-017-1597-y
   Web of Science ®Google Scholar
• Jung M, Ma Y, Iyer RP, et al. IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation. Basic Res Cardiol. 2017. doi:10.1007/s00395-017-0622-5
   Web of Science ®Google Scholar
• Tammimäki A, Männistö PT. Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis. Pharmacogenet Genomics. 2012. doi:10.1097/FPC.0b013e3283560c46
   Web of Science ®Google Scholar
• Sadhu N, Jhun EH, Yao Y, et al. Genetic variants of GCH1 associate with chronic and acute crisis pain in African Americans with sickle cell disease. Exp Hematol. 2018. doi:10.1016/j.exphem.2018.07.004
   Web of Science ®Google Scholar
• Muneer S. Utilizing pharmacogenomics when selecting personalized medicine for patients with chronic pain. American Health and Drug Benefits. Faculty Perspectives in Chronic Pain. 2016.
   Google Scholar
• Světlík S, Hronová K, Bakhouche H, Matoušková O, Slanař O. Pharmacogenetics of chronic pain and its treatment. Mediators Inflamm. 2013. doi:10.1155/2013/864319
   Web of Science ®Google Scholar
• Jara-Oseguera A, Simon SA, Rosenbaum T. TRPV1: on the road to pain relief. Curr Mol Pharmacol. 2008;1(3):255–269.20021438
   PubMedGoogle Scholar
• Valdes AM, De WG, Doherty SA, et al. The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis. Ann Rheum Dis. 2011;70(9):1556–1561. doi:10.1136/ARD.2010.14812221616913
   PubMed Web of Science ®Google Scholar
• Binder A, May D, Baron R, et al. Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. Gaetano C, ed PLoS One. 2011;6(3):e17387. doi:10.1371/journal.pone.001738721468319
   PubMed Web of Science ®Google Scholar
• Tsantoulas C, Denk F, Signore M, Nassar MA, Futai K, McMahon SB. Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity. Pain. 2018. doi:10.1097/j.pain.0000000000001255
   Web of Science ®Google Scholar
• Nissenbaum J. From mouse to humans: discovery of the CACNG2 pain susceptibility gene. Clin Genet. 2012. doi:10.1111/j.1399-0004.2012.01924.x
   Web of Science ®Google Scholar
• Neely GG, Hess A, Costigan M, et al. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell. 2010. doi:10.1016/j.cell.2010.09.047
   Web of Science ®Google Scholar
• Viet CT, Dang D, Aouizerat BE, et al. OPRM1 methylation contributes to opioid tolerance in cancer patients. J Pain. 2017. doi:10.1016/j.jpain.2017.04.001
   Web of Science ®Google Scholar
• Mahmoud S, Thorsell A, Sommer WH, et al. Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine-and fentanyl-mediated modulation of Ca2+ channels in humanized mouse sensory neurons. Anesthesiology. 2011. doi:10.1097/ALN.0b013e318231fc11
   Web of Science ®Google Scholar
• Giovannitti JA, Thoms SM, Crawford JJ. Alpha-2 Adrenergic Receptor Agonists: a Review of Current Clinical Applications. Anesth Prog. 2015. doi:10.2344/0003-3006-62.1.31
   Google Scholar
• Deng Y, Huang J, Zhang H, Zhu X, Gong Q. Association of expression of DRD2 rs1800497 polymorphism with migraine risk in Han Chinese individuals. J Pain Res. 2018. doi:10.2147/JPR.S151350
   Web of Science ®Google Scholar
• Treister R, Pud D, Ebstein RP, et al. Associations between polymorphisms in dopamine neurotransmitter pathway genes and pain response in healthy humans. Pain. 2009. doi:10.1016/j.pain.2009.09.001
   Web of Science ®Google Scholar
