Physicians’ Knowledge and Attitudes Regarding Point-of-Care Pharmacogenetic Testing: A Hospital-Based Cross-Sectional Study

References

• Huang RS, Ratain MJ. Pharmacogenetics and pharmacogenomics of anticancer agents. CA Cancer J Clin. 2009;59(1):42–55. doi:10.3322/caac.20002
   Web of Science ®Google Scholar
• Haga SB, Moaddeb J. Comparison of delivery strategies for pharmacogenetic testing services. Pharmacogenet Genomics. 2014;24(3):139. doi:10.1097/FPC.0000000000000028
   PubMed Web of Science ®Google Scholar
• Saldivar J-S, Taylor D, Sugarman EA, et al. Initial assessment of the benefits of implementing pharmacogenetics into the medical management of patients in a long-term care facility. Pharmgenomics Pers Med. 2016;9:1. doi:10.2147/PGPM.S93480
   PubMed Web of Science ®Google Scholar
• Ventola CL. Role of pharmacogenomic biomarkers in predicting and improving drug response: part 1: the clinical significance of pharmacogenetic variants. Pharmacol Ther. 2013;38(9):545.
   Google Scholar
• Knisely MR, Carpenter JS, Von Ah D. Pharmacogenomics in the nursing literature: an integrative review. J Nurs Outlook. 2014;62(4):285–296. doi:10.1016/j.outlook.2014.03.004
   PubMed Web of Science ®Google Scholar
• Cabello AJ, Gavilán ED, Jiménez FJ, Rodríguez CM, Del Castillo JDD, Cañas EP. Drug-related mortality among inpatients: a retrospective observational study. Eur J Clin Pharmacol. 2016;72(6):731–736. doi:10.1007/s00228-016-2026-0
   Web of Science ®Google Scholar
• Nivya K, Sri Sai Kiran V, Ragoo N, Jayaprakash B, Sonal Sekhar M. Systemic review on drug related hospital admissions – a pubmed based search. Saudi Pharm J. 2015;23(1):1–8. doi:10.1016/j.jsps.2013.05.006
   Web of Science ®Google Scholar
• Pirmohamed M, James S, Meakin S, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004;329(7456):15–19. doi:10.1136/bmj.329.7456.15
   PubMed Web of Science ®Google Scholar
• Hoop JG, Lapid MI, Paulson RM, Roberts LW. Clinical and ethical considerations in pharmacogenetic testing: views of physicians in 3 “early adopting” departments of psychiatry. J Clin Psychiatry. 2010;71(6):745–753. doi:10.4088/JCP.08m04695whi
   PubMed Web of Science ®Google Scholar
• Thompson C, Hamilton SP, Hippman C. Psychiatrist attitudes towards pharmacogenetic testing, direct-to-consumer genetic testing, and integrating genetic counseling into psychiatric patient care. Psychiatry Res. 2015;226(1):68–72. doi:10.1016/j.psychres.2014.11.044
   PubMed Web of Science ®Google Scholar
• Haddy CA, Ward HM, Angley MT, McKinnon RA. Consumers’ views of pharmacogenetics—a qualitative study. Res Social Adm Pharm. 2010;6(3):221–231. doi:10.1016/j.sapharm.2009.08.002
   Web of Science ®Google Scholar
• Perlis RH, Patrick A, Smoller JW, Wang PS. When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR* D study. Neuropsychopharmacology. 2009;34(10):2227–2236. doi:10.1038/npp.2009.50
   Web of Science ®Google Scholar
• Priest VL, Begg EJ, Gardiner SJ, et al. Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease. Pharmacoeconomics. 2006;24(8):767–781. doi:10.2165/00019053-200624080-00004
   PubMed Web of Science ®Google Scholar
• Haga SB, Burke W, Ginsburg GS, Mills R, Agans RJ. Primary care physicians‘ knowledge of and experience with pharmacogenetic testing. Clin Genet. 2012;82(4):388–394. doi:10.1111/j.1399-0004.2012.01908.x
   PubMed Web of Science ®Google Scholar
• Rogausch A, Prause D, Schallenberg A, Brockmöller J, Himmel W. Patients’ and physicians’ perspectives on pharmacogenetic testing. Pharmacogenomics. 2006;7(1):49–59. doi:10.2217/14622416.7.1.49
   PubMed Web of Science ®Google Scholar
• Ielmini M, Poloni N, Caselli I, et al. The utility of pharmacogenetic testing to support the treatment of bipolar disorder. Pharmgenomics Pers Med. 2018;11:35.
