98
Views
0
CrossRef citations to date
0
Altmetric
Original Research

A Missense Variant in Granulysin is Associated with the Efficacy of Pegylated-Interferon-Alpha Therapy in Chinese Patients with HBeAg-Positive Chronic Hepatitis B

, , , , &
Pages 1505-1515 | Published online: 23 Nov 2021

References

  • Razavi-Shearer D, Gamkrelidze I, Nguyen MH. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. Lancet Gastroenterol Hepatol. 2018;3(6):383–403. doi:10.1016/S2468-1253(18)30056-6
  • Seto WK, Lo YR, Pawlotsky JM, Yuen MF. Chronic hepatitis B virus infection. Lancet. 2018;392(10161):2313–2324. doi:10.1016/S0140-6736(18)31865-8
  • Tang LSY, Covert E, Wilson E, Kottilil S. Chronic hepatitis B infection: a review. JAMA. 2018;319(17):1802–1813. doi:10.1001/jama.2018.3795
  • Marcellin P, Bonino F, Lau GK, et al. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a. Gastroenterology. 2009;136(7):2169–2179 e1–e4. doi:10.1053/j.gastro.2009.03.006
  • Lin SM, Yu ML, Lee CM, et al. Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma. J Hepatol. 2007;46(1):45–52. doi:10.1016/j.jhep.2006.08.021
  • Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560–1599.
  • Hou FQ, Song LW, Yuan Q, et al. Quantitative hepatitis B core antibody level is a new predictor for treatment response in HBeAg-positive chronic hepatitis B patients receiving peginterferon. Theranostics. 2015;5(3):218–226. doi:10.7150/thno.10636
  • Chen H, Sun J, Zhou B, et al. Variants in STAT4 associated with cure of chronic HBV infection in HBeAg-positive patients treated with pegylated interferon-alpha. Clin Gastroenterol Hepatol. 2020;18(1):196–204 e8. doi:10.1016/j.cgh.2019.04.044
  • Trepo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet. 2014;384(9959):2053–2063. doi:10.1016/S0140-6736(14)60220-8
  • Xun Z, Lin J, Yu Q, et al. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function. Cell Mol Immunol. 2021;18(2):461–471. doi:10.1038/s41423-020-00601-8
  • Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009;461(7262):399–401. doi:10.1038/nature08309
  • Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461(7265):798–801. doi:10.1038/nature08463
  • Prokunina-Olsson L, Muchmore B, Tang W, et al. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet. 2013;45(2):164–171. doi:10.1038/ng.2521
  • Jiang DK, Sun J, Cao G, et al. Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet. 2013;45(1):72–75. doi:10.1038/ng.2483
  • Jiang DK, Ma XP, Wu X, et al. Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis. Sci Rep. 2015;5:16278. doi:10.1038/srep16278
  • Jiang DK, Wu X, Qian J, et al. Genetic variation in STAT4 predicts response to interferon-alpha therapy for hepatitis B e antigen-positive chronic hepatitis B. Hepatology. 2016;63(4):1102–1111. doi:10.1002/hep.28423
  • Jiang DK, Ma XP, Yu H, et al. Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. Hepatology. 2015;62(1):118–128. doi:10.1002/hep.27794
  • Chen H, Sun J, Zhou B, et al. A missense variant in complement factor B (CFB) is a potential predictor of 24-week off-treatment response to PegIFNalpha therapy in Chinese HBeAg-positive chronic hepatitis B patients. Aliment Pharmacol Ther. 2020;51(4):469–478. doi:10.1111/apt.15624
  • Junqueira C, Barbosa CRR, Costa PAC, et al. Cytotoxic CD8(+) T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med. 2018;24(9):1330–1336. doi:10.1038/s41591-018-0117-4
  • Lu CC, Wu TS, Hsu YJ, et al. NK cells kill mycobacteria directly by releasing perforin and granulysin. J Leukoc Biol. 2014;96(6):1119–1129. doi:10.1189/jlb.4A0713-363RR
  • Zhang JY, Wang XM, Xing X, et al. Single-cell landscape of immunological responses in patients with COVID-19. Nat Immunol. 2020;21(9):1107–1118. doi:10.1038/s41590-020-0762-x
  • Sun Q, Burton RL, Lucas KG. Cytokine production and cytolytic mechanism of CD4(+) cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus-specific T-cell cultures. Blood. 2002;99(9):3302–3309. doi:10.1182/blood.V99.9.3302
  • Sparrow E, Bodman-Smith MD. Granulysin: the attractive side of a natural born killer. Immunol Lett. 2020;217:126–132. doi:10.1016/j.imlet.2019.11.005