• Hooten WM, Hartman WR, Black JL, Laures HJ, Walker DL. Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain. BMC Med Genet. 2013. doi:10.1186/1471-2350-14-78
   Web of Science ®Google Scholar
• Zhao Z, Lv B, Zhao XZ, Zhang Y. Effects of OPRM1 and ABCB1 gene polymorphisms on the analgesic effect and dose of sufentanil after thoracoscopic-assisted radical resection of lung cancer. Biosci Rep. 2019;39(1). doi:10.1042/BSR20181211
   Web of Science ®Google Scholar
• Owusu Obeng A, Hamadeh I, Smith M. Review of opioid pharmacogenetics and considerations for pain management. Pharmacotherapy. 2017;37(9):1105–1121. doi:10.1002/phar.198628699646
   PubMed Web of Science ®Google Scholar
• Nielsen LM, Olesen AE, Branford R, Christrup LL, Sato H, Drewes AM. Association between human pain-related genotypes and variability in opioid analgesia: an updated review. Pain Pract. 2015;15(6):580–594. doi:10.1111/papr.1223225201705
   PubMed Web of Science ®Google Scholar
• Cohen M, Sadhasivam S, Vinks AA. Pharmacogenetics in perioperative medicine. Curr Opin Anaesthesiol. 2012;25(4):419–427. doi:10.1097/ACO.0b013e328355612922673786
   PubMed Web of Science ®Google Scholar
• Crist RC, Ambrose-Lanci LM, Vaswani M, et al. Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations. Drug Alcohol Depend. 2013;127(1–3):122–128. doi:10.1016/j.drugalcdep.2012.06.02322795689
   PubMed Web of Science ®Google Scholar
• Butelman ER, Yuferov V, Kreek MJ. κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends Neurosci. 2012;35(10):587–596. doi:10.1016/j.tins.2012.05.00522709632
   PubMed Web of Science ®Google Scholar
• Horn JR, Hansten PD. Get to know an enzyme: CYP2D6. Pharm Times. Available from: https://www.pharmacytimes.com/publications/issue/2008/2008-07/2008-07-8624. Published 2008. Accessed April 24, 2019.
   Google Scholar
• Ting S, Schug S. The pharmacogenomics of pain management: prospects for personalized medicine. J Pain Res. 2016;9:49–56.26929662
   PubMed Web of Science ®Google Scholar
• Holthe M, Klepstad P, Zahlsen K, et al. Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy. Eur J Clin Pharmacol. 2002;58(5):353–356. doi:10.1007/s00228-002-0490-112185559
   PubMed Web of Science ®Google Scholar
• Klepstad P, Rakvag TT, Kaasa S, et al. The 118 A>G polymorphism in the human u-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand. 2004;48(10):1232–1239. doi:10.1111/j.1399-6576.2004.00517.x15504181
   PubMed Web of Science ®Google Scholar
• Sadhasivam S, Chidambaran V, Zhang X, et al. Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics. Pharmacogenomics J. 2015;15(2):119–126. doi:10.1038/tpj.2014.5625311385
   PubMed Web of Science ®Google Scholar
• Kirchheiner J, Schmidt H, Tzvetkov M, et al. Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J. 2007;7:257–265. doi:10.1038/sj.tpj.650040616819548
   PubMed Web of Science ®Google Scholar
• Crews KR, Gaedigk A, Dunnenberger HM, et al. Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update. Clin. Pharmacol. Ther. 2014;95(4):376–382.
   Google Scholar
• US Food and Drug Administration. FDA Drug Safety Communication: FDA Requires Labeling Changes for Prescription Opioid Cough and Cold Medicines to Limit Their Use to Adults 18 Years and Older. Available from: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-requires-labeling-changes-prescription-opioid-cough-and-cold. Accessed May 30, 2019.
   Google Scholar
• Stamer UM, Stüber F, Muders T, Musshoff F. Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication. Anesth Analg. 2008;107(3):926–929. doi:10.1213/ane.0b013e31817b796e18713907
   PubMed Web of Science ®Google Scholar
• Stauble ME, Moore AW, Langman LJ, et al. Hydrocodone in postoperative personalized pain management: pro-drug or drug? Clin Chim Acta. 2014;429:26–29. doi:10.1016/j.cca.2013.11.01524269714
   PubMed Web of Science ®Google Scholar
• Linares OA, Fudin J, Daly AL, Boston RC. Individualized hydrocodone therapy based on phenotype,pharmacogenetics, and pharmacokinetic dosing. Clin J Pain. 2015;31(12):1026–1035. doi:10.1097/AJP.000000000000021425621429
   PubMed Web of Science ®Google Scholar
• Romand S, Spaggiari D, Marsousi N, et al. Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases. J Pharm Biomed Anal. 2017;144:129–137. doi:10.1016/j.jpba.2016.09.02427692933
   PubMed Web of Science ®Google Scholar
• Holmquist GL. Opioid metabolism and effects of cytochrome P450. Pain Med. 2009;10(suppl1):S20–S29. doi:10.1111/j.1526-4637.2009.00596.x
   Web of Science ®Google Scholar
• Zwisler ST, Enggaard TP, Mikkelsen S, Brosen K, Sindrup SH. Impact of the CYP2D6 genotype on post-operative intravenous oxycodone analgesia. Acta Anaesthesiol Scand. 2010;54(2):232–240. doi:10.1111/j.1399-6576.2009.02104.x19719813
   PubMed Web of Science ®Google Scholar
• Naito T, Takashina Y, Yamamoto K, et al. CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone. J Clin Pharmacol. 2011;51(11):1529–1538. doi:10.1177/009127001038803321209234
   PubMed Web of Science ®Google Scholar
• Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR. Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nat Struct Biol. 2003;10(5):349–356. doi:10.1038/nsb91912679808
   PubMedGoogle Scholar
• Takashina Y, Naito T, Mino Y, Yagi T, Ohnishi K, Kawakami J. Impact of CYP3A5 and ABCB1 gene polymorphisms on fentanyl pharmacokinetics and clinical responses in cancer patients undergoing conversion to a transdermal system. Drug Metab Pharmacokinet. 2012;27(4):414–421.22277678
   PubMed Web of Science ®Google Scholar
• Clarke T-K, Crist RC, Ang A, et al. Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females. Pharmacogenomics J. 2014;14(3):303–308. doi:10.1038/tpj.2013.3024126707
   PubMed Web of Science ®Google Scholar
• Kapur BM, Lala PK, Shaw JLV. Pharmacogenetics of chronic pain management. Clin Biochem. 2014;47(13–14):1169–1187. doi:10.1016/j.clinbiochem.2014.05.06524912048
   PubMed Web of Science ®Google Scholar
• Carbonell N, Verstuyft C, Massard J, et al. CYP2C9*3 loss-of-function allele is associated with acute upper gastrointestinal bleeding related to the use of NSAIDs other than aspirin. Clin Pharmacol Ther. 2010;87(6):693–698. doi:10.1038/clpt.2010.3320445534
   PubMed Web of Science ®Google Scholar
• Saba R, Kaye AD, Urman RD. Pharmacogenomics in pain management. Anesthesiol Clin. 2017;35(2):295–304. doi:10.1016/j.anclin.2017.01.01528526150
   PubMedGoogle Scholar
• Liem EB, Teresa VJ, Tsueda K, Sessler DI. Increased sensitivity to thermal pain and reduced subcutaneous lidocaine efficacy in redheads. Anesthesiology. 2005;102(3):509–514.15731586
   PubMed Web of Science ®Google Scholar
• Stein DJ, Newman TK, Savitz J, Ramesar R. Warriors versus worriers: the role of COMT gene variants. CNS Spectr. 2006;11(10):745–748. Accessed May 4, 2019. doi:10.1017/S1092852900014863.17008817
   PubMed Web of Science ®Google Scholar
• Diatchenko L, Nackley AG, Slade GD, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain. 2006;125(3):216–224. doi:10.1016/j.pain.2006.05.02416837133
   PubMed Web of Science ®Google Scholar
• Vuilleumier PH, Stamer UM, Landau R. Pharmacogenomic considerations in opioid analgesia. Pharmgenomics Pers Med. 2012;5:73–87. doi:10.2147/PGPM.S2342223226064
   PubMedGoogle Scholar
• Jensen KB, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val158met Polymorphism. Toland AE, ed PLoS One. 2009;4(6):e6016. doi:10.1371/journal.pone.000601619547755
   PubMed Web of Science ®Google Scholar
• Hicks J, Bishop J, Sangkuhl K, et al. Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors. Clin Pharmacol Ther. 2015;98(2):127–134. doi:10.1002/cpt.14725974703
   PubMed Web of Science ®Google Scholar
• Obeng AO, Hamadeh I, Smith M. Review of opioid pharmacogenetics and considerations for pain management. Pharmacotherapy. 2017;37(9):1105–1121. doi:10.1002/phar.198628699646
   PubMed Web of Science ®Google Scholar
• Reyes-Gibby CC, Shete S, Rakvåg T, et al. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain. 2007;130(1–2):25–30. doi:10.1016/j.pain.2006.10.02317156920
   PubMed Web of Science ®Google Scholar
• James S. Human pain and genetics: some basics. Br J Pain. 2013;7(4):171–178. doi:10.1177/204946371350640826516521
   PubMedGoogle Scholar
• Yoshida K, Nishizawa D, Ide S, Ichinohe T, Fukuda K, Ikeda K. A pharmacogenetics approach to pain management. Neuropsychopharmacol Rep. 2018;38(1):2–8. doi:10.1002/npr2.1200330106264
   PubMedGoogle Scholar
• Purchase A, Marschler M, Webster L. Pharmacogenomics in pain management personalized pain therapy. doi:10.1016/j.cll.2016.05.007 Available from: https://prahs.com/resources/whitepapers/Pharmacogenomics-in-Pain-Management.pdf
   Google Scholar
• Belfer I. Personalized Pain Medicine: Pharmacogenetic Testing for Pain and Opioid Addiction PA I N M E D I C I N E N E W S • S E P T E M B E R 2 0 1 5. Available from: https://www.painmedicinenews.com/Review-Articles/Article/09-15/Personalized-Pain-Medicine-Pharmacogenetic-Testing-for-Pain-and-Opioid-Addiction/33480/ses=ogst?%20target=
   Google Scholar
• Ko T-M, Wong C-S, Wu J-Y, Chen Y-T. Pharmacogenomics for personalized pain medicine. Acta Anaesthesiol Taiwanica. 2016;54(1):24–30. doi:10.1016/J.AAT.2016.02.001
   Google Scholar
• Bijl MJ, Visser LE, Hofman A, et al. Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008;65(4):558–564. doi:10.1111/j.1365-2125.2007.03052.x18070221
   PubMed Web of Science ®Google Scholar
• Bernard S, Neville KA, Nguyen AT, Flockhart DA. Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications. Oncologist. 2006;11(2):126–135. doi:10.1634/theoncologist.11-2-12616476833
   PubMed Web of Science ®Google Scholar
• Zhou S-F, Liu J-P, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev. 2009;41(2):89–295. doi:10.1080/0360253090284348319514967
   PubMed Web of Science ®Google Scholar
• Dean L. Codeine Therapy and CYP2D6 Genotype. Bethesda (MD): National Center for Biotechnology Information (US); 2012 Available from: http://www.ncbi.nlm.nih.gov/pubmed/28520350. Accessed 430, 2019.
   Google Scholar
• Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Klein T, Leeder JS. Prediction of CYP2D6 phenotype from genotype across world populations. Genet Med. 2017;19(1):69–76. doi:10.1038/gim.2016.8027388693
   PubMed Web of Science ®Google Scholar
• Del Tredici AL, Malhotra A, Dedek M, et al. Frequency of CYP2D6 alleles including structural variants in the United States. Front Pharmacol. 2018;9:305. doi:10.3389/fphar.2018.0030529674966
   PubMed Web of Science ®Google Scholar