   PubMed Web of Science ®Google Scholar
• Ielmini M, Poloni N, Caselli I, Diurni M, Grecchi A, Callegari C. The role of pharmacogenetic testing in the treatment of bipolar disorder: preliminary results. Minerva Psichiatr. 2018;59(1):10–15.
   Web of Science ®Google Scholar
• Roberts JD, Wells GA, Le May MR, et al. Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial. Lancet. 2012;379(9827):1705–1711. doi:10.1016/S0140-6736(12)60161-5
   PubMed Web of Science ®Google Scholar
• Louie RF, Tang Z, Shelby DG, Kost GJJ. Point-of-care testing: millennium technology for critical care. Lab Med. 2000;31(7):402–408.
   Web of Science ®Google Scholar
• Haga SB. Challenges of development and implementation of point of care pharmacogenetic testing. Expert Rev Mol Diagn. 2016;16(9):949–960. doi:10.1080/14737159.2016.1211934
   PubMed Web of Science ®Google Scholar
• Howard R, Leathart JBS, French DJ, et al. Genotyping for CYP2C9 and VKORC1 alleles by a novel point of care assay with HyBeacon® probes. Clin Chim Acta. 2011;412(23–24):2063–2069. doi:10.1016/j.cca.2011.07.013
   PubMed Web of Science ®Google Scholar
• Shahabi P, Siest G, Visvikis-Siest SJP. Clinical interest of point-of-care pharmacogenomic testing: clopidogrel behind warfarin. Pharmacogenomics. 2012;13(11):1215–1218. doi:10.2217/pgs.12.85
   Web of Science ®Google Scholar
• Epstein RS, Moyer TP, Aubert RE, et al. Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study). J Am Coll of Cardiol. 2010;55(25):2804–2812. doi:10.1016/j.jacc.2010.03.009
   PubMed Web of Science ®Google Scholar
• Nutescu EA, Drozda K, Bress AP, et al. Feasibility of implementing a comprehensive warfarin pharmacogenetics service. Pharmacotherapy. 2013;33(11):1156–1164. doi:10.1002/phar.1329
   PubMed Web of Science ®Google Scholar
• Jarrar YJ. Perception of primary care physicians’ toward pharmacogenetics in Jordan. Jordan Med J. 2019;53(3):81–89.
   Google Scholar
• Table of pharmacogenomic biomarkers in drug labeling. 2021. Available from: https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling. Accessed May 8, 2021.
   Google Scholar
• Stanek E, Sanders C, Taber KAJ, et al. Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey. Clin Pharmacol Ther. 2012;91(3):450–458. doi:10.1038/clpt.2011.306
   PubMed Web of Science ®Google Scholar
• Rogers EM. Diffusion of Innovations. Simon and Schuster; 2010.
   Google Scholar
• Sahin IJ. Detailed review of Rogers’ diffusion of innovations theory and educational technology-related studies based on Rogers’ theory. Turkish Online J Educ Technol. 2006;5(2):14–23.
   Google Scholar
• Taber KAJ, Dickinson BD. Pharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties. Pharmgenomics Pers Med. 2014;7:145.
   PubMedGoogle Scholar
• Accreditation Council for Pharmacy Education. Accreditation Standards and Key Elements for the Professional Program in Pharmacy Leading to the Doctor of Pharmacy Degree. Chicago, IL: Accreditation Council for Pharmacy Education; 2015.
   Google Scholar
• Adams SM, Anderson KB, Coons JC, et al. Advancing pharmacogenomics education in the Core PharmD curriculum through student personal genomic testing. Am J Pharm Educ. 2016;80(1):1. doi:10.5688/ajpe8013
   Web of Science ®Google Scholar
• Ma TKW, Lam -Y-Y, Tan VP, Yan BP. Variability in response to clopidogrel: how important are pharmacogenetics and drug interactions? Br J Clin Pharmacol. 2011;72(4):697–706. doi:10.1111/j.1365-2125.2011.03949.x
   PubMed Web of Science ®Google Scholar
• Roederer MW, Van Riper M, Valgus J, Knafl G, McLeod H. Knowledge, attitudes and education of pharmacists regarding pharmacogenetic testing. Pers Med. 2012;9(1):19–27. doi:10.2217/pme.11.87
   Web of Science ®Google Scholar
• Raosoft Io. Raosoft. Sample size calculator. 2014. Available from: http://www.raosoft.com/samplesize.html. Accessed May 8, 2021.
   Google Scholar
• Jordan Medical Association (JMA). Annual report Amman. 2021. Available from: http://www.jma.org.jo/Contents/Annual_Reportar.aspx. Accessed May 8, 2021.
   Google Scholar
• Stanek EJ, Sanders CL, Frueh FW. Physician awareness and utilization of Food and Drug Administration (FDA)-approved labeling for pharmacogenomic testing information. J Pers Med. 2013;3(2):111–123. doi:10.3390/jpm3020111
   PubMedGoogle Scholar
• Powell KP, Cogswell WA, Christianson CA, et al. Primary care physicians’ awareness, experience and opinions of direct-to-consumer genetic testing. J Genet Couns. 2012;21(1):113–126. doi:10.1007/s10897-011-9390-9
   PubMed Web of Science ®Google Scholar
• Dressler LG, Deal AM, Patel J, Markey J, Riper MV, McLeod HL. Cancer pharmacogenomics, adoption by oncologists and patient benefit. Per Med. 2014;11(2):143–153. doi:10.2217/pme.14.1
   Web of Science ®Google Scholar
• Shields AE, Blumenthal D, Weiss KB, Comstock CB, Currivan D, Lerman C. Barriers to translating emerging genetic research on smoking into clinical practice: perspectives of primary care physicians. J Gen Intern Med. 2005;20(2):131–138. doi:10.1111/j.1525-1497.2005.30429.x
   Web of Science ®Google Scholar
• Rahma AT, Elsheik M, Ali BR, et al. Knowledge, attitudes, and perceived barriers toward genetic testing and pharmacogenomics among healthcare workers in the United Arab Emirates: a Cross-Sectional Study. J Pers Med. 2020;10(4):216.
   Web of Science ®Google Scholar
• Albassam A, Alshammari S, Ouda G, Koshy S, Awad A, Rovers J. Knowledge, perceptions and confidence of physicians and pharmacists towards pharmacogenetics practice in Kuwait. PLoS One. 2018;13(9):e0203033. doi:10.1371/journal.pone.0203033
   PubMed Web of Science ®Google Scholar
• Walden LM, Brandl EJ, Changasi A, et al. Physicians‘ opinions following pharmacogenetic testing for psychotropic medication. Psychiatry Res. 2015;229(3):913–918. doi:10.1016/j.psychres.2015.07.032
   PubMed Web of Science ®Google Scholar
• Moaddeb J, Mills R, Haga SB. Community pharmacists’ experience with pharmacogenetic testing. J Am Pharm Assoc. 2015;55(6):587–594. doi:10.1331/JAPhA.2015.15017
   Google Scholar
• Klitzman R, Chung W, Marder K, et al. Attitudes and practices among internists concerning genetic testing. J Genet Couns. 2013;22(1):90–100. doi:10.1007/s10897-012-9504-z
   PubMed Web of Science ®Google Scholar
• Callegari C, Isella C, Caselli I, Poloni N, Ielmini M. Pharmacogenetic tests in reducing accesses to emergency services and days of hospitalization in bipolar disorder: a 2-year mirror analysis. J Pers Med. 2019;9(2):22. doi:10.3390/jpm9020022
   Web of Science ®Google Scholar