  • Hata A, Zerboni L, Sommer M, et al. Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells. Viral Immunol. 2001;14(2):125–133. doi:10.1089/088282401750234501
  • Park GH, Kim KY, Cheong JY, Cho SW, Kwack K. Association of GNLY genetic polymorphisms with chronic liver disease in a Korean population. DNA Cell Biol. 2012;31(9):1492–1498. doi:10.1089/dna.2012.1709
  • Hou SH, Hu J, Zhang Y, Li QL, Guo JJ. Effects of interaction between genetic variants in human leukocyte antigen DQ and granulysin genes in Chinese Han subjects infected with hepatitis B virus. Microbiol Immunol. 2015;59(4):209–218. doi:10.1111/1348-0421.12239
  • Sun J, Xie Q, Tan D, et al. The 104-week efficacy and safety of telbivudine-based optimization strategy in chronic hepatitis B patients: a randomized, controlled study. Hepatology. 2014;59(4):1283–1292. doi:10.1002/hep.26885
  • Liang X, Cheng J, Sun Y, et al. Randomized, three-arm study to optimize lamivudine efficacy in hepatitis B e antigen-positive chronic hepatitis B patients. J Gastroenterol Hepatol. 2015;30(4):748–755. doi:10.1111/jgh.12835
  • Sun J, Ma H, Xie Q, et al. Response-guided peginterferon therapy in patients with HBeAg-positive chronic hepatitis B: a randomized controlled study. J Hepatol. 2016;65(4):674–682. doi:10.1016/j.jhep.2016.05.024
  • Hou FQ, Yin YL, Zeng LY, et al. Clinical effect and safety of pegylated interferon-alpha-2b injection (Y shape, 40 kD) in treatment of HBeAg-positive chronic hepatitis B patients. Zhonghua Gan Zang Bing Za Zhi. 2017;25(8):589–596.
  • van Campenhout MJH, van Bommel F, Pfefferkorn M, et al. Serum hepatitis B virus RNA predicts response to peginterferon treatment in HBeAg-positive chronic hepatitis B. J Viral Hepat. 2020;27(6):610–619. doi:10.1111/jvh.13272
  • Enomoto H, Aizawa N, Hasegawa K, et al. Possible relevance of PNPLA3 and TLL1 gene polymorphisms to the efficacy of PEG-IFN therapy for HBV-infected patients. Int J Mol Sci. 2020;21(9):3089. doi:10.3390/ijms21093089
  • Brouwer WP, Chan HLY, Lampertico P, et al. Genome-wide association study identifies genetic variants associated with early and sustained response to (pegylated) interferon in chronic hepatitis B patients: the GIANT-B study. Clin Infect Dis. 2019;69(11):1969–1979. doi:10.1093/cid/ciz084
  • Chan HLY, Messinger D, Papatheodoridis GV, et al. A baseline tool for predicting response to peginterferon alfa-2a in HBeAg-positive patients with chronic hepatitis B. Aliment Pharmacol Ther. 2018;48(5):547–555. doi:10.1111/apt.14862
  • Xie DY, Wang SM, Yang JM, et al. IFIT1 polymorphisms predict interferon-alpha treatment efficiency for hepatitis B virus infection. World J Gastroenterol. 2016;22(44):9813–9821. doi:10.3748/wjg.v22.i44.9813
  • Pei Y, Wang C, Yan SF, Liu LG. Past, current, and future developments of therapeutic agents for treatment of chronic hepatitis B virus infection. J Med Chem. 2017;60(15):6461–6479. doi:10.1021/acs.jmedchem.6b01442
  • Lampertico P, Vigano M, Colombo M. Why do I treat HBeAg-negative chronic hepatitis B patients with pegylated interferon? Liver Int. 2013;33(Suppl 1):157–163. doi:10.1111/liv.12064
  • Kao JH. HBeAg-positive chronic hepatitis B: why do I treat my patients with pegylated interferon? Liver Int. 2014;34(Suppl 1):112–119. doi:10.1111/liv.12400
  • Bazinet M, Pantea V, Placinta G, et al. Safety and efficacy of 48 weeks REP 2139 or REP 2165, tenofovir disoproxil, and pegylated interferon Alfa-2a in patients with chronic HBV infection naive to nucleos(t)ide therapy. Gastroenterology. 2020;158(8):2180–2194. doi:10.1053/j.gastro.2020.02.058
  • Liang KH, Hsu CW, Chang ML, Chen YC, Lai MW, Yeh CT. Peginterferon is superior to nucleos(t)ide analogues for prevention of hepatocellular carcinoma in chronic hepatitis B. J Infect Dis. 2016;213(6):966–974. doi:10.1093/infdis/jiv547
  • Walch M, Dotiwala F, Mulik S, et al. Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell. 2014;157(6):1309–1323. doi:10.1016/j.cell.2014.03.062
  • Gellert-Kristensen H, Richardson TG, Davey Smith G, Nordestgaard BG, Tybjaerg-Hansen A, Stender S. Combined effect of PNPLA3, TM6SF2, and HSD17B13 variants on risk of cirrhosis and hepatocellular carcinoma in the general population. Hepatology. 2020;72(3):845–856. doi:10.1002/hep.